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91. 发明授权

US07206632B2 Patient sensory response evaluation for neuromodulation efficacy rating 有权
标题翻译：患者感觉反应评估神经调节功效评定
公开(公告)号：US07206632B2
公开(公告)日：2007-04-17
申请号：US10768352
申请日：2004-01-30
申请人： Gary W. King
发明人： Gary W. King
IPC分类号： A61B5/00
CPC分类号： A61N1/36021 , A61N1/36025 , A61N1/36071 , G06F19/00 , G06F19/3481
摘要： The invention is directed to a technique for rating neuromodulation efficacy based on evaluation of the response of the patient to sensory stimuli with and without delivery of neuromodulation therapy. In addition, the invention may provide a system capable of delivering sensory stimuli on a quantitative basis in a coordinated manner with delivery of neuromodulation therapy. A device programmer may provide a platform for controlling delivery of the sensory stimuli, delivery of neuromodulation therapy, and generation of rating information for neuromodulation efficacy based on patient sensory response to the stimuli. In operation, the programmer controls application of selected sensory stimuli to the patient's body and records the patient's verbal or physiological responses to the stimuli. This invention can be used to be a diagnostic or prognostic test that a given neuromodulation therapy, such as neurostimulation or drug delivery, is and will be successful.
摘要翻译：本发明涉及一种用于评估神经调节功效的技术，其基于评估患者对具有和不具有神经调节治疗的神经调节治疗的感觉刺激的反应。此外，本发明可以提供能够以协调的方式与神经调节治疗的递送在定量基础上递送感觉刺激的系统。设备程序员可以提供用于控制感觉刺激的递送，神经调节治疗的递送以及基于患者对刺激的感觉反应来产生神经调节功效的评分信息的平台。在操作中，程序员控制所选择的感觉刺激对患者身体的应用，并将患者的口头或生理反应记录到刺激物上。本发明可以用于诊断或预后测试，给定的神经调节治疗，例如神经刺激或药物递送，并且将是成功的。

92. 发明授权

US07066891B2 Method and apparatus for gauging severity of myocardial ischemic episodes 失效
标题翻译：测量心肌缺血发作严重程度的方法和装置
公开(公告)号：US07066891B2
公开(公告)日：2006-06-27
申请号：US10325076
申请日：2002-12-20
申请人： Robert W. Stadler , Steven N. Lu , Gary W. King , Thomas R. Moore
发明人： Robert W. Stadler , Steven N. Lu , Gary W. King , Thomas R. Moore
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61N1/362 , G06F19/00
摘要： An implantable medical device (IMD) for gauging the severity of ischemia in a patient's heart includes a data collection module configured to receive data about the patient's heart, a data processing module configured to process the data to identify an episode of ischemia in the patient and to determine if the episode is stable or unstable, and a reporting module configured to provide an alarm to the patient if the episode is unstable. A method executable by an implantable medical device to detect ischemia in a human heart suitably includes the steps of receiving data about the heart at the implantable medical device, processing the data within the implantable medical device to determine the severity of ischemia, and providing a response from the implantable medical device to the patient if ischemia is indicated.
摘要翻译：用于测量患者心脏的严重程度的可植入医疗装置（IMD）包括：数据收集模块，被配置为接收关于患者心脏的数据;数据处理模块，被配置为处理所述数据以识别患者的局部缺血发作;以及以确定剧集是否稳定或不稳定，并且报告模块被配置为如果发作不稳定则向患者提供警报。可植入医疗装置可检测人心脏缺血的方法适当地包括以下步骤：在可植入医疗装置处接收关于心脏的数据，处理可植入医疗装置内的数据以确定局部缺血的严重性，并提供反应从可植入的医疗装置到患者，如果指示缺血。

93. 发明授权

US07010345B2 Method and apparatus to minimize effects of a cardiac insult 失效
公开(公告)号：US07010345B2
公开(公告)日：2006-03-07
申请号：US09999723
申请日：2001-10-26
申请人： Michael R. S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
发明人： Michael R. S. Hill , Gary W. King , Thomas J. Mullen , Xiaohong Zhou
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided at the spinal canal or on the chest wall of the patient through cutaneous electrodes.

94. 发明授权

US06795737B2 Techniques for positioning therapy delivery elements within a spinal cord or a brain 失效
标题翻译：将治疗递送元件定位在脊髓或脑内的技术
公开(公告)号：US06795737B2
公开(公告)日：2004-09-21
申请号：US09934001
申请日：2001-08-21
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N118
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment therapy, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。治疗递送元件此后可以用位置控制机构和/或位置控制器原位调整以改善期望的治疗疗法，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

95. 发明授权

US06714822B2 Apparatus and method for expanding a stimulation lead body in situ 失效
公开(公告)号：US06714822B2
公开(公告)日：2004-03-30
申请号：US10158521
申请日：2002-05-30
申请人： Gary W. King , Mark T. Rise , Michael J. Schendel , Richard Schallhorn
发明人： Gary W. King , Mark T. Rise , Michael J. Schendel , Richard Schallhorn
IPC分类号： A61N105
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/056
摘要： An implantable lead is provided with at least one extendable member to position therapy delivery elements, which may be electrodes or drug delivery ports, after the lead has been inserted into the body. The lead may formed as a resilient element which is contained in a retainer tube that may be removed to permit the lead to deploy. Alternatively, a non-resilient lead may be provided with a slotted retainer tube. A series of mechanical linkages for expanding and retracting the lead within the human body may be actuated with various mechanisms. A control system may be provided for closed-loop feedback control of the position of the extendable members. The invention also includes a method for expanding an implantable lead in situ.

96. 发明授权

US06505078B1 Technique for adjusting the locus of excitation of electrically excitable tissue 有权
公开(公告)号：US06505078B1
公开(公告)日：2003-01-07
申请号：US09523072
申请日：2000-03-10
申请人： Gary W. King , Robert Leinders , Greg Hrdlicka , Michael D. Baudino
发明人： Gary W. King , Robert Leinders , Greg Hrdlicka , Michael D. Baudino
IPC分类号： A61N136
CPC分类号： A61N1/36164 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/36017 , A61N1/36071 , A61N1/36167
摘要： The locus of electrically excitable tissue where action potentials are induced can be controlled using the physiological principle of electrotonus. In one embodiment, first and second pulses are applied to first and second electrodes, respectively, to generate first and second subthreshold potential areas, respectively, within the tissue. The locus within the tissue where action potentials are induced is determined by a superposition of the first and second subthreshold areas according to the physiological principle of electrotonus. In another embodiment, a two-dimensional array of electrodes are formed. The cathode may be positioned near the center of the two-dimensional array or may be left out. The first and second subthreshold areas may thereby be steered. An array of anodal rings may be used to contain the field of excitation.

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