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91. 外观设计

USD997382S1 Component of a holder and storage device for reagent tubes 有权
公开(公告)号：USD997382S1
公开(公告)日：2023-08-29
申请号：US29771377
申请日：2021-02-22
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG
设计人： Alex Weymann , Detlev Kramny
摘要： FIG. 1 is a front view of a component of a holder and storage device for reagent tubes in an open position;
FIG. 2 is a rear view thereof;
FIG. 3 is a right side view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a top view thereof;
FIG. 6 is a bottom view thereof;
FIG. 7 is a perspective view thereof; and
FIG. 8 is a front view of a component of the holder and storage device for reagent tubes in a closed position;
FIG. 9 is a rear view thereof;
FIG. 10 is a left side view thereof;
FIG. 11 is a right side view thereof;
FIG. 12 is a top view thereof; and,
FIG. 13 is a bottom view thereof.
The broken lines depict portions of the component of a holder and storage device for reagent tubes that form no part of the claimed design.

92. 发明公开

US20230250162A1 PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OR PREVENTION OF A C5-RELATED DISEASE AND A METHOD FOR TREATING OR PREVENTING A C5-RELATED DISEASE 审中-公开
公开(公告)号：US20230250162A1
公开(公告)日：2023-08-10
申请号：US18181641
申请日：2023-03-10
申请人： Chugai Seiyaku Kabushiki Kaisha , F. Hoffmann-La Roche AG
发明人： Kenji SHINOMIYA , Koichiro YONEYAMA , Norihito SHIBAHARA , Yoshinori TSUBOI , Taku FUKUZAWA , Kenta HARAYA , Zenjiro SAMPEI , Katrijn BOGMAN , Jean Eric CHAROIN
IPC分类号： C07K16/18 , A61P7/00 , A61P37/06
CPC分类号： C07K16/18 , A61P7/00 , A61P37/06 , A61K2039/505
摘要： The present invention relates to pharmaceutical compositions for use in the treatment or prevention of a C5-related disease and methods for treating or preventing a C5-related disease. The present invention further relates to dosages and administrations of anti-C5 antibody or pharmaceutical compositions containing the anti-C5 antibody.

93. 外观设计

USD993311S1 Package leaflet 有权
公开(公告)号：USD993311S1
公开(公告)日：2023-07-25
申请号：US35512869
申请日：2021-07-20
申请人： F. Hoffmann-La Roche AG
设计人： Rémy Kohler
摘要： The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
Fig. 1 is a front view of the package leaflet showing my new design; and,
Fig. 2 is another front view of the package leaflet.
Color is shown only in Figure 2 and is part of the claim as to Figure 2. Color is not part of the claim as to Figure 1.
The thickness of the package leaflet forms no part of the claimed design. The rear surface of the package leaflet is not claimed.

94. 外观设计

USD987849S1 Holder and storage device for reagent tubes 有权
公开(公告)号：USD987849S1
公开(公告)日：2023-05-30
申请号：US29771373
申请日：2021-02-22
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG
设计人： Alex Weymann , Detlev Kramny
摘要： FIG. 1 is a front view of a first embodiment of a holder and storage device for reagent tubes of the present invention;
FIG. 2 is a rear view thereof;
FIG. 3 is a left side view thereof;
FIG. 4 is a right side view thereof;
FIG. 5 is a top view thereof;
FIG. 6 is a bottom view thereof; and
FIG. 7 is a perspective view thereof;
FIG. 8 is a front view of a second embodiment of the holder and storage device for reagent tubes of the present invention;
FIG. 9 is a rear view thereof;
FIG. 10 is a left side view thereof;
FIG. 11 is a right side view thereof;
FIG. 12 is a top view thereof;
FIG. 13 is a bottom view thereof; and
FIG. 14 is a perspective view thereof;
FIG. 15 is a front view of a third embodiment of the holder and storage device for reagent tubes of the present invention;
FIG. 16 is a rear view thereof;
FIG. 17 is a right side view thereof;
FIG. 18 is a left side view thereof;
FIG. 19 is a top view thereof;
FIG. 20 is a bottom view thereof; and,
FIG. 21 is a perspective view thereof.
The broken lines depict portions of the holder and storage device for reagent tubes that form no part of the claimed design.

95. 发明申请

US20230114626A1 METHODS AND COMPOSITIONS FOR TREATING TRIPLE-NEGATIVE BREAST CANCER 有权
公开(公告)号：US20230114626A1
公开(公告)日：2023-04-13
申请号：US18065921
申请日：2022-12-14
申请人： Genentech, Inc. , F. Hoffmann-La Roche AG
发明人： Anh NGUYEN DUC , Stephen Chui
IPC分类号： A61K39/395 , A61K31/337 , A61K31/704 , A61K31/675 , A61K31/196 , A61K31/513 , A61K31/198 , A61K31/4184 , A61K9/00 , A61P35/00
摘要： The invention provides methods and compositions (e.g., pharmaceutical compositions) for treating breast cancer (e.g., TNBC (e.g., eTNBC)) in a subject. In some aspects, the methods include administering a treatment regimen including a PD-1 axis binding antagonist (e.g., an anti-PD-L1 antibody (e.g., atezolizumab) or an anti-PD-1 antibody), a taxane (e.g., nab-paclitaxel or paclitaxel), an anthracycline (e.g., doxorubicin or epirubicin), and an alkylating agent (e.g., a nitrogen mustard derivative (e.g., cyclophosphamide)) to the subject. In some aspects, the treatment regimen increases the subject's likelihood of having a pathologic complete response (pCR) as compared to treatment with the taxane, the anthracycline, and the alkylating agent without the PD-1 axis binding antagonist. Also provided are pharmaceutical compositions for use in treating breast cancer (e.g., TNBC (e.g., eTNBC)) in a subject.

96. 发明申请

US20220389103A1 DIAGNOSTIC AND THERAPEUTIC METHODS FOR TREATMENT OF HEMATOLOGIC CANCERS 有权
公开(公告)号：US20220389103A1
公开(公告)日：2022-12-08
申请号：US17774952
申请日：2020-11-05
申请人： Genentech, Inc. , F. Hoffmann-La Roche AG
发明人： Huang HUANG , Aparna RAVAL
IPC分类号： C07K16/28 , G01N33/574 , A61P35/00
摘要： Disclosed herein are diagnostic and therapeutic methods for the treatment of hematologic cancers, including multiple myeloma (MM), as well as related compositions. In particular, the invention relates to diagnostic and therapeutic methods for treatments involving a PD-L1 axis binding antagonist (e.g., an anti-PD-L1 antibody, e.g., atezolizumab) and an anti-CD38 antibody (e.g., an anti-CD38 antagonist antibody, e.g., daratumumab) for use in treating hematologic cancer (e.g., a multiple myeloma (MM), e.g., a relapsed or refractory MM).

97. 发明申请

US20220241260A9 Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists 有权
公开(公告)号：US20220241260A9
公开(公告)日：2022-08-04
申请号：US17083386
申请日：2020-10-29
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Ashish Chatterji , Jingjun Huang , Stephanie Koennings , Kal Lindenstruth , Harpreet Sandhu , Navnit Shah
IPC分类号： A61K31/4439 , A61K9/16 , A61K9/20 , A61K9/50 , A61K9/48 , A61K47/32 , A61K47/38 , A61K9/28
摘要： Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binder and fillers in either matrix pellet, matrix tablet or coated pellets. The compositions provide a pH-independent in vitro release profile with NMT 70% in one hour, NMT 85% in 4 hour, and NLT 80% in 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment-Resistant Depression (TRD) and Fragile X Syndrome.

98. 发明申请

US20220143064A1 TAU ANTISENSE OLIGOMERS AND USES THEREOF 有权
公开(公告)号：US20220143064A1
公开(公告)日：2022-05-12
申请号：US17367242
申请日：2021-07-02
申请人： F. Hoffmann-La Roche AG
发明人： Richard E. Olson , Angela M. Cacace , Peter Hagedorn , Anja Mølhart Høg , Marianne Lerbech Jensen , Niels Fisker Nielsen , Dong Li , Jeffrey M. Brown , Stephen E. Mercer
IPC分类号： A61K31/712 , C12N15/113 , A61P25/28
摘要： The present invention relates to oligomer compounds (oligomers), which target Tau mRNA in a cell, leading to reduced expression of Tau protein. Reduction of Tau protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.

99. 发明授权

US11118194B2 Modified site-directed modifying polypeptides and methods of use thereof 有权
公开(公告)号：US11118194B2
公开(公告)日：2021-09-14
申请号：US16061291
申请日：2016-12-15
申请人： The Regents of the University of California , F. Hoffmann-La Roche AG
发明人： Jennifer A. Doudna , Brett T. Staahl , Anirvan Ghosh
IPC分类号： C12N9/22 , C12P21/02 , C12N15/90 , C12P19/34
摘要： The present disclosure provides modified site-directed modifying polypeptides, and ribonucleoproteins comprising the modified polypeptides. The modified site-directed modifying polypeptides are modified for passive entry into target cells. The modified site-directed modifying polypeptides are useful in a variety of methods for target nucleic acid modification, which methods are also provided.

100. 发明申请

US20210052816A1 PREFILLED SYRINGE AND METHOD OF STERILIZING A PREFILLED SYRINGE 有权
公开(公告)号：US20210052816A1
公开(公告)日：2021-02-25
申请号：US16966500
申请日：2019-02-01
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Neil B. CAMMISH , Markus HEMMINGER , Cyrille BLINTZ , Mayumi BOWEN , Joshua HORVATH
IPC分类号： A61M5/315 , A61M5/31
摘要： A prefilled syringe is disclosed that includes a barrel, a stopper displaceable within and defining a sealed chamber in an interior of the barrel, a liquid filled in the chamber of the barrel, and a plunger extending within the barrel. The stopper expels the liquid out of the barrel via an orifice when being forwarded towards the orifice by the plunger such that a volume of the chamber is reduced. The plunger includes a proximal portion, a distal portion and a rod portion extending between the proximal portion and the distal portion. The plunger is shaped to form a pathway between an opening of the barrel and a segment where the proximal portion of the plunger is neighboring the stopper such that a sterilizing agent can be provided through the opening of the barrel to the segment where the proximal portion of the plunger is neighboring the stopper.

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