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91. 发明申请

US20080086041A1 Analyte Monitoring Device And Methods Of Use 审中-公开
公开(公告)号：US20080086041A1
公开(公告)日：2008-04-10
申请号：US11928968
申请日：2007-10-30
申请人： Adam Heller , Steven Drucker , Robert Jin , Jeffery Funderburk
发明人： Adam Heller , Steven Drucker , Robert Jin , Jeffery Funderburk
IPC分类号： A61B5/1468
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/0022 , A61B5/0031 , A61B5/076 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B5/6849 , A61B5/7405 , A61B5/742 , A61B5/743 , A61B5/7445 , A61B2560/0252 , A61B2560/0412 , A61B2560/063 , A61N1/08 , H04B1/707 , H04L1/0071
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

92. 发明申请

US20080086040A1 Analyte Monitoring Device And Methods Of Use 审中-公开
标题翻译：分析物监测装置及使用方法
公开(公告)号：US20080086040A1
公开(公告)日：2008-04-10
申请号：US11928891
申请日：2007-10-30
申请人： Adam Heller , Steven Drucker , Robert Jin , Jeffery Funderburk
发明人： Adam Heller , Steven Drucker , Robert Jin , Jeffery Funderburk
IPC分类号： A61B5/1468
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/0022 , A61B5/0031 , A61B5/076 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B5/6849 , A61B5/7405 , A61B5/742 , A61B5/743 , A61B5/7445 , A61B2560/0252 , A61B2560/0412 , A61B2560/063 , A61N1/08 , H04B1/707 , H04L1/0071
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
摘要翻译：分析物监测器包括传感器，传感器控制单元和显示单元。传感器具有例如基板，形成在基板中的凹陷通道，以及设置在凹陷通道中以形成工作电极的导电材料。传感器控制单元通常具有适于放置在皮肤上并适于接收电化学传感器的一部分的壳体。传感器控制单元还包括设置在壳体上并被配置为耦合到传感器上的两个或更多个接触垫的两个或更多个导电触头。发射器设置在壳体中并且耦合到多个导电接触件，用于传送使用传感器获得的数据。显示单元具有用于接收由传感器控制单元的发送器发送的数据的接收器和耦合到接收器的显示器，用于显示分析物水平的指示。分析物监测器也可以是药物递送系统的一部分，用于基于使用传感器获得的数据来改变分析物的水平。

93. 发明申请

US20080076997A1 ANALYTE MONITORING DEVICE AND METHODS OF USE 审中-公开
标题翻译：分析监测装置及其使用方法
公开(公告)号：US20080076997A1
公开(公告)日：2008-03-27
申请号：US11849200
申请日：2007-08-31
申请人： Thomas Peyser , Marc Taub , Susan Tall , Adam Heller
发明人： Thomas Peyser , Marc Taub , Susan Tall , Adam Heller
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/14532 , A61B5/412 , A61B2560/0252 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , H01L2924/00
摘要： In one aspect, a housing comprising, a data processing unit, a data communication unit in communication with the data processing unit to communicate one or more signals related to an analyte level of a person of interest, and an insulin inhalation unit to deliver an inhalable dose of insulin, where the data processing unit is configured determine one or more discrete inhalable insulin dose amount based on the one or more signals related to the analyte level is provided.
摘要翻译：一方面，一种壳体，包括：数据处理单元，与数据处理单元通信的数据通信单元，用于传达与感兴趣的人的分析物水平相关的一个或多个信号;以及胰岛素吸入单元，用于传送可吸入的提供了配置数据处理单元的胰岛素剂量，其基于与分析物水平相关的一个或多个信号来确定一个或多个离散可吸入的胰岛素剂量。

94. 发明申请

US20070244380A1 ANALYTE MONITORING DEVICE AND METHODS OF USE 有权
公开(公告)号：US20070244380A1
公开(公告)日：2007-10-18
申请号：US11766686
申请日：2007-06-21
申请人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
发明人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

95. 发明申请

US20070213610A1 Analyte Monitoring Device and Methods of Use 有权
公开(公告)号：US20070213610A1
公开(公告)日：2007-09-13
申请号：US11681730
申请日：2007-03-02
申请人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
发明人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

96. 发明授权

US07238442B2 Biological fuel cell and methods 有权
标题翻译：生物燃料电池和方法
公开(公告)号：US07238442B2
公开(公告)日：2007-07-03
申请号：US11277696
申请日：2006-03-28
申请人： Adam Heller
发明人： Adam Heller
IPC分类号： H01M8/16
CPC分类号： H01M8/16 , H01M4/9008 , H01M2250/30 , Y02B90/18 , Y02E60/527
摘要： A fuel cell has an anode and a cathode with anode enzyme disposed on the anode and cathode enzyme is disposed on the cathode. The anode is configured and arranged to electrooxidize an anode reductant in the presence of the anode enzyme. Likewise, the cathode is configured and arranged to electroreduce a cathode oxidant in the presence of the cathode enzyme. In addition, anode redox hydrogel may be disposed on the anode to transduce a current between the anode and the anode enzyme and cathode redox hydrogel may be disposed on the cathode to transduce a current between the cathode and the cathode enzyme.
摘要翻译：燃料电池具有阳极和阴极，阳极酶设置在阳极上，阴极酶设置在阴极上。阳极配置和布置成在阳极酶存在下使阳极还原剂电氧化。同样，阴极被配置和布置成在阴极酶的存在下电解还原阴极氧化剂。此外，阳极氧化还原水凝胶可以设置在阳极上以在阳极和阳极酶之间转换电流，并且阴极氧化还原水凝胶可以设置在阴极上以转换阴极和阴极酶之间的电流。

97. 发明申请

US20070149874A1 Analyte Monitoring Device and Methods of Use 有权
公开(公告)号：US20070149874A1
公开(公告)日：2007-06-28
申请号：US11683408
申请日：2007-03-07
申请人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
发明人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

98. 发明申请

US20070149873A1 Analyte Monitoring Device and Methods of Use 有权
公开(公告)号：US20070149873A1
公开(公告)日：2007-06-28
申请号：US11683371
申请日：2007-03-07
申请人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
发明人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke , Keith Friedman , Fredric Colman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

99. 发明申请

US20060118415A1 Electrochemical Analyte Sensor 有权
标题翻译：电化学分析物传感器
公开(公告)号：US20060118415A1
公开(公告)日：2006-06-08
申请号：US11276238
申请日：2006-02-20
申请人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke
发明人： James Say , Michael Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip Plante , Mark Vreeke
IPC分类号： G01N33/487
CPC分类号： A61B5/14532 , A61B5/01 , A61B5/14542 , A61B5/14546 , A61B5/14735 , A61B5/1486 , A61B5/14865 , C12Q1/001 , C12Q1/006
摘要： An electrochemical analyte sensor having conductive traces on a substrate is used to determine a level of analyte in in vitro or in vivo analyte-containing fluids. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the fluid.
摘要翻译：使用在基底上具有导电迹线的电化学分析物传感器来测定体外或体内含分析物的流体中分析物的水平。电化学分析物传感器包括设置在基板上的基板和导电材料，导电材料形成工作电极。在一些传感器中，导电材料设置在形成在传感器表面中的凹槽中。可以提供电子转移剂和/或催化剂以促进分析物或其水平取决于分析物水平的第二化合物的电解。在工作电极和参比电极或反/参比电极之间形成电位，所得到的电流是流体中分析物浓度的函数。

100. 发明授权

US07056664B1 Method of the electrochemical detection of nucleic acid oligomer hybrids 失效
标题翻译：核酸低聚物杂交体电化学检测方法
公开(公告)号：US07056664B1
公开(公告)日：2006-06-06
申请号：US09856543
申请日：1999-11-19
申请人： Gerhard Hartwich , Adam Heller
发明人： Gerhard Hartwich , Adam Heller
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to a method for the electrochemical detection of sequence-specific nucleic acid oligomer hybridization events. To this end single DNA/RNA/PNA oligomer strands which at one end are covalently joined to a support surface and at the other, free end, covalently linked to a redox pair, are used as hybridization matrix (probe). As a result of treatment with the oligonucleotide solution (target) to be examined, the electric communication between the conductive support surface and the redox pair bridged by the single-strand oligonucleotide, which communication initially is either absent or very weak, is modified. In case of hybridization, the electric communication between the support surface and the redox pair, which is now bridged by a hybridized double-strand oligonucleotide, is increased. This permits the detection of a hybridization event by electrochemical methods such as cyclic voltametry, amperometry or conductivity measurement.
摘要翻译：本发明涉及序列特异性核酸寡聚体杂交事件的电化学检测方法。为此，将单一的DNA / RNA / PNA低聚物链用作杂交基质（探针），其一端共价连接到载体表面，另一端与氧化还原对共价连接。作为待检测的寡核苷酸溶液（靶）的结果，导电性支持体表面与由单链寡核苷酸桥连的氧化还原对之间的电连通性最初不存在或非常弱。在杂交的情况下，载体表面和目前被杂交的双链寡核苷酸桥接的氧化还原对之间的电连通性增加。这允许通过电化学方法如循环伏安法，电流分析法或电导率测量来检测杂交事件。

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