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91. 发明申请

US20110052674A1 ANGIOTENSIN II RECEPTOR BLOCKER DERIVATIVES 审中-公开
标题翻译： ANGIOTENSIN II受体阻断剂衍生物
公开(公告)号：US20110052674A1
公开(公告)日：2011-03-03
申请号：US12866688
申请日：2009-02-19
申请人： Nicoletta Almirante , Alessia Nicotra , Valentino Mandelli , Stefano Biondi , Silvia Stefanini , Iyassu K. Sebhat , Michael Man-Chu Lo
发明人： Nicoletta Almirante , Alessia Nicotra , Valentino Mandelli , Stefano Biondi , Silvia Stefanini , Iyassu K. Sebhat , Michael Man-Chu Lo
IPC分类号： A61K9/127 , C07D403/10 , A61K31/41 , C07D403/14 , C07D471/04 , A61K31/519 , C07D257/04 , A61K31/4184 , C07D409/06 , A61K31/4178 , A61K9/12 , A61K9/28 , A61K9/48 , A61P9/00 , A61P13/12 , A61P27/06 , A61P25/00
CPC分类号： C07D403/10 , C07D403/14 , C07D405/14
摘要： New angiotensin II receptor blocker nitroderivatives of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof: and their use for treating cardiovascular, renal and chronic liver diseases, inflammatory processes and metabolic syndromes.
摘要翻译：通式（I）的新型血管紧张素II受体阻断剂硝基衍生物及其药学上可接受的盐或立体异构体及其用于治疗心血管，肾脏和慢性肝脏疾病，炎症过程和代谢综合征的用途。

92. 发明授权

US07883714B2 Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use 有权
标题翻译：硝化非甾体抗炎化合物，组合物和使用方法
公开(公告)号：US07883714B2
公开(公告)日：2011-02-08
申请号：US12636306
申请日：2009-12-11
申请人： Richard A. Earl , Maiko Ezawa , Xinqin Fang , David S. Garvey , Ricky D. Gaston , Subhash P. Khanapure , L. Gordon Letts , Chia-En Lin , Ramani R. Ranatunge , Stewart K. Richardson , Joseph D. Schroeder , Cheri A. Stevenson , Shiow-Jyi Wey
发明人： Richard A. Earl , Maiko Ezawa , Xinqin Fang , David S. Garvey , Ricky D. Gaston , Subhash P. Khanapure , L. Gordon Letts , Chia-En Lin , Ramani R. Ranatunge , Stewart K. Richardson , Joseph D. Schroeder , Cheri A. Stevenson , Shiow-Jyi Wey
IPC分类号： A61K9/00 , A61K31/21 , C07C203/04
CPC分类号： C07D493/04 , C07C291/02 , C07C311/17 , C07C317/18 , C07C323/12 , C07C327/28 , C07D209/18 , C07D211/22 , C07D211/56
摘要： The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.
摘要翻译：本发明描述了新型亚硝化非甾体抗炎药（NSAID）及其药学上可接受的盐，以及包含至少一种亚硝化NSAID的新组合物，以及任选地至少一种捐赠，转移或释放一氧化氮的化合物，刺激一氧化氮的内源性合成升高内源性内源性松弛因子水平，或是一氧化氮合酶的底物和/或至少一种治疗剂。本发明还提供了包含至少一种亚硝化NSAID和至少一种捐赠，转移或释放一氧化氮的化合物的新型组合物，提高内源性内皮衍生的舒张因子水平，刺激一氧化氮的内源性合成，或是一氧化氮的底物合酶和/或至少一种治疗剂。本发明还提供了包含至少一种亚硝化NSAID和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新型试剂盒。本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗胃肠道疾病; 促进伤口愈合; 用于治疗和/或预防由使用非甾体抗炎化合物引起的胃肠道，肾脏和/或呼吸道毒性物质; 用于治疗炎性疾病状态和/或病症; 并用于治疗和/或预防眼科疾病和/或病症。

93. 发明申请

US20100286264A1 COMPOSITION COMPRISING A NITROOXYDERIVATIVE OF ACETAMINOPHEN AND A ANTICONVULSANT DRUG FOR THE TREATMENT OF NEUROPATHIC PAIN 审中-公开
标题翻译：含有乙酰氨基酚的硝基苯甲酸和用于治疗神经病性疼痛的抗惊厥药物的组合物
公开(公告)号：US20100286264A1
公开(公告)日：2010-11-11
申请号：US12811358
申请日：2008-12-09
申请人： Francesco Impagnatiello , Juan F. Herrero , Francesca Benedini
发明人： Francesco Impagnatiello , Juan F. Herrero , Francesca Benedini
IPC分类号： A61K31/222 , A61P25/06 , A61P25/08
CPC分类号： A61K31/195 , A61K31/167 , A61K31/4535 , A61K2300/00
摘要： The present invention relates to compositions comprising a nitric oxide releasing paracetamol and an anticonvulsant drug. The compositions of the invention can be used use in the treatment of neuropathic pain in particular diabetic neuropathic pain, painful post-infarct syndrome, pain caused by chemotherapeutic treatment or pain arising from infections by viral agents.
摘要翻译：本发明涉及包含一氧化氮释放对乙酰氨基酚和抗惊厥药物的组合物。本发明的组合物可用于治疗神经性疼痛，特别是糖尿病性神经性疼痛，疼痛性梗塞后综合征，由化学治疗引起的疼痛或由病毒感染引起的疼痛。

94. 发明申请

US20100266683A1 NEW SELF EMULSIFYING DRUG DELIVERY SYSTEM 审中-公开
标题翻译：新型自动感染药物输送系统
公开(公告)号：US20100266683A1
公开(公告)日：2010-10-21
申请号：US12768820
申请日：2010-04-28
申请人： Christina HOLMBERG , Britta Siekmann
发明人： Christina HOLMBERG , Britta Siekmann
IPC分类号： A61K31/24 , A61K9/64 , A61P29/00
CPC分类号： A61K9/4866 , A61K31/216
摘要： The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising (i) a compound of the formula (I) (ii) one or more surfactants; (iii) optionally an oil or semi-solid fat; said composition forming an in-situ oil-in-water emulsion upon contact with aqueous media such as gastrointestinal fluids. The composition may optionally also comprise one or more short-chain alcohols. The pharmaceutical composition is useful in the treatment of pain and inflammation.
摘要翻译：本发明要求并公开了一种适于口服给药的药物组合物，其形式为乳液预浓缩物，其包含（i）式（I）化合物（ii）一种或多种表面活性剂; （iii）任选的油或半固体脂肪; 所述组合物在与含水介质如胃肠液接触时形成原位水包油乳液。组合物可以任选地还包含一种或多种短链醇。该药物组合物可用于治疗疼痛和炎症。

95. 发明授权

US07815933B2 Self emulsifying drug delivery system 失效
标题翻译：自乳化药物输送系统
公开(公告)号：US07815933B2
公开(公告)日：2010-10-19
申请号：US10488585
申请日：2002-09-05
申请人： Christina Holmberg
发明人： Christina Holmberg
IPC分类号： A61K9/127 , A61K9/10 , A61K9/107
CPC分类号： A61K31/407 , A61K9/1075 , A61K9/4858 , A61K31/21 , A61K31/381 , A61K31/403 , A61K31/4035 , A61K31/405 , A61K31/685 , Y10S514/937 , Y10S514/938 , A61K2300/00
摘要： The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising (i) one or more NO-releasing NSAID(s); (ii) one or more surfactants, of which at least one is phospholipid; said composition forming an in-situ oil-in-water emulsion upon contact with gastrointestinal fluids. The composition may optionally also comprise an additional oil or semi-solid fat. Further, one or more short-chain alcohols can optionally be included in the composition. Also within the scope of the invention is a combination with a proton pump inhibitor. The pharmaceutical composition is useful in the treatment of pain and inflammation. Further within the scope of the invention is kit comprising a pharmaceutical composition according to the invention in a unit dosage form, in combination with a proton pump inhibitor, and said proton pump inhibitor is enteric coated.
摘要翻译：本发明要求并且公开了一种适于口服给药的药物组合物，其形式为乳液预浓缩物，其包含（i）一种或多种NO释放NSAID; （ii）一种或多种表面活性剂，其中至少一种是磷脂; 所述组合物在与胃肠液接触时形成原位水包油乳剂。组合物可以任选地还包含另外的油或半固体脂肪。此外，一种或多种短链醇可以任选地包括在组合物中。也在本发明的范围内是与质子泵抑制剂的组合。该药物组合物可用于治疗疼痛和炎症。进一步在本发明的范围内的是包含根据本发明的药物组合物的单位剂型与质子泵抑制剂组合的试剂盒，所述质子泵抑制剂是肠溶包衣的。

96. 发明申请

US20100179192A1 USE OF NITRIC OXIDE RELEASING COMPOUNDS IN THE TREATMENT OF CHRONIC PAIN 审中-公开
标题翻译：硝酸氧化物释放化合物在治疗慢性疼痛中的应用
公开(公告)号：US20100179192A1
公开(公告)日：2010-07-15
申请号：US12663497
申请日：2008-06-24
申请人： Francesco Impagnatiello , Daniela Ronchetti , Ennio Ongini , Francesca Benedini
发明人： Francesco Impagnatiello , Daniela Ronchetti , Ennio Ongini , Francesca Benedini
IPC分类号： A61K31/21 , C07C203/00 , A61K31/4535 , A61P29/00
CPC分类号： C07C203/04 , A61K31/192 , C07C235/34
摘要： The present invention relates to nitrooxyderivative of antioxidant compounds of formula (I) and pharmaceutically acceptable salts or stereoisomers thereof for the treatment of chronic pain, in particular chronic neuropathic pain. The invention also describes composition comprising a nitrooxyderivative of a antioxidant compound of formula (I) and an analgesic drugs.
摘要翻译：本发明涉及用于治疗慢性疼痛，特别是慢性神经性疼痛的式（I）的抗氧化剂化合物及其药学上可接受的盐或立体异构体的硝基氧化活性。本发明还描述了包含式（I）的抗氧化剂化合物的硝基氧基衍生物和镇痛药物的组合物。

97. 发明申请

US20100174075A1 USE OF NITRIC OXIDE-RELEASING STATINS IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 审中-公开
标题翻译：硝酸氧化酶释放统计学处理肺动脉高压症的应用
公开(公告)号：US20100174075A1
公开(公告)日：2010-07-08
申请号：US12599240
申请日：2008-05-12
申请人： John Wharton , Angela Monopoli
发明人： John Wharton , Angela Monopoli
IPC分类号： C07D239/42 , C07D209/10 , C07D207/34 , C07C69/34 , C07D213/02
CPC分类号： A61K31/22 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/505
摘要： The present invention relates to the use of nitric oxide-releasing statins of formula (I) for the treatment of pulmonary arterial hypertension.
摘要翻译：本发明涉及式（I）的一氧化氮释放他汀类药物用于治疗肺动脉高压的用途。

98. 发明申请

US20100152274A1 CRYSTALLINE FORMS OF ATORVASTATIN 4-(NITROOXY) BUTYL ESTER 审中-公开
标题翻译： 4-（硝基）丁酯酯的结晶形式
公开(公告)号：US20100152274A1
公开(公告)日：2010-06-17
申请号：US12594511
申请日：2008-03-19
申请人： Francesca Benedini , Stefano Biondi , Annalisa Bonfanti , Fabio Nicoli
发明人： Francesca Benedini , Stefano Biondi , Annalisa Bonfanti , Fabio Nicoli
IPC分类号： A61K31/40 , C07D207/327 , A61P9/00 , A61P29/00 , A61P7/02 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07D207/34
摘要： The present invention relates to two crystalline forms designated as form A and form B, of (βR,δR)-2(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbon-yl]-1H-pyrrole-1-heptanoic acid 4-(nitrooxy)butyl ester (atorvastatin 4-(nitrooxy)butyl ester), represented by the formula (I), The invention also relates to processes for the preparation of the forms A and B, to pharmaceutical compositions comprising the two forms, and to their use for treating and/or preventing acute coronary syndromes, stroke, neurodegenerative disorders, such as Alzheimer's and Parkinson's disease as well as autoimmune diseases, such as multiple sclerosis.
摘要翻译：本发明涉及两种结晶形式，其命名为（＆bgr; R，δR）-2（4-氟苯基） - ，b-，δ-二羟基-5-（1-甲基乙基）-3-苯基的形式A和形式B -4 - [（苯基氨基）碳基] -1H-吡咯-1-庚酸4-（硝基氧基）丁酯（阿托伐他汀4-（硝基氧基）丁酯），由式（I）表示，本发明还涉及用于制备形式A和B的方法，包含两种形式的药物组合物及其用于治疗和/或预防急性冠状动脉综合征，中风，神经变性疾病如阿尔茨海默病和帕金森病以及自身免疫疾病的用途，如多发性硬化症。

99. 发明授权

US07718656B2 Prostaglandin derivatives 失效
标题翻译：前列腺素衍生物
公开(公告)号：US07718656B2
公开(公告)日：2010-05-18
申请号：US11478129
申请日：2006-06-28
申请人： Francesca Benedini , Valerio Chiroli , Wesley Kwan Mung Chong , Achim Hans-Peter Krauss , Michael Ross Niesman , Ennio Ongini
发明人： Francesca Benedini , Valerio Chiroli , Wesley Kwan Mung Chong , Achim Hans-Peter Krauss , Michael Ross Niesman , Ennio Ongini
IPC分类号： A61K31/495 , A61K31/445 , A61K31/215 , C07D241/04 , C07D211/06 , C07C69/76
CPC分类号： C07C405/00 , C07D207/08 , C07D295/12 , C07D295/13
摘要： Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译：描述了具有改善的药理活性和增强的耐受性的前列腺素酰胺的硝基衍生物。可用于治疗青光眼和高眼压症。

100. 发明授权

US07696230B2 Drugs for chronic pains 失效
标题翻译：药物用于慢性疼痛
公开(公告)号：US07696230B2
公开(公告)日：2010-04-13
申请号：US11705752
申请日：2007-02-14
申请人： Piero Del Soldato , Ennio Ongini
发明人： Piero Del Soldato , Ennio Ongini
IPC分类号： A61K31/445 , C07D409/00
CPC分类号： A61K31/4184 , A61K31/21 , A61K31/425 , A61K31/55 , A61K31/60 , A61K31/7024 , C07C203/04 , C07C291/02
摘要： Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A-(B)b0-(C)c0—NO2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R-T1-, wherein R is the radical of an analgesic drug for the chronic pain, in particular for the neuropathic pain; B is such that its precursor is selected from aminoacids, hydroxyacids, polyalcohols, compounds containing at least one acid function; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
摘要翻译：具有以下通式（I）的硝基氧化衍生化合物或其盐：A-（B）b0-（C）c0-NO2其中：c0为整数，为0或1，b0为整数，为0或1 A = R-T1-，其中R是用于慢性疼痛的镇痛药物的基团，特别是神经性疼痛; B的前体选自氨基酸，羟基酸，多元醇，含有至少一个酸官能团的化合物; C是含有脂族，杂环或芳族基团的二价基团。

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