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1. 发明授权

US11572351B1 Bis-Schiff base compositions and formulations 有权
公开(公告)号：US11572351B1
公开(公告)日：2023-02-07
申请号：US17332237
申请日：2021-05-27
申请人： Systima Technologies, Inc.
发明人： Richard D. Hreha , Tat H. Tong
IPC分类号： C07D307/34
摘要： A chemical formulation having at least one solvent and a chemical having the structure of Formula (I): where R includes at least one aromatic moiety, and X and X′ may both or independently include an aromatic moiety, an aliphatic moiety, or a hydrogen.

2. 发明授权

US11096931B2 Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases 有权
公开(公告)号：US11096931B2
公开(公告)日：2021-08-24
申请号：US16798199
申请日：2020-02-21
申请人： Janssen Sciences Ireland Unlimited Company
发明人： Stefaan Julien Last , Bart Rudolf Romanie Kesteleyn , Sandrine Céline Grosse , Tim Hugo Maria Jonckers , Jan Martin Berke , Geerwin Yvonne Paul Haché , Edgar Jacoby , Carolina Martinez Lamenca , Morgan Charles R. Lecomte , Abdellah Tahri , Sarah Sauviller , Karen Maria Vergauwen
IPC分类号： A61K31/4439 , C07D403/12 , C07D405/14 , C07D307/34 , A61P31/20 , A61K31/4192 , C07D409/14 , A61K31/40 , A61K31/41 , A61K31/4178 , C07D401/14 , C07D207/34
摘要： The application relates to amide derivatives, processes for their preparation, pharmaceutical compositions, and their uses, more particularly their uses in treating chronic hepatitis B virus (HBV) infection.

3. 发明申请

US20170233327A1 A METHOD AND APPARATUS FOR PRODUCING BIOFUEL IN AN OSCILLATING FLOW PRODUCTION LINE UNDER SUPERCRITICAL FLUID CONDITIONS 审中-公开
公开(公告)号：US20170233327A1
公开(公告)日：2017-08-17
申请号：US15324914
申请日：2015-07-09
申请人： Ib JOHANSEN
发明人： Ib JOHANNSEN , Anders Peter Stubkjær ADAMSEN , Bjørn Sjøren KILSGAARD , Viktor MILKEVYCH
IPC分类号： C07C67/08 , C07C51/00 , C07C37/00 , C10L1/02 , C07D307/34
CPC分类号： C07C67/08 , B01J2219/00164 , C07C37/004 , C07C51/00 , C07D307/34 , C10L1/02 , C10L1/026 , C10L8/00 , C10L2200/0476 , C10L2270/026 , C10L2290/06 , Y02E50/13 , Y02P20/544
摘要： The invention discloses a method for producing bio-fuel (BF) from a high-viscosity biomass using thermo-chemical conversion of the biomass in a production line (10) with pumping means (PM), heating means (HM) and cooling means (CM). The method has the steps of 1) operating the pumping means, the heating means and the cooling means so that the production line is under supercritical fluid conditions (SCF) to induce biomass conversion in a conversion zone (CZ) within the production line, and 2) operating the pumping means so that at least part of the production line is in an oscillatory flow (OF) mode. The invention is advantageous for providing an improved method for producing biofuel from a high-viscosity biomass. This is performed by an advantageous combination of two operating modes: supercritical fluid (SCF) conditions and oscillatory flow (OF).

4. 发明授权

US09650354B2 Process for producing furan and its derivatives 有权
公开(公告)号：US09650354B2
公开(公告)日：2017-05-16
申请号：US14392288
申请日：2014-06-25
申请人： Council of Scientific & Industrial Research
发明人： Srinivas Darbha , Bhogeswararao Seemala
IPC分类号： C07D307/34 , C07D307/36 , B01J21/04 , B01J23/44
CPC分类号： C07D307/36 , B01J21/04 , B01J23/44
摘要： An efficient, hydrogen gas-free, high yielding, moderate temperature and safe-to-handle process for producing furan and its derivatives from furfural, which comprises contacting furfural and water-isopropanol mixture with a supported Pd or Pt catalyst at a temperature in the range of 200-250° C., is reported.

5. 发明授权

US09284290B2 Process for the production of the mixture 2,4 furandicarboxylic acid (FDCA) and 2,5 furandicarboxylic acid via disproportionation reaction 有权
标题翻译：通过歧化反应生产混合物2,4-呋喃二羧酸（FDCA）和2,5-呋喃二羧酸的方法
公开(公告)号：US09284290B2
公开(公告)日：2016-03-15
申请号：US14368676
申请日：2011-12-29
申请人： Jacco van Haveren , Shanmugam Thiyagarajan , Augusto Teruo Morita
发明人： Jacco van Haveren , Shanmugam Thiyagarajan , Augusto Teruo Morita
IPC分类号： C07D307/34 , C07D307/68 , C08G63/181
CPC分类号： C07D307/68 , C08G63/181
摘要： The present invention refers to a process for production of a mixture including 2,4-furandicarboxylic acid (2,4-FDCA) and 2,5 furandicarboxylic acid (2,5-FDCA) through the disproportionation route, using as base compounds oxidation products of furfural. This invention also relates to a process for production of 2,4-FDCA as a result of a disproportionation route and the use of 2,4-FDCA as a monomer or comonomer to synthesize esters or any compounds which can generate macromolecules, such as polyesters.
摘要翻译：本发明涉及通过歧化路线生产包含2,4-呋喃二羧酸（2,4-FDCA）和2,5-呋喃二羧酸（2,5-FDCA）的混合物的方法，使用氧化产物的糠醛本发明还涉及作为歧化途径的结果生产2,4-FDCA的方法和使用2,4-FDCA作为单体或共聚单体合成酯或任何可产生大分子的化合物，例如聚酯。

6. 发明授权

US09249118B2 Purifying crude furan 2,5-dicarboxylic acid by hydrogenation 有权
公开(公告)号：US09249118B2
公开(公告)日：2016-02-02
申请号：US14309010
申请日：2014-06-19
申请人： Eastman Chemical Company
发明人： Mesfin Ejerssa Janka , Charles Edwan Sumner, Jr. , Shane Kipley Kirk , Ashfaq Shahanawaz Shaikh , Kenny Randolph Parker
IPC分类号： A61K31/341 , C07D307/34 , C07D307/68
CPC分类号： C07D307/68
摘要： A process for purifying a crude furan 2,5-dicarboxylic acid composition (cFDCA) by hydrogenation of a FDCA composition dissolved in a hydrogenation solvent such as water, and hydrogenating under mild conditions, such as at a temperature within a range of 130° C. to 225° C. by contacting the solvated FDCA composition with hydrogen in the presence of a hydrogenation catalyst under a hydrogen partial pressure within a range of 10 psi to 900 psi. A product FDCA composition is produced having a low amount of tetrahydrofuran dicarboxylic acid, a low b*, and a low amount of 5-formyl furan-2-carboxylic acid (FFCA).

7. 发明授权

US08901326B2 Preparation of aminomethyl furans and alkoxymethyl furan derivatives from carbohydrates 有权
标题翻译：从碳水化合物制备氨基甲基呋喃和烷氧基甲基呋喃衍生物
公开(公告)号：US08901326B2
公开(公告)日：2014-12-02
申请号：US14085080
申请日：2013-11-20
申请人： Archer Daniels Midland Company
发明人： Stephen Howard , Alexandra Sanborn
IPC分类号： C07D307/04 , C07D307/34 , C07D307/42 , C07D307/14 , C07D307/12 , C07D307/44 , C07D307/52
CPC分类号： C07D307/12 , C07D307/14 , C07D307/42 , C07D307/44 , C07D307/52
摘要： Described herein are single step methods of making various classes of alkylamine derivatives of furan and tetrahydrofuran by simultaneous contact of a sugar with H2, an acid catalyst and hydrogenation catalyst in the presence of an alkylamide solvent. The hydrogenation catalyst is a heterogeneous catalyst comprising a metal selected from the group consisting of Pt, Pd, and nickel. The acid catalysts may be homogeneous mineral acid or a heterogeneous acid catalyst on substrate. In a preferred practice the two catalysts are provided on a common heterogeneous bifunctional support. Using similar combinations of acid and hydrogenation catalysts, there is also described single step methods for making furandimethanol by simultaneously contacting a hexose with the two separate catalysts in the presence of H2 in an aprotic solvent, such as dimethylformamide. With the same catalyst system and similar reaction conditions, 2, 5 furan dialkylethers can also be made in a single step when the solvent includes an ROH alcohol.
摘要翻译：本文描述了通过在烷基酰胺溶剂存在下，通过糖与H 2，酸催化剂和氢化催化剂的同时接触来制备呋喃和四氢呋喃的各种类型的烷基胺衍生物的单步方法。氢化催化剂是包含选自Pt，Pd和镍的金属的多相催化剂。酸催化剂可以是基质上均相无机酸或多相酸催化剂。在优选的实践中，两种催化剂提供在共同的异构双功能载体上。使用酸和氢化催化剂的类似组合，还描述了通过在非质子溶剂如二甲基甲酰胺中在H 2存在下同时使己糖与两种分离的催化剂接触来制备呋喃二甲醇的单步方法。在相同的催化剂体系和类似的反应条件下，当溶剂包括ROH醇时，也可以在一个步骤中制备2,5,5-呋喃二烷基醚。

8. 发明授权

US08350058B2 Method for producing alkenyl succinic anhydrides 有权
标题翻译：烯基琥珀酸酐的制备方法
公开(公告)号：US08350058B2
公开(公告)日：2013-01-08
申请号：US11793431
申请日：2005-12-03
申请人： Dirk Leinweber , Tobias Rau
发明人： Dirk Leinweber , Tobias Rau
IPC分类号： C07D307/36 , C07D307/34
CPC分类号： C07C51/353 , C07C55/02
摘要： The invention relates to a method for producing alkenyl succinic anhydrides of formula (1), in which R represents a C4 to C250 alkylene radical that can be linear or branched. The method involves the reaction of maleic acid, maleic anhydride, fumaric acid or esters thereof and an alkene which contains 4-250 carbon atoms at from 150 to 250° C. in the presence of a synergistic mixture of a primary antioxidant, a secondary antioxidant, and a metal deactivator.
摘要翻译：本发明涉及一种制备式（1）烯基琥珀酸酐的方法，其中R表示可以是直链或支链的C4至C250亚烷基。该方法包括在主抗氧化剂，辅助抗氧化剂的协同混合物存在下，在150-250℃下马来酸，马来酸酐，富马酸或其酯与含有4-250个碳原子的烯烃反应，和金属钝化剂。

9. 发明申请

US20120165560A1 VAPOR PHASE DECARBONYLATION PROCESS 有权
标题翻译：蒸气相脱氮工艺
公开(公告)号：US20120165560A1
公开(公告)日：2012-06-28
申请号：US13392541
申请日：2010-08-31
申请人： Ronnie Ozer
发明人： Ronnie Ozer
IPC分类号： C07D307/34
CPC分类号： C07D307/36
摘要： A process is provided for the synthesis of furan and related compounds by vapor-phase decarbonylation of furfural and derivatives, using a palladium/metal aluminate catalyst. The use of such catalysts, which are inherently less acidic than alumina, results in improved lifetime and high productivity. The compounds so produced can be used as starting materials for industrial chemicals for use as pharmaceuticals, herbicides, stabilizers, and polymers such as polyether ester elastomers and polyurethane elastomers.
摘要翻译：提供了通过使用钯/金属铝酸盐催化剂通过糠醛和衍生物的气相脱羰来合成呋喃和相关化合物的方法。使用这种比氧化铝固有地酸性低的催化剂可以改善寿命和高生产率。如此生产的化合物可用作用作药物，除草剂，稳定剂和聚合物如聚醚酯弹性体和聚氨酯弹性体的工业化学品的起始材料。

10. 发明申请

US20110207739A1 Novel 1, 2-Disubstituted Amido-anthraquinone Derivatives, Preparation Method and application thereof 有权
标题翻译：新型1,2-二取代酰胺 - 蒽醌衍生物，其制备方法和应用
公开(公告)号：US20110207739A1
公开(公告)日：2011-08-25
申请号：US12712644
申请日：2010-02-25
申请人： Hsu-Shan HUANG
发明人： Hsu-Shan HUANG
IPC分类号： A61K31/506 , C07C233/00 , A61K31/165 , C07D307/34 , A61K31/34 , C07D333/22 , A61K31/381 , C07D261/06 , A61K31/42 , C07D241/04 , A61K31/495 , C07D213/56 , A61K31/44 , C07D207/08 , A61K31/40 , C07D211/30 , A61K31/445 , C07D491/10 , A61K31/438 , C07D265/30 , A61K31/5375 , C07D279/12 , A61K31/54 , C07D401/04 , A61K31/496 , A61P35/00
CPC分类号： C07C233/43 , C07C233/44 , C07C233/62 , C07C233/80 , C07C235/24 , C07C237/10 , C07C2601/02 , C07C2601/14 , C07C2603/24 , C07D213/38 , C07D213/74 , C07D239/42 , C07D261/18 , C07D295/15 , C07D307/68 , C07D317/28 , C07D333/38 , C07D491/10
摘要： A series of novel 1,2-disubstituted amido-anthraquinone derivatives, and the preparation method and application of said derivatives. Said application includes said derivatives with therapeutically effective amount being prepared into pharmaceutical compositions for inhibition of cancer cell growth, further treating cancer.
摘要翻译：一系列新型1,2-二取代酰胺 - 蒽醌衍生物及其衍生物的制备方法和应用。所述应用包括具有治疗有效量的所述衍生物被制备成用于抑制癌细胞生长的药物组合物，进一步治疗癌症。

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