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1. 发明授权

US08729293B2 Fatty acid acetylated salicylates and their uses 有权
公开(公告)号：US08729293B2
公开(公告)日：2014-05-20
申请号：US13427644
申请日：2012-03-22
申请人： Jill C. Milne , Michael R. Jirousek , Jean E. Bemis , Jesse J. Smith
发明人： Jill C. Milne , Michael R. Jirousek , Jean E. Bemis , Jesse J. Smith
IPC分类号： C07C269/00 , A61K31/195 , C07C229/02
CPC分类号： A61K31/609 , A61K31/60 , C07C69/86 , C07C69/94 , C07C233/18 , C07C233/49 , C07C233/55 , C07C235/52 , C07C235/60 , C07C237/22 , C07C271/28 , C07C275/42 , C07D295/182 , C07D295/192
摘要： The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.

2. 发明授权

US08692000B2 Phase transfer catalysts 失效
标题翻译：相转移催化剂
公开(公告)号：US08692000B2
公开(公告)日：2014-04-08
申请号：US13881819
申请日：2011-10-27
申请人： Choon Hong Tan , Kuo Wei Huang , Ting Ma , Xiao Fu
发明人： Choon Hong Tan , Kuo Wei Huang , Ting Ma , Xiao Fu
IPC分类号： C07D403/12 , C07C229/02
CPC分类号： B01J31/0275 , B01J31/0244 , B01J31/0271 , C07C251/24 , C07D233/44 , C07D235/30 , C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24
摘要： Compounds of formula (I): wherein R1 to R8, and X− are defined herein. Also disclosed are methods of making and using these compounds.
摘要翻译：式（I）化合物：其中R 1至R 8和X如本文所定义。还公开了制备和使用这些化合物的方法。

3. 发明授权

US08481044B2 Neprilysin inhibitors 有权
标题翻译： Neprilysin抑制剂
公开(公告)号：US08481044B2
公开(公告)日：2013-07-09
申请号：US13398015
申请日：2012-02-16
申请人： Melissa Fleury , Roland Gendron , Adam D. Hughes
发明人： Melissa Fleury , Roland Gendron , Adam D. Hughes
IPC分类号： A61K9/00 , A61K31/33 , A61K33/36 , A61P35/00 , C07C229/02 , C07C271/10
CPC分类号： A61K31/675 , A61K31/351 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/50 , A61K31/505 , A61K31/5377 , A61K45/06 , C07B2200/07 , C07C229/34 , C07C271/22 , C07D231/14 , C07D231/18 , C07D231/20 , C07D233/70 , C07D233/90 , C07D235/08 , C07D237/14 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/18 , C07D261/12 , C07D263/18 , C07D295/10 , C07D309/32 , C07D309/40 , C07D319/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07F9/6518
摘要： In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译：一方面，本发明涉及具有下式的化合物：其中R 1 -R 6，a，b，Z和X如说明书中所定义，或其药学上可接受的盐。这些化合物具有去血清抑制活性。另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

4. 发明授权

US08449890B2 Neprilysin inhibitors 有权
标题翻译： Neprilysin抑制剂
公开(公告)号：US08449890B2
公开(公告)日：2013-05-28
申请号：US13398027
申请日：2012-02-16
申请人： Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
发明人： Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
IPC分类号： A61K9/00 , A61K31/33 , A61K33/36 , A61P35/00 , C07C229/02 , C07C271/10
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/505 , A61K45/06 , C07C243/28 , C07C271/22 , C07C2601/02 , C07D231/14 , C07D231/20 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/10 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D403/04 , C07D487/04
摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译：一方面，本发明涉及具有下式的化合物：其中R1，R2a，R2b，R3-R6，a，b，Z和X如说明书中所定义，或其药学上可接受的盐。这些化合物具有去血清抑制活性。另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

5. 发明授权

US08367108B2 Functionalized non-phenolic amino acids and absorbable polymers therefrom 有权
公开(公告)号：US08367108B2
公开(公告)日：2013-02-05
申请号：US11847042
申请日：2007-08-29
申请人： Rao S. Bezwada
发明人： Rao S. Bezwada
IPC分类号： A61K9/00 , A61F2/00 , A61M37/00 , C07C229/02 , C08L89/00
CPC分类号： A61K47/34 , A61K9/0024 , A61L27/227 , A61L27/54 , A61L27/58 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/00 , C07C235/12 , Y10T428/1362 , Y10T428/1397 , Y10T442/40 , Y10T442/50
摘要： The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

6. 发明授权

US08217137B2 Fullerene-based amino acids 有权
标题翻译：富勒烯基氨基酸
公开(公告)号：US08217137B2
公开(公告)日：2012-07-10
申请号：US10585277
申请日：2005-01-14
申请人： Andrew R. Barron , Jianzhong Yang
发明人： Andrew R. Barron , Jianzhong Yang
IPC分类号： C07C229/02 , C07K2/00
CPC分类号： B82Y30/00 , A61K31/185 , A61K31/195 , B82Y40/00 , C01B32/15 , C01B32/152 , C07K1/003 , C07K5/06078 , C07K5/06086 , C07K7/06 , C07K7/08 , C07K14/001
摘要： The present invention is directed to a series of new compounds, combining the unique properties of fullerenes and bio-active amino acid residues, and to methods for making such compounds. The present invention is directed toward fullerene-based amino acids, and to amino acid residues, peptide chains, proteins, and polypeptides made from such fullerene-based amino acids. The present invention is further directed to amino acid residues, peptide chains, proteins, and polypeptides comprising such fullerene-based amino acids and into which such fullerene-based amino acids have been incorporated. Exemplary compounds have been prepared, and these compounds have been characterized and confirmed with infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), etc. These new compounds, which are additions to the existing amino acid residue family, may potentially possess useful pharmaceutical application and may provide a new platform for further exploration in cancer therapy, and peptide and protein engineering.
摘要翻译：本发明涉及一系列新的化合物，其结合了富勒烯和生物活性氨基酸残基的独特性质，以及制备这些化合物的方法。本发明涉及基于富勒烯的氨基酸以及由这种基于富勒烯的氨基酸制成的氨基酸残基，肽链，蛋白质和多肽。本发明进一步涉及包含这种基于富勒烯的氨基酸的氨基酸残基，肽链，蛋白质和多肽，并且其中掺入了这种基于富勒烯的氨基酸。已经制备了示例性化合物，并且已经用红外（IR）光谱，核磁共振（NMR）光谱，质谱（MS）等来表征和证实了这些化合物。这些新化合物是现有氨基酸残基的添加物家族，可能潜在地拥有有用的药物应用，并可能为癌症治疗和肽和蛋白质工程的进一步探索提供新的平台。

7. 发明申请

US20110091570A1 Compositions and Devices for Antisepsis and Anticoagulation 审中-公开
标题翻译：用于抗菌和抗凝的组合物和装置
公开(公告)号：US20110091570A1
公开(公告)日：2011-04-21
申请号：US12990381
申请日：2009-03-17
申请人： Waldemar Gottardi
发明人： Waldemar Gottardi
IPC分类号： A61K33/00 , C07C309/14 , A61K31/185 , A61K9/00 , A61K31/727 , A61K38/02 , C07C229/02 , A61K31/197 , C07K2/00 , C07C239/04 , A61K31/131 , A61P31/00 , A61P7/02 , C01B21/09
CPC分类号： A61K31/185 , A61K2300/00
摘要： Disclosed herein are compositions, methods, uses, and devices having antiseptic and anticoagulation properties in a mammal. The compositions, methods, uses, and devices are based on a therapeutically effective amount of one or more N-halogenated or N,N-dihalogenated amines, analogues or derivatives thereof, or pharmaceutically acceptable salts and esters. The preferred compound is N-chlorotaurine.
摘要翻译：本文公开了在哺乳动物中具有抗菌和抗凝性能的组合物，方法，用途和装置。组合物，方法，用途和装置基于治疗有效量的一种或多种N-卤化或N，N-二卤代胺，其类似物或衍生物或其药学上可接受的盐和酯。优选的化合物是N-氯牛磺酸盐。

8. 发明授权

US07858378B2 Method for the determination of body odor 有权
标题翻译：测定身体异味的方法
公开(公告)号：US07858378B2
公开(公告)日：2010-12-28
申请号：US12537034
申请日：2009-08-06
申请人： Masayuki Yabuki , Yoshihiro Hasegawa , Shun Nakamura
发明人： Masayuki Yabuki , Yoshihiro Hasegawa , Shun Nakamura
IPC分类号： G01N33/50 , C07C229/02 , G01N33/48 , G01N33/00
CPC分类号： G01N33/5308 , C07C323/58 , Y10T436/173845
摘要： A method for determining potential for body odor and a method for determining the effectiveness of a deodorant carried out by detecting a substance represented by the following formula (1) or a derivative thereof: wherein R1 is a hydrogen atom or a methyl group, R2 is an alkyl group containing 1 to 5 carbon atoms, and R3 is a hydrogen atom or a methyl group.
摘要翻译：一种用于确定体臭的潜力的方法和通过检测由下式（1）表示的物质或其衍生物来确定除臭剂的有效性的方法：其中R1是氢原子或甲基，R2是含有1至5个碳原子的烷基，R 3是氢原子或甲基。

9. 发明申请

US20100305165A1 THIOCOLCHICINE DERIVATIVES, METHOD OF MAKING AND METHODS OF USE THEREOF 有权
标题翻译：噻吗啉衍生物，其制备方法及其使用方法
公开(公告)号：US20100305165A1
公开(公告)日：2010-12-02
申请号：US12788634
申请日：2010-05-27
申请人： Rajesh Manchanda
发明人： Rajesh Manchanda
IPC分类号： A61K31/222 , C07C69/017 , C07D333/38 , C07C69/76 , C07C69/66 , C07D213/79 , C07C317/00 , C07C229/02 , A61K31/225 , A61K31/24 , A61K31/381 , A61K31/4409 , A61P21/02 , A61P29/00
CPC分类号： C07C323/41 , A61K31/222 , A61K31/225 , A61K31/24 , A61K31/381 , A61K31/4409 , C07C2603/34 , C07D213/79 , C07D333/38
摘要： Disclosed herein are thiocolchicine derivatives suitable for use as muscle relaxants, methods of making the derivatives, and compositions comprising the derivatives.
摘要翻译：本文公开了适合用作肌肉松弛剂的硫代秋水仙碱衍生物，制备衍生物的方法和包含衍生物的组合物。

10. 发明申请

US20100125146A1 METHOD FOR MAKING PHARMACEUTICAL COMPOUNDS 审中-公开
标题翻译：制备药物化合物的方法
公开(公告)号：US20100125146A1
公开(公告)日：2010-05-20
申请号：US12273825
申请日：2008-11-19
申请人： James J. Mencel , Paul Fishbein
发明人： James J. Mencel , Paul Fishbein
IPC分类号： C07C305/00 , C07C229/02 , C07C211/01
CPC分类号： C07C209/00 , C07C227/16 , C07C231/12 , C07D263/22 , C07C211/27 , C07C229/24 , C07C233/05
摘要： A method of making a phenylethylamine of formula B: wherein R2, R3, R4, R5, R6, Rα, Rβ and Rn are each independently selected from hydrogen, alkyl, acyl, aryl, amido, amino acids, sugars and nucleotides. The method includes the reduction of a compound of formula A in the absence of base: wherein R2, R3, R4, R5, R6, Rα, Rβ and Rn are as defined above.
摘要翻译：制备式B的苯基乙胺的方法：其中R2，R3，R4，R5，R6，Rα，R＆bgr; 和R n各自独立地选自氢，烷基，酰基，芳基，酰氨基，氨基酸，糖和核苷酸。该方法包括在不存在碱的情况下还原式A化合物：其中R2，R3，R4，R5，R6，Rα，R＆bgr; 和Rn如上所定义。

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