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1. 发明授权

US09976941B2 In situ heat induced antigen recovery and staining method 有权
公开(公告)号：US09976941B2
公开(公告)日：2018-05-22
申请号：US15256159
申请日：2016-09-02
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N1/30 , G01N1/31 , G01N33/52 , G01N1/44 , G01N33/53 , G01N35/00 , B01L9/00
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological specimen on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.

2. 发明授权

US09817010B2 Telescoping closed-tube sampling assembly 有权
公开(公告)号：US09817010B2
公开(公告)日：2017-11-14
申请号：US14272649
申请日：2014-05-08
申请人： INSTRUMENTATION LABORATORY COMPANY
发明人： Matthew Blouin , Gregory Murphy , Diana Mackenzie , Alan Weeks , Daniel Kobrenski
IPC分类号： G01N35/02 , B01L3/02 , G01N35/10 , B01L99/00
CPC分类号： G01N35/026 , B01L3/021 , B01L99/00 , B01L2300/0672 , B01L2400/0487 , G01N35/1004 , G01N35/1011 , G01N35/1079 , G01N2035/1006 , Y10T436/114998 , Y10T436/2575
摘要： A clinical diagnostic sample analyzer for analyzing a sample of a patient is disclosed. The analyzer includes a telescoping closed-tube sampling assembly with a sample probe concentrically housed within a piercing probe and a venting mechanism. The closed-tube sampling assembly is used for aspirating a sample from a sample tube for analysis by a clinical diagnostic sample analyzer.

3. 发明申请

US20160370390A1 IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING METHOD 审中-公开
标题翻译：在现场热诱导的抗原恢复和染色方法
公开(公告)号：US20160370390A1
公开(公告)日：2016-12-22
申请号：US15256159
申请日：2016-09-02
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N35/00 , G01N1/44 , G01N1/31
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological specimen on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。用于处理载玻片的反应条件可以独立地进行控制，包括将试剂单独施加到每个载玻片上，以及每个载玻片的个体化处理。

4. 发明授权

US09400286B2 Apparatus and method for analyzing samples 有权
标题翻译：用于分析样品的仪器和方法
公开(公告)号：US09400286B2
公开(公告)日：2016-07-26
申请号：US14625483
申请日：2015-02-18
申请人： SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
发明人： Zhihong Wang , Zhi Xu , Chuanfen Xie , Feng Li
IPC分类号： G01N35/02 , G01N35/00 , G01N35/10
CPC分类号： G01N35/025 , G01N35/0092 , G01N35/1002 , G01N35/1004 , G01N2035/1032 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998
摘要： A sample analyzer comprises a reaction tray, a sample/reagent tray, and a probe. The reaction tray performs a first number of stops and rotations during an operating cycle, wherein the first number is configured to cause each of the reaction vessels to stop once at a position for the test before any of the number of the reaction vessels stops at the position for a second time. The sample/reagent tray rotates one of a sample container and reagent containers to a sample/reagent retrieving position during an operating cycle. The probe dispenses test sample(s), first reagent, and second reagent during different periods in different stop periods during an operating cycle. A method for analyzing samples is also disclosed.
摘要翻译：样品分析仪包括反应托盘，样品/试剂托盘和探针。反应塔板在操作循环期间执行第一次停止和转动，其中第一个数量被配置成使得每个反应容器在任何数量的反应容器停止之前在试验位置停止一次位置第二次在操作周期中，样品/试剂盘将样品容器和试剂容器之一旋转到样品/试剂检索位置。在操作周期内，探针在不同的停止期间的不同时段内分配测试样品，第一试剂和第二试剂。还公开了一种用于分析样品的方法。

5. 发明申请

US20160084862A1 INFORMATION NOTIFICATION SAMPLE PROCESSING SYSTEM AND METHODS OF BIOLOGICAL SLIDE PROCESSING 审中-公开
标题翻译：信息通报样品处理系统和生物滑动加工方法
公开(公告)号：US20160084862A1
公开(公告)日：2016-03-24
申请号：US14959741
申请日：2015-12-04
申请人： Dako Denmark A/S
发明人： Gordon Feingold , Marc Key , John Favuzzi , Rosanne Welcher
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
摘要翻译：公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在可能是远程的某些显示器处的通知。可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

6. 发明授权

US09182324B2 Systems and methods for the automated pre-treatment and processing of biological samples 有权
标题翻译：用于生物样品自动预处理和处理的系统和方法
公开(公告)号：US09182324B2
公开(公告)日：2015-11-10
申请号：US13345605
申请日：2012-01-06
申请人： Gordon Alan Feingold , James B. Gilmartin , Mark Richard Holbrook , John A. Favuzzi , Marc E. Key
发明人： Gordon Alan Feingold , James B. Gilmartin , Mark Richard Holbrook , John A. Favuzzi , Marc E. Key
IPC分类号： G01N21/00 , G01N31/00 , G01N33/00 , G01N1/31 , G01N35/00 , G06F19/00
CPC分类号： G01N1/312 , G01N35/0092 , G01N35/0099 , G06F19/00 , G16H40/63 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： Systems and methods in accordance with embodiments of the present invention allow for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.
摘要翻译：根据本发明的实施例的系统和方法允许对存在于装置内的载玻片上的生物样品的染色装置进行自动控制和调度。在一些实施例中，可以对与染色设备耦合的机器人的动作进行优先级排列，所述机器人根据各自的协议在各个幻灯片上执行一些染色任务。在一些实施例中，调度可导致增加或最大化幻灯片的吞吐量。在一些实施例中，机器人调度确保各个滑块基本上在其各自协议规定的公差内被处理。在一些实施例中，机器人调度器可以响应自发的用户动作并且自适应地调度或重新调度机器人动作。

7. 发明授权

US09176033B2 In situ heat induced antigen recovery and staining method 有权
标题翻译：原位热诱导抗原回收和染色方法
公开(公告)号：US09176033B2
公开(公告)日：2015-11-03
申请号：US14072481
申请日：2013-11-05
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N21/00 , G01N1/30 , G01N1/31 , G01N33/52 , G01N1/44 , G01N33/53 , B01L9/00
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
摘要翻译：一种用于处理多个显微镜载片的自动原位热诱导抗原恢复和染色方法和装置。在相同的装置中进行热诱导的抗原恢复过程和在显微镜载玻片上染色生物样品的过程，其中显微镜幻灯片不需要从一个装置物理移除到另一个装置。用于处理载玻片的反应条件可以独立地进行控制，包括将试剂单独施加到每个载玻片上，以及每个载玻片的个体化处理。

8. 发明申请

US20150037896A1 Sample Distribution 审中-公开
标题翻译：样本分配
公开(公告)号：US20150037896A1
公开(公告)日：2015-02-05
申请号：US14285907
申请日：2014-05-23
申请人： Paul Frank , Andreas Gisler , Robert Huesler , Rolf Knobel , Siegfried Mueller , Urs Schnieper , Heinz Trueeb
发明人： Paul Frank , Andreas Gisler , Robert Huesler , Rolf Knobel , Siegfried Mueller , Urs Schnieper , Heinz Trueeb
IPC分类号： G01N35/10 , G01N35/02
CPC分类号： G01N35/1095 , B01L3/0275 , G01N35/0098 , G01N35/028 , G01N35/1067 , G01N35/1074 , G01N2035/00326 , G01N2035/103 , G01N2035/1069 , Y10T436/11 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.
摘要翻译：描述了一种用于将自动分析仪中的样品从样品容器的线性排列分布到二维n×m布置的处理板的方法，其中样品被分类，然后用具有线性排列的移液装置转移到处理容器以二维n×m布置，并且使用具有二维n×m布置的第二移液装置对样品进行后续处理。

9. 发明申请

US20140242706A1 SPECIMEN ANALYZING APPARATUS 有权
标题翻译：样本分析仪
公开(公告)号：US20140242706A1
公开(公告)日：2014-08-28
申请号：US14189654
申请日：2014-02-25
申请人： Sysmex Corporation
发明人： Takahito MIHARA , Takaaki NAGAI
IPC分类号： G01N35/10
CPC分类号： G01N35/1004 , G01N2035/0412 , Y10T436/114998
摘要： To provide a specimen analyzing apparatus capable of preventing a reduction in analysis accuracy caused by contamination of a measurement sample by a substance attached to a cleaning unit, the present invention provides a blood analyzer 100 which includes a cleaning unit 7 for cleaning an aspirating tube 1 positioned within a through-hole 72, a vertical moving unit 5 for moving the aspirating tube 1 along a through-hole relative to the cleaning unit 7, and a blade 8 for removing a substance attached to the outer side of the cleaning unit 7, wherein an aspirating tube 1 is provided for aspirating a sample, a through-hole 72 is formed to allow the aspirating tube 1 to pass therethrough, and a supply path 73 is formed for supplying a cleaning liquid to the through-hole 72.
摘要翻译：为了提供能够防止由附着在清洗单元上的物质污染测定样品而产生的分析精度降低的检体分析装置，本发明提供一种血液分析装置100，其具备：清洗单元7，用于清洗吸气管1 位于通孔72内的垂直移动单元5，用于相对于清洁单元7沿着通孔移动吸引管1;以及用于去除附着在清洁单元7的外侧的物质的刀片8，其特征在于，设置抽吸管1以抽吸样品，形成通孔72以允许抽吸管1通过，并且形成用于将清洁液供给到通孔72的供给路径73。

10. 发明授权

US08788217B2 Information notification sample processing system and methods of biological slide processing 有权
标题翻译：信息通知样本处理系统和生物幻灯片处理方法
公开(公告)号：US08788217B2
公开(公告)日：2014-07-22
申请号：US13747949
申请日：2013-01-23
申请人： DAKO Denmark A/S
发明人： Gordon Feingold , Marc Key , John Favuzzi , Rosanne Welcher
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
摘要翻译：公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在可能是远程的某些显示器处的通知。可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

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