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1. 发明申请

US20050271686A1 HIV vaccine 有权
标题翻译：艾滋病毒疫苗
公开(公告)号：US20050271686A1
公开(公告)日：2005-12-08
申请号：US11107364
申请日：2005-04-15
申请人： Chil-Yong Kang , Yan Li
发明人： Chil-Yong Kang , Yan Li
IPC分类号： C07K14/16 , C12N7/04 , C12N15/48 , A61K39/12 , A61K39/21 , C12N7/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5252 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/555 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N2710/14143 , C12N2710/16061 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16322
摘要： Novel HIV vaccines comprising an avirulent and non-cytolytic recombinant HIVs are provided.
摘要翻译：提供了包含无毒和非溶细胞重组HIV的新型HIV疫苗。

2. 发明授权

US06221360B1 Infectious bovine rhinotracheitis vaccines and methods 失效
标题翻译：传染性牛鼻气管炎疫苗和方法
公开(公告)号：US06221360B1
公开(公告)日：2001-04-24
申请号：US08607323
申请日：1996-02-26
申请人： Shafiqul I. Chowdhury
发明人： Shafiqul I. Chowdhury
IPC分类号： A61K39265
CPC分类号： C12N7/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N2710/16061 , C12N2710/16722
摘要： The disclosed invention is directed to (1) recombinant bovine herpesvirus genes having foreign genes inserted therein, (2) infectious recombinant bovine herpesviruses carrying these recombinant genes, (3) methods of producing these recombinant bovine herpesviruses, (4) methods of immunizing animals against diseases caused by bovine herpesviruses using these recombinant bovine herpesviruses as vaccines, and (5) methods of detecting infection of an animal by these recombinant bovine herpesviruses. In its preferred form, the invention is directed to the construction of an infectious recombinant bovine herpesvirus type 1 having a functional &bgr;-galactosidase gene inserted in and thereby inactivating the thymidine kinase gene (e.g., Gal-TK); infection of an animal with the resultant avirulent vaccine virus is detected by assaying the animal's respiratory secretions for the presence of virus having &bgr;-galactosidase activity in host cells.
摘要翻译：所公开的发明涉及（1）在其中插入有外源基因的重组牛疱疹病毒基因，（2）携带这些重组基因的感染性重组牛疱疹病毒，（3）产生这些重组牛疱疹病毒的方法，（4）使用这些重组牛疱疹病毒作为疫苗的牛疱疹病毒引起的疾病，以及（5）通过这些重组牛疱疹病毒检测动物感染的方法。在其优选形式中，本发明涉及一种具有插入功能性β-半乳糖苷酶基因并由此使胸苷激酶基因（例如Gal-TK）失活的感染性重组牛疱疹病毒1型的构建; 通过测定动物的呼吸道分泌物以检测宿主细胞中具有β-半乳糖苷酶活性的病毒的存在来检测具有所得无毒力疫苗病毒的动物的感染。

3. 发明授权

US08986707B2 gM-negative EHV-mutants without heterologous elements 有权
公开(公告)号：US08986707B2
公开(公告)日：2015-03-24
申请号：US13446558
申请日：2012-04-13
申请人： Antonie Neubauer , Christina Ziegler
发明人： Antonie Neubauer , Christina Ziegler
IPC分类号： A61K39/245 , C12N7/01 , C12N7/04 , C12N15/00 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N7/00 , C12N2710/16022 , C12N2710/16061 , C12N2710/16734
摘要： The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous elements. Further aspects of the invention relate to pharmaceutical compositions comprising said viruses, uses thereof, and methods for the prophylaxis and treatment of EHV infections. The invention also relates to pharmaceutical compositions comprising the combination of EHV-1 and EHV-4 viruses wherein the gene encoding the protein gM is absent and which is free of heterologous elements.

4. 发明申请

US20050255085A1 Prevention of recurrence and metastasis of cancer 审中-公开
标题翻译：预防癌症的复发和转移
公开(公告)号：US20050255085A1
公开(公告)日：2005-11-17
申请号：US10505375
申请日：2003-03-03
申请人： Yuman Fong , Richard Wong
发明人： Yuman Fong , Richard Wong
IPC分类号： A61B17/00 , A61K31/7088 , A61K35/76 , A61K35/763 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , A61P35/04 , C12N7/04 , C12N15/86 , C12N15/869
CPC分类号： C12N7/00 , A61K35/763 , A61K38/00 , A61K39/395 , A61K45/06 , A61K2039/5254 , C12N15/86 , C12N2710/16061 , C12N2710/16632 , C12N2710/16643 , A61K2300/00
摘要： The invention provides methods of preventing and treating cancer, involving the use of attenuated, replication-com-petent, oncolytic herpes viruses.
摘要翻译：本发明提供了预防和治疗癌症的方法，其涉及使用减毒，复制，溶瘤性疱疹病毒。

5. 发明授权

US07141243B2 gM-negative EHV-mutants without heterologous elements 有权
公开(公告)号：US07141243B2
公开(公告)日：2006-11-28
申请号：US10624149
申请日：2003-07-21
申请人： Antonie Neubauer , Christina Ziegler
发明人： Antonie Neubauer , Christina Ziegler
IPC分类号： A61K39/245
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N7/00 , C12N2710/16022 , C12N2710/16061 , C12N2710/16734
摘要： The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous elements. Further aspects of the invention relate to pharmaceutical compositions comprising said viruses, uses thereof, and methods for the prophylaxis and treatment of EHV infections. The invention also relates to pharmaceutical compositions comprising the combination of EHV-1 and EHV-4 viruses wherein the gene encoding the protein gM is absent and which is free of heterologous elements.

6. 发明申请

US20040109873A1 gM-negative EHV-mutants without heterologous elements 有权
标题翻译：没有异源元件的gM阴性EHV突变体
公开(公告)号：US20040109873A1
公开(公告)日：2004-06-10
申请号：US10624149
申请日：2003-07-21
申请人： Boehringer Ingelheim Vetmedica GmbH
发明人： Antonie Neubauer , Christina Ziegler
IPC分类号： A61K039/12 , C12N007/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N7/00 , C12N2710/16022 , C12N2710/16061 , C12N2710/16734
摘要： The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous elements. Further aspects of the invention relate to pharmaceutical compositions comprising said viruses, uses thereof, and methods for the prophylaxis and treatment of EHV infections. The invention also relates to pharmaceutical compositions comprising the combination of EHV-1 and EHV-4 viruses wherein the gene encoding the protein gM is absent and which is free of heterologous elements.
摘要翻译：本发明涉及动物健康领域，特别是马氏疱疹病毒（EHV）领域，其中编码蛋白质gM的基因不存在，且不含异源元件。本发明的其它方面涉及包含所述病毒的药物组合物，其用途和预防和治疗EHV感染的方法。本发明还涉及包含EHV-1和EHV-4病毒的组合的药物组合物，其中编码蛋白质gM的基因不存在并且不含异源元件。

7. 发明申请

US20120195927A1 GM-NEGATIVE EHV-MUTANTS WITHOUT HETEROLOGOUS ELEMENTS 审中-公开
标题翻译：没有异位元素的GM-阴性EHV-MUTANT
公开(公告)号：US20120195927A1
公开(公告)日：2012-08-02
申请号：US13446558
申请日：2012-04-13
申请人： Antonie NEUBAUER , Christina ZIEGLER
发明人： Antonie NEUBAUER , Christina ZIEGLER
IPC分类号： A61K39/245 , A61P31/22 , C12N7/00 , A61P37/04
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N7/00 , C12N2710/16022 , C12N2710/16061 , C12N2710/16734
摘要： The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous elements. Further aspects of the invention relate to pharmaceutical compositions comprising said viruses, uses thereof, and methods for the prophylaxis and treatment of EHV infections. The invention also relates to pharmaceutical compositions comprising the combination of EHV-1 and EHV-4 viruses wherein the gene encoding the protein gM is absent and which is free of heterologous elements.
摘要翻译：本发明涉及动物健康领域，特别是马氏疱疹病毒（EHV）领域，其中编码蛋白质gM的基因不存在，且不含异源元件。本发明的其它方面涉及包含所述病毒的药物组合物，其用途和预防和治疗EHV感染的方法。本发明还涉及包含EHV-1和EHV-4病毒的组合的药物组合物，其中编码蛋白质gM的基因不存在并且不含异源元件。

8. 发明授权

US07608273B2 Recombinant lentivirus encoding modified GP 120 signal sequences 有权
标题翻译：编码修饰的GP120信号序列的重组慢病毒
公开(公告)号：US07608273B2
公开(公告)日：2009-10-27
申请号：US11107364
申请日：2005-04-15
申请人： Chil-Yong Kang , Yan Li
发明人： Chil-Yong Kang , Yan Li
IPC分类号： A61K39/21 , A61K39/12
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5252 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/555 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N2710/14143 , C12N2710/16061 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16322
摘要： Novel HIV vaccines comprising an avirulent and non-cytolytic recombinant HIVs are provided.
摘要翻译：提供了包含无毒和非溶细胞重组HIV的新型HIV疫苗。

9. 发明申请

US20090162396A1 gM-NEGATIVE EHV-MUTANTS WITHOUT HETEROLOGOUS ELEMENTS 有权
标题翻译：没有异位元素的gM阴性EHV-MUTANT
公开(公告)号：US20090162396A1
公开(公告)日：2009-06-25
申请号：US12392302
申请日：2009-02-25
申请人： Antonie Neubauer , Christina Ziegler
发明人： Antonie Neubauer , Christina Ziegler
IPC分类号： A61K39/12 , C12N7/00 , C12N15/87 , C12N5/06 , C12N15/11
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N7/00 , C12N2710/16022 , C12N2710/16061 , C12N2710/16734
摘要： The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous elements. Further aspects of the invention relate to pharmaceutical compositions comprising said viruses, uses thereof, and methods for the prophylaxis and treatment of EHV infections. The invention also relates to pharmaceutical compositions comprising the combination of EHV-1 and EHV-4 viruses wherein the gene encoding the protein gM is absent and which is free of heterologous elements.
摘要翻译：本发明涉及动物健康领域，特别是马氏疱疹病毒（EHV）领域，其中编码蛋白质gM的基因不存在，且不含异源元件。本发明的其它方面涉及包含所述病毒的药物组合物，其用途和预防和治疗EHV感染的方法。本发明还涉及包含EHV-1和EHV-4病毒的组合的药物组合物，其中编码蛋白质gM的基因不存在并且不含异源元件。

10. 发明授权

US06322793B1 Channel catfish virus vaccine 失效
标题翻译：渠鲶病毒疫苗
公开(公告)号：US06322793B1
公开(公告)日：2001-11-27
申请号：US09334181
申请日：1999-06-16
申请人： Nathalie Vanderheijden , Joseph A. Martial , Larry A. Hanson
发明人： Nathalie Vanderheijden , Joseph A. Martial , Larry A. Hanson
IPC分类号： A61K39245
CPC分类号： C12N7/00 , A61K39/12 , A61K39/245 , A61K2039/525 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N15/86 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16061 , Y10S424/817
摘要： An attenuated, avirulent recombinant vaccine providing challenged protection against channel catfish virus comprises deletion of gene 50. Gene 50 encodes a secreted glycoprotein. Removal of gene 50, or replacement of gene 50 with foreign genetic material, provides a vaccine with which induces virus specific immunity against CCV disease.
摘要翻译：提供针对鲶鱼鲶鱼病毒攻击保护的减毒无毒重组疫苗包括基因50的缺失。基因50编码分泌的糖蛋白。移除基因50或用外来遗传物质替代基因50提供了诱导针对CCV疾病的病毒特异性免疫的疫苗。

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