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1. 发明授权

US07722877B2 Coccidiosis vaccines 失效
标题翻译：球虫病疫苗
公开(公告)号：US07722877B2
公开(公告)日：2010-05-25
申请号：US11594367
申请日：2006-11-07
申请人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
发明人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
IPC分类号： A61K39/00 , A61K39/012 , C07H21/04 , C12P21/06
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
摘要翻译：本发明涉及亲水艾美球虫多肽，编码那些肽的DNA片段，包含此类DNA片段的重组DNA分子，包含该DNA片段或重组DNA分子的活重组载体和包含该DNA片段的宿主细胞，重组DNA分子或活重组载体。此外，本发明涉及基于所述多肽的针对多肽的抗体和针对球虫病的疫苗。本发明还涉及制备这种抗体和疫苗的方法，以及用于检测艾美虫寄生虫和针对艾美虫寄生虫的抗体的方法。

2. 发明授权

US07691987B2 Use of a novel eimeria gene and corresponding protein 失效
标题翻译：使用新颖的艾美虫基因和相应的蛋白质
公开(公告)号：US07691987B2
公开(公告)日：2010-04-06
申请号：US10562324
申请日：2004-06-30
申请人： Gisela Greif , Ralf Hosse , Jürgen Krücken , Frank Wunderlich
发明人： Gisela Greif , Ralf Hosse , Jürgen Krücken , Frank Wunderlich
IPC分类号： C07H21/04 , C07H21/02 , C12N15/63 , C12N15/85 , C12N15/86 , C12N1/20 , C12N15/00 , C12Q1/68
CPC分类号： C07K16/20 , A61K39/012 , A61K2039/505 , A61K2039/53 , C07K14/455
摘要： The invention relates to a novel oocyst sporocyst protein (EtOs22) belonging to the parasite of the species Eimeria tenella and to the polynucleotide encoding this protein, to vectors which contain this polynucleotide, to cells which are transformed with these vectors, to antibodies which are directed against the protein, to vaccines which comprise the polynucleotide, the protein, or fragments thereof, the abovementioned vectors or antibodies directed against the protein, and to the use of polynucleotide or of polypeptide for finding active compounds for treating an infection with Eimeria and active compounds which are suitable for the therapy of an infection with Eimeria.
摘要翻译：本发明涉及属于艾美球虫种类的寄生虫和编码该蛋白质的多核苷酸的新型卵囊孢子蛋白（EtOs22）与含有该多核苷酸的载体对于被这些载体转化的细胞与被定向的抗体针对蛋白质的疫苗，涉及包含多核苷酸，蛋白质或其片段的疫苗，针对蛋白质的上述载体或抗体，以及使用多核苷酸或多肽寻找用于治疗艾美球虫感染和活性化合物的活性化合物其适用于艾美球虫感染的治疗。

3. 发明申请

US20090196888A1 Nucleic acids encoding recombinant 56 and 82 kDa antigents from gametocytes of Eimeria maxima and their uses 有权
标题翻译：编码重组56和82 kDa抗原的核酸从艾美球虫的配子体及其用途
公开(公告)号：US20090196888A1
公开(公告)日：2009-08-06
申请号：US12156206
申请日：2008-05-30
申请人： Sabina I. Belli , Nicholas C. Smith , Michael Wallach
发明人： Sabina I. Belli , Nicholas C. Smith , Michael Wallach
IPC分类号： A61K39/012 , C07H21/00 , C12N15/74 , C12N5/10 , C12N1/20 , C07K14/00 , A61P37/04 , A61P33/02
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention provides the recombinant cloning and sequencing of two of the major Eimeria maxima gametocyte antigens having molecular weights of 56 and 82 kDa and the expression of these recombinant antigens in an E. coli expression system using the plasmid pTrcHis. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen. The subject invention also provides two 30 kDa proteins and three 14 kDa proteins from Eimeria maxima gametocytes having at the N-terminal end the amino acid sequence described herein. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen and any of the aforementioned proteins. Additionally, the subject invention also provides a method of immunizing a subject against infection by Eimeria tenella, Eimeria maxima, Eimeria acervulina, Eimeria necatrix, Eimeria praecox, Eimeria mitis or Eimeria brunetti, or a microorganism expressing an immunologically cross-reactive antigen, comprising the step of administering to the subject any of the aforementioned vaccines.
摘要翻译：本发明提供了分子量为56和82kDa的两种主要的艾美球虫最大配子型抗原的重组克隆和测序，以及这些重组抗原在使用质粒pTrcHis的大肠杆菌表达系统中的表达。本发明还提供了包含重组56kDa或82kDa抗原的针对球虫病的疫苗。本发明还提供了在最终端具有本文所述氨基酸序列的来自艾美球虫最大配子配子的两个30kDa蛋白质和三个14kDa蛋白质。本发明还提供了包含重组56kDa或82kDa抗原和任何上述蛋白质的抗球虫病疫苗。此外，本发明还提供了免疫受试者免受艾美球虫艾美球虫，艾美球虫艾美球虫，艾美球虫，艾美球虫，艾美球虫或艾美球虫艾美球虫或表达免疫交叉反应性抗原的微生物的感染的方法，其包含向受试者施用任何上述疫苗的步骤。

4. 发明申请

US20090136999A1 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES 有权
标题翻译：癌症和感染性疾病免疫组合物和方法
公开(公告)号：US20090136999A1
公开(公告)日：2009-05-28
申请号：US12102292
申请日：2008-04-14
申请人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John W. Judge , Barnett Rosenberg , Igor V. Zlatkin , Tatiana Zlatkin
发明人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John W. Judge , Barnett Rosenberg , Igor V. Zlatkin , Tatiana Zlatkin
IPC分类号： C12P21/00 , A61K38/16 , A61K31/7088 , A61K35/12 , A61P35/00 , C07K16/18 , C12N5/10 , C07H21/00 , A61K38/21 , A61K38/20 , A61K39/395 , A61K38/19
CPC分类号： A61K39/39 , A61K38/16 , A61K39/012 , A61K2039/55516 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.
摘要翻译：本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。特别地，本发明提供了具有免疫刺激活性的Apicocplexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。提供了包含ARP的组合。还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法。

5. 发明申请

US20060115498A1 DNA encoding an antigenic protein of Eimeria apical membrane antigen 1 and use thereof 有权
标题翻译：编码艾美球虫顶膜抗原1抗原蛋白的DNA及其应用
公开(公告)号：US20060115498A1
公开(公告)日：2006-06-01
申请号：US11290422
申请日：2006-01-20
申请人： Takanori Sato
发明人： Takanori Sato
IPC分类号： A61K39/012 , C07H21/04 , A61K48/00 , C07K14/455
CPC分类号： C07K14/455 , A61K39/00
摘要： This invention provides a novel DNA for preventing avian coccidiosis and use thereof. The novel DNA encodes an antigenic protein of Eimeria apical membrane antigen 1, and is used for DNA vaccine and/or for vaccine comprising the recombinant protein deduced from the said DNA sequence as a main ingredient. The chickens immunized with vaccines described herein can be induced immunity against coccidiosis.
摘要翻译：本发明提供了用于预防禽类球虫病的新型DNA及其应用。该新型DNA编码艾美球虫顶端膜抗原1的抗原性蛋白，并用于DNA疫苗和/或包含从所述DNA序列推导的重组蛋白作为主要成分的疫苗。用本文所述的疫苗免疫的鸡可诱导针对球虫病的免疫。

6. 发明授权

US06203801B1 Coccidiosis polypeptide and vaccines 失效
标题翻译：球虫病多肽和疫苗
公开(公告)号：US06203801B1
公开(公告)日：2001-03-20
申请号：US09411578
申请日：1999-10-04
申请人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
发明人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
IPC分类号： A61K39012
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
摘要翻译：本发明涉及亲水艾美球虫多肽，编码那些肽的DNA片段，包含此类DNA片段的重组DNA分子，包含该DNA片段或重组DNA分子的活重组载体和包含该DNA片段的宿主细胞，重组DNA分子或活重组载体。此外，本发明涉及基于所述多肽的针对多肽的抗体和针对球虫病的疫苗。本发明还涉及制备这种抗体和疫苗的方法，以及用于检测艾美虫寄生虫和针对艾美虫寄生虫的抗体的方法。

7. 发明授权

US6100241A Coccidiosis poultry vaccine 失效
标题翻译：球虫病家禽疫苗
公开(公告)号：US6100241A
公开(公告)日：2000-08-08
申请号：US676882
申请日：1996-07-03
申请人： Jacobus Johannes Kok , Paul van den Boogaart , Arnodus Nicolaas Vermeulen
发明人： Jacobus Johannes Kok , Paul van den Boogaart , Arnodus Nicolaas Vermeulen
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/012 , A61P33/02 , C07K14/435 , C07K14/44 , C07K14/455 , C07K16/00 , C07K16/20 , C12N9/04 , C12N15/00 , C12N15/30 , C12N15/53 , C12P21/02 , C12R1/90 , A01N43/04 , A61K31/70 , C12N15/63
CPC分类号： A61K39/012 , C07K14/455 , C07K16/20 , C12N9/0006 , A61K2039/51 , A61K2039/53 , A61K38/00 , A61K39/00
摘要： This invention relates to Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.
摘要翻译：本发明涉及具有免疫原性的艾美球虫蛋白质以及编码这些蛋白质的DNA序列。这些蛋白质可以施用于家禽，从而保护鸟类免于球虫病。此外，编码这些蛋白质的DNA可用于制备针对球虫病的载体疫苗。

8. 发明授权

US6008342A DNA encoding eimeria antigen 失效
标题翻译：编码艾美球虫抗原的DNA
公开(公告)号：US6008342A
公开(公告)日：1999-12-28
申请号：US770035
申请日：1996-12-19
申请人： Mary-Helen Binger , Luis Pasamontes
发明人： Mary-Helen Binger , Luis Pasamontes
IPC分类号： A61K39/00 , C07K14/455 , C07H21/04 , A61K39/012 , C12N1/20 , C12P21/04
CPC分类号： C07K14/455 , A61K39/00 , C12N2799/023 , C12N2799/028
摘要： The invention provides an immunogenic polypeptide having the amino acid sequenceM A K S M L S G I V F A G L V A A A A A - S S A N S A A N V S V L E S G P A V Q E - V P A R T V T A R L A K P L L L L S A L - A A T L A A A F L V L Q C F N I I S S N - N Q Q T S V R R L A A G G A C G D E E D - A D E G T S Q Q A S R R R R K P D T P A - A D K Y D F V G G T P V S V T E P N V D - E V L I Q I R N K Q I F L K N P W T G Q - E E Q V L V L E R Q S E E P I L I V A R - T R Q T L E G Y L G S Q A L A Q D G K T - A K E E K V E G G K T H R R Y K V K S S - D P G Y G F P Y T T V L D G V P V G T D - E D G Y V V E V L M K T G P H G G V D M - M T S T A S Q G K F C G V L M D D G K G - N L V D G Q G R K I T A V I G M L T Q P - D T E F R S G P G D D E D D E (SEQ ID NO:1) and fragments thereof,which polypeptides are capable of inducing an immune response against Eimeria parasites, and the DNA encoding such polypeptides, as well as recombinant vectors and recombinant viruses containing the said DNA or fragments thereof and transformed microorganisms containing such vectors and viruses and coccidiosis vaccines comprising such polypeptides.
摘要翻译：本发明提供了具有氨基酸序列的免疫原性多肽 - MAKSMLSGIVFAGLVAAAAA - - SSANSAANVSVLESGPAVQE - - VPARTVTARLAKPLLLLSAL - - AATLAAAFLVLQCFNIISSN - - NQQTSVRRLAAGGACGDEED - - ADEGTSQQASRRRRKPDTPA - - ADKYDFVGGTPVSVTEPNVD - - EVLIQIRNKQIFLKNPWTGQ - - EEQVLVLERQSEEPILIVAR - - TRQTLEGYLGSQALAQDGKT - - AKEEKVEGGKTHRRYKVKSS - - DPGYGFPYTTVLDGVPVGTD - - EDGYVVEVLMKTGPHGGVDM - - MTSTASQGKFCGVLMDDGKG - - NLVDGQGRKITAVIGMLTQP - - DTEFRSGPGDDEDDE（SEQ ID NO：1）及其片段，其能够诱导针对艾美虫寄生虫的免疫应答，以及编码这些多肽的DNA，以及重组载体和重组病毒将所述DNA或其片段和含有这样的载体和病毒的转化微生物以及包含这种多肽的球虫病疫苗。

9. 发明授权

US5843722A Coccidiosis poultry vaccine 失效
公开(公告)号：US5843722A
公开(公告)日：1998-12-01
申请号：US668416
申请日：1996-06-21
申请人： Janene Marilyn Bumstead , Paul Patrick James Dunn , Fiona Margaret Tomley , Arnoldus Nicolaas Vermeulen
发明人： Janene Marilyn Bumstead , Paul Patrick James Dunn , Fiona Margaret Tomley , Arnoldus Nicolaas Vermeulen
IPC分类号： G01N33/569 , A61K39/00 , A61K39/012 , A61K39/395 , A61P33/02 , C07K14/455 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/30 , C12P21/02 , C12R1/19 , C12R1/91 , A61K39/002
CPC分类号： C07K14/455 , A61K39/00 , Y10S435/81
摘要： This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.

10. 发明授权

US5792644A DNA encoding an Eimeria 200 kd antigen 失效
标题翻译：编码艾美球虫200kd抗原的DNA
公开(公告)号：US5792644A
公开(公告)日：1998-08-11
申请号：US468852
申请日：1995-06-06
申请人： Arnoldus Nicolaas Vermeulen , Paul van den Boogaart , Jacobus Johannus Kok
发明人： Arnoldus Nicolaas Vermeulen , Paul van den Boogaart , Jacobus Johannus Kok
IPC分类号： C12N15/09 , A61K20060101 , A61K39/00 , A61K39/002 , A61K39/012 , A61K39/395 , A61P33/02 , C07D20060101 , C07K20060101 , C07K14/455 , C07K16/20 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/30 , C12N15/63 , C12N15/83 , C12P20060101 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/19
CPC分类号： C07K14/455 , C07K16/20 , A61K39/00
摘要： The invention is concerned with novel Eimeria proteins with immunogenic properties as well as with DNA sequences encoding these proteins. These proteins can be administered to chickens thereby protecting the chickens against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.
摘要翻译：本发明涉及具有免疫原性的新颖艾美球虫蛋白以及编码这些蛋白质的DNA序列。这些蛋白质可以施用于鸡，从而保护鸡免于球虫病。此外，编码这些蛋白质的DNA可用于制备针对球虫病的载体疫苗。

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