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1. 发明公开

US20240141067A1 Administration of Anti-HPA-1a Antibodies 审中-公开
公开(公告)号：US20240141067A1
公开(公告)日：2024-05-02
申请号：US18575805
申请日：2022-06-30
申请人： Rallybio IPA, LLC
发明人： Steven Ryder , Douglas L. Sheridan
IPC分类号： C07K16/34 , A61P37/06
CPC分类号： C07K16/34 , A61P37/06 , A61K2039/505
摘要： Provided is a regimen for administration of anti-HPA-1a antibodies to a pregnant subject for prevention of maternal alloimmunization with HPA-1a and fetal and neonatal alloimmune thrombocytopenia (FNAIT).

2. 发明授权

US11725063B2 Antibodies against HPA-1a 有权
公开(公告)号：US11725063B2
公开(公告)日：2023-08-15
申请号：US17116882
申请日：2020-12-09
申请人： Rallybio IPA, LLC
发明人： Terje Michaelsen , Oistein Ihle , Tor Brynjar Stuge , Anne Husebekk , Heidi Tiller , Mariana Eksteen , Bjorn Ragnar Skogen
IPC分类号： C07K16/34 , C07K16/28 , G01N33/68
CPC分类号： C07K16/34 , C07K16/2848 , G01N33/6893 , C07K2317/51 , C07K2317/515 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/76 , C07K2317/92 , G01N2333/705 , G01N2800/38
摘要： Provided is an isolated antibody that specifically binds to HPA-1a. Also provided is a nucleic acid molecule that encodes the antibody, and compositions comprising the antibody. Also provided is a method of producing the antibody and methods and uses which employ the antibody. Also provided are therapeutic uses of the antibody, for example in the treatment or prophylaxis of fetal and neonatal alloimmune thrombocytopenia (FNAIT).

3. 发明授权

US10882919B2 Antibodies against HPA-1a 有权
公开(公告)号：US10882919B2
公开(公告)日：2021-01-05
申请号：US15300656
申请日：2015-03-31
申请人： Rallybio IPA, LLC
发明人： Terje Michaelsen , Oistein Ihle , Tor Brynjar Stuge , Anne Husebekk , Heidi Tiller , Mariana Eksteen , Bjorn Ragnar Skogen
IPC分类号： C07K16/34 , C07K16/28 , G01N33/68
摘要： The present invention provides an isolated antibody that specifically binds to HPA-1a. Also provided is a nucleic acid molecule that encodes the antibody, and compositions comprising the antibody. Also provided is a method of producing the antibody and methods and uses which employ the antibody. Also provided are therapeutic uses of the antibody, for example in the treatment or prophylaxis of fetal and neonatal alloimmune thrombocytopenia (FNAIT).

4. 发明授权

US6139821A Materials and methods utilizing a temporary visual indicator 失效
标题翻译：使用临时视觉指标的材料和方法
公开(公告)号：US6139821A
公开(公告)日：2000-10-31
申请号：US362164
申请日：1999-07-27
申请人： Ronnie S. Fuerst , Christopher D. Batich , Richard J. Melker
发明人： Ronnie S. Fuerst , Christopher D. Batich , Richard J. Melker
IPC分类号： A61K6/00 , A61K8/04 , A61K8/49 , A61K31/34 , A61Q17/04 , C09D7/00 , C11D3/40 , G01N31/22 , A61K7/42 , A61K7/44 , A61K31/74
CPC分类号： G01N31/221 , A61K6/0017 , A61K6/0058 , A61K8/046 , A61K8/4973 , A61Q17/04 , C09D7/00 , C11D3/40 , A61K2800/45 , Y10T428/13 , Y10T428/1352 , Y10T428/1397
摘要： This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.
摘要翻译：本发明涉及含有临时视觉指示剂和使用这些组合物的方法的新型组合物。具体地说，本发明涉及一种防晒组合物，其含有当该物质施用于皮肤时可见的指示剂，但在施用后不久即可看见。指示器的持续存在允许指示器临时重新启动到可见形式，使得用户可以验证防晒剂的存在。可视指示器确保防晒霜均匀且完全地涂覆到要保护的区域，但变得不可见，以免干扰防晒霜的作用或使皮肤变色。

5. 发明授权

US6007797A Disappearing color sunscreen compositions 失效
公开(公告)号：US6007797A
公开(公告)日：1999-12-28
申请号：US129938
申请日：1998-08-06
申请人： Robert Bell , Denman Gray
发明人： Robert Bell , Denman Gray
IPC分类号： A61K8/06 , A61K8/27 , A61K8/29 , A61Q17/04 , A61K7/42 , A61K7/00 , A61K7/44
CPC分类号： A61Q17/04 , A61K8/06 , A61K8/27 , A61K8/29 , A61K2800/43
摘要： Sunscreens are colored with oil-soluble dyes approved for use in skin care products (such as sunscreens, lotions, etc.). The color imparted by the dyes substantially disappears shortly after the sunscreen emulsion is applied to skin. This colored sunscreen emulsion includes a oil-soluble phase, at least one sunscreen active agent, water, and an emulsifier. The oil-soluble phase comprises from about 0.0005 to about 0.5 percent by weight of the complete emulsion of at least one oil-soluble dye. The dye imparts a color other than white to the sunscreen emulsion.The sunscreen active ingredient is provided in an amount effective to protect against the actinic radiation of the sun. Sufficient water is provided to form the colored emulsion. The emulsion additionally contains at least one emulsifier in an amount effective to provide an at least substantially stable emulsion. Other optional ingredients may also be compounded into the sunscreen formulations.

6. 发明公开

US20240141066A1 Method of Administering Anti-HPA-1a Monoclonal Antibody 审中-公开
公开(公告)号：US20240141066A1
公开(公告)日：2024-05-02
申请号：US18575804
申请日：2022-06-30
申请人： Rallybio IPA, LLC
发明人： Douglas L. Sheridan
IPC分类号： C07K16/34 , A61P37/06
CPC分类号： C07K16/34 , A61P37/06
摘要： Methods are described for administering to a subject an anti-human platelet antigen (HPA)-1a monoclonal antibody. The methods include parenterally administering to the subject a pharmaceutical composition comprising an anti-HPA-1a monoclonal antibody in an amount of about 0.02 ng/mL to about 0.4 ng/mL, and/or an amount effective to achieve a maximum plasma concentration of the anti-HPA-1a monoclonal antibody of about 0.01 IU/mL to about 10 IU/mL in the subject.

7. 发明授权

US6146618A Disappearing color sunscreen compositions 失效
标题翻译：消失的防晒组合物
公开(公告)号：US6146618A
公开(公告)日：2000-11-14
申请号：US472390
申请日：1999-12-23
申请人： Robert Bell , Denman Gray
发明人： Robert Bell , Denman Gray
IPC分类号： A61K8/06 , A61K8/27 , A61K8/29 , A61Q17/04 , A61K7/42 , A61K7/00 , A61K7/44
CPC分类号： A61Q17/04 , A61K8/06 , A61K8/27 , A61K8/29 , A61K2800/43
摘要： Sunscreens are colored with oil-soluble dyes approved for use in skin care products (such as sunscreens, lotions, etc.). The color imparted by the dyes substantially disappears shortly after the sunscreen emulsion is applied to skin. This colored sunscreen emulsion includes a oil-soluble phase, at least one sunscreen active agent, water, and an emulsifier. The oil-soluble phase comprises from about 0.0005 to about 0.5 percent by weight of the complete emulsion of at least one oil-soluble dye. The dye imparts a color other than white to the sunscreen emulsion.The sunscreen active ingredient is provided in an amount effective to protect against the actinic radiation of the sun. Sufficient water is provided to form the colored emulsion. The emulsion additionally contains at least one emulsifier in an amount effective to provide an at least substantially stable emulsion. Other optional ingredients may also be compounded into the sunscreen formulations.
摘要翻译：防晒霜用经过认可用于护肤品（如防晒霜，洗剂等）的油溶性染料着色。在将防晒乳剂施用于皮肤后，由染料赋予的颜色基本上消失。这种着色的防晒乳液包括油溶性相，至少一种防晒活性剂，水和乳化剂。油溶性相包含至少一种油溶性染料的完全乳液的约0.0005至约0.5重量％。染料赋予防晒乳液以外的白色以外的颜色。提供防晒活性成分的量有效地防止太阳的光化辐射。提供足够的水以形成着色乳液。该乳液还含有至少一种乳化剂，其量有效提供至少基本稳定的乳液。其他任选的成分也可以混合到防晒制剂中。

8. 发明授权

US6086858A Colored formulations for application to human skin 失效
标题翻译：用于人体皮肤的有色配方
公开(公告)号：US6086858A
公开(公告)日：2000-07-11
申请号：US333088
申请日：1999-06-15
申请人： John McEleney , Wende Reenstra , Curtis A. Vock
发明人： John McEleney , Wende Reenstra , Curtis A. Vock
IPC分类号： A61K8/49 , A61K31/74 , A61Q17/04 , A61K7/42 , A61K7/00 , A61K7/44
CPC分类号： A61K8/498 , A61K8/4973 , A61Q17/04 , A61K2800/45 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/946 , Y10S514/947
摘要： A lotion such as a sunscreen includes a color indicator which brightly colorizes the lotion until the lotion is applied to human skin, wherein after the colored lotion changes color or turns clear. A physiological color indicator such as a pH indicator, a colorant or color indicator can be used, alone or in combination, to colorize the lotion in accord with the invention. The lotion is suitable for use in lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protection sunscreens so that a user can ensure even distribution of the sunscreen on the body. A sunscreen of the invention can also include an emollient, such as jojoba oil, an emulsifier, a surfactant, such as sorbitol, water, and a pH adjuster, such as triethanolaminie.
摘要翻译：诸如防晒剂的洗剂包括颜色指示剂，其将洗剂亮度着色，直到洗剂被施用于人体皮肤，其中在彩色洗剂改变颜色或变透明之后。根据本发明，可以单独或组合地使用诸如pH指示剂，着色剂或颜色指示剂的生理颜色指示剂来使洗剂着色。洗剂适用于以均匀均匀的方式最适用于皮肤的乳液，凝胶，摩丝或药物。因此，本发明的一个优选用途是在防紫外线防晒剂中，使得用户可以确保防晒剂在身体上的均匀分布。本发明的防晒剂还可以包括软化剂，例如霍霍巴油，乳化剂，表面活性剂如山梨醇，水和pH调节剂，例如三乙醇胺。

9. 发明申请

US20210189005A1 Antibodies Against HPA-1a 有权
公开(公告)号：US20210189005A1
公开(公告)日：2021-06-24
申请号：US17116882
申请日：2020-12-09
申请人： Rallybio IPA, LLC
发明人： Terje Michaelsen , Oistein Ihle , Tor Brynjar Stuge , Anne Husebekk , Heidi Tiller , Mariana Eksteen , Bjorn Ragnar Skogen
IPC分类号： C07K16/34 , C07K16/28 , G01N33/68
摘要： Provided is an isolated antibody that specifically binds to HPA-1a. Also provided is a nucleic acid molecule that encodes the antibody, and compositions comprising the antibody. Also provided is a method of producing the antibody and methods and uses which employ the antibody. Also provided are therapeutic uses of the antibody, for example in the treatment or prophylaxis of fetal and neonatal alloimmune thrombocytopenia (FNAIT).

10. 发明授权

US5997891A Materials and methods utilizing a temporary visual indicator 失效
公开(公告)号：US5997891A
公开(公告)日：1999-12-07
申请号：US135768
申请日：1998-08-18
申请人： Ronnie S. Fuerst , Richard Melker , Christopher D. Batich
发明人： Ronnie S. Fuerst , Richard Melker , Christopher D. Batich
IPC分类号： A61K6/00 , A61K8/04 , A61K8/49 , A61K31/34 , A61Q17/04 , C09D7/00 , C11D3/40 , G01N31/22 , A61K7/00 , A61K7/42
CPC分类号： G01N31/221 , A61K6/0017 , A61K6/0058 , A61K8/046 , A61K8/4973 , A61Q17/04 , C09D7/00 , C11D3/40 , A61K2800/45 , Y10T428/13 , Y10T428/1352 , Y10T428/1397 , Y10T428/249995 , Y10T428/249997
摘要： This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.

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