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1. 发明授权

US07203683B2 Method and a system for automating the execution of AMoRe over a heterogenous network of computers 失效
标题翻译：用于通过异构网络计算机自动执行AMoRe的方法和系统
公开(公告)号：US07203683B2
公开(公告)日：2007-04-10
申请号：US10269401
申请日：2002-10-11
申请人： Mark B. Mixon , Michael Feese , Lance Stewart , Sridhar Prasad
发明人： Mark B. Mixon , Michael Feese , Lance Stewart , Sridhar Prasad
IPC分类号： G06F17/30
CPC分类号： G06F19/28 , G06F19/16 , Y10S707/99945
摘要： This invention encompasses an apparatus for creating a database containing the results of distributed molecular replacement searches, which comprise data input system for inputting the results of distributed molecular replacement searches and related information and a database generator coupled to said data input system for receiving the results of distributed molecular replacement searches and related information and creating a database for storing the results of distributed molecular replacement searches and related information. The invention includes method of managing the invention of distributed molecular replacement searches.
摘要翻译：本发明包括用于创建包含分布式分子替代搜索结果的数据库的装置，其包括用于输入分布式分子置换搜索结果的数据输入系统和相关信息，以及耦合到所述数据输入系统的数据库生成器，用于接收分布式分子替代搜索和相关信息，并创建一个数据库，用于存储分布式分子替代搜索和相关信息的结果。本发明包括管理分布式分子替换搜索的发明的方法。

2. 发明申请

US20050003502A1 Structures and methods for designing topoisomerase I inhibitors 审中-公开
标题翻译：拓扑异构酶I抑制剂的结构和方法
公开(公告)号：US20050003502A1
公开(公告)日：2005-01-06
申请号：US09993245
申请日：2001-11-14
申请人： Alex Burgin , Kathyrn Hjerrild , Hidong Kim , Bart Staker , Lance Stewart , Craig Behnke , Michael Feese
发明人： Alex Burgin , Kathyrn Hjerrild , Hidong Kim , Bart Staker , Lance Stewart , Craig Behnke , Michael Feese
IPC分类号： C12N9/90 , G06F19/00 , C12N9/99
CPC分类号： C12N9/90 , C07K2299/00
摘要： This invention relates to crystalline structures of the topoisomerase I and their use in designing new anti-cancer agents anti-viral agents and anti-microbial agents.
摘要翻译：本发明涉及拓扑异构酶I的结晶结构及其在设计新的抗癌剂抗病毒剂和抗微生物剂中的用途。

3. 发明申请

US20140073055A1 NANOVOLUME MICROCAPILLARY CRYSTALLIZATION SYSTEM 审中-公开
标题翻译：纳米微晶微结晶系统
公开(公告)号：US20140073055A1
公开(公告)日：2014-03-13
申请号：US13776526
申请日：2013-02-25
申请人： EMERALD BIOSTRUCTURES, INC.
发明人： Cory John Gerdts , Mark William Elliott , Peter Kurt Nollert-von Specht , Lansing Joseph Stewart
IPC分类号： B01D9/00
CPC分类号： B01D9/0072 , B01D9/00 , Y10T428/31855
摘要： A nanovolume microcapillary crystallization system allows nanoliter-volume screening of crystallization conditions in a crystal card that allows crystals to either be removed for traditional cryoprotection or in situ X-ray diffraction studies on protein crystals that grow within. The system integrates formulation of crystallization cocktails with preparation of the crystallization experiments. The system allows the researcher to select either gradient screening in crystallization experiments for efficient exploration of crystallization phase space or a combination of sparse matrix with gradient screening to execute one comprehensive hybrid crystallization trial.
摘要翻译：纳米级微毛细管结晶系统允许纳米级体积筛选晶体卡中的结晶条件，其允许将晶体除去用于传统的冷冻保护或在其内生长的蛋白质晶体的原位X射线衍射研究。该系统将结晶鸡尾酒配方与结晶实验的准备相结合。该系统允许研究者选择结晶实验中的梯度筛选，以有效探索结晶相空间，或者通过梯度筛选稀释基质的组合进行一次综合混合结晶试验。

4. 发明申请

US20040215398A1 Method and a system for automating the execution of AMoRe over a heterogenous network of computers 失效
标题翻译：用于通过异构网络计算机自动执行AMoRe的方法和系统
公开(公告)号：US20040215398A1
公开(公告)日：2004-10-28
申请号：US10269401
申请日：2002-10-11
申请人： Emerald Biostructures, Inc.
发明人： Mark B. Mixon , Michael Feese , Lance J. Stewart , Sridhar Prasad
IPC分类号： G06F019/00 , G01N033/48 , G01N033/50
CPC分类号： G06F19/28 , G06F19/16 , Y10S707/99945
摘要： This invention encompasses an apparatus for creating a database containing the results of distributed molecular replacement searches, which comprise data input system for inputting the results of distributed molecular replacement searches and related information and a database generator coupled to said data input system for receiving the results of distributed molecular replacement searches and related information and creating a database for storing the results of distributed molecular replacement searches and related information. The invention includes method of managing the invention of distributed molecular replacement searches.
摘要翻译：本发明包括用于创建包含分布式分子替代搜索结果的数据库的装置，其包括用于输入分布式分子置换搜索结果的数据输入系统和相关信息，以及耦合到所述数据输入系统的数据库生成器，用于接收分布式分子替代搜索和相关信息，并创建一个数据库，用于存储分布式分子替代搜索和相关信息的结果。本发明包括管理分布式分子替换搜索的发明的方法。

5. 发明授权

US6039804A Crystallization tray 有权
标题翻译：结晶托盘
公开(公告)号：US6039804A
公开(公告)日：2000-03-21
申请号：US150629
申请日：1998-09-09
申请人： Hidong Kim , Lansing Joseph Stewart
发明人： Hidong Kim , Lansing Joseph Stewart
IPC分类号： G01N23/20 , C30B7/00 , C30B29/58 , G01N1/28 , C30B35/00
CPC分类号： C30B7/00 , C30B29/58 , Y10S117/901 , Y10T117/1024
摘要： The present invention provides a crystallization unit including a solvent reservoir in gaseous communication with a plurality of chambers. Preferably, a plurality of crystallization units are arrayed in the form of a crystallization tray. A first preferred embodiment of the present invention provides a crystallization tray 10 including a rectangular array of crystallization units 26. Each crystallization unit includes a central reservoir 28 and four drop chambers 32 arranged in a cruciform configuration around central reservoir 28. Each drop chamber 32 is connected to central reservoir 28 by a diffusion channel 30. Each drop chamber 32 also includes a shoulder which is capable of supporting a cover slip from which a drop of solution, containing the substance to be crystallized, can be suspended. A second preferred embodiment of the present invention is identical to the first preferred embodiment except that central reservoir 28 is divided into four equal sections by dividers extending vertically from the bottom of central reservoir 28.
摘要翻译：本发明提供一种结晶单元，其包括与多个室气态连通的溶剂储存器。优选地，多个结晶单元以结晶托盘的形式排列。本发明的第一优选实施方案提供了包括结晶单元26的矩形阵列的结晶托盘10.每个结晶单元包括中央储存器28和围绕中央储存器28布置成十字形构造的四个液滴室32.每个液滴室32 通过扩散通道30连接到中央储存器28.每个液滴室32还包括肩部，该肩部能够支撑覆盖层，可以悬挂含有待结晶物质的一滴溶液。本发明的第二优选实施例与第一优选实施例相同，除了中央储存器28由中央储存器28的底部垂直延伸的分隔件分成四个相等的部分。

6. 发明授权

US06950757B2 Screening methods for identifying ligands 失效
标题翻译：鉴定配体的筛选方法
公开(公告)号：US06950757B2
公开(公告)日：2005-09-27
申请号：US10121094
申请日：2002-04-11
申请人： Lansing J. Stewart
发明人： Lansing J. Stewart
IPC分类号： B01D9/02 , C12Q1/68 , G01N31/00 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/68 , G06F19/00
CPC分类号： G01N33/54313 , G01N33/68
摘要： This invention relates to crystallization based assays for identifying ligands that bind to a macromolecule.
摘要翻译：本发明涉及用于鉴定结合大分子的配体的基于结晶的测定法。

7. 发明申请

US20030072683A1 Robot for mixing crystallization trial matrices 失效
标题翻译：用于混合结晶试验基质的机器人
公开(公告)号：US20030072683A1
公开(公告)日：2003-04-17
申请号：US10184037
申请日：2002-06-26
申请人： Emerald BioStructures, Inc.
发明人： Lansing J. Stewart , Alexandrina Muntianu , Robin Clark
IPC分类号： B01L003/02
CPC分类号： C30B7/00 , C30B29/58 , Y10S117/90 , Y10T117/10 , Y10T117/1004
摘要： A matrix mixing robot includes a plurality of precision pumps (such as precision syringe pumps), a distributor and a processor system. Each pump, under the control of the processor system, draws an associated stock solution from a stock solution source, and pumps the drawn stock solution out through an outlet. The distributor, also under the control of the processor system, directs a stock solution from a particular pump outlet to a selected solution receptacle. A multi-port distribution valve may be associated with each precision pump. Each valve, under control of the processor system, can connect its associated pump to one the pump's inlets or outlets.
摘要翻译：矩阵混合机器人包括多个精密泵（例如精密注射泵），分配器和处理器系统。处理器系统控制下的每个泵从原液解决方案中抽出一个相关的库存解决方案，并通过一个出口将抽出的库存溶液抽出来。分配器也在处理器系统的控制下，将库存溶液从特定的泵出口引导到选定的溶液容器。多口分配阀可以与每个精密泵相关联。处理器系统控制下的每个阀都可以将其相关的泵连接到泵的入口或出口。

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