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1. 发明授权

US5968789A Method of producing a taxane-type diterpene and a method of obtaining cultured cells which produce the taxane-type diterpene at a high rate 失效
标题翻译：紫杉烷类双萜的制造方法以及高速生成紫杉烷类双萜的培养细胞的制造方法
公开(公告)号：US5968789A
公开(公告)日：1999-10-19
申请号：US808218
申请日：1997-02-28
申请人： Yukihito Yukimune , Yasuhiro Hara , Yosuke Higashi , Naoto Ohnishi , Homare Tabata , Chuzo Suga , Kouichi Matsubara
发明人： Yukihito Yukimune , Yasuhiro Hara , Yosuke Higashi , Naoto Ohnishi , Homare Tabata , Chuzo Suga , Kouichi Matsubara
IPC分类号： C12N5/00 , C12N5/04 , C12P17/02
CPC分类号： C12N5/04 , C12N5/0025 , C12P17/02
摘要： This invention relates to a method of producing a taxane-type diterpene(s) wherein tissues or cells of a plant which produces taxane-type diterpene(s) is cultured in the presence of at least one selected from the group consisting of jasmonic acids, compounds containing a heavy metal, complex ions containing a heavy metal, heavy metal ions, amines and antiethylene agents, a method of producing a taxane-type diterpene wherein the tissues or the cells of the plant are cultured by controlling the oxygen concentration in a gas phase in a culture vessel to less than the oxygen concentration in the atmosphere from the initial stage of the culture, or by controlling the dissolved oxygen concentration in a fluid medium which is in contact with the tissue or the cell to less than the saturated dissolved oxygen concentration at that temperature from the initial stage of the culture, a method of producing a taxane-type diterpene wherein the tissue or the cell of the plant is cultured in a culture vessel, while oxygenic gas containing 0.03-10% of carbon dioxide is used as aeration gas to be introduced to the vessel, and a method of obtaining highly productive cultured cells for the taxane-type diterpene wherein cultured cells of the plant which produces the taxane-type diterpene are separated into a plurality of layers according to the difference in their specific gravities, and the cells contained in at least one layer are cultured, then highly productive cultured cells for the taxane-type diterpene are selected from among those cultured cells.The present invention allows industrial production of a taxane-type diterpene such as taxol which is useful as a therapeutic agent for cancer.
摘要翻译：本发明涉及一种生产紫杉烷类双萜的方法，其中在选自茉莉酸，茉莉酮酸，缬氨酸，缬氨酸，含有重金属的化合物，含有重金属的配合离子，重金属离子，胺类和抗乙烯剂等，制备紫杉烷类双萜的方法，其中通过控制气体中的氧浓度来培养植物的组织或细胞培养容器中的相位低于培养初期的大气中的氧浓度，或通过将与组织或细胞接触的流体培养基中的溶解氧浓度控制为小于饱和溶解氧从培养的初始阶段开始的温度下的浓度，制备紫杉烷类双萜的方法，其中在培养物中培养植物的组织或细胞容器，而含有0.03-10％二氧化碳的含氧气体用作引入容器的通气气体，以及获得紫杉烷类双萜高产培养细胞的方法，其中产生紫杉烷的植物培养细胞型二萜根据其比重差异分离成多个层，培养至少一层所含的细胞，然后从培养的细胞中选出紫杉烷类双萜的高效培养细胞。本发明允许工业生产可用作癌症治疗剂的紫杉烷类二萜类例如紫杉醇。

2. 发明授权

US5637484A Method of producing a taxane-type diterpene and a method of obtaining cultured cells which produce the taxane-type diterpene at a high rate 失效
标题翻译：紫杉烷类双萜的制造方法以及高速生成紫杉烷类双萜的培养细胞的制造方法
公开(公告)号：US5637484A
公开(公告)日：1997-06-10
申请号：US491844
申请日：1995-07-14
申请人： Yukihito Yukimune , Yasuhiro Hara , Yosuke Higashi , Naoto Ohnishi , Homare Tabata , Chuzo Suga , Kouichi Matsubara
发明人： Yukihito Yukimune , Yasuhiro Hara , Yosuke Higashi , Naoto Ohnishi , Homare Tabata , Chuzo Suga , Kouichi Matsubara
IPC分类号： C12N5/00 , C12N5/04 , C12P17/02 , C12P1/00 , C12P15/00
CPC分类号： C12N5/04 , C12N5/0025 , C12P17/02
摘要： This invention relates to a method of producing a taxane-type diterpene(s) wherein tissues or cells of a plant which produces taxane-type diterpene(s) are cultured in the presence of at least one member selected from the group consisting of jasmonic acids, wherein the tissues or the cells of the plant are cultured by controlling the oxygen concentration in a gas phase in a culture vessel to less than the oxygen concentration in the atmosphere from the initial stage of the culture, or by controlling the dissolved oxygen concentration in a fluid medium which is in contact with the tissue or the cell to less than the saturated dissolved oxygen concentration at that temperature from the initial stage of the culture, while oxygenic gas containing 0.03-10% of carbon dioxide is used as aeration gas to be introduced to the vessel, and a method of obtaining highly productive cultured cells for the taxane-type diterpene wherein cultured cells of the plant which produces the taxane-type diterpene are separated into a plurality of layers according to the difference in their specific gravities, and the cells contained in at least one layer are cultured, then highly productive cultured cells for the taxane-type diterpene are selected from among those cultured cells. The present invention allows industrial production of a taxane-type diterpene such as taxol which is useful as a therapeutic agent for cancer.
摘要翻译： PCT No.PCT / JP94 / 01880 Sec。 371 1995年7月14日第 102（e）日期1995年7月14日PCT 1994年11月9日PCT PCT。 WO95 / 14103 PCT出版物日期1995年5月26日本发明涉及一种生产紫杉烷型双萜的方法，其中在存在有至少一种选自下组的成员的情况下培养产生紫杉烷类双萜的植物的组织或细胞由茉莉酸组成，其中通过将培养容器中的气相中的氧浓度控制为从培养初期的大气中的氧浓度来培养植物的组织或细胞，或者通过控制在与培养初期接触的流体介质中的溶解氧浓度低于培养初期的该温度下的饱和溶解氧浓度，而使用含有0.03-10％二氧化碳的含氧气体作为要引入容器的曝气气体，以及获得紫杉烷类双萜高产培养细胞的方法，其中产生分类单位的植物培养细胞根据其比重差异将ne型双萜分离成多个层，并培养至少一层中所含的细胞，然后从培养细胞中选出紫杉烷类双萜的高效培养细胞。本发明允许工业生产可用作癌症治疗剂的紫杉烷类二萜类例如紫杉醇。

3. 发明授权

US06403343B2 Method of producing a taxane-type diterpene and a method of obtaining cultured cells which produce the taxane-type dilterpene at a high rate 有权
标题翻译：紫杉烷类双萜的制造方法以及获得以高速率生产紫杉烷类萜烯的培养细胞的方法
公开(公告)号：US06403343B2
公开(公告)日：2002-06-11
申请号：US09301075
申请日：1999-04-28
申请人： Yukihito Yukimune , Yasuhiro Hara , Yosuke Higashi , Naoto Ohnishi , Homare Tabata , Chuzo Suga , Kouichi Matsubara
发明人： Yukihito Yukimune , Yasuhiro Hara , Yosuke Higashi , Naoto Ohnishi , Homare Tabata , Chuzo Suga , Kouichi Matsubara
IPC分类号： C12P1702
CPC分类号： C12N5/04 , C12N5/0025 , C12P17/02
摘要： This invention relates to a method of producing a taxane-type diterpene(s) wherein tissues or cells of a plant which produces taxane-type diterpene(s) is cultured in the presence of at least one selected from the group consisting of jasmonic acids, compounds containing a heavy metal, complex ions containing a heavy metal, heavy metal ions, amines and antiethylene agents, a method of producing a taxane-type diterpene wherein the tissues or the cells of the plant are cultured by controlling the oxygen concentration in a gas phase in a culture vessel to less than the oxygen concentration in the atmosphere from the initial stage of the culture, or by controlling the dissolved oxygen concentration in a fluid medium which is in contact with the tissue or the cell to less than the saturated dissolved oxygen concentration at that temperature from the initial stage of the culture, a method of producing a taxane-type diterpene wherein the tissue or the cell of the plant is cultured in a culture vessel, while oxygenic gas containing 0.03-10 % of carbon dioxide is used as aeration gas to be introduced to the vessel, and a method of obtaining highly productive cultured cells for the taxane-type diterpene wherein cultured cells of the plant which produces the taxane-type diterpene are separated into a plurality of layers according to the difference in their specific gravities, and the cells contained in at least one layer are cultured, then highly productive cultured cells for the taxane-type diterpene are selected from among those cultured cells. The present invention allows industrial production of a taxane-type diterpene such as taxol which is useful as a therapeutic agent for cancer.
摘要翻译：本发明涉及一种生产紫杉烷类双萜的方法，其中在选自茉莉酸，茉莉酮酸，缬氨酸，缬氨酸，含有重金属的化合物，含有重金属的配合离子，重金属离子，胺类和抗乙烯剂等，制备紫杉烷类双萜的方法，其中通过控制气体中的氧浓度来培养植物的组织或细胞培养容器中的相位低于培养初期的大气中的氧浓度，或通过将与组织或细胞接触的流体培养基中的溶解氧浓度控制为小于饱和溶解氧从培养的初始阶段开始的温度下的浓度，制备紫杉烷类双萜的方法，其中在培养物中培养植物的组织或细胞容器，而含有0.03-10％二氧化碳的含氧气体用作引入容器的通气气体，以及获得紫杉烷类双萜高产培养细胞的方法，其中产生紫杉烷的植物培养细胞型二萜根据其比重差异分离成多个层，培养至少一层所含的细胞，然后从那些培养的细胞中选出紫杉烷类双萜的高效培养细胞。本发明允许工业生产可用作癌症治疗剂的紫杉烷类二萜类例如紫杉醇。

4. 发明申请

US20070202233A1 Plant Cell-Derived Pectin 审中-公开
标题翻译：植物细胞衍生的果胶
公开(公告)号：US20070202233A1
公开(公告)日：2007-08-30
申请号：US10593648
申请日：2005-02-21
申请人： Yoshihiro Kato , Kouichi Matsubara , Homare Tabata
发明人： Yoshihiro Kato , Kouichi Matsubara , Homare Tabata
IPC分类号： A23L1/05
CPC分类号： C12P19/04 , A61K8/73 , A61K8/97 , A61Q1/02 , A61Q1/08 , A61Q19/00 , C08B37/0045
摘要： It is intended to find characteristics of a pectin having a high molecular weight as compared with the existing pectins which are obtained by extracting plants and provide a method whereby the pectin can be supplied in a large amount. A callus derived from a plant is cultured so as to produce a pectin having a high molecular weight in the culture or the culture broth. Then the desired pectin is obtained by separating from the thus obtained culture or culture broth and purifying. The pectin thus obtained of the present invention has favorable properties as a moisturizer and, therefore, is excellent as a cosmetic material.
摘要翻译：旨在发现与通过提取植物获得的现有果胶相比具有高分子量的果胶的特征，并提供可以大量供应果胶的方法。培养来自植物的愈伤组织以在培养物或培养液中产生具有高分子量的果胶。然后通过从如此获得的培养物或培养液中分离并纯化获得所需的果胶。由此得到的本发明的果胶作为保湿剂具有良好的性能，因此作为化妆品材料是优异的。

5. 发明申请

US20120094296A1 ENZYME PREPARATION CONTAINING THERMOSTABLE DNA POLYMERASE, METHOD FOR PRODUCING SAME, AND METHOD FOR DETECTING SUBJECT ORGANISM TO BE DETECTED 有权
标题翻译：含有热稳定性DNA聚合酶的酶制剂，其生产方法和检测待检测的有机体的方法
公开(公告)号：US20120094296A1
公开(公告)日：2012-04-19
申请号：US13144175
申请日：2009-01-15
申请人： Homare Tabata , Hiroshi Minami , Hideki Niimi , Isao Kitajima , Tomohiro Ueno , Shiroh Hayashi , Masashi Mori
发明人： Homare Tabata , Hiroshi Minami , Hideki Niimi , Isao Kitajima , Tomohiro Ueno , Shiroh Hayashi , Masashi Mori
IPC分类号： C12Q1/68 , C12N9/12
CPC分类号： C12Q1/689 , C12N9/1252 , C12P19/34 , C12Q1/68 , C12Q1/686 , C12Q1/6895 , C12Y207/07007
摘要： Disclosed is a thermostable DNA polymerase preparation which can illimitably reduce the risk of false positivity in the detection of a subject microorganism utilizing a gene amplification reaction and therefore enables the selective amplification of DNA for detecting the subject microorganism even when the amount of the subject microorganism is small and therefore the amount of DNA collected therefrom is extremely small, and can be produced at a reduced cost. Also disclosed is a method for quantifying or quantifying/identifying a subject organism to be detected rapidly, conveniently and with high sensitivity using the preparation of the present invention.
摘要翻译：公开了一种耐热性DNA聚合酶制剂，其可以不利地降低使用基因扩增反应检测受试微生物的假阳性风险，因此即使当受试微生物的量为因此从其收集的DNA的量非常小，并且可以以降低的成本生产。还公开了使用本发明的制剂来快速，方便地且高灵敏度地定量或鉴定待检测物体的方法。

6. 发明授权

US09243272B2 Enzyme preparation containing thermostable DNA polymerase, method for producing same, and method for detecting subject organism to be detected 有权
标题翻译：含有热稳定性DNA聚合酶的酶制剂及其制造方法以及检测被检测体的方法
公开(公告)号：US09243272B2
公开(公告)日：2016-01-26
申请号：US13144175
申请日：2010-01-15
申请人： Homare Tabata , Hiroshi Minami , Hideki Niimi , Isao Kitajima , Tomohiro Ueno , Shiroh Hayashi , Masashi Mori
发明人： Homare Tabata , Hiroshi Minami , Hideki Niimi , Isao Kitajima , Tomohiro Ueno , Shiroh Hayashi , Masashi Mori
IPC分类号： C12Q1/68 , C12P19/34 , C12N9/12
CPC分类号： C12Q1/689 , C12N9/1252 , C12P19/34 , C12Q1/68 , C12Q1/686 , C12Q1/6895 , C12Y207/07007
摘要： Disclosed is a thermostable DNA polymerase preparation which can illimitably reduce the risk of false positivity in the detection of a subject microorganism utilizing a gene amplification reaction and therefore enables the selective amplification of DNA for detecting the subject microorganism even when the amount of the subject microorganism is small and therefore the amount of DNA collected therefrom is extremely small, and can be produced at a reduced cost. Also disclosed is a method for quantifying or quantifying/identifying a subject organism to be detected rapidly, conveniently and with high sensitivity using the preparation of the present invention.
摘要翻译：公开了一种耐热性DNA聚合酶制剂，其可以不利地降低使用基因扩增反应检测受试微生物的假阳性风险，因此即使当受试微生物的量为因此从其收集的DNA的量非常小，并且可以以降低的成本生产。还公开了使用本发明的制剂来快速，方便地且高灵敏度地定量或鉴定待检测物体的方法。

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