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1. 发明授权

US06476186B1 Process for preparing octreotide and derivatives thereof 有权
标题翻译：制备奥曲肽及其衍生物的方法
公开(公告)号：US06476186B1
公开(公告)日：2002-11-05
申请号：US09576769
申请日：2000-05-24
申请人： Yao-Tsung Hsieh , Shiang-Rong Chang , Shyh-Yi Chyi , Hui-Lan Wu , Shu-Ling Chen , Henton Huang , Te-Wei Lee , Tian-Fu Huang
发明人： Yao-Tsung Hsieh , Shiang-Rong Chang , Shyh-Yi Chyi , Hui-Lan Wu , Shu-Ling Chen , Henton Huang , Te-Wei Lee , Tian-Fu Huang
IPC分类号： C07K104
CPC分类号： C07K14/6555 , Y02P20/55
摘要： This invention relates a process for preparing octreotide and derivatives thereof. The starting material, Thr(ol)(tBu)-2-chlorotrityl resin is coupled with the various amino acids. The straight peptide-resin of D-Phe-Cys(Trt)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)(tBu)-2-chlorotrityl resin or D-Phe-Cys(Trt)-Tyr(tBu)-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)(tBu)-2-chlorotrityl resin was obtained. Cleavage of the peptide from the resin was achieved by strong acid solution. The cleaved peptide reacted with charcoal to give disulfide-containing peptide of
摘要翻译：本发明涉及制备奥曲肽及其衍生物的方法。起始物质Thr（ol）（tBu）-2-氯三苯甲基树脂与各种氨基酸偶联。 D-Phe-Cys（Trt）-Phe-D-Trp（Boc）-Lys（Boc）-Thr（tBu）-Cys（Trt）-Thr（ol）（tBu）-2-氯三苯甲基树脂或D-Phe-Cys（Trt）-Tyr（tBu）-D-Trp（Boc）-Lys（Boc）-Thr（tBu）-Cys（Trt）-Thr（ol）（tBu）-2-氯三苯甲基树脂获得。通过强酸溶液从树脂中切下肽。裂解的肽与木炭反应，得到含二硫化物的肽

2. 发明授权

US5889146A Method for synthesis of bifunctional chelating agents-peptides 失效
标题翻译：双功能螯合剂 - 肽的合成方法
公开(公告)号：US5889146A
公开(公告)日：1999-03-30
申请号：US978615
申请日：1997-11-26
申请人： Te-Wei Lee , Shui-Tein Chen , Shiang-Rong Chang , Shyh-Yi Chyi , Chang-Mau Shing , Tian-Fu Huang , Lie-Hang Shen , Zei-Tsan Tsai , Kung-Tsung Wang , Gann Ting
发明人： Te-Wei Lee , Shui-Tein Chen , Shiang-Rong Chang , Shyh-Yi Chyi , Chang-Mau Shing , Tian-Fu Huang , Lie-Hang Shen , Zei-Tsan Tsai , Kung-Tsung Wang , Gann Ting
IPC分类号： A61K51/08 , C07K7/06 , A61K38/12 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K7/06 , A61K51/083 , A61K51/088 , A61K2123/00
摘要： This invention is a novel synthesis of BCA-peptides (BCA: bifunctional chelating agents). In this method, the starting material--Fmoc-Thr(ol)-Terephthal-Acetal-Amide Resin is coupled with the various amino acids. The straight peptide-resin of D-Phe-Cys(Trt)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)-Terephthal-Acetal-Amide Resin was obtained. This compound reacted with iodine to give disulfide-containing peptide resin of ##STR1## Cleavage of the peptide from the resin was achieved by TFA. The cleavaged peptide was protected by the reaction of octreotide with di-t-butyldicarbonate. BCA was coupled to the selectively protected octreotide. This product was obtained by reaction of protected BCA-peptides with TFA. The final product was labeled by radioisotope .sup.111 InCl.sub.3 for tumor imaging radiopharmaceuticals.
摘要翻译：本发明是BCA肽（BCA：双功能螯合剂）的新型合成。在该方法中，起始物质-Fmoc-Thr（ol） - 对 - 对 - 乙酰胺树脂与各种氨基酸偶联。 D-Phe-Cys（Trt）-Phe-D-Trp（Boc）-Lys（Boc）-Thr（tBu）-Cys（Trt）-Thr（ol） - 对 - 缩醛酰胺树脂的直链肽 - 树脂获得。该化合物与碘反应，得到含二硫化物的肽树脂，通过TFA实现了树脂中肽的切割。通过奥曲肽与二碳酸二叔丁酯的反应来保护切割的肽。 BCA与选择性保护的奥曲肽偶联。该产物通过保护的BCA-肽与TFA的反应获得。最终产品用放射性同位素111InCl3标记用于肿瘤成像放射性药物。

3. 发明授权

US08141205B2 Hinge mechanism and portable electronic device using the same 失效
标题翻译：铰链机构和使用其的便携式电子设备
公开(公告)号：US08141205B2
公开(公告)日：2012-03-27
申请号：US12538273
申请日：2009-08-10
申请人： Yu Zhang , Tian-Fu Huang
发明人： Yu Zhang , Tian-Fu Huang
IPC分类号： E05F1/08
CPC分类号： H04M1/0216 , G06F1/1681 , Y10T16/53826 , Y10T16/5385 , Y10T16/5387
摘要： A hinge mechanism comprises a follower, a cam and a first spring. The first spring is spiral, one end of the first spring is mounted to the follower, another end of the first spring is mounted to the cam. The cam rotates relative to the follower about a rotating axis, the first spring is compressed to accumulate elastic force, until the line connecting two ends of the first spring is parallel to the rotating axis where the first spring is mostly compressed to accumulate maximum of the elastic force and the hinge mechanism is in an intermediate state. Once the cam is rotated over the intermediate state, the first spring is expanded under previously accumulated elastic force, which drive the cam continuously rotated relative to the follower.
摘要翻译：铰链机构包括从动件，凸轮和第一弹簧。第一弹簧是螺旋形的，第一弹簧的一端安装在从动件上，第一弹簧的另一端安装在凸轮上。凸轮相对于从动件围绕旋转轴线旋转，第一弹簧被压缩以累积弹性力，直到连接第一弹簧的两端的线平行于旋转轴线，其中第一弹簧被大部分压缩以累积最大值弹性力和铰链机构处于中间状态。一旦凸轮在中间状态下旋转，则第一弹簧在预先累积的弹力下膨胀，从而驱动凸轮相对于从动件连续旋转。

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