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1. 发明授权

US07192752B2 Real time electronic cell sensing systems and applications for cell-based assays 有权
标题翻译：实时电子传感系统和基于细胞的测定的应用
公开(公告)号：US07192752B2
公开(公告)日：2007-03-20
申请号：US10987732
申请日：2004-11-12
申请人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
发明人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
IPC分类号： C12N13/00
CPC分类号： G01N33/6854 , C12M25/08 , C12M41/36 , G01N33/4836 , G01N33/5005 , G01N2500/10
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了一种电池衬底监测系统，其包括一个或多个电池衬底监测装置，其中每个电池衬底监测装置包括各自具有电极阵列的多个阱，阻抗分析器，将各个阱的阵列连接到阻抗分析仪的装置站以及软件用于控制设备站和阻抗分析仪。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。在一些优选的方面，设计测定法以研究化合物对细胞的影响，例如细胞毒性测定。在其它优选方面，设计这些测定法来研究影响细胞对抗原的IgE介导的反应的化合物。

2. 发明申请

US20050153425A1 Real time electronic cell sensing systems and applications for cell-based assays 有权
标题翻译：实时电子传感系统和基于细胞的测定的应用
公开(公告)号：US20050153425A1
公开(公告)日：2005-07-14
申请号：US10987732
申请日：2004-11-12
申请人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
发明人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
IPC分类号： C12M1/34 , C12M1/42 , C12N20060101 , G01N33/487 , H01M4/50
CPC分类号： G01N33/6854 , C12M25/08 , C12M41/36 , G01N33/4836 , G01N33/5005 , G01N2500/10
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了一种电池衬底监测系统，其包括一个或多个电池衬底监测装置，其中每个电池衬底监测装置包括各自具有电极阵列的多个阱，阻抗分析器，将各个阱的阵列连接到阻抗分析仪的装置站以及软件用于控制设备站和阻抗分析仪。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。在一些优选的方面，设计测定法以研究化合物对细胞的影响，例如细胞毒性测定。在其它优选方面，设计这些测定法来研究影响细胞对抗原的IgE介导的反应的化合物。

3. 发明申请

US20070172939A1 Real time electronic cell sensing system and applications for cell-based assays 有权
标题翻译：实时电子传感系统和基于细胞的测定应用
公开(公告)号：US20070172939A1
公开(公告)日：2007-07-26
申请号：US11725040
申请日：2007-03-15
申请人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
发明人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
IPC分类号： C12M1/34
CPC分类号： G01N33/6854 , C12M25/08 , C12M41/36 , G01N33/4836 , G01N33/5005 , G01N2500/10
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了一种电池衬底监测系统，其包括一个或多个电池衬底监测装置，其中每个电池衬底监测装置包括各自具有电极阵列的多个阱，阻抗分析器，将各个阱的阵列连接到阻抗分析仪的装置站以及软件用于控制设备站和阻抗分析仪。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。在一些优选的方面，设计测定法以研究化合物对细胞的影响，例如细胞毒性测定。在其它优选方面，设计这些测定法来研究影响细胞对抗原的IgE介导的反应的化合物。

4. 发明授权

US09625472B2 Real time electronic cell sensing systems and applications for cell-based assays 有权
公开(公告)号：US09625472B2
公开(公告)日：2017-04-18
申请号：US13244004
申请日：2011-09-23
申请人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
发明人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
IPC分类号： C12M1/34 , G01N33/68 , C12M1/12 , G01N33/50 , G01N33/483
CPC分类号： G01N33/6854 , C12M25/08 , C12M41/36 , G01N33/4836 , G01N33/5005 , G01N2500/10
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays.

5. 发明申请

US20120142031A1 REAL TIME ELECTRONIC CELL SENSING SYSTEMS AND APPLICATIONS FOR CELL-BASED ASSAYS 有权
标题翻译：实时电子细胞感测系统和基于细胞测定的应用
公开(公告)号：US20120142031A1
公开(公告)日：2012-06-07
申请号：US13244004
申请日：2011-09-23
申请人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
发明人： Xiao Xu , Yama Abassi , Xiaobo Wang , Jiangbo Gan
IPC分类号： G01N33/566 , C12Q1/02 , G01N33/53 , C12Q1/06
CPC分类号： G01N33/6854 , C12M25/08 , C12M41/36 , G01N33/4836 , G01N33/5005 , G01N2500/10
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。在一些优选的方面，设计测定法以研究化合物对细胞的影响，例如细胞毒性测定。

6. 发明授权

US08026080B2 Real time electronic cell sensing system and applications for cell-based assays 有权
标题翻译：实时电子传感系统和基于细胞的测定应用
公开(公告)号：US08026080B2
公开(公告)日：2011-09-27
申请号：US11725040
申请日：2007-03-15
申请人： Xiaobo Wang , Yama A. Abassi , Xiao Xu , Jiangbo Gan
发明人： Xiaobo Wang , Yama A. Abassi , Xiao Xu , Jiangbo Gan
IPC分类号： C12Q1/20 , C12Q1/08 , C12M1/34
CPC分类号： G01N33/6854 , C12M25/08 , C12M41/36 , G01N33/4836 , G01N33/5005 , G01N2500/10
摘要： The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.
摘要翻译：本发明包括使用细胞 - 基底阻抗监测来测定细胞的装置，系统和方法。在一个方面，本发明提供了包括非导电衬底上的电极阵列的电池衬底阻抗监测装置，其中每个阵列在整个阵列上具有大致均匀的电极电阻。在另一方面，本发明提供了一种电池衬底监测系统，其包括一个或多个电池衬底监测装置，其中每个电池衬底监测装置包括各自具有电极阵列的多个阱，阻抗分析器，将各个阱的阵列连接到阻抗分析仪的装置站以及软件用于控制设备站和阻抗分析仪。在另一方面，本发明提供了使用阻抗监测来检测细胞行为或状态的变化的细胞测定。在一些优选的方面，设计测定法以研究化合物对细胞的影响，例如细胞毒性测定。在其它优选方面，设计这些测定法来研究影响细胞对抗原的IgE介导的反应的化合物。

7. 发明申请

US20080165040A1 Calibrating a digital-to-analog converter 有权
公开(公告)号：US20080165040A1
公开(公告)日：2008-07-10
申请号：US11651858
申请日：2007-01-10
申请人： Christian J. Rotchford , Brandt Braswell , Jiangbo Gan , Michael L. Gomez , Gerald P. Miaille , Boris V. Razmyslovitch
发明人： Christian J. Rotchford , Brandt Braswell , Jiangbo Gan , Michael L. Gomez , Gerald P. Miaille , Boris V. Razmyslovitch
IPC分类号： H03M1/10
CPC分类号： H03M1/1047 , H03M1/66
摘要： Methods and corresponding systems for calibrating a digital-to-analog converter include selecting first and second code regions in the digital-to-analog converter, wherein the first and second code regions are separated by a boundary. Thereafter a waveform sequence is input into the digital-to-analog converter, wherein the waveform sequence has a zero offset at the boundary. Then a relative compensation value between the first and second code regions is adjusted to reduce a distortion in an output of the digital-to-analog converter. A magnitude of a third harmonic distortion of the waveform sequence can be used to measure distortion in the output. Adjusting the relative compensation can include converting the output of the digital-to-analog converter to a digital sequence, filtering the digital sequence, and measuring a harmonic distortion in the digital sequence.

8. 发明授权

US08068797B2 Gain control methods for wireless devices and transmitters 有权
标题翻译：无线设备和发射机的增益控制方法
公开(公告)号：US08068797B2
公开(公告)日：2011-11-29
申请号：US12249649
申请日：2008-10-10
申请人： Jiangbo Gan , Srinivasa R. Bommareddy , Pravin Premakanthan
发明人： Jiangbo Gan , Srinivasa R. Bommareddy , Pravin Premakanthan
IPC分类号： H04B1/04 , H04K3/00
CPC分类号： H04B1/0475 , H03G3/3036
摘要： A gain control process (1102) executed at a transmitter (500) generates (1314) a gain ramp signal (1206) having a delay component (1224) and a gain component (1226). The process (1102) further generates (1304) and incorporates (1306) a gain arc (1202) into a digital signal to form a digital gain signal (1204) having a digital gain change (1218). A combiner (502) combines a digital input signal (512) with the digital gain signal (1204) to generate a pre-compensated digital signal (516). A variable gain amplifier (508) applies a sequence of gains (1234,1236,1238,1240,1242) in the gain component (1126) of the gain ramp signal (1206) to a pre-adjusted analog signal (520) in order to generate a gain-adjusted analog signal (524). Application of the gain component (1126) and the digital gain change (1218) occurs when a portion (1212) of the gain arc (1202) indicates a low instantaneous signal power at an antenna (106) in order to reduce ACLR degradation.
摘要翻译：在发射机（500）处执行的增益控制处理（1102）生成具有延迟分量（1224）和增益分量（1226）的增益斜坡信号（1206）（1314）。过程（1102）进一步产生（1304）并且将增益电弧（1202）并入（1306）到数字信号中以形成具有数字增益变化的数字增益信号（1204）（1218）。组合器（502）将数字输入信号（512）与数字增益信号（1204）组合以产生预补偿数字信号（516）。可变增益放大器（508）将增益斜坡信号（1206）的增益分量（1126）中的增益序列（1234,1236,1238,1240,1242）按顺序应用于预调节的模拟信号（520）以产生增益调整的模拟信号（524）。当增益电弧（1202）的部分（1212）指示天线（106）处的低瞬时信号功率以便减少ACLR劣化时，发生增益分量（1126）和数字增益变化（1218）的应用。

9. 发明申请

US20090088102A1 GAIN CONTROL METHODS FOR WIRELESS DEVICES AND TRANSMITTERS 有权
标题翻译：无线设备和发射机的增益控制方法
公开(公告)号：US20090088102A1
公开(公告)日：2009-04-02
申请号：US12249649
申请日：2008-10-10
申请人： Jiangbo Gan , Srinivasa R. Bommareddy , Pravin Premakanthan
发明人： Jiangbo Gan , Srinivasa R. Bommareddy , Pravin Premakanthan
IPC分类号： H04B1/04 , H03G3/20
CPC分类号： H04B1/0475 , H03G3/3036
摘要： A gain control process (1102) executed at a transmitter (500) generates (1314) a gain ramp signal (1206) having a delay component (1224) and a gain component (1226). The process (1102) further generates (1304) and incorporates (1306) a gain arc (1202) into a digital signal to form a digital gain signal (1204) having a digital gain change (1218). A combiner (502) combines a digital input signal (512) with the digital gain signal (1204) to generate a pre-compensated digital signal (516). A variable gain amplifier (508) applies a sequence of gains (1234,1236,1238,1240,1242) in the gain component (1126) of the gain ramp signal (1206) to a pre-adjusted analog signal (520) in order to generate a gain-adjusted analog signal (524). Application of the gain component (1126) and the digital gain change (1218) occurs when a portion (1212) of the gain arc (1202) indicates a low instantaneous signal power at an antenna (106) in order to reduce ACLR degradation.
摘要翻译：在发射机（500）处执行的增益控制处理（1102）生成具有延迟分量（1224）和增益分量（1226）的增益斜坡信号（1206）（1314）。过程（1102）进一步产生（1304）并且将增益电弧（1202）并入（1306）到数字信号中以形成具有数字增益变化的数字增益信号（1204）（1218）。组合器（502）将数字输入信号（512）与数字增益信号（1204）组合以产生预补偿数字信号（516）。可变增益放大器（508）将增益斜坡信号（1206）的增益分量（1126）中的增益序列（1234,1236,1238,1240,1242）按顺序应用于预调节的模拟信号（520）以产生增益调整的模拟信号（524）。当增益电弧（1202）的部分（1212）指示天线（106）处的低瞬时信号功率以便减少ACLR劣化时，发生增益分量（1126）和数字增益变化（1218）的应用。

10. 发明授权

US07443323B2 Calibrating a digital-to-analog converter 有权
标题翻译：校准数模转换器
公开(公告)号：US07443323B2
公开(公告)日：2008-10-28
申请号：US11651858
申请日：2007-01-10
申请人： Christian J. Rotchford , Brandt Braswell , Jiangbo Gan , Michael L. Gomez , Gerald P. Miaille , Boris V. Razmyslovitch
发明人： Christian J. Rotchford , Brandt Braswell , Jiangbo Gan , Michael L. Gomez , Gerald P. Miaille , Boris V. Razmyslovitch
IPC分类号： H03M1/10
CPC分类号： H03M1/1047 , H03M1/66
摘要： Methods and corresponding systems for calibrating a digital-to-analog converter include selecting first and second code regions in the digital-to-analog converter, wherein the first and second code regions are separated by a boundary. Thereafter a waveform sequence is input into the digital-to-analog converter, wherein the waveform sequence has a zero offset at the boundary. Then a relative compensation value between the first and second code regions is adjusted to reduce a distortion in an output of the digital-to-analog converter. A magnitude of a third harmonic distortion of the waveform sequence can be used to measure distortion in the output. Adjusting the relative compensation can include converting the output of the digital-to-analog converter to a digital sequence, filtering the digital sequence, and measuring a harmonic distortion in the digital sequence.
摘要翻译：用于校准数模转换器的方法和相应的系统包括选择数模转换器中的第一和第二代码区，其中第一和第二代码区被边界分隔开。此后，将波形序列输入到数模转换器，其中波形序列在边界处具有零偏移。然后调整第一和第二代码区之间的相对补偿值以减小数模转换器的输出中的失真。可以使用波形序列的三次谐波失真的大小来测量输出中的失真。调整相对补偿可以包括将数模转换器的输出转换为数字序列，对数字序列进行滤波，并测量数字序列中的谐波失真。

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