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1. 发明授权

US07534445B2 Chlamydia protein, sequence and uses thereof 失效
标题翻译：衣原体蛋白，其序列和用途
公开(公告)号：US07534445B2
公开(公告)日：2009-05-19
申请号：US10766711
申请日：2004-01-27
申请人： W. James Jackson , John L. Pace
发明人： W. James Jackson , John L. Pace
IPC分类号： A61K39/118 , C07K14/295 , C12P21/04 , C07H21/04
CPC分类号： G01N33/56927 , A61K38/00 , A61K39/00 , C07K14/295 , C07K16/125 , G01N2333/295 , Y10S514/885 , Y10S514/931 , Y10S514/937 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： A high molecular weight (“HMW”) protein of chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
摘要翻译：公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和与HMW蛋白特异性结合的抗体，以及编码该HMW蛋白的核酸序列。还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其部分的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

2. 发明授权

US06693186B2 Neisseria meningitidis polypeptide, nucleic acid sequence and uses thereof 失效
公开(公告)号：US06693186B2
公开(公告)日：2004-02-17
申请号：US09388089
申请日：1999-08-31
申请人： W. James Jackson , Andrea M. Harris
发明人： W. James Jackson , Andrea M. Harris
IPC分类号： C07H2104
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention discloses the Neisseria meningitidis NMASP polypeptide, polypeptides derived therefrom (NMASP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that specifically bind the NMASP polypeptide and/or NMASP-derived polypeptides. Also disclosed are prophylactic or therapeutic compositions, including immunogenic compositions, e.g., vaccines, comprising NMASP polypeptide and/or a NMASP-derived polypeptide. The invention additionally discloses methods of inducing a immune response to Neisseria meningitidis and Neisseria meningitidis NMASP polypeptide and an NMASP-derived polypeptide in animals.

3. 发明授权

US06642023B1 Chlamydia protein, gene sequence and uses thereof 失效
标题翻译：衣原体蛋白，基因序列及其用途
公开(公告)号：US06642023B1
公开(公告)日：2003-11-04
申请号：US09612402
申请日：2000-07-06
申请人： W. James Jackson , John L. Pace
发明人： W. James Jackson , John L. Pace
IPC分类号： C12P2106
CPC分类号： G01N33/56927 , A61K38/00 , A61K39/00 , C07K14/295 , C07K16/125 , G01N2333/295 , Y10S514/885 , Y10S514/931 , Y10S514/937 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
摘要翻译：公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和特异性结合HMW蛋白的抗体以及编码该HMW蛋白的核酸序列。还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其部分的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

4. 发明授权

US07537772B1 Chlamydia protein, gene sequence and the uses thereof 失效
标题翻译：衣原体蛋白，基因序列及其用途
公开(公告)号：US07537772B1
公开(公告)日：2009-05-26
申请号：US09677752
申请日：2000-10-02
申请人： W. James Jackson
发明人： W. James Jackson
IPC分类号： A61K39/118 , A61K39/00 , A61K39/02 , A61K39/116 , A61K38/00
CPC分类号： C07K14/295 , A61K39/00 , A61K2039/53 , C07K2319/00
摘要： The invention discloses the Chlamydia PMPE and PMPI polypeptide, polypeptides derived thereof (PMP-derived polypeptides), nucleotide sequences encoding said polypeptides, antibodies that specifically bind the PMP polypeptides and PMP-derived polypeptides and T-cells specific for PMP polypeptides and PMP-derived polypeptides. Also disclosed are prophylactic and therapeutic compositions, including immunogenic compositions, e.g., vaccines, comprising PMP polypeptides or PMP-derived polypeptides or antibodies thereto. The invention additionally discloses methods of inducing in animals an immune response to Chlamydia cells, Chlamydia elementary bodies, and/or cells expressing Chlamydial proteins, e.g., cell infected with Chlamydia.
摘要翻译：本发明公开了衣原体PMPE和PMPI多肽，其衍生的多肽（PMP衍生的多肽），编码所述多肽的核苷酸序列，特异性结合PMP多肽和PMP衍生多肽的抗体以及对PMP多肽和PMP衍生的多肽特异的T细胞多肽。还公开了预防和治疗组合物，包括免疫原性组合物，例如包含PMP多肽或PMP衍生的多肽或其抗体的疫苗。本发明还公开了在动物中诱导对衣原体细胞，衣原体基因体和/或表达衣原体蛋白（例如感染衣原体的细胞）的细胞的免疫应答的方法。

5. 发明授权

US07419807B2 Chlamydia protein, gene sequence and uses thereof 失效
标题翻译：衣原体蛋白，基因序列及其用途
公开(公告)号：US07419807B2
公开(公告)日：2008-09-02
申请号：US10701844
申请日：2003-11-04
申请人： W. James Jackson , John L. Pace
发明人： W. James Jackson , John L. Pace
IPC分类号： C12P21/08 , C12N5/12 , C07H21/04 , C07K16/00 , A61K39/118
CPC分类号： G01N33/56927 , A61K38/00 , A61K39/00 , C07K14/295 , C07K16/125 , G01N2333/295 , Y10S514/885 , Y10S514/931 , Y10S514/937 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
摘要翻译：公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和特异性结合HMW蛋白的抗体以及编码该HMW蛋白的核酸序列。还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其部分的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

6. 发明授权

US06887843B1 Chlamydia protein, gene sequence and uses thereof 失效
标题翻译：衣原体蛋白，基因序列及其用途
公开(公告)号：US06887843B1
公开(公告)日：2005-05-03
申请号：US09542520
申请日：2000-04-03
申请人： W. James Jackson , John L. Pace
发明人： W. James Jackson , John L. Pace
IPC分类号： G01N33/563 , A61K31/711 , A61K38/00 , A61K39/00 , A61K39/118 , A61K39/395 , A61K39/40 , A61K48/00 , A61P31/04 , A61P43/00 , C07K14/295 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/569 , G01N33/571 , A01N25/00 , A61K39/02 , A61K39/38
CPC分类号： G01N33/56927 , A61K38/00 , A61K39/00 , C07K14/295 , C07K16/125 , G01N2333/295 , Y10S514/885 , Y10S514/931 , Y10S514/937 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a protein thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
摘要翻译：公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和特异性结合HMW蛋白的抗体以及编码该HMW蛋白的核酸序列。还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其蛋白质的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

7. 发明授权

US07851609B2 Chlamydia PMP proteins, gene sequences and uses thereof 失效
标题翻译：衣原体PMP蛋白，基因序列及其用途
公开(公告)号：US07851609B2
公开(公告)日：2010-12-14
申请号：US11781199
申请日：2007-07-20
申请人： W. James Jackson
发明人： W. James Jackson
IPC分类号： C07H21/04 , C07H21/02 , A61K39/38 , A61K39/118
CPC分类号： A61K39/118 , A01K2227/105 , A01K2267/0337 , A61K39/00 , A61K49/0008 , A61K2039/505 , A61K2039/543 , A61K2039/55544 , C07H21/04 , C07K14/295 , C07K16/125 , C12Q1/6893 , G01N33/56927 , G01N2333/295
摘要： The invention discloses the Chlamydia PMPE and PMPI polypeptide, polypeptides derived therefrp, (PMP-derived polypeptides), nucleotide sequences encoding said polypeptides, antibodies that specifically bind the PMP polypeptides and PMP-derived polypeptides and T-cells specific for PMP polypeptides and PMP-derived polypeptides. Also disclosed are prophylactic and therapeutic compositions, including immunogenic compositions, e.g., vaccines, comprising PMP polypeptides or PMP-derived polypeptides or antibodies thereto. The invention additionally discloses methods of inducing in animals an immune response to Chlamydia cells, Chlamydia elementary bodies, and/or cells expressing Chlamydial proteins, e.g., cell infected with Chlamydia.
摘要翻译：本发明公开了衣原体PMPE和PMPI多肽，来自其的多肽，（PMP衍生的多肽），编码所述多肽的核苷酸序列，特异性结合PMP多肽和PMP衍生多肽的抗体以及对PMP多肽和PMP- 衍生的多肽。还公开了预防和治疗组合物，包括免疫原性组合物，例如包含PMP多肽或PMP衍生的多肽或其抗体的疫苗。本发明还公开了在动物中诱导对衣原体细胞，衣原体基因体和/或表达衣原体蛋白（例如感染衣原体的细胞）的细胞的免疫应答的方法。

8. 发明授权

US07803388B2 Chlamydia PMP proteins, gene sequences and uses thereof 失效
标题翻译：衣原体PMP蛋白，基因序列及其用途
公开(公告)号：US07803388B2
公开(公告)日：2010-09-28
申请号：US11781203
申请日：2007-07-20
申请人： W. James Jackson
发明人： W. James Jackson
IPC分类号： A61K39/118 , A61K39/38 , A61K39/02 , A61K39/00 , A61K38/00
CPC分类号： A61K39/118 , A01K2227/105 , A01K2267/0337 , A61K39/00 , A61K49/0008 , A61K2039/505 , A61K2039/543 , A61K2039/55544 , C07H21/04 , C07K14/295 , C07K16/125 , C12Q1/6893 , G01N33/56927 , G01N2333/295
摘要： The invention discloses the Chlamydia PMPE and PMPI polypeptide, polypeptides derived therefrom, (PMP-derived polypeptides), nucleotide sequences encoding said polypeptides, antibodies that specifically bind the PMP polypeptides and PMP-derived polypeptides and T-cells specific for PMP polypeptides and PMP-derived polypeptides. Also disclosed are prophylactic and therapeutic compositions, including immunogenic compositions, e.g., vaccines, comprising PMP polypeptides or PMP-derived polypeptides or antibodies thereto. The invention additionally discloses methods of inducing in animals an immune response to Chlamydia cells, Chlamydia elementary bodies, and/or cells expressing Chlamydial proteins, e.g., cell infected with Chlamydia.
摘要翻译：本发明公开了衣原体PMPE和PMPI多肽，由其衍生的多肽（PMP衍生多肽），编码所述多肽的核苷酸序列，特异性结合PMP多肽和PMP衍生多肽的抗体以及对PMP多肽和PMP- 衍生的多肽。还公开了预防和治疗组合物，包括免疫原性组合物，例如包含PMP多肽或PMP衍生的多肽或其抗体的疫苗。本发明还公开了在动物中诱导对衣原体细胞，衣原体基因体和/或表达衣原体蛋白（例如感染衣原体的细胞）的细胞的免疫应答的方法。

9. 发明授权

US07731980B2 Chlamydia PMP proteins, gene sequences and uses thereof 失效
公开(公告)号：US07731980B2
公开(公告)日：2010-06-08
申请号：US10398248
申请日：2001-09-28
申请人： W. James Jackson
发明人： W. James Jackson
IPC分类号： A61K39/118 , A61K39/00 , A61K39/02 , C07K1/00
CPC分类号： A61K39/118 , A01K2227/105 , A01K2267/0337 , A61K39/00 , A61K49/0008 , A61K2039/505 , A61K2039/543 , A61K2039/55544 , C07H21/04 , C07K14/295 , C07K16/125 , C12Q1/6893 , G01N33/56927 , G01N2333/295
摘要： The invention discloses the Chlamydia PMPE and PMPI polypeptide, polypeptides derived therefrp, (PMP-derived polypeptides), nucleotide sequences encoding said polypeptides, antibodies that specifically bind the PMP polypeptides and PMP-derived polypeptides and T-cells specific for PMP polypeptides and PMP-derived polypeptides. Also disclosed are prophylactic and therapeutic compositions, including immunogenic compositions, e.g., vaccines, comprising PMP polypeptides or PMP-derived polypeptides or antibodies thereto. The invention additionally discloses methods of inducing in animals an immune response to Chlamydia cells, Chlamydia elementary bodies, and/or cells expressing Chlamydial proteins, e.g., cell infected with Chlamydia.

10. 发明申请

US20110027321A1 Chlamydia Vaccine Comprising HtrA Polypeptides 审中-公开
标题翻译：衣原体疫苗包括HtrA多肽
公开(公告)号：US20110027321A1
公开(公告)日：2011-02-03
申请号：US12601431
申请日：2008-05-23
申请人： Hang Lu , Gary S. Nabors , W. James Jackson , Xuan Z. Ding , Steven F. Roberts
发明人： Hang Lu , Gary S. Nabors , W. James Jackson , Xuan Z. Ding , Steven F. Roberts
IPC分类号： A61K39/118 , C12N15/31 , C12N15/63 , C12N1/00 , A61K31/7052 , A61K38/16 , C12P21/00 , C12Q1/68 , G01N33/571 , A61P37/00 , A61P31/04
CPC分类号： A61K39/118 , Y02A50/484
摘要： The present invention provides vaccine compositions useful in prevention and treatment of Chlamydia sp. (e.g., C. trachomatis or C. pneumoniae) infection. Provided are polypeptide vaccine antigens comprising Chlamydia HtrA-derived sequences, including epitopic fragments, analogs, derivatives, and variants. Also provided are a method for inducing an immune response to a subject against Chlamydia infection, a method for preventing Chlamydia infection, or a method for treating a disease or symptom caused by or resulting from infection with Chlamydia, for instance, C. trachomatis or C. pneumoniae. In one embodiment, the present invention is drawn to C. trachomatis HtrA, which induces a cellular immune response and imparts partial protective immunity in vivo.
摘要翻译：本发明提供了可用于预防和治疗衣原体的疫苗组合物。（例如沙眼衣原体或肺炎衣原体）感染。提供了包含来自衣原体HtrA的序列的多肽疫苗抗原，包括表位片段，类似物，衍生物和变体。还提供了诱导针对衣原体感染的受试者的免疫应答的方法，预防衣原体感染的方法或用于治疗由衣原体感染引起的或由其产生的疾病或症状的方法，例如沙眼衣原体或C 肺炎支原体在一个实施方案中，本发明涉及沙眼衣原体HtrA，其诱导细胞免疫应答并在体内赋予部分保护性免疫。

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