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1. 发明授权

US08916376B2 Metal-binding peptides 有权
标题翻译：金属结合肽
公开(公告)号：US08916376B2
公开(公告)日：2014-12-23
申请号：US12121658
申请日：2008-05-15
申请人： Victor G. Stepanov , Yamei Liu , George E. Fox , George W. Jackson , Roger J. McNichols
发明人： Victor G. Stepanov , Yamei Liu , George E. Fox , George W. Jackson , Roger J. McNichols
IPC分类号： C12N15/63 , C12N15/10
CPC分类号： C12N15/1048
摘要： The present invention is generally directed to novel functionalized biomolecules and methods for generating such biomolecules. Biomolecules may generally include nucleic acids, peptides, multicomponent molecular complexes and/or any other molecular products that may be produced by living organisms. The present invention is further directed to cells and/or organisms manipulated to produce such functionalized biomolecules. The cells contemplated by the present invention include both prokaryotic as well as eukaryotic cells. The functionalized biomolecules are produced via materials introduced into the cell using standard molecular biology techniques or are incorporated within the genomic nucleic acid of a cell by standard recombination techniques. Further contemplated is the use of such cells for sequestration of target molecules within the cells.
摘要翻译：本发明一般涉及新的功能化生物分子和产生这种生物分子的方法。生物分子通常可以包括可由活生物体产生的核酸，肽，多组分分子复合物和/或任何其它分子产物。本发明进一步涉及被操作以产生这种官能化生物分子的细胞和/或生物。本发明考虑的细胞包括原核细胞以及真核细胞。功能化生物分子通过使用标准分子生物学技术引入细胞的材料产生，或通过标准重组技术并入细胞的基因组核酸中。进一步考虑的是使用这种细胞来封存细胞内的靶分子。

2. 发明申请

US20120165225A1 FUNCTIONAL BIOMOLECULES AND METHODS 有权
标题翻译：功能生物分子和方法
公开(公告)号：US20120165225A1
公开(公告)日：2012-06-28
申请号：US12121658
申请日：2008-05-15
申请人： Victor G. Stepanov , Yamei Liu , George E. Fox , George W. Jackson , Roger J. McNichols
发明人： Victor G. Stepanov , Yamei Liu , George E. Fox , George W. Jackson , Roger J. McNichols
IPC分类号： C40B40/02 , C12N1/21 , C12N15/63
CPC分类号： C12N15/1048
摘要： The present invention is generally directed to novel functionalized biomolecules and methods for generating such biomolecules. Biomolecules may generally include nucleic acids, peptides, multicomponent molecular complexes and/or any other molecular products that may be produced by living organisms. The present invention is further directed to cells and/or organisms manipulated to produce such functionalized biomolecules. The cells contemplated by the present invention include both prokaryotic as well as eukaryotic cells. The functionalized biomolecules are produced via materials introduced into the cell using standard molecular biology techniques or are incorporated within the genomic nucleic acid of a cell by standard recombination techniques. Further contemplated is the use of such cells for sequestration of target molecules within the cells.
摘要翻译：本发明一般涉及新的功能化生物分子和产生这种生物分子的方法。生物分子通常可以包括可由活生物体产生的核酸，肽，多组分分子复合物和/或任何其它分子产物。本发明进一步涉及被操作以产生这种官能化生物分子的细胞和/或生物。本发明考虑的细胞包括原核细胞以及真核细胞。功能化生物分子通过使用标准分子生物学技术引入细胞的材料产生，或通过标准重组技术并入细胞的基因组核酸中。进一步考虑的是使用这种细胞来封存细胞内的靶分子。

3. 发明授权

US07412141B2 Light diffusing tip 有权
标题翻译：光散射尖
公开(公告)号：US07412141B2
公开(公告)日：2008-08-12
申请号：US11777856
申请日：2007-07-13
申请人： Ashok Gowda , Roger J. McNichols , Marc Gelnett , Matthew Fox
发明人： Ashok Gowda , Roger J. McNichols , Marc Gelnett , Matthew Fox
IPC分类号： G02B6/06 , A61B18/18
CPC分类号： G02B6/241 , A61N5/0603 , A61N5/062 , G02B6/262
摘要： A light diffusing tip is provided. The light diffusing tip comprises a housing and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region at a first position, the scattering region having a first scattering property and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing. A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide, a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide.
摘要翻译：提供光扩散尖端。光扩散尖端包括壳体和布置在壳体内的单片光散射介质。单片光散射介质包括在第一位置处的第一散射区域，具有第一散射特性的散射区域和第二位置处的第二散射区域，第二散射区域具有不同于第一散射特性的第二散射特性，其中第一散射区域和第二散射区域沿着壳体的长度的大部分共同延伸。还提供了光漫射施加器。所述光漫射施加器包括至少一个光波导，耦合到所述至少一个光波导的第一端的第一终端，耦合到光源的第一终端和耦合到所述至少一个光波导的第二端的光漫射末端一个光波导。

4. 发明授权

US06755849B1 Method for delivering energy to tissue and apparatus 有权
标题翻译：将能量传递给组织和设备的方法
公开(公告)号：US06755849B1
公开(公告)日：2004-06-29
申请号：US10109540
申请日：2002-03-28
申请人： Ashok Gowda , Roger J. McNichols , Massoud Motamedi , Pankaj J. Pasricha
发明人： Ashok Gowda , Roger J. McNichols , Massoud Motamedi , Pankaj J. Pasricha
IPC分类号： A61N5067
CPC分类号： A61B18/18 , A61B18/1815 , A61B2017/22051 , A61B2018/00023 , A61B2018/2261
摘要： Disclosed is a method for delivering energy to a tissue. The method includes providing an apparatus which includes an energy delivery component and an inflatable member disposed around the energy delivery component. At a minimum, the inflatable member is constructed of a flexible inner wall and a flexible outer wall, which, taken together, enclose a cavity therebetween. The inflatable member is expanded such that the inflatable member's outer wall contacts the tissue's surface. Cooling fluid is disposed in the cavity, and energy is delivered to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member's inner wall, through the cooling fluid disposed in the cavity, through the inflatable member's outer wall, and into the tissue. Various apparatus suitable for use in delivering energy to tissues are also disclosed, as is a method for treating GERD or otherwise reducing reflux of a subject's stomach contents into the subject's esophagus.
摘要翻译：公开了一种向组织输送能量的方法。该方法包括提供一种包括能量输送部件和围绕能量输送部件设置的可充气部件的装置。至少，可膨胀构件由柔性内壁和柔性外壁构成，它们一起在其间包围空腔。可膨胀构件被膨胀，使得可膨胀构件的外壁接触组织的表面。冷却流体设置在空腔中，并且能量被输送到能量输送部件，使得输送到能量输送部件的能量的至少一部分通过可膨胀构件的内壁，穿过设置在空腔中的冷却流体，通过充气构件的外壁，并进入组织。还公开了适用于向组织递送能量的各种装置，以及用于治疗GERD或以其它方式减少受试者的胃内容物回流到受试者的食道中的方法。

5. 发明申请

US20120197112A1 SPATIALLY-LOCALIZED OPTICAL COHERENCE TOMOGRAPHY IMAGING 审中-公开
标题翻译：空间局部光学相干成像
公开(公告)号：US20120197112A1
公开(公告)日：2012-08-02
申请号：US13361946
申请日：2012-01-30
申请人： Roger J. McNichols
发明人： Roger J. McNichols
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B1/303 , A61B5/066 , A61B5/4318 , A61B5/6847 , A61B34/20 , A61B2034/2051 , A61B2090/3735
摘要： This invention generally relates to devices and methods for optical coherence tomography (OCT), and also to devices and methods for spatially-localized OCT imaging. In one aspect, a spatially-localized OCT imaging system may include an OCT probe, a spatially-resolvable positioning device, a tracking system, and a data acquisition system. Some or all of the components may also be linked and/or otherwise combined.
摘要翻译：本发明一般涉及用于光学相干断层摄影（OCT）的装置和方法，以及用于空间定位的OCT成像的装置和方法。在一个方面，空间定位的OCT成像系统可以包括OCT探针，空间可分辨的定位装置，跟踪系统和数据采集系统。部分或全部组分也可以连接和/或以其他方式组合。

6. 发明授权

US07074233B1 Method for delivering energy to tissue and apparatus 有权
标题翻译：将能量传递给组织和设备的方法
公开(公告)号：US07074233B1
公开(公告)日：2006-07-11
申请号：US10877811
申请日：2004-06-25
申请人： Ashok Gowda , Roger J. McNichols , Massoud Motamedi , Pankaj J. Pasricha
发明人： Ashok Gowda , Roger J. McNichols , Massoud Motamedi , Pankaj J. Pasricha
IPC分类号： A61N5/067
CPC分类号： A61B18/18 , A61B18/1815 , A61B2017/22051 , A61B2018/00023 , A61B2018/2261
摘要： Disclosed is a method for delivering energy to a tissue. The method includes providing an apparatus which includes an energy delivery component and an inflatable member disposed around the energy delivery component. At a minimum, the inflatable member is constructed of a flexible inner wall and a flexible outer wall, which, taken together, enclose a cavity therebetween. The inflatable member is expanded such that the inflatable member's outer wall contacts the tissue's surface. Cooling fluid is disposed in the cavity, and energy is delivered to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member's inner wall, through the cooling fluid disposed in the cavity, through the inflatable member's outer wall, and into the tissue. Various apparatus suitable for use in delivering energy to tissues are also disclosed, as is a method for treating GERD or otherwise reducing reflux of a subject's stomach contents into the subject's esophagus.
摘要翻译：公开了一种向组织输送能量的方法。该方法包括提供一种包括能量输送部件和围绕能量输送部件设置的可充气部件的装置。至少，可膨胀构件由柔性内壁和柔性外壁构成，它们一起在其间包围空腔。可膨胀构件被膨胀，使得可膨胀构件的外壁接触组织的表面。冷却流体设置在空腔中，并且能量被输送到能量输送部件，使得输送到能量输送部件的能量的至少一部分通过可膨胀构件的内壁，穿过设置在空腔中的冷却流体，通过充气构件的外壁，并进入组织。还公开了适用于向组织递送能量的各种装置，以及用于治疗GERD或以其它方式减少受试者的胃内容物回流到受试者的食道中的方法。

7. 发明授权

US06671535B1 Method and system for controlling heat delivery to a target 有权
公开(公告)号：US06671535B1
公开(公告)日：2003-12-30
申请号：US10324973
申请日：2002-12-20
申请人： Roger J. McNichols , Ashok Gowda
发明人： Roger J. McNichols , Ashok Gowda
IPC分类号： A61B500
CPC分类号： A61B5/0008 , A61B5/015 , A61B5/055 , A61B18/08 , A61B18/18 , A61B18/20 , A61B90/37 , A61B2017/0007 , A61B2017/00084 , A61B2018/00636 , A61B2018/00642 , A61B2018/00714 , A61B2018/00791 , A61B2090/374 , A61N1/403 , A61N5/04 , A61N5/0601 , A61N7/02
摘要： A method and system for using real time closed loop feedback to control the delivery of heat energy is disclosed herein. An energy delivery system may be used to deliver heat energy to a target to effect a change in the target. For example, medical professionals use laser energy to irreversibly damage cells found in cancerous tumors without damaging the surrounding healthy cells. The energy delivery system includes a temperature detection system, a data processor, and a heat generating device. The temperature detection system obtains temperature data from a target and transmits the data to the data processor. The data processor may process the temperature data to provide real time feedback control to the heat generating system, as well as display the data as one or more images on a graphical user interface. The heat generating system receives control commands from the data processor and modulates its heat output accordingly.

8. 发明授权

US06542767B1 Method and system for controlling heat delivery to a target 有权
标题翻译：用于控制向目标传热的方法和系统
公开(公告)号：US06542767B1
公开(公告)日：2003-04-01
申请号：US09710694
申请日：2000-11-08
申请人： Roger J. McNichols , Ashok Gowda
发明人： Roger J. McNichols , Ashok Gowda
IPC分类号： A61B500
CPC分类号： A61B5/0008 , A61B5/015 , A61B5/055 , A61B18/08 , A61B18/18 , A61B18/20 , A61B90/37 , A61B2017/0007 , A61B2017/00084 , A61B2018/00636 , A61B2018/00642 , A61B2018/00714 , A61B2018/00791 , A61B2090/374 , A61N1/403 , A61N5/04 , A61N5/0601 , A61N7/02
摘要： A method and system for using real time closed loop feedback to control the delivery of heat energy is disclosed herein. An energy delivery system may be used to deliver heat energy to a target to effect a change in the target. For example, medical professionals use laser energy to irreversibly damage cells found in cancerous tumors without damaging the surrounding healthy cells. The energy delivery system includes a temperature detection system, a data processor, and a heat generating device. The temperature detection system obtains temperature data from a target and transmits the data to the data processor. The data processor may process the temperature data to provide real time feedback control to the heat generating system, as well as display the data as one or more images on a graphical user interface. The heat generating system receives control commands from the data processor and modulates its heat output accordingly.
摘要翻译：本文公开了一种使用实时闭环反馈来控制热能传递的方法和系统。能量输送系统可用于将热能传递到目标以实现目标的变化。例如，医疗专业人员使用激光能量不可逆地损伤在癌肿瘤中发现的细胞，而不损害周围的健康细胞。能量输送系统包括温度检测系统，数据处理器和发热装置。温度检测系统从目标获得温度数据并将数据发送到数据处理器。数据处理器可以处理温度数据以向发热系统提供实时反馈控制，以及在图形用户界面上将数据显示为一个或多个图像。发热系统从数据处理器接收控制命令并相应地调节其热量输出。

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