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1. 发明授权

US5200053A Reference electrode 失效
标题翻译：参考电极
公开(公告)号：US5200053A
公开(公告)日：1993-04-06
申请号：US490636
申请日：1990-05-24
申请人： Takeshi Shimomura , Shuichiro Yamaguchi , Naoto Uchida , Takehisa Mori , Teruaki Katsube
发明人： Takeshi Shimomura , Shuichiro Yamaguchi , Naoto Uchida , Takehisa Mori , Teruaki Katsube
IPC分类号： G01N27/30
CPC分类号： G01N27/301
摘要： A reference electrode according to the present invention includes a silver layer (2) and an insulating hydrophobic material layer (5) which is formed by atomic beam sputtering and containing silver halide dispersed therein, on the surface of a conductive substrate (1).The resulting reference electrode is of a solid type, is almost free from outflow of silver halide, can be miniaturized easily, is not affected by ion concentration, provides a stable potential and has high durability.The conductive substrate (1) may be a field effect transistor having a gate insulator film and the layer (5) may be a laminate film obtained by laminating alternately a thin layer or layers of silver halide and a thin layer or layers of insulating hydrophobic material.

2. 发明授权

US5296122A Apparatus for forming thin film 失效
标题翻译：用于形成薄膜的装置
公开(公告)号：US5296122A
公开(公告)日：1994-03-22
申请号：US837873
申请日：1992-02-18
申请人： Teruaki Katsube , Shuichiro Yamaguchi , Naoto Uchida , Takeshi Shimomura
发明人： Teruaki Katsube , Shuichiro Yamaguchi , Naoto Uchida , Takeshi Shimomura
IPC分类号： C23C14/12 , C23C14/46 , G01N27/414
CPC分类号： C23C14/46 , C23C14/12 , G01N27/4145
摘要： In the manufacture of a substrate with a hydrophobic film used for a reference electrode of an ion sensor or the like, a hydrophobic film is formed on a substrate by irradiating a target consisting of a hydrophobic compound with a neutral atom beam and thereby effecting sputtering. The apparatus for effecting the sputtering comprises a target base disposed in a vacuum chamber, an atom beam gun for irradiating a target on the target base with a neutral beam, a substrate base and a shutter for controlling the passage of sputtered particles. A thin film that is manufactured is suitable for an ion sensor, such as an ISFET or the like or an enzyme sensor.
摘要翻译：在制造具有用于离子传感器等的参比电极的疏水膜的基板时，通过用由中性原子束照射由疏水性化合物构成的靶，从而进行溅射，在基板上形成疏水膜。用于进行溅射的装置包括设置在真空室中的靶基底，用中性光束照射目标基底上的靶的原子束枪，用于控制溅射粒子通过的基底和快门。制造的薄膜适用于离子传感器，例如ISFET等或酶传感器。

3. 发明授权

US5213675A Reference electrode, ion sensor and method of manufacturing the same 失效
标题翻译：参比电极，离子传感器及其制造方法
公开(公告)号：US5213675A
公开(公告)日：1993-05-25
申请号：US717645
申请日：1991-06-19
申请人： Shuichiro Yamaguchi , Takeshi Shimomura , Naoto Uchida , Teruaki Katsube , Noboru Oyama
发明人： Shuichiro Yamaguchi , Takeshi Shimomura , Naoto Uchida , Teruaki Katsube , Noboru Oyama
IPC分类号： G01N27/30
CPC分类号： G01N27/414
摘要： A reference electrode for generating a reference potential on an ion sensor is disclosed. The reference electrode has a lamination film covering a surface of an electrically conductive substrate and formed by alternately laminating silver halide thin films and hydrophobic resin thin films.
摘要翻译：公开了一种用于在离子传感器上产生参考电位的参考电极。参考电极具有覆盖导电性基板的表面并通过交替层叠卤化银薄膜和疏水性树脂薄膜而形成的层叠膜。

4. 发明授权

US5066383A Reference electrode, ion sensor and method of manufacturing the same 失效
标题翻译：参考电极，离子传感器及其制造方法
公开(公告)号：US5066383A
公开(公告)日：1991-11-19
申请号：US426713
申请日：1989-10-26
申请人： Shuichiro Yamaguchi , Takeshi Shimomura , Naoto Uchida , Teruaki Katsube , Noboru Oyama
发明人： Shuichiro Yamaguchi , Takeshi Shimomura , Naoto Uchida , Teruaki Katsube , Noboru Oyama
IPC分类号： G01N27/30
CPC分类号： G01N27/301 , G01N27/414
摘要： A reference electrode for generating a reference potential on an ion sensor is disclosed. The reference electrode has a lamination film covering a surface of an electrically conductive substrate and formed by alternately laminating silver halide thin films and hydrophobic resin thin films.

5. 发明授权

US4927516A Enzyme sensor 失效
标题翻译：酶传感器
公开(公告)号：US4927516A
公开(公告)日：1990-05-22
申请号：US65908
申请日：1987-06-24
申请人： Shuichiro Yamaguchi , Naoto Uchida , Takeshi Shimomura , Noboru Oyama
发明人： Shuichiro Yamaguchi , Naoto Uchida , Takeshi Shimomura , Noboru Oyama
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/58
CPC分类号： C12Q1/004 , Y10S435/817
摘要： Disclosed is an enzyme sensor for measuring a predetermined substrate concentration by potentiometric or amperometric response on the basis of an enzyme. In one aspect, a solid-state enzyme sensor measures a predetermined substrate concentration by potentiometric response and includes a solid enzyme membrane-coated electrically conductive base, redox layer or ion-sensitive layer. In another aspect, a solid-state enzyme sensor measures a predetermined substrate concentration by amperometric response and includes a solid enzyme membrane-coated oxygen reduction catalyst layer. Also disclosed is an enzyme control layer for controlling the outflow and inflow of the enzyme layer.
摘要翻译：公开了一种用于通过基于酶的电位或电流响应来测量预定底物浓度的酶传感器。一方面，固体酶传感器通过电位响应测量预定的底物浓度，并且包括固体酶膜涂覆的导电性碱，氧化还原层或离子敏感层。另一方面，固态酶传感器通过电流响应测量预定的底物浓度，并且包括固体酶膜包被的氧还原催化剂层。还公开了用于控制酶层的流出和流入的酶控制层。

6. 发明授权

US5190636A Ion-sensitive film, method of producing the same and ion sensor 失效
标题翻译：离子敏感膜，其制造方法和离子传感器
公开(公告)号：US5190636A
公开(公告)日：1993-03-02
申请号：US602230
申请日：1990-10-24
申请人： Norihiko Ushizawa , Shuichiro Yamaguchi , Naoto Uchida , Takeshi Shimomura
发明人： Norihiko Ushizawa , Shuichiro Yamaguchi , Naoto Uchida , Takeshi Shimomura
IPC分类号： G01N27/02 , G01N27/333
CPC分类号： G01N27/3335
摘要： The present invention provides an ion sensitive film (6) comprising a mixed layer containing a redox manifesting substance manifesting redox function and a polymeric compound containing an ion carrier substance. The present invention also provides a method of producing the ion sensitive film (6) and an ion sensor which uses the film (6). The ion sensitive film (6) of the present invention enables the provision of an ion sensor having excellent durability, preservative stability and sensor characteristics.

7. 发明授权

US5186808A Film-coated sensor 失效
标题翻译：薄膜传感器
公开(公告)号：US5186808A
公开(公告)日：1993-02-16
申请号：US548931
申请日：1990-07-27
申请人： Shuichiro Yamaguchi , Naoto Uchida , Satoru Kasai , Takeshi Shimomura , Noboru Oyama
发明人： Shuichiro Yamaguchi , Naoto Uchida , Satoru Kasai , Takeshi Shimomura , Noboru Oyama
IPC分类号： G01N27/333 , A61B5/145 , A61B5/1473 , A61B5/15 , G01N27/30 , G01N27/327
CPC分类号： A61B5/14542 , A61B5/14865 , A61B2562/02
摘要： A film-coated sensor is formed by providing an electrically conductive substrate (2), which has a sectional area of less than 10.sup.-5 cm.sup.2, connected to a lead wire (5) at one end of an insulative capillary (1) and inscribed in the capillary (1), and providing a coating film (7) at another end, which is open, of the capillary (1) by an electrolytic polymerization process.The film-coated sensor obtained has a surface which is uniform, the film coating is easy to control, and since the sensor is not readily susceptible to flow of a specimen fluid, there is little drift and response is quick. Owing to its small size, the sensor is capable of measuring very small samples and of performing measurement upon being directly inserted into a living body or tissue.The sensor can be used also as an enzyme sensor by coating the surface of the film-coated sensor with a fixing enzyme film.
摘要翻译： PCT No.PCT / JP89 / 00085 Sec。 371日期1990年7月27日第 102（e）1990年7月27日PCT PCT 1989年1月27日PCT公布。公开号WO89 / 07262 日本1989年8月10日。薄膜涂层传感器是通过提供导电基片（2）形成的，导电基片（2）的截面积小于10-5厘米2，与导线（5）的一端连接绝缘毛细管（1）并内接在毛细管（1）中，并通过电解聚合过程在毛细管（1）的开口的另一端提供涂膜（7）。获得的涂膜传感器具有均匀的表面，膜涂层易于控制，并且由于传感器不容易受到样品流体的流动，因此几乎没有漂移和响应快。由于传感器尺寸小，所以传感器能够测量非常小的样品，并且直接插入生物体或组织中进行测量。传感器也可以通过用固定酶膜涂覆薄膜传感器的表面作为酶传感器。

8. 发明授权

US5126937A Biological information measurement apparatus 失效
标题翻译：生物信息测量仪器
公开(公告)号：US5126937A
公开(公告)日：1992-06-30
申请号：US626413
申请日：1990-12-14
申请人： Shuichiro Yamaguchi , Norihiko Ushizawa , Norio Daikuhara , Takeshi Shimomura , Naoto Uchida
发明人： Shuichiro Yamaguchi , Norihiko Ushizawa , Norio Daikuhara , Takeshi Shimomura , Naoto Uchida
IPC分类号： A61B5/145 , A61B5/00 , G01N33/487 , G01N33/49
CPC分类号： A61B5/14539 , A61B5/145 , G01N33/492
摘要： A biological information measurement apparatus is adapted to measure biological information in an extracorporeal circuration or in a living body by various measurement circuits comprising circuit elements which are not affected by electrical disturbances, and to transmit the results of measurement in the form of a non-electrical signal which is not affected by electrical disturbances. Measured values from measurement sections are gathered at a central processing section separated from the measurement sections. The processing section converts the measured values into output values, compensates the values for temperature and outputs the values to a display unit and recorder.
摘要翻译：生物信息测量装置适于通过包括不受电扰动影响的电路元件的各种测量电路来测量体外循环或生物体内的生物信息，并以非电气形式传输测量结果信号不受电气干扰影响。来自测量部分的测量值在与测量部分分离的中央处理部分收集。处理部分将测量值转换为输出值，补偿温度值并将其输出到显示单元和记录器。

9. 发明授权

US4968400A Enzyme sensor 失效
标题翻译：酶传感器
公开(公告)号：US4968400A
公开(公告)日：1990-11-06
申请号：US359763
申请日：1989-07-19
申请人： Takeshi Shimomura , Shuichiro Yamaguchi , Naoto Uchida
发明人： Takeshi Shimomura , Shuichiro Yamaguchi , Naoto Uchida
IPC分类号： G01N27/30 , C12Q1/00 , C12Q1/26 , C12Q1/54 , G01N27/327 , G01N27/414
CPC分类号： C12Q1/004 , G01N27/4145 , Y10S435/817
摘要： PCT Filed Nov. 19, 1987 PCT Pub. No. WO88/04050 PCT Pub. Date Jun. 2, 1988.An insulative substrate (1) is coated with an electrically conductive layer (2) and a redox layer (3) which comprises an electrolytic polymerization film of 2,6-dimethylphenol, and the surface of the redox layer is provided with an enzyme-fixed (7). The enzyme electrode thus obtained exhibits a potentiometric response, and the enzyme-fixed layer has a strong adhesion. As a result, sensitivity is high, there is little drift and service life is prolonged. An ion-selective field-effect transistor can be used instead of the insulative substrate (1).

10. 发明申请

US20110160138A1 COMPOSITION FOR IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION 有权
标题翻译：用于改善脑功能的组合物和用于改善脑功能的方法
公开(公告)号：US20110160138A1
公开(公告)日：2011-06-30
申请号：US12889652
申请日：2010-09-24
申请人： Kazuhito OHSAWA , Naoto Uchida , Kohji Ohki
发明人： Kazuhito OHSAWA , Naoto Uchida , Kohji Ohki
IPC分类号： A61K38/16 , C07K14/00 , A61P25/00
CPC分类号： A61K38/10 , A61K38/1703 , C07K7/08
摘要： The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, the composition comprising, as an active ingredient, X-Met-His-Gln-Pro-His-Gln-Pro-Leu-Pro-Pro-Thr-Val-Met-Phe-Pro-Pro-Gln-Ser-Val-Leu (SEQ ID NO: 6) or a salt thereof, wherein X is absent or represents Ser-Trp or Leu-Gln-Ser-Trp (SEQ ID NO: 7).
摘要翻译：本发明提供可以以小剂量口服摄取以改善脑功能的组合物，以及改善脑功能的方法。本发明是一种用于改善脑功能的组合物，该组合物包含作为活性成分的X-Met-His-Gln-Pro-His-Gln-Pro-Leu-Pro-Thr-Val-Met-Phe- Pro-Pro-Gln-Ser-Val-Leu（SEQ ID NO：6）或其盐，其中X不存在或表示Ser-Trp或Leu-Gln-Ser-Trp（SEQ ID NO：7）。

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