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    • 1. 发明授权
    • Method and reagent for measuring mevalonic acid, 3-hydroxymethylglutaryl coenzyme A, and coenzyme A
    • 测量甲羟戊酸,3-羟甲基戊二酰辅酶A和辅酶A的方法和试剂
    • US09458491B2
    • 2016-10-04
    • US13144710
    • 2010-01-19
    • Takeshi Matsuoka
    • Takeshi Matsuoka
    • C12Q1/26C12Q1/48C12N9/02C12N9/04C12N9/12C07K1/00C07H21/02C12Q1/00C12R1/01C12R1/38G01N33/53C12N1/20
    • The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that catalyzes a reaction represented by Reaction Formula 1 and an enzyme that catalyzes a reaction represented by Reaction Formula 2 to act on a test solution containing mevalonic acid and/or 3 -hydroxymethylglutaryl coenzyme A in the presence of a hydrogen acceptor X, a hydrogen donor Y, and coenzyme A; and (q) a step of measuring an amount of: a reduced hydrogen acceptor X that is produced; or an oxidized hydrogen donor Y that is produced; or a hydrogen acceptor X that is decreased; or a hydrogen donor Y that is decreased, wherein the hydrogen donor Y and the reduced hydrogen acceptor X are not the same.
    • 本发明提供了一种用于测量测试溶液中分析物浓度的方法,其中分析物是甲羟戊酸和/或3-羟甲基戊二酰辅酶A,包括以下步骤(p)和(q):(p)步骤 允许催化由反应式1表示的反应的酶和催化由反应式2表示的反应的酶作用于含有甲羟甲酸和/或3-羟甲基戊二酰辅酶A的试验溶液中,在氢受体X的存在下, 氢供体Y和辅酶A; 和(q)测量生成的还原氢受体X的量的步骤; 或产生的氧化氢供体Y; 或降低的氢受体X; 或降低的氢供体Y,其中氢供体Y和还原氢受体X不相同。
    • 7. 发明授权
    • Method for stabilizing leuco-type colorant
    • 稳定无色型着色剂的方法
    • US08268017B2
    • 2012-09-18
    • US12034793
    • 2008-02-21
    • Shigeru UedaTakeshi MatsuokaAkihiko Kan
    • Shigeru UedaTakeshi MatsuokaAkihiko Kan
    • C09B67/00D06P5/00G01N33/72G03C8/00C08B37/16C12N9/00C12Q1/00C12Q1/37C12Q1/26
    • C12Q1/28C09B67/0077
    • Provided are a method of stabilizing a leuco dye storable as a liquid for a long time, a method of reducing nonspecific color development thereof at a time of a color development reaction, and a stable liquid reagent composition using the methods. The inventors of the present invention found that coexistence of the leuco dye with a specific reducing agent resulted in suppression of self color development and its remarkably improved stability in a solution, and that when a color development reaction of the leuco dye with hydrogen peroxide was performed, coexistence of the leuco dye, in a reaction solution, with another dye which had an absorption spectrum not influencing a measurement wavelength of the leuco dye and did not react with hydrogen peroxide suppressed nonspecific color development and lowered a reagent blank value, which was applied to an analytical reagent.
    • 提供一种稳定长时间保存为液体的无色染料的方法,在显色反应时减少其非特异性显色的方法和使用该方法的稳定的液体试剂组合物。 本发明人发现,无色染料与特定的还原剂共存导致自色显影的抑制和其在溶液中的显着提高的稳定性,并且当进行无色染料与过氧化氢的显色反应时 在无色染料的反应溶液中与另一种不影响无色染料的测定波长的吸收光谱并且不与过氧化氢反应的染料共存抑制非特异性显色,降低试剂空白值 分析试剂。