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1. 发明申请

US20080286241A1 Transplantation of Differentiated Immature Adipocytes and Biodegradable Scaffold for Tissue Augmentation 审中-公开
标题翻译：移植分化不成熟脂肪细胞和生物可降解支架进行组织增生
公开(公告)号：US20080286241A1
公开(公告)日：2008-11-20
申请号：US11912108
申请日：2006-04-21
申请人： Sung-Koo Lee , Mi-Hyung Kim , In-Ok Kim
发明人： Sung-Koo Lee , Mi-Hyung Kim , In-Ok Kim
IPC分类号： A61K35/12 , C12N5/00 , C12N5/06 , A61P43/00 , G01N33/53
CPC分类号： A61L27/3804 , A61K35/12 , A61L27/3895 , C12N5/0653 , C12N2533/56 , C12N2533/74
摘要： Provided is a technology involving differentiating preadipocytes, derived from human adipose tissues, into adipocytes and transplanting the differentiated adipocytes in conjunction with a biodegradable scaffold into the body. According to the present invention, when immature adipocytes having a cell diameter of 20 to 40 μm, obtained by differentiation of adipose tissue-derived preadipocytes into adipose tissues, are used in conjunction with a scaffold in autologous or allogeneic transplantation, maturation of adipocytes at the target transplantation site leads to a gradual increase in the volume of adipocytes. Therefore, the adipocyte-scaffold composition according to the present invention can be utilized as an effective body volume replacement and can treat various disorders due to defects of soft tissues or aesthetic defects in appearance.
摘要翻译：提供了一种涉及将来自人类脂肪组织的前脂肪细胞分化成脂肪细胞并将分化的脂肪细胞与可生物降解的支架结合移植到体内的技术。根据本发明，通过将脂肪组织衍生的前脂肪细胞分化为脂肪组织而获得的细胞直径为20〜40μm的未成熟脂肪细胞与自体或同种异体移植中的支架结合使用，在目标移植部位导致脂肪细胞体积逐渐增加。因此，根据本发明的脂肪细胞 - 支架组合物可以用作有效的体积更换，并且可以治疗由于软组织的缺陷或外观上的美观缺陷引起的各种疾病。

2. 发明申请

US20120020937A1 AUTOLOGOUS AND ALLOGENIC ADIPOSE-DERIVED STROMAL STEM CELL COMPOSITION FOR TREATING FISTULAS 审中-公开
标题翻译：自动和同种异体衍生的结构干细胞组合物
公开(公告)号：US20120020937A1
公开(公告)日：2012-01-26
申请号：US13260115
申请日：2009-06-09
申请人： Sung-Koo Lee , Mi-Hyung Kim
发明人： Sung-Koo Lee , Mi-Hyung Kim
IPC分类号： A61K35/12 , C12N5/0775 , A61P43/00
CPC分类号： C12N5/0667 , A61K35/12 , A61K35/28 , C12N2501/115
摘要： The present invention relates to a method for producing clinically effective quantities of human adipose tissue-derived stromal cells for treating fistulas and a composition made with the same. The method of the present invention can efficiently produce clinically effective number of adipose tissue-derived stromal cells within a short period by improving conventional standard culturing methods. The adipose stem cells composition containing the adipose tissue-derived stromal cells obtained by the method of the present invention exhibit superior multipotency and immunomodulatory activity over those of a cell composition produced by conventional methods, and thus is more suitable for treating fistulas. The cell composition of the present invention has excellent clinical usages especially since immune response is suppressed in allogenic adipose-derived stem cells.
摘要翻译：本发明涉及一种临床有效量的用于治疗瘘的人体脂肪组织来源的基质细胞的方法及其制备的组合物。本发明的方法可以通过改进常规的标准培养方法在短时间内有效地产生临床有效数量的脂肪组织来源的基质细胞。含有通过本发明方法获得的脂肪组织来源的基质细胞的脂肪干细胞组合物与通过常规方法制备的细胞组合物相比具有优异的多能性和免疫调节活性，因此更适合于治疗瘘。本发明的细胞组合物具有优异的临床用途，特别是因为在同种异体脂肪干细胞中免疫应答被抑制。

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