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1. 发明授权

US07537936B2 Method of testing multiple fluid samples with multiple biopolymer arrays 失效
标题翻译：用多个生物聚合物阵列测试多个流体样品的方法
公开(公告)号：US07537936B2
公开(公告)日：2009-05-26
申请号：US11136227
申请日：2005-05-23
申请人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
发明人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
IPC分类号： G01N30/00
CPC分类号： B01L3/502 , B01L3/5025 , B01L7/00 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0803 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

2. 发明授权

US07247497B2 Testing multiple fluid samples with multiple biopolymer arrays 有权
标题翻译：用多个生物聚合物阵列测试多个流体样品
公开(公告)号：US07247497B2
公开(公告)日：2007-07-24
申请号：US10160620
申请日：2002-05-31
申请人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
发明人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
IPC分类号： G01N30/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L9/52 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0803 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

3. 发明授权

US06399394B1 Testing multiple fluid samples with multiple biopolymer arrays 失效
标题翻译：用多个生物聚合物阵列测试多个流体样品
公开(公告)号：US06399394B1
公开(公告)日：2002-06-04
申请号：US09343645
申请日：1999-06-30
申请人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
发明人： SueAnn C. Dahm , Arthur Schleifer , Carol T. Schembri , Douglas A. Amorese
IPC分类号： G01N110
CPC分类号： B01L3/5025 , B01L3/5027 , B01L9/52 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0803 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

4. 发明授权

US06682702B2 Apparatus and method for simultaneously conducting multiple chemical reactions 有权
标题翻译：同时进行多次化学反应的装置和方法
公开(公告)号：US06682702B2
公开(公告)日：2004-01-27
申请号：US09938909
申请日：2001-08-24
申请人： Phillip W. Barth , Douglas A. Amorese , Carol T. Schembri
发明人： Phillip W. Barth , Douglas A. Amorese , Carol T. Schembri
IPC分类号： B01L300
CPC分类号： G01N35/028 , G01N2035/00158 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A method and apparatus for simultaneously conducting multiple chemical reactions combine a test sample with a chemical reactant in a plurality of closed reaction chambers to produce reaction products. The method comprises assembling a plate having the test sample in a plurality of spatially arranged wells with a microarray of similarly spatially arranged surface bound chemical reactants to form the sealed apparatus having the plurality of closed reaction chambers. The apparatus is sealed such that it is gas, liquid and/or fluid tight. The seal may be accomplished with a flexible array substrate or a flexible gasket, and one or more of mechanical clamps, external fluid pressure, radiation, heat, vacuum and an adhesive. The sealed apparatus can be subjected to various reaction conditions, such as intense mechanical agitation and a controlled temperature environment. A kit comprises one or more of the elements of the apparatus.
摘要翻译：用于同时进行多个化学反应的方法和装置将测试样品与多个封闭反应室中的化学反应物组合以产生反应产物。该方法包括将具有测试样品的板组装在具有类似空间布置的表面结合的化学反应物的微阵列的多个空间排列的孔中，以形成具有多个封闭反应室的密封装置。该装置被密封，使得其是气体，液体和/或流体密封的。密封可以用柔性阵列基底或柔性垫片以及机械夹具，外部流体压力，辐射，热量，真空和粘合剂中的一种或多种完成。密封装置可以经受各种反应条件，例如强烈的机械搅拌和受控的温度环境。套件包括装置的一个或多个元件。

5. 发明授权

US06518056B2 Apparatus, systems and method for assaying biological materials using an annular format 失效
标题翻译：使用环形格式测定生物材料的装置，系统和方法
公开(公告)号：US06518056B2
公开(公告)日：2003-02-11
申请号：US09302011
申请日：1999-04-27
申请人： Carol T. Schembri , Arthur Schleifer
发明人： Carol T. Schembri , Arthur Schleifer
IPC分类号： C12M134
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00421 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00722 , B01L3/5085 , C12Q1/6832 , C12Q1/6837 , C40B40/06 , C40B50/14 , C40B60/14 , G01N1/2813 , G01N33/54366 , G01N35/00069 , G01N35/025 , G01N35/1083 , G01N2035/00158 , G01N2035/00504 , C12Q2523/32
摘要： An apparatus, systems and methods use an r, &thgr; format for the manufacture and analysis of biological materials. The apparatus is an array of biological material in an annular region on a substrate. The apparatus is formed with a system for synthesizing arrays that includes a spinner assembly for rotating the substrate during the synthesis of the biological material thereon. The apparatus is hybridized with complementary biological material using a system for hybridizing that includes a spinner assembly to spin the apparatus after the complementary biological material is added. The hybridized apparatus is optically interrogated with a system for interrogation that includes a light source, optics, and a scanning assembly that holds and rotates the apparatus so that the light source can remain stationary. The method of assaying biological materials uses the systems for synthesizing, hybridizing and optically interrogating the apparatus in accordance with the invention.
摘要翻译：设备，系统和方法使用r，θ格式来生产和分析生物材料。该装置是在衬底上的环形区域中的生物材料阵列。该装置形成有用于合成阵列的系统，该系统包括用于在其上生物材料的合成期间旋转衬底的旋转器组件。该装置与互补生物材料杂交，使用包含旋转器组件的用于杂交的系统以在补充生物材料被添加之后旋转该装置。杂交装置用询问系统进行光学询问，该系统包括光源，光学器件和保持和旋转设备的扫描组件，使得光源可以保持静止。测定生物材料的方法使用根据本发明的用于合成，杂交和光学询问装置的系统。

6. 发明授权

US06461812B2 Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效
标题翻译：用于制造生物分子阵列的方法和多储层装置
公开(公告)号：US06461812B2
公开(公告)日：2002-10-08
申请号：US09150507
申请日：1998-09-09
申请人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
发明人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
IPC分类号： C12Q168
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B41J2/14145 , B41J2002/14387 , C12Q1/6837 , C40B40/06 , C40B60/14
摘要： Apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological material, includes a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.
摘要翻译：用于将多个不同生物材料输送到接收表面上的离散位置上的装置，例如制造不同生物材料的阵列，包括孔口构件中的多个孔，至少六个输送腔，其各自与所述孔中的至少一个，多个储存器，每个储存器各自与至少一个输送室流体连通，与每个孔相关联的装置，用于将流体从与所述孔流体导通关系的输送室相推进，以及用于通常排放至少两个储存器的通风口。在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。

7. 发明授权

US06372483B2 Preparation of biopolymer arrays 失效
标题翻译：生物聚合物阵列的制备
公开(公告)号：US06372483B2
公开(公告)日：2002-04-16
申请号：US09820476
申请日：2001-03-28
申请人： Arthur Schleifer , Carol T. Schembri , Michael P. Caren
发明人： Arthur Schleifer , Carol T. Schembri , Michael P. Caren
IPC分类号： C12M134
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/14 , C40B60/14 , G01N35/1074 , G01N2035/1041
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can dispense droplets onto a substrate, the jet including a chamber with an orifice, and including an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes positioning the head with the orifice facing the substrate. Multiple droplets of the biopolymer or biomonomer fluid are dispensed from the head orifice so as to form an array of droplets on the substrate. A gas flow is directed through a venturi which has a throat opening communicating with the dispensing head chamber. A venturi control valve which particularly communicate with an outlet of the venturi, is adjusted to alter the chamber pressure. The venturi may be driven by a source of inert anhydrous compressed gas which assists in maintaining fluid in the head isolated from moisture.
摘要翻译：一种使用生物聚合物或生物混合物流体，并使用流体分配头在衬底上制造生物聚合物阵列的方法和装置。头部具有至少一个喷射器，其可以将液滴分配到基底上，喷射器包括具有孔口的腔室，并且包括喷射器，当被激活时，喷射器使得液滴从孔口喷出。该方法包括将头部定位成孔口面向衬底。生物聚合物或生物混合物流体的多个液滴从头孔分配，以在基底上形成液滴阵列。气流被引导通过文丘里管，其具有与分配头腔室连通的喉部开口。特别与文丘里管的出口连通的文氏管控制阀被调节以改变腔室压力。文氏管可以由惰性无水压缩气体源驱动，这有助于保持与水分隔离的头部中的流体。

8. 发明授权

US07026124B2 Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效
标题翻译：用于制造生物分子阵列的方法和多储层装置
公开(公告)号：US07026124B2
公开(公告)日：2006-04-11
申请号：US10267913
申请日：2002-10-08
申请人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
发明人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
IPC分类号： C12Q1/68 , C12M1/00 , G01N15/06 , B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B41J2/14145 , B41J2002/14387 , C12Q1/6837 , C40B40/06 , C40B60/14
摘要： Methods and apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological materials. The apparatus and methods may include a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.
摘要翻译：用于将多种不同生物材料递送到接收表面上的离散位置上的方法和装置，例如制造不同生物材料的阵列。该装置和方法可以包括孔口构件中的多个孔口，至少六个输送腔室，其各自与至少一个孔口形成流体传导关系;多个储存器，每个储存器与至少一个输送室流体连通，与每个孔口相关联的装置，用于将流体从与所述孔口处于流体导通关系的输送室相关联的孔口推进，以及用于通常排放至少两个储存器的通风口。在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。

9. 发明授权

US06458583B1 Method and apparatus for making nucleic acid arrays 失效
标题翻译：制备核酸阵列的方法和装置
公开(公告)号：US06458583B1
公开(公告)日：2002-10-01
申请号：US09150504
申请日：1998-09-09
申请人： Laurakay Bruhn , Michael P. Caren , Carol T. Schembri , Arthur Schleifer
发明人： Laurakay Bruhn , Michael P. Caren , Carol T. Schembri , Arthur Schleifer
IPC分类号： C12M134
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00529 , B01J2219/0059 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00677 , B01J2219/00722 , B01L2400/0442 , B82Y30/00 , C40B40/06 , C40B60/14 , Y10T436/143333
摘要： Methods and devices for depositing a nucleic acid on a substrate surface are provided. In the subject methods, a thermal inkjet head loaded with nucleic acid fluid composition is positioned in opposing relationship to, e.g. over, a substrate surface. Actuation of the thermal inkjet results in the expulsion of volume of the nucleic acid composition onto the substrate surface. The subject methods and devices find use in a variety of applications, particularly in the preparation of nucleic acid arrays, and more particular arrays of oligonucleotides or polynucleotides, e.g. cDNAs.
摘要翻译：提供了用于在基底表面上沉积核酸的方法和装置。在本发明的方法中，装载有核酸流体组合物的热喷墨头与例如，在基底表面上。热喷墨的致动导致将核酸组合物的体积排出到基底表面上。本发明的方法和装置可用于各种应用，特别是在制备核酸阵列，以及更具体的寡核苷酸或多核苷酸阵列，例如， cDNAs。

10. 发明授权

US06242266B1 Preparation of biopolymer arrays 失效
标题翻译：生物聚合物阵列的制备
公开(公告)号：US06242266B1
公开(公告)日：2001-06-05
申请号：US09302899
申请日：1999-04-30
申请人： Arthur Schleifer , Carol T. Schembri , Michael P. Caren
发明人： Arthur Schleifer , Carol T. Schembri , Michael P. Caren
IPC分类号： G01N33543
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/14 , C40B60/14 , G01N35/1074 , G01N2035/1041
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can dispense droplets onto a substrate, the jet including a chamber with an orifice, and including an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes positioning the head with the orifice facing the substrate. Multiple droplets of the biopolymer or biomonomer fluid are dispensed from the head orifice so as to form an array of droplets on the substrate. A gas flow is directed through a venturi which has a throat opening communicating with the dispensing head chamber. A venturi control valve which particularly communicate with an outlet of the venturi, is adjusted to alter the chamber pressure. The venturi may be driven by a source of inert anhydrous compressed gas which assists in maintaining fluid in the head isolated from moisture.
摘要翻译：一种使用生物聚合物或生物混合物流体，并使用流体分配头在衬底上制造生物聚合物阵列的方法和装置。头部具有至少一个喷射器，其可以将液滴分配到基底上，喷射器包括具有孔口的腔室，并且包括喷射器，当被激活时，喷射器使得液滴从孔口喷出。该方法包括将头部定位成孔口面向衬底。生物聚合物或生物混合物流体的多个液滴从头孔分配，以在基底上形成液滴阵列。气流被引导通过文丘里管，其具有与分配头腔室连通的喉部开口。特别与文丘里管的出口连通的文氏管控制阀被调节以改变腔室压力。文氏管可以由惰性无水压缩气体源驱动，这有助于保持与水分隔离的头部中的流体。

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