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1. 发明授权

US08925976B2 Flanged fitting for use with tubing containment system 有权
标题翻译：用于管道密封系统的法兰配件
公开(公告)号：US08925976B2
公开(公告)日：2015-01-06
申请号：US12715426
申请日：2010-03-02
申请人： Steven A. Treichel , Mark Miller
发明人： Steven A. Treichel , Mark Miller
IPC分类号： F16L23/12 , F16L23/028 , F16L25/00
CPC分类号： F16L23/0283 , F16L25/0036 , F16L33/26
摘要： A fitting for use with metal tubing in a jacket, the fitting including: an adapter, the adapter having a tubular member defining a longitudinal passage having a longitudinal axis for fluid flow; a body for receiving the tubing, the body positioned opposite the adapter and aligned with the longitudinal axis; a sealing member positioned between the adapter and the body; a retainer positioned external to the sealing member, the retainer receiving the adapter and receiving the body; a first flange located near the adapter and a second flange located near the body; and a fastener for drawing the first flange and second flange towards each other.
摘要翻译：一种用于与夹套中的金属管一起使用的配件，所述配件包括：适配器，所述适配器具有限定具有用于流体流动的纵向轴线的纵向通道的管状构件; 用于接收管道的主体，所述主体与所述适配器相对并且与所述纵向轴线对齐; 定位在适配器和主体之间的密封构件; 位于所述密封构件外部的保持器，所述保持器接收所述适配器并容纳所述主体; 位于适配器附近的第一凸缘和位于主体附近的第二凸缘; 以及用于将第一凸缘和第二凸缘朝向彼此拉出的紧固件。

2. 发明申请

US20110215570A1 Flanged Fitting For Use With Tubing Containment System 有权
标题翻译：用于管道密封系统的法兰配件
公开(公告)号：US20110215570A1
公开(公告)日：2011-09-08
申请号：US12715426
申请日：2010-03-02
申请人： Steven A. Treichel , Mark Miller
发明人： Steven A. Treichel , Mark Miller
IPC分类号： F16L23/12 , F16L23/02
CPC分类号： F16L23/0283 , F16L25/0036 , F16L33/26
摘要： A fitting for use with metal tubing in a jacket, the fitting including: an adapter, the adapter having a tubular member defining a longitudinal passage having a longitudinal axis for fluid flow; a body for receiving the tubing, the body positioned opposite the adapter and aligned with the longitudinal axis; a sealing member positioned between the adapter and the body; a retainer positioned external to the sealing member, the retainer receiving the adapter and receiving the body; a first flange located near the adapter and a second flange located near the body; and a fastener for drawing the first flange and second flange towards each other.
摘要翻译：一种用于与夹套中的金属管一起使用的配件，所述配件包括：适配器，所述适配器具有限定具有用于流体流动的纵向轴线的纵向通道的管状构件; 用于接收管道的主体，所述主体与所述适配器相对并且与所述纵向轴线对齐; 定位在适配器和主体之间的密封构件; 位于所述密封构件外部的保持器，所述保持器接收所述适配器并接收所述主体; 位于适配器附近的第一凸缘和位于主体附近的第二凸缘; 以及用于将第一凸缘和第二凸缘朝向彼此拉出的紧固件。

3. 发明申请

US20100117358A1 Reusable Fitting For Tubing 有权
标题翻译：可重复使用的管件
公开(公告)号：US20100117358A1
公开(公告)日：2010-05-13
申请号：US12692950
申请日：2010-01-25
申请人： Steven A. Treichel , Mark Miller
发明人： Steven A. Treichel , Mark Miller
IPC分类号： F16L21/06 , F16L19/04
CPC分类号： F16L25/0054 , F16L19/065 , F16L25/0036 , F16L33/26 , Y10S285/903
摘要： A fitting for use with corrugated tubing, the fitting comprising: a nut having a passage therethrough for receiving the tubing, the tubing being corrugated tubing having a series of peaks and valleys; a plurality of retainers positioned forward of the nut, the retainers having a sealing surface for placement in a valley of the corrugated tubing; a body having an annular pocket formed circumferentially around the retainers, the body having a body sealing surface, wherein upon sealing, the tubing is compressed between the sealing surface and the body sealing surface; a spring positioned within a cavity in the retainers, the spring driving the retainers into the pocket when the fitting is not sealed.
摘要翻译：一种用于波纹管的配件，该配件包括：螺母，其具有用于接收管道的通道，该管道是具有一系列峰和谷的波纹管; 多个保持器，位于螺母的前方，保持器具有用于放置在波纹管的谷部中的密封表面; 主体具有围绕保持器周向形成的环形袋，主体具有主体密封表面，其中密封时，管道在密封表面和主体密封表面之间被压缩; 定位在保持器中的空腔内的弹簧，当配件未被密封时，弹簧将保持器驱动到口袋中。

4. 发明授权

US07677609B2 Reusable fitting for corrugated tubing 有权
标题翻译：波纹管可重复使用的配件
公开(公告)号：US07677609B2
公开(公告)日：2010-03-16
申请号：US11166537
申请日：2005-06-24
申请人： Steven A. Treichel , Mark Miller
发明人： Steven A. Treichel , Mark Miller
IPC分类号： F16L19/08
CPC分类号： F16L25/0054 , F16L19/065 , F16L25/0036 , F16L33/26 , Y10S285/903
摘要： A fitting for use with corrugated tubing, the fitting comprising: a nut having a passage therethrough for receiving the tubing, the tubing being corrugated tubing having a series of peaks and valleys; a plurality of retainers positioned forward of the nut, the retainers having a sealing surface for placement in a valley of the corrugated tubing; a body having an annular pocket formed circumferentially around the retainers, the body having a body sealing surface, wherein upon sealing, the tubing is compressed between the sealing surface and the body sealing surface; a spring positioned within a cavity in the retainers, the spring driving the retainers into the pocket when the fitting is not sealed.
摘要翻译：一种用于波纹管的配件，该配件包括：螺母，其具有用于接收管道的通道，该管道是具有一系列峰和谷的波纹管; 位于螺母之前的多个保持器，保持器具有用于放置在波纹管的谷部中的密封表面; 主体具有围绕保持器周向形成的环形袋，主体具有主体密封表面，其中密封时，管道在密封表面和主体密封表面之间被压缩; 定位在保持器中的空腔内的弹簧，当配件未被密封时，弹簧将保持器驱动到口袋中。

5. 发明授权

US09251644B2 Amusement devices and games including means for processing electronic data where users can change selections 有权
标题翻译：娱乐设备和游戏包括用于处理用户可以改变选择的电子数据的装置
公开(公告)号：US09251644B2
公开(公告)日：2016-02-02
申请号：US13620160
申请日：2012-09-14
申请人： Dean P. Alderucci , Charles Plott , Mark Miller
发明人： Dean P. Alderucci , Charles Plott , Mark Miller
IPC分类号： A63F13/00 , G07F17/32
CPC分类号： G07F17/3244 , G07F17/32 , G07F17/3209 , G07F17/3211 , G07F17/3227 , G07F17/323 , G07F17/3272 , G07F17/3276 , G07F17/3293
摘要： Games related to the provision of information are described. Games may be formulated to exploit biases such as long shot bias and favorite bias. Games related to the provision of information are described. Games may be formulated to exploit biases relating to the Monty Hall paradox. Games related to the provision of information are described. Games may include wagering on hands of cards, e.g., poker wagering games.
摘要翻译：描述与提供信息相关的游戏。可以制定游戏以利用偏见，例如长射偏差和偏爱偏好。描述与提供信息相关的游戏。可以制定游戏，以利用与蒙蒂霍尔悖论相关的偏见。描述与提供信息相关的游戏。游戏可以包括扑克牌，例如扑克赌注游戏。

6. 发明授权

US08993600B2 Modulators of ATP-binding cassette transporters 有权
标题翻译： ATP结合盒转运蛋白的调节剂
公开(公告)号：US08993600B2
公开(公告)日：2015-03-31
申请号：US12114935
申请日：2008-05-05
申请人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
发明人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： A61K31/443 , C07D405/12 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D405/14
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

7. 发明授权

US08969386B2 Modulators of CFTR 有权
标题翻译： CFTR调制器
公开(公告)号：US08969386B2
公开(公告)日：2015-03-03
申请号：US12117941
申请日：2008-05-09
申请人： Sara Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
发明人： Sara Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
IPC分类号： A61K31/44 , C07D401/00 , C07D401/04 , A61K31/444
CPC分类号： C07D405/14 , A61K31/444 , C07D213/75 , C07D401/04 , G01N33/502 , G01N2333/705 , G01N2500/04 , G01N2500/10
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗CFTR介导的疾病的方法。

8. 发明申请

US20130317020A1 Pyridyl Derivatives as CFTR Modulators 有权
标题翻译：吡啶衍生物作为CFTR调节剂
公开(公告)号：US20130317020A1
公开(公告)日：2013-11-28
申请号：US13957678
申请日：2013-08-02
申请人： Sara Hadida Ruah , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
发明人： Sara Hadida Ruah , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
IPC分类号： C07D213/74 , C07D405/14 , C07D413/14 , C07D405/12
CPC分类号： C07D213/74 , C07D213/75 , C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译：本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”），其组合物及其方法。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

9. 发明申请

US20130245011A1 Modulators of ATP-Binding Cassette Transporters 审中-公开
标题翻译： ATP结合盒转运蛋白的调节剂
公开(公告)号：US20130245011A1
公开(公告)日：2013-09-19
申请号：US13887839
申请日：2013-05-06
申请人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
发明人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： A61K31/5377 , A61K45/06 , C07D405/14 , A61K31/4545 , C07D405/12 , A61K31/443
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTC”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

10. 发明授权

US08524910B2 Pyridyl derivatives as CFTR modulators 有权
标题翻译：吡啶衍生物作为CFTR调节剂
公开(公告)号：US08524910B2
公开(公告)日：2013-09-03
申请号：US13533326
申请日：2012-06-26
申请人： Sara Hadida Ruah , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
发明人： Sara Hadida Ruah , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
IPC分类号： A61K31/44 , C07D405/00
CPC分类号： C07D213/74 , C07D213/75 , C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to modulators of Formula I and the accompanying definitions herein of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases such as cystic fibrosis using such modulators.
摘要翻译：本发明涉及式I的调节剂以及ATP结合盒（“ABC”）转运蛋白或其片段（包括囊性纤维化跨膜电导调节剂（“CFTR”）及其组合物的随附定义。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病如囊性纤维化的方法。

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