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1. 发明申请

US20070031470A1 NONWOVEN TISSUE SCAFFOLD 有权
标题翻译：非金属组织SCAFFOLD
公开(公告)号：US20070031470A1
公开(公告)日：2007-02-08
申请号：US11427477
申请日：2006-06-29
申请人： Stephanie Kladakis , Joseph Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
发明人： Stephanie Kladakis , Joseph Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

2. 发明申请

US20120165939A1 NONWOVEN TISSUE SCAFFOLD 审中-公开
标题翻译：非金属组织SCAFFOLD
公开(公告)号：US20120165939A1
公开(公告)日：2012-06-28
申请号：US13341366
申请日：2011-12-30
申请人： Stephanie M. Kladakis , Joseph J. Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
发明人： Stephanie M. Kladakis , Joseph J. Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
IPC分类号： A61F2/08 , A61K35/12 , A61K38/18 , A61K35/16 , A61K38/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

3. 发明申请

US20050232967A1 Nonwoven tissue scaffold 有权
标题翻译：无纺布组织支架
公开(公告)号：US20050232967A1
公开(公告)日：2005-10-20
申请号：US10828838
申请日：2004-04-20
申请人： Stephanie Kladakis , Joseph Hammer , Dhanuraj Shetty , Sridevi Dhanaraj
发明人： Stephanie Kladakis , Joseph Hammer , Dhanuraj Shetty , Sridevi Dhanaraj
IPC分类号： A61L27/00 , A61F2/30 , A61F2/38 , A61L27/14 , A61L27/18 , A61L27/44 , A61L27/56 , A61B17/12
CPC分类号： A61L27/56 , A61F2/3872 , A61L27/18 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

4. 发明申请

US20050177249A1 Scaffolds with viable tissue 审中-公开
标题翻译：具有活组织的支架
公开(公告)号：US20050177249A1
公开(公告)日：2005-08-11
申请号：US10775034
申请日：2004-02-09
申请人： Stephanie Kladakis , Sridevi Dhanaraj , Robert Boock
发明人： Stephanie Kladakis , Sridevi Dhanaraj , Robert Boock
IPC分类号： A61L27/00 , A61F2/00 , A61L27/36 , A61L27/48 , A61L27/56 , A61L27/58 , A61F2/02
CPC分类号： A61L27/48 , A61L27/56 , A61L27/58
摘要： A composite implant is provided for repairing a tissue defect in a patient. In one embodiment, the implant is a porous tissue scaffold having at least one pocket formed therein and adapted to contain a viable tissue. The tissue scaffold can have a variety of configurations, and in one embodiment it includes top and bottom portions that can be at least partially mated to one another, and in an exemplary embodiment that are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween. The pocket is preferably sealed with a viable tissue disposed therein. In another embodiment, the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold, and/or at least one lumen extending into the tissue scaffold. The tissue scaffold can also optionally include at least one surface feature formed thereof to promote blood vessel formation.
摘要翻译：提供复合植入物来修复患者的组织缺损。在一个实施例中，植入物是多孔组织支架，其具有形成在其中的至少一个口袋并且适于容纳活组织。组织支架可以具有各种构造，并且在一个实施例中，其包括可以彼此至少部分地配合的顶部和底部部分，并且在示例性实施例中，围绕其周边彼此加热密封以形成封闭口袋。口袋优选用设置在其中的活组织密封。在另一个实施例中，组织支架基本上是楔形的，并且口袋包括形成在组织支架中的中空内部和/或延伸到组织支架中的至少一个腔。组织支架还可以任选地包括形成于其中的至少一个表面特征以促进血管形成。

5. 发明授权

US08221780B2 Nonwoven tissue scaffold 有权
标题翻译：无纺布组织支架
公开(公告)号：US08221780B2
公开(公告)日：2012-07-17
申请号：US11427477
申请日：2006-06-29
申请人： Sridevi Dhanaraj , Stephanie M. Kladakis , Joseph J. Hammer , Dhanuraj Shetty , Mark Timmer
发明人： Sridevi Dhanaraj , Stephanie M. Kladakis , Joseph J. Hammer , Dhanuraj Shetty , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

6. 发明授权

US08105621B2 Nonwoven tissue scaffold 有权
公开(公告)号：US08105621B2
公开(公告)日：2012-01-31
申请号：US11427477
申请日：2006-06-29
申请人： Sridevi Dhanaraj , Stephanie M. Kladakis , Joseph J. Hammer , Dhanuraj Shetty , Mark Timmer
发明人： Sridevi Dhanaraj , Stephanie M. Kladakis , Joseph J. Hammer , Dhanuraj Shetty , Mark Timmer
IPC分类号： A61F2/00
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.

7. 发明授权

US11179422B2 Method of differentiating umbilical cord tissue into a chondrogenic phenotype 有权
公开(公告)号：US11179422B2
公开(公告)日：2021-11-23
申请号：US11315969
申请日：2005-12-22
申请人： Laura Brown , Sridevi Dhanaraj , Agnieszka Seyda
发明人： Laura Brown , Sridevi Dhanaraj , Agnieszka Seyda
IPC分类号： A61K48/00 , A61K35/51 , C12N5/074 , C12N5/073 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/27 , C12N5/0735 , A61K35/50 , A61K35/12
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis.

8. 发明申请

US20130157368A1 INDUCED PLURIPOTENT STEM CELLS PREPARED FROM HUMAN KIDNEY-DERIVED CELLS 审中-公开
标题翻译：诱导人源性细胞产生的诱导型干细胞
公开(公告)号：US20130157368A1
公开(公告)日：2013-06-20
申请号：US13331283
申请日：2011-12-20
申请人： Charito Buensuceso , Agnieszka Seyda , David C. Colter , Sridevi Dhanaraj , Brian C. Kramer , Jason Elliot Ekert , Amanda Lynn Kauffman
发明人： Charito Buensuceso , Agnieszka Seyda , David C. Colter , Sridevi Dhanaraj , Brian C. Kramer , Jason Elliot Ekert , Amanda Lynn Kauffman
IPC分类号： C12N5/071 , C12N15/867
CPC分类号： C12N15/86 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/25 , C12N2510/00
摘要： We have disclosed an induced pluripotent stem cell and the method of preparing the induced pluripotent stem cell from a human kidney-derived cell. More particularly, we have disclosed a human kidney-derived iPS cell which may be differentiated into cells of ectoderm, mesoderm, and endoderm lineages.
摘要翻译：我们已经公开了诱导多能干细胞和从人肾源细胞制备诱导的多能干细胞的方法。更具体地，我们已经公开了可以分化成外胚层，中胚层和内胚层谱系的细胞的人肾来源的iPS细胞。

9. 发明申请

US20130157365A1 INDUCED PLURIPOTENT STEM CELLS FROM HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS 审中-公开
标题翻译：人脐带组织细胞诱导的大脑干细胞
公开(公告)号：US20130157365A1
公开(公告)日：2013-06-20
申请号：US13330931
申请日：2011-12-20
申请人： Charito Buensuceso , Agnieszka Seyda , David C. Colter , Sridevi Dhanaraj , Brian C. Kramer
发明人： Charito Buensuceso , Agnieszka Seyda , David C. Colter , Sridevi Dhanaraj , Brian C. Kramer
IPC分类号： C12N5/071
CPC分类号： C12N5/0605 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/025
摘要： We have disclosed an induced pluripotent stem cell and the method of preparing the induced pluripotent stem cell from a human umbilical cord tissue-derived cell. More particularly, we have disclosed a human umbilical cord tissue-derived iPS cell which may be differentiated into cells of ectoderm, mesoderm, and endoderm lineages.
摘要翻译：我们已经公开了诱导多能干细胞和从人脐带组织来源的细胞制备诱导的多能干细胞的方法。更具体地，我们已经公开了可以分化成外胚层，中胚层和内胚层谱系细胞的人脐带组织来源的iPS细胞。

10. 发明申请

US20090155245A1 Treatment for Organ Regeneration with Combination of Drug and Biologics 审中-公开
标题翻译：用药物和生物制剂联合治疗器官再生
公开(公告)号：US20090155245A1
公开(公告)日：2009-06-18
申请号：US12330704
申请日：2008-12-09
申请人： Carrie H. Fang , Sridevi Dhanaraj , Jeffrey C. Geesin
发明人： Carrie H. Fang , Sridevi Dhanaraj , Jeffrey C. Geesin
IPC分类号： A61K35/12 , A61K35/28 , A61K39/395 , A61P13/12
CPC分类号： A61K45/06 , A61K35/22 , A61K35/28 , A61K38/1841 , A61K38/553 , A61K38/556 , A61K2300/00
摘要： Combination therapies of drugs and biologics for treatment of acute and chronic organ degeneration are disclosed. More specifically, the use of morphogens, stem cells, and anti-inflammatories or inhibitors for the renin-angiotensin-aldosterone system (RAAS) for the treatment of acute and chronic renal disease is disclosed.
摘要翻译：公开了用于治疗急性和慢性器官退行性疾病的药物和生物制剂的组合疗法。更具体地，公开了用于治疗急性和慢性肾脏疾病的肾素 - 血管紧张素 - 醛固酮系统（RAAS）的形态发生剂，干细胞和抗炎剂或抑制剂的用途。

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