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1. 发明申请

US20200375516A1 DRUG DELIVERY DEVICE WITH ELECTRICALLY CONTROLLED VOLUME CHANGING MEANS 审中-公开
公开(公告)号：US20200375516A1
公开(公告)日：2020-12-03
申请号：US16999213
申请日：2020-08-21
申请人： SteadyMed Ltd.
发明人： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
IPC分类号： A61B5/157 , A61M5/145 , A61B5/15
摘要： A displacement-generating battery cell for driving a drug-delivery device is described. The cell may include at least one volume-changing element. The cell may include a housing formed according to a concertina-shaped design with folds in the walls thereof and may contain an internal chemical reaction system. The chemical reaction system may include an electrode. The electrode may be the volume-changing element. The arrangement of said chemical reaction system may be such that an expansion of the volume-changing element in a direction lengthens the cell and thus reduces the extent of the folds. Drug-delivery devices including the displacement-generating battery cell are also described.

2. 发明申请

US20200368425A1 DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20200368425A1
公开(公告)日：2020-11-26
申请号：US16986544
申请日：2020-08-06
申请人： SteadyMed Ltd.
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/145 , A61M5/172 , A61M5/20 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , A61M5/142
摘要： The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

3. 发明申请

US20180250465A1 DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20180250465A1
公开(公告)日：2018-09-06
申请号：US15972322
申请日：2018-05-07
申请人： SteadyMed Ltd.
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/145 , A61M5/142 , H01M10/05 , H01M10/02 , H01M2/02 , A61M5/172 , A61M5/20 , H01M10/42
CPC分类号： A61M5/145 , A61M5/14248 , A61M5/14276 , A61M5/1452 , A61M5/14586 , A61M5/172 , A61M5/1723 , A61M5/2046 , A61M2005/14204 , A61M2005/14252 , A61M2005/14513 , A61M2205/35 , A61M2205/8206 , A61M2230/201 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , H01M2220/30
摘要： The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

4. 发明申请

US20180035935A1 DRUG DELIVERY DEVICE WITH ELECTRICALLY CONTROLLED VOLUME CHANGING MEANS 审中-公开
公开(公告)号：US20180035935A1
公开(公告)日：2018-02-08
申请号：US15634880
申请日：2017-06-27
申请人： SteadyMed Ltd.
发明人： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
IPC分类号： A61B5/157 , A61M5/145 , A61B5/15
摘要： Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.

5. 发明授权

US10750987B2 Drug delivery device with electrically controlled volume changing means 有权
公开(公告)号：US10750987B2
公开(公告)日：2020-08-25
申请号：US15634880
申请日：2017-06-27
申请人： SteadyMed Ltd.
发明人： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
IPC分类号： H01M2/02 , A61B5/157 , A61M5/145 , A61B5/15 , A61M5/142
摘要： Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.

6. 发明授权

US10737017B2 Drug delivery device 有权
公开(公告)号：US10737017B2
公开(公告)日：2020-08-11
申请号：US15972322
申请日：2018-05-07
申请人： SteadyMed Ltd.
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/145 , A61M5/142 , A61M5/20 , A61M5/172 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42
摘要： The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

7. 发明授权

US09687186B2 Drug delivery device 有权
公开(公告)号：US09687186B2
公开(公告)日：2017-06-27
申请号：US13956965
申请日：2013-08-01
申请人： SteadyMed Ltd.
发明人： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
IPC分类号： A61K9/22 , A61B5/157 , A61B5/15 , A61M5/145 , A61M5/142
CPC分类号： A61B5/157 , A61B5/15003 , A61B5/150992 , A61M5/1452 , A61M5/14526 , A61M2005/14204
摘要： Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.

8. 发明申请

US20150017493A1 DRUG DELIVERY DEVICE 有权
标题翻译：药物递送装置
公开(公告)号：US20150017493A1
公开(公告)日：2015-01-15
申请号：US14456416
申请日：2014-08-11
申请人： SteadyMed Ltd.
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/145 , H01M10/42 , H01M2/02 , H01M10/05 , A61M5/172 , H01M10/02
CPC分类号： A61M5/145 , A61M5/14248 , A61M5/14276 , A61M5/1452 , A61M5/14586 , A61M5/172 , A61M5/1723 , A61M5/2046 , A61M2005/14204 , A61M2005/14252 , A61M2005/14513 , A61M2205/35 , A61M2205/8206 , A61M2230/201 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , H01M2220/30
摘要： The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.
摘要翻译：本申请提供了一种药物递送装置，其包括药物储存室16，其包含与药物施用装置18流体连接的待递送物质，以及电控电池单元10，其包括至少一个位移产生电池单元 19通过联接装置14耦合到药物储存室16，该布置使得从电池单元10获得的位移被耦合装置14输送到药物储存室16，使得物质从药物储存器中排出腔室16朝向药物管理装置18。

9. 发明授权

US10010671B2 Drug delivery device 有权
公开(公告)号：US10010671B2
公开(公告)日：2018-07-03
申请号：US14456416
申请日：2014-08-11
申请人： SteadyMed Ltd.
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/14 , A61M5/145 , A61M5/142 , A61M5/20 , A61M5/172 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42
CPC分类号： A61M5/145 , A61M5/14248 , A61M5/14276 , A61M5/1452 , A61M5/14586 , A61M5/172 , A61M5/1723 , A61M5/2046 , A61M2005/14204 , A61M2005/14252 , A61M2005/14513 , A61M2205/35 , A61M2205/8206 , A61M2230/201 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , H01M2220/30
摘要： Embodiments include a displacement-generating battery cell for driving a drug-delivery device. The cell includes at least one volume-changing element. The cell also includes a housing formed according to a concertina-shaped design with folds in the walls thereof and containing an internal chemical reaction system. The arrangement of the chemical reaction system is such that as the cell is discharged, the volume-changing element expands, thereby lengthening the battery and thus reducing the extent of said folds, such that the cell becomes taller to reflect the expansion of the volume-changing component.

10. 发明申请

US20140163339A1 DRUG DELIVERY DEVICE 有权
标题翻译：药物递送装置
公开(公告)号：US20140163339A1
公开(公告)日：2014-06-12
申请号：US13956965
申请日：2013-08-01
申请人： STEADYMED LTD.
发明人： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
IPC分类号： A61M5/142 , A61M5/172 , A61B5/157
CPC分类号： A61B5/157 , A61B5/15003 , A61B5/150992 , A61M5/1452 , A61M5/14526 , A61M2005/14204
摘要： Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.
摘要翻译：本发明的实施方案提供了药物递送装置，其包括药物储存室，所述药物储存室包含与药物施用装置流体连接的待递送物质，以及通过联接装置连接到所述药物储存室的至少一个位移产生电池单元，所述至少一个位移产生电池单体包括由于电池单元的放电而改变形状的元件，以引起电池单元内的位移，该布置使得从所述电池单元导出的位移被传送通过所述联接装置引起所述药物储存室的壁的至少一部分的位移减小所述药物储存室的体积，使得所述物质在排出时从所述药物储存室朝向所述药物施用装置排出，从而是自力药物输送装置。

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