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1. 发明申请

US20130158022A1 Acrylamide Compounds And Use Thereof For Inhibiting Apoptosis 有权
标题翻译：丙烯酰胺化合物及其用于抑制细胞凋亡
公开(公告)号：US20130158022A1
公开(公告)日：2013-06-20
申请号：US13697810
申请日：2010-05-14
申请人： Kunlun He , Song Li , Wu Zhong , Juan Liu , Lili Wang , Xin Li , Guoliang Hu , Jie Wang , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Ruijun Li , Chunlei Liu , Jie Tang
发明人： Kunlun He , Song Li , Wu Zhong , Juan Liu , Lili Wang , Xin Li , Guoliang Hu , Jie Wang , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Ruijun Li , Chunlei Liu , Jie Tang
IPC分类号： C07D409/12 , C07D295/194 , C07C335/12 , C07D333/24
CPC分类号： A61K31/18 , A61K31/17 , A61K31/381 , A61K31/435 , A61K31/4453 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C335/12 , C07D295/194 , C07D295/21 , C07D333/24 , C07D409/12
摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译：本发明涉及式I化合物或其化合物的异构体，药学上可接受的盐和溶剂合物，以及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物的组合物和药学上可接受的载体，赋形剂或稀释剂。本发明还涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物用于防治凋亡，预防或治疗与凋亡相关的疾病或病症的用途; 特别是用于保护心肌细胞，并用于预防或治疗与心肌细胞凋亡相关的疾病或病症。

2. 发明申请

US20130116256A1 HEXENONE COMPOUNDS AND MEDICAL USE THEREOF 有权
标题翻译： HEXENONE化合物及其医疗用途
公开(公告)号：US20130116256A1
公开(公告)日：2013-05-09
申请号：US13696697
申请日：2011-05-16
申请人： Song Li , Wu Zhong , Juan Liu , Lili Wang , Kunlun He , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Xin Li , Guoliang Hu
发明人： Song Li , Wu Zhong , Juan Liu , Lili Wang , Kunlun He , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Xin Li , Guoliang Hu
IPC分类号： C07D295/215
CPC分类号： C07D295/215 , C07D295/194
摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent; and also to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, or preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, or preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译：本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂化物; 涉及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物以及药学上可接受的载体，赋形剂或稀释剂的组合物; 并且还使用式I化合物或其异构体，药学上可接受的盐和溶剂化物来防治凋亡，或预防或治疗与细胞凋亡相关的疾病或病症; 特别是用于保护心肌细胞，或预防或治疗与心肌细胞凋亡相关的疾病或病症。

3. 发明授权

US09260384B2 Urea compounds and use thereof for inhibiting apoptosis 有权
标题翻译：尿素化合物及其用于抑制凋亡的用途
公开(公告)号：US09260384B2
公开(公告)日：2016-02-16
申请号：US13697888
申请日：2010-05-14
申请人： Kunlun He , Song Li , Wu Zhong , Juan Liu , Lili Wang , Xin Li , Guoliang Hu , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Ruijun Li , Chunlei Liu , Jie Bai
发明人： Kunlun He , Song Li , Wu Zhong , Juan Liu , Lili Wang , Xin Li , Guoliang Hu , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Ruijun Li , Chunlei Liu , Jie Bai
IPC分类号： A61K31/47 , C07C275/28 , C07D215/40
CPC分类号： C07C275/28 , C07D215/40
摘要： A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents, is provided. Further, use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof for anti-apoptosis is provided, preventing or treating a disease or disorder associated with apoptosis; especially for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译：提供式I化合物或其异构体，药学上可接受的盐或溶剂合物。此外，还提供含有式I化合物或其异构体，药学上可接受的盐或溶剂合物，以及药学上可接受的载体，赋形剂或稀释剂的组合物。此外，提供了式I化合物或其异构体，其药学上可接受的盐或溶剂合物用于抗凋亡的用途，用于预防或治疗与凋亡相关的疾病或病症; 特别是用于保护心肌细胞，预防或治疗与心肌细胞凋亡相关的疾病或病症。

4. 发明授权

US08884007B2 Hexenone compounds and medical use thereof 有权
标题翻译：己烯酮化合物及其医疗用途
公开(公告)号：US08884007B2
公开(公告)日：2014-11-11
申请号：US13696697
申请日：2011-05-16
申请人： Song Li , Wu Zhong , Juan Liu , Lili Wang , Kunlun He , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Xin Li , Guoliang Hu
发明人： Song Li , Wu Zhong , Juan Liu , Lili Wang , Kunlun He , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Xin Li , Guoliang Hu
IPC分类号： C07D295/215 , C07D295/194
CPC分类号： C07D295/215 , C07D295/194
摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent; and also to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, or preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, or preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译：本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂化物; 涉及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物以及药学上可接受的载体，赋形剂或稀释剂的组合物; 并且还使用式I化合物或其异构体，药学上可接受的盐和溶剂化物来防治凋亡，或预防或治疗与细胞凋亡相关的疾病或病症; 特别是用于保护心肌细胞，或预防或治疗与心肌细胞凋亡相关的疾病或病症。

5. 发明申请

US20130123300A1 UREA COMPOUNDS AND USE THEREOF FOR INHIBITING APOPTOSIS 有权
标题翻译：尿素化合物及其用于抑制药物的用途
公开(公告)号：US20130123300A1
公开(公告)日：2013-05-16
申请号：US13697888
申请日：2010-05-14
申请人： Kunlun He , Song Li , Wu Zhong , Juan Liu , Lili Wang , Xin Li , Guoliang Hu , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Ruijun Li , Chunlei Liu , Jie Bai
发明人： Kunlun He , Song Li , Wu Zhong , Juan Liu , Lili Wang , Xin Li , Guoliang Hu , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Ruijun Li , Chunlei Liu , Jie Bai
IPC分类号： C07C275/28 , C07D215/40
CPC分类号： C07C275/28 , C07D215/40
摘要： A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents, is provided. Further, use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof for anti-apoptosis is provided, preventing or treating a disease or disorder associated with apoptosis; especially for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译：提供式I化合物或其异构体，药学上可接受的盐或溶剂合物。此外，还提供含有式I化合物或其异构体，药学上可接受的盐或溶剂合物，以及药学上可接受的载体，赋形剂或稀释剂的组合物。此外，提供了式I化合物或其异构体，其药学上可接受的盐或溶剂合物用于抗凋亡的用途，用于预防或治疗与凋亡相关的疾病或病症; 特别是用于保护心肌细胞，预防或治疗与心肌细胞凋亡相关的疾病或病症。

6. 发明授权

US09199978B2 Acrylamide compounds and use thereof for inhibiting apoptosis 有权
标题翻译：丙烯酰胺化合物及其用于抑制凋亡的用途
公开(公告)号：US09199978B2
公开(公告)日：2015-12-01
申请号：US13697810
申请日：2010-05-14
申请人： Kunluu He , Song Li , Wu Zhong , Juan Liu , Lili Wang , Xin Li , Guoliang Hu , Jie Wang , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Ruijun Li , Chunlei Liu , Jie Tang
发明人： Kunluu He , Song Li , Wu Zhong , Juan Liu , Lili Wang , Xin Li , Guoliang Hu , Jie Wang , Long Long , Junhai Xiao , Zhibing Zheng , Wei Li , Ruijun Li , Chunlei Liu , Jie Tang
IPC分类号： A61K31/5377 , C07D295/194 , C07D295/21 , C07D409/12 , A61K31/17 , A61K31/381 , A61K31/435 , A61K31/4709 , A61K31/496 , C07C335/12 , C07D333/24
CPC分类号： A61K31/18 , A61K31/17 , A61K31/381 , A61K31/435 , A61K31/4453 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C335/12 , C07D295/194 , C07D295/21 , C07D333/24 , C07D409/12
摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译：本发明涉及式I化合物或其化合物的异构体，药学上可接受的盐和溶剂合物，以及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物的组合物和药学上可接受的载体，赋形剂或稀释剂。本发明还涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物用于防治凋亡，预防或治疗与凋亡相关的疾病或病症的用途; 特别是用于保护心肌细胞，并用于预防或治疗与心肌细胞凋亡相关的疾病或病症。

7. 发明申请

US20140079280A1 AUTOMATIC DETECTION OF PERSISTENT CHANGES IN NATURALLY VARYING SCENES 有权
标题翻译：自动检测自然变化场景中的随机变化
公开(公告)号：US20140079280A1
公开(公告)日：2014-03-20
申请号：US13617965
申请日：2012-09-14
申请人： Robert R. Price , Juan Liu , Ajay Raghavan
发明人： Robert R. Price , Juan Liu , Ajay Raghavan
IPC分类号： G06K9/62
CPC分类号： G06K9/62 , G06K9/00771
摘要： A method for detecting a persistent change in a dynamically varying scene includes: obtaining a set of reference images of the scene; transforming the reference images into an abstract feature space; classifying pixels of the reference images in the abstract feature space; generating a stable reduced-reference image based on the classifications of corresponding pixels; obtaining a set of test images of the scene; transforming the test images into the abstract feature space; classifying pixels of the test images in the abstract feature space; generating a stable test image based on the classifications of corresponding pixels; and comparing the stable reduced-reference and test images to one another to detect a difference therein, the difference corresponding to a persistent change in the dynamically varying scene occurring between when the reference images and the test images were obtained.
摘要翻译：一种用于检测动态变化场景中的持续变化的方法包括：获得一组场景的参考图像; 将参考图像转换为抽象特征空间; 在抽象特征空间中分类参考图像的像素; 基于相应像素的分类生成稳定的缩小参考图像; 获取一组场景的测试图像; 将测试图像转换为抽象特征空间; 在抽象特征空间中分类测试图像的像素; 基于相应像素的分类生成稳定的测试图像; 并且将稳定的缩小参考和测试图像彼此进行比较以检测其中的差异，所述差异对应于在获得参考图像和测试图像之间发生的动态变化场景中的持续变化。

8. 发明授权

US08473785B2 Computationally efficient tiered inference for multiple fault diagnosis 有权
标题翻译：用于多故障诊断的计算有效的分层推理
公开(公告)号：US08473785B2
公开(公告)日：2013-06-25
申请号：US12610700
申请日：2009-11-02
申请人： Juan Liu , Johan de Kleer , Lukas D. Kuhn
发明人： Juan Liu , Johan de Kleer , Lukas D. Kuhn
IPC分类号： G06F11/00
CPC分类号： G05B19/0428 , G05B2219/24077 , G06N5/046
摘要： A computer based method and system for tiered inference multiple fault diagnosis is provided. The method includes using a computer processor to dissect a hypothesis space representing a production system having a plurality of production modules into tiers. Production modules in the current tier are partitioned into a group or a set of sub-groups. A fault diagnosis algorithm is applied to the group of each sub-group to identify an acceptable fault diagnosis. When no acceptable fault diagnosis is found, the process moves to the next tier to perform further investigations. The process continues to move to higher tiers until an acceptable fault diagnosis is obtained or the system instructs the process to end.
摘要翻译：提供了一种基于计算机的分层推理多故障诊断方法和系统。该方法包括使用计算机处理器来将表示具有多个生产模块的生产系统的假设空间解剖为层。当前层中的生产模块被分成一组或一组子组。将故障诊断算法应用于每个子组的组，以识别可接受的故障诊断。当没有发现可接受的故障诊断时，流程进入下一层进行进一步的调查。该过程继续移动到更高级别，直到获得可接受的故障诊断或系统指示过程结束。

9. 发明授权

US08390885B2 Methods and system for improved color characterization 有权
标题翻译：改进颜色表征的方法和系统
公开(公告)号：US08390885B2
公开(公告)日：2013-03-05
申请号：US12557994
申请日：2009-09-11
申请人： Juan Liu , Haitham Hindi , Lalit Keshav Mestha , Kenneth J. Mihalyov
发明人： Juan Liu , Haitham Hindi , Lalit Keshav Mestha , Kenneth J. Mihalyov
IPC分类号： H04N1/60
CPC分类号： H04N1/6033 , H04N1/40006
摘要： Methods and systems are presented for characterizing a printer, display or other color reproduction device in which parametric and nonparametric forward color transforms are generated to construct a forward color device transform to characterize the mapping of CMYK input data to La*b* data of the device, with the parametric transform adapted to compensate for drifting performance of the color reproduction device.
摘要翻译：呈现用于表征打印机，显示器或其他颜色再现设备的方法和系统，其中生成参数和非参数的前向颜色变换以构建前向颜色设备变换，以表征CMYK输入数据到设备的La * b *数据的映射，其中参数变换适于补偿色彩再现装置的漂移性能。

10. 发明授权

US08171105B2 Modification of information utility based upon context 有权
标题翻译：基于上下文修改信息效用
公开(公告)号：US08171105B2
公开(公告)日：2012-05-01
申请号：US11428430
申请日：2006-07-03
申请人： Juan Liu , Daniel H. Greene , Qingfeng Huang , James E. Reich , Marc E. Mosko
发明人： Juan Liu , Daniel H. Greene , Qingfeng Huang , James E. Reich , Marc E. Mosko
IPC分类号： G01C21/26 , H04B7/02
CPC分类号： H04L12/189 , H04L12/1854 , H04L12/1895 , H04L47/12 , H04L47/14 , H04L47/15 , H04W4/04 , H04W84/18
摘要： A method of disseminating information in system having data sources and data recipients includes receiving a generic utility function at a data source for information to be delivered to a data recipient based upon an application for which the information is to be used. Data related to an environment in which the information is to be propagated is used to modify the generic utility function.
摘要翻译：在具有数据源和数据收件人的系统中传播信息的方法包括：在数据源处接收用于基于要使用该信息的应用传送给数据接收者的信息的通用效用函数。与信息传播的环境相关的数据用于修改通用效用函数。

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