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1. 发明授权

US07771351B1 Method and apparatus for eddy current compensation in a radio frequency probe 有权
标题翻译：无线电频率探头中涡流补偿的方法和装置
公开(公告)号：US07771351B1
公开(公告)日：2010-08-10
申请号：US11441851
申请日：2006-05-26
申请人： James R. Talman , Aaron J. Fleischman , Brian L. Sauer , Shuvo Roy
发明人： James R. Talman , Aaron J. Fleischman , Brian L. Sauer , Shuvo Roy
IPC分类号： A61B5/07 , A61B5/00
CPC分类号： A61B5/0031 , A61B5/076 , A61B2562/028
摘要： Systems and methods are provided for determining a characteristic of an associated in vivo sensor within a living body. A transmit coil produces an excitation signal, having a first orientation, to excite the in vivo sensor to produce a response signal. A receive coil produces a current in response to the response signal. The receive coil is oriented to interact with signals having a second orientation that is substantially orthogonal to first orientation. The probe further comprises at least one eddy current compensation coil that produces a compensation field. A component of the compensation field along the second orientation has a magnitude at the receive coil substantially equal and opposite to a magnitude of a similarly oriented component of a magnetic field associated with eddy currents induced within the body.
摘要翻译：提供了用于确定活体内的相关体内传感器的特性的系统和方法。发射线圈产生具有第一取向的激励信号，以激发体内传感器以产生响应信号。接收线圈响应于响应信号产生电流。接收线圈定向成与具有基本上与第一取向正交的第二取向的信号相互作用。探头还包括产生补偿场的至少一个涡流补偿线圈。沿着第二取向的补偿场的分量在接收线圈处具有与在体内引起的涡流相关联的磁场的类似取向分量的幅度基本相等的量值。

2. 发明授权

US07491179B2 Apparatus and method for assessing loads on adjacent bones 失效
公开(公告)号：US07491179B2
公开(公告)日：2009-02-17
申请号：US11700219
申请日：2007-01-30
申请人： Shuvo Roy , Aaron J Fleischman , Edward C. Benzel , Lisa Ferrara
发明人： Shuvo Roy , Aaron J Fleischman , Edward C. Benzel , Lisa Ferrara
IPC分类号： A61B5/117 , A61B5/103
CPC分类号： A61F2/442 , A61B5/0031 , A61B5/036 , A61B5/4504 , A61B17/7044 , A61B2562/0247 , A61B2562/0261 , A61B2562/028 , A61F2/30744 , A61F2/446 , A61F2002/2835 , A61F2002/30563 , A61F2002/3067 , A61F2002/30772 , A61F2002/3085 , A61F2002/4666 , A61F2250/0002
摘要： An apparatus (10) that utilizes microelectromechanical systems (MEMS) technology to provide an in vivo assessment of loads on adjacent bones (24 and 26) comprises a body (34) for insertion between the adjacent bones. At least one sensor (42) is associated with the body (34). The sensor (42) generates an output signal in response to and indicative of a load being applied to the body (34) through the adjacent bones (24 and 26). A telemetric device (40) is operatively coupled with the sensor (42). The telemetric device (40) is operable to receive the output signal from the sensor (42) and to transmit an EMF signal dependent upon the output signal. According to various aspects of the invention, the sensor comprises a pressure sensor (42), a load cell (320), and/or at least one strain gauge (142).

3. 发明授权

US06790372B2 Microneedle array module and method of fabricating the same 失效
公开(公告)号：US06790372B2
公开(公告)日：2004-09-14
申请号：US10162848
申请日：2002-06-05
申请人： Shuvo Roy , Aaron J. Fleischman
发明人： Shuvo Roy , Aaron J. Fleischman
IPC分类号： B61C100
CPC分类号： B81C1/00111 , A61M37/0015 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , B81B2201/055
摘要： A microneedle array module is disclosed comprising a multiplicity of microneedles affixed to and protruding outwardly from a front surface of a substrate to form the array, each microneedle of the array having a hollow section which extends through its center to an opening in the tip thereof. A method of fabricating the microneedle array module is also disclosed comprising the steps of: providing etch resistant mask layers to one and another opposite surfaces of a substrate to predetermined thicknesses; patterning the etch resistant mask layer of the one surface for outer dimensions of the microneedles of the array; patterning the etch resistant mask layer of the other surface for inner dimensions of the microneedles of the array; etching unmasked portions of the substrate from one and the other surfaces to first and second predetermined depths, respectively; and removing the mask layers from the one and the other surfaces. One embodiment of the method includes the steps of: providing an etch resistant mask layer to the other surface of the substrate to a predetermined thickness; patterning the etch resistant mask layer of the other surface to define a reservoir region in the substrate; and etching away the unmasked reservoir region of the substrate to form a reservoir well in the other surface of the substrate. A layer of material may be provided to the other surface to enclose the reservoir well and a passageway is provided through the layer to the well region.

4. 发明授权

US07878208B2 Method and apparatus for determining a characteristic of an in vivo sensor 有权
标题翻译：用于确定体内传感器特征的方法和装置
公开(公告)号：US07878208B2
公开(公告)日：2011-02-01
申请号：US11441854
申请日：2006-05-26
申请人： James R. Talman , Shuvo Roy , Brian L. Sauer , Aaron J. Fleischman
发明人： James R. Talman , Shuvo Roy , Brian L. Sauer , Aaron J. Fleischman
IPC分类号： A61B19/00
CPC分类号： A61B5/0031 , A61B3/16 , A61B5/0215 , A61B5/026 , A61B5/03 , A61B5/031 , A61B5/036 , A61B5/076
摘要： Methods and systems are provided for determining a characteristic of an in vivo sensor. A transmit field, operative to induce a response signal in an associated in vivo sensor, is generated at a transmitting component having an associated orientation. The response signal is received at a receiving component, having an associated orientation. The coupling between the transmitting component and the receiving component is measured. The associated orientation of at least one of the transmitting component and the receiving component is rotated as to reduce the measured coupling.
摘要翻译：提供了用于确定体内传感器特征的方法和系统。在具有相关定向的发射部件处产生用于在相关的体内传感器中诱导响应信号的发射场。响应信号在接收组件处被接收，具有相关联的取向。测量发射部件和接收部件之间的耦合。旋转发射部件和接收部件中的至少一个的相关取向以减少测量的耦合。

5. 发明授权

US07284442B2 Method and apparatus for in vivo sensing 有权
标题翻译：用于体内检测的方法和装置
公开(公告)号：US07284442B2
公开(公告)日：2007-10-23
申请号：US11441855
申请日：2006-05-26
申请人： Aaron J. Fleischman , James R. Talman , Shuvo Roy
发明人： Aaron J. Fleischman , James R. Talman , Shuvo Roy
IPC分类号： A61B5/05
CPC分类号： A61B5/0031 , A61B5/02014 , A61B5/07 , A61B5/6821 , H04W84/18
摘要： Systems and methods for in vivo sensing are provided. An excitation signal is produced, having a first frequency component and a second frequency component. The first frequency component is swept through a plurality of excitation frequencies within a frequency range of interest. A response signal is received from an in vivo sensor. The response signal includes a mix component having a frequency equal to one of a sum of a first excitation frequency associated with the first frequency component and a second excitation frequency associated with the second frequency component and a difference between the first and second excitation frequencies. The mix component is evaluated to determine a resonant frequency of the in vivo sensor.
摘要翻译：提供了用于体内感测的系统和方法。产生具有第一频率分量和第二频率分量的激励信号。第一频率分量被扫描在感兴趣的频率范围内的多个激励频率。从体内传感器接收响应信号。响应信号包括频率等于与第一频率分量相关联的第一激励频率和与第二频率分量相关联的第二激励频率之和的频率和第一和第二激励频率之间的差的混合分量。评估混合组分以确定体内传感器的共振频率。

6. 发明授权

US07262068B2 Microneedle array module and method of fabricating the same 有权
标题翻译：微针阵列模块及其制造方法
公开(公告)号：US07262068B2
公开(公告)日：2007-08-28
申请号：US10885402
申请日：2004-07-06
申请人： Shuvo Roy , Aaron J. Fleischman
发明人： Shuvo Roy , Aaron J. Fleischman
IPC分类号： H01L21/00 , B61C1/00
CPC分类号： B81C1/00111 , A61M37/0015 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , B81B2201/055
摘要： A microneedle array module is disclosed comprising a multiplicity of microneedles affixed to and protruding outwardly from a front surface of a substrate to form the array, each microneedle of the array having a hollow section which extends through its center to an opening in the tip thereof. A method of fabricating the microneedle array module is also disclosed comprising the steps of: providing etch resistant mask layers to one and another opposite surfaces of a substrate to predetermined thicknesses; patterning the etch resistant mask layer of the one surface for outer dimensions of the microneedles of the array; patterning the etch resistant mask layer of the other surface for inner dimensions of the microneedles of the array; etching unmasked portions of the substrate from one and the other surfaces to first and second predetermined depths, respectively; and removing the mask layers from the one and the other surfaces. One embodiment of the method includes the steps of: providing an etch resistant mask layer to the other surface of the substrate to a predetermined thickness; patterning the etch resistant mask layer of the other surface to define a reservoir region in the substrate; and etching away the unmasked reservoir region of the substrate to form a reservoir well in the other surface of the substrate. A layer of material may be provided to the other surface to enclose the reservoir well and a passageway is provided through the layer to the well region.
摘要翻译：公开了一种微针阵列模块，其包括固定到衬底的前表面并从衬底的前表面向外突出的多个微针以形成阵列，阵列的每个微针具有中空部分，该中空部分通过其中心延伸到其尖端中的开口。还公开了一种制造微针阵列模块的方法，包括以下步骤：将衬底的一个和另一个相对表面的抗蚀刻掩模层提供到预定厚度; 图案化该阵列的微针的外部尺寸的一个表面的耐蚀刻掩模层; 为阵列的微针的内部尺寸构图另一表面的耐蚀刻掩模层; 将衬底的未掩模部分从一个和另一个表面蚀刻到第一和第二预定深度; 以及从一个和另一个表面去除掩模层。该方法的一个实施例包括以下步骤：向衬底的另一表面提供预定厚度的耐蚀刻掩模层; 图案化另一表面的耐蚀刻掩模层以限定衬底中的储存器区域; 并蚀刻掉衬底的未掩模的储存区域，以在衬底的另一表面中形成储存器孔。可以将一层材料提供到另一表面以封闭储存器井，并且通过该层将通道提供到井区。

7. 发明授权

US07182736B2 Apparatus and method for assessing loads on adjacent bones 有权
标题翻译：用于评估相邻骨骼上的载荷的装置和方法
公开(公告)号：US07182736B2
公开(公告)日：2007-02-27
申请号：US10769823
申请日：2004-02-02
申请人： Shuvo Roy , Aaron J. Fleischman , Edward C. Benzel , Lisa Ferrara
发明人： Shuvo Roy , Aaron J. Fleischman , Edward C. Benzel , Lisa Ferrara
IPC分类号： A61B5/117 , A61B5/103
CPC分类号： A61F2/442 , A61B5/0031 , A61B5/036 , A61B5/4504 , A61B17/7044 , A61B2562/0247 , A61B2562/0261 , A61B2562/028 , A61F2/30744 , A61F2/446 , A61F2002/2835 , A61F2002/30563 , A61F2002/3067 , A61F2002/30772 , A61F2002/3085 , A61F2002/4666 , A61F2250/0002
摘要： An apparatus (10) that utilizes microelectromechanical systems (MEMS) technology to provide an in vivo assessment of loads on adjacent bones (24 and 26) comprises a body (34) for insertion between the adjacent bones. At least one sensor (42) is associated with the body (34). The sensor (42) generates an output signal in response to and indicative of a load being applied to the body (34) through the adjacent bones (24 and 26). A telemetric device (40) is operatively coupled with the sensor (42). The telemetric device (40) is operable to receive the output signal from the sensor (42) and to transmit an EMF signal dependent upon the output signal. According to various aspects of the invention, the sensor comprises a pressure sensor (42), a load cell (320), and/or at least one strain gauge (142).
摘要翻译：使用微机电系统（MEMS）技术来提供对相邻骨骼（24和26）上的负载的体内评估的装置（10）包括用于在相邻骨头之间插入的主体（34）。至少一个传感器（42）与主体（34）相关联。传感器（42）响应于并且指示通过相邻骨骼（24和26）施加到身体（34）的负载而产生输出信号。遥测装置（40）可操作地与传感器（42）耦合。遥测装置（40）可操作以从传感器（42）接收输出信号，并根据输出信号发送EMF信号。根据本发明的各个方面，传感器包括压力传感器（42），称重传感器（320）和/或至少一个应变计（142）。

8. 发明授权

US07169106B2 Intraocular pressure measurement system including a sensor mounted in a contact lens 有权
标题翻译：眼内压测量系统，包括安装在隐形眼镜中的传感器
公开(公告)号：US07169106B2
公开(公告)日：2007-01-30
申请号：US10841996
申请日：2004-05-07
申请人： Aaron J. Fleischman , Shuvo Roy , Hilel Lewis
发明人： Aaron J. Fleischman , Shuvo Roy , Hilel Lewis
IPC分类号： A61B3/16 , A61B5/00
CPC分类号： A61B3/16 , A61B2562/028
摘要： An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.
摘要翻译：一种用于测量眼内压（IOP）的装置（180）包括隐形眼镜（40），所述隐形眼镜包括形成于眼睛（36）的表面部分（34）的外表面（42）和设置在所述触点镜片。传感器（10）包括用于与眼睛（36）的表面部分（34）接触的接触表面（14）。接触表面（14）包括外部非顺应性区域（16）和内部顺应性区域（18），该内部顺应性区域（18）被制造为当内部顺应性区域改变形状时阻抗变化的阻抗元件。传感器（10）还包括电耦合到柔性区域（18）的阻抗元件的导电材料（38）的区域，并且响应于外部信号来激励阻抗元件，使得可以确定IOP。

9. 发明授权

US06994672B2 Apparatus and method for measuring intraocular pressure 失效
标题翻译：用于测量眼内压的装置和方法
公开(公告)号：US06994672B2
公开(公告)日：2006-02-07
申请号：US10118440
申请日：2002-04-08
申请人： Aaron J. Fleischman , Shuvo Roy
发明人： Aaron J. Fleischman , Shuvo Roy
IPC分类号： A61B3/16
CPC分类号： A61B3/16 , A61B2562/0247
摘要： An apparatus (176) for measuring intraocular pressure (IOP) comprises an applanation tonometer (180) having a distal end that is movable toward the eye and a disposable module (188) positioned at the distal end. The module (188) includes a sensor carrier (192) and a sensor (10) connected to the sensor carrier. The sensor (10) comprises a contact surface (14) for making contact with a surface portion of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.
摘要翻译：用于测量眼内压（IOP）的装置（176）包括具有能够朝向眼睛移动的远端的压平眼压计（180）和位于远端的一次性模块（188）。模块（188）包括连接到传感器载体的传感器载体（192）和传感器（10）。传感器（10）包括用于与眼睛（36）的表面部分接触的接触表面（14）。接触表面（14）包括外部非顺应性区域（16）和内部顺应性区域（18），该内部顺应性区域（18）被制造为当内部顺应性区域改变形状时阻抗变化的阻抗元件。传感器（10）还包括电耦合到柔性区域（18）的阻抗元件的导电材料（38）的区域，并且响应于外部信号来激励阻抗元件，使得可以确定IOP。

10. 发明授权

US06749568B2 Intraocular pressure measurement system including a sensor mounted in a contact lens 有权
标题翻译：眼内压测量系统，包括安装在隐形眼镜中的传感器
公开(公告)号：US06749568B2
公开(公告)日：2004-06-15
申请号：US10128321
申请日：2002-04-22
申请人： Aaron J. Fleischman , Shuvo Roy , Hilel Lewis
发明人： Aaron J. Fleischman , Shuvo Roy , Hilel Lewis
IPC分类号： A61B316
CPC分类号： A61B3/16 , A61B2562/028
摘要： An apparatus for measuring intraocular pressure (IOP) comprises a contact lens including an inner surface contoured to a surface portion of an eye and a sensor disposed in the contact lens. The sensor comprises a contact surface for making contact with the surface portion of the eye. The contact surface includes an outer non-compliant region and an inner compliant region fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor further comprises a region of conductive material electrically coupled to the impedance element of the compliant region and responsive to an external signal for energizing the impedance element so that the IOP may be determined.
摘要翻译：用于测量眼内压（IOP）的装置包括隐形眼镜，其包括形成眼睛表面部分的内表面和设置在隐形眼镜中的传感器。传感器包括用于与眼睛的表面部分接触的接触表面。接触表面包括外部非顺应性区域和制造为阻抗元件的内部顺应性区域，其随着内部顺应性区域改变形状而阻抗变化。该传感器还包括导电材料的区域，该区域电耦合到柔性区域的阻抗元件，并且响应外部信号以激发阻抗元件，使得可以确定IOP。

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