专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100261176A1 Methods of Tissue-Based Diagnosis 有权
标题翻译：基于组织的诊断方法
公开(公告)号：US20100261176A1
公开(公告)日：2010-10-14
申请号：US12664994
申请日：2008-08-06
申请人： Samir M. Mitragotri , Sumit Paliwal , Makoto Ogura
发明人： Samir M. Mitragotri , Sumit Paliwal , Makoto Ogura
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53 , C12Q1/60 , C12Q1/04
CPC分类号： C12M45/02 , G01N1/286
摘要： The current invention provides methods, as well as compositions useful in such methods, involving application of energy to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). Determination of tissue composition can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications.
摘要翻译：本发明提供方法以及可用于这些方法的组合物，包括将能量施加到感兴趣的组织以产生包含组织成分的液化样品，以提供快速组织取样，以及定性和/或定量检测的分析物，其可以是组织成分的一部分（例如，几种类型的生物分子，药物和微生物）。组织成分的测定可用于各种应用，包括局部和全身疾病的诊断或预后，药物给药后评估治疗药物在不同组织中的生物利用度，药物滥用药物的法医检测，评估组织变化暴露于有害物质后的微环境，以及各种其他应用。

2. 发明授权

US09909098B2 Methods of tissue-based diagnosis 有权
公开(公告)号：US09909098B2
公开(公告)日：2018-03-06
申请号：US12664994
申请日：2008-08-06
申请人： Samir M. Mitragotri , Sumit Paliwal , Makoto Ogura
发明人： Samir M. Mitragotri , Sumit Paliwal , Makoto Ogura
IPC分类号： G01N1/00 , A61K9/10 , A61K49/00 , C12M1/33 , G01N1/28
CPC分类号： C12M45/02 , G01N1/286
摘要： The current invention provides methods, as well as compositions useful in such methods, involving application of energy to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). Determination of tissue composition can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications.

3. 发明申请

US20120128756A1 Skin Permeating And Cell Entering (SPACE) Peptides and Methods of Use Thereof 有权
标题翻译：皮肤渗透和细胞进入（SPACE）肽及其使用方法
公开(公告)号：US20120128756A1
公开(公告)日：2012-05-24
申请号：US13253796
申请日：2011-10-05
申请人： Tracy HSU , Samir M. Mitragotri
发明人： Tracy HSU , Samir M. Mitragotri
IPC分类号： A61K9/127 , C12Q1/02 , C07K7/06 , C07K7/64 , C07K14/00 , C07K7/08 , A61K39/395 , A61K38/08
CPC分类号： C12N15/1136 , A61K9/127 , A61K38/00 , A61K38/164 , A61K39/395 , A61K47/64 , A61K47/6929 , A61K49/0056 , C07K7/06 , C07K7/08 , C07K7/64 , C07K16/46 , C12N15/1137 , C12N2310/14 , C12N2310/3513 , C12N2320/32
摘要： The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells.
摘要翻译：本公开提供了肽和肽组合物，其有助于递送活性剂或活性剂载体，其中组合物能够穿透活细胞的角质层（SC）和/或细胞膜。

4. 发明授权

US08518871B2 Skin permeating and cell entering (SPACE) peptides and methods of use thereof 有权
标题翻译：皮肤渗透和细胞进入（SPACE）肽及其使用方法
公开(公告)号：US08518871B2
公开(公告)日：2013-08-27
申请号：US13253796
申请日：2011-10-05
申请人： Tracy Hsu , Samir M. Mitragotri
发明人： Tracy Hsu , Samir M. Mitragotri
IPC分类号： A61K38/00 , A61K38/12 , A61K38/16 , A61K38/10 , A61K38/08 , A61K38/04 , A61K39/00 , A61K9/127 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K1/00 , C07K14/00 , C12N5/00 , C12N5/02 , C12N15/00
CPC分类号： C12N15/1136 , A61K9/127 , A61K38/00 , A61K38/164 , A61K39/395 , A61K47/64 , A61K47/6929 , A61K49/0056 , C07K7/06 , C07K7/08 , C07K7/64 , C07K16/46 , C12N15/1137 , C12N2310/14 , C12N2310/3513 , C12N2320/32
摘要： The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells.
摘要翻译：本公开提供了肽和肽组合物，其有助于递送活性剂或活性剂载体，其中组合物能够穿透活细胞的角质层（SC）和/或细胞膜。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式