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1. 发明授权

US5855885A Isolation and production of catalytic antibodies using phage technology 失效
标题翻译：使用噬菌体技术分离和生产催化抗体
公开(公告)号：US5855885A
公开(公告)日：1999-01-05
申请号：US273146
申请日：1994-07-14
申请人： Rodger Smith , John McCafferty , David Chiswell , Michael J. Darsley , Kevin Fitzgerald , John H. Kenten , Mark T. Martin , Richard C. Titmas , Richard O. Williams
发明人： Rodger Smith , John McCafferty , David Chiswell , Michael J. Darsley , Kevin Fitzgerald , John H. Kenten , Mark T. Martin , Richard C. Titmas , Richard O. Williams
IPC分类号： C12N9/00 , A61K39/395 , A61K9/00 , A61K38/43
CPC分类号： C12N9/0002
摘要： Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation of catalytic antibodies. Also disclosed and claimed are the products themselves, the catalytic antibodies, made from the phage technology. In addition, catalytic antibodies produced from the phage technology and useful in prodrug activation are disclosed and claimed. And finally, the invention also understands the production of catalytic antibodies to phosphonates.
摘要翻译：公开并要求保护的是从噬菌体产生催化抗体，包括人类催化抗体的方法。该方法需要克隆，选择，筛选和分离催化抗体。还公开和要求的是产品本身，由噬菌体技术制成的催化抗体。此外，公开并要求保护从噬菌体技术产生并可用于前药活化的催化抗体。最后，本发明还了解了产生针对膦酸盐的催化抗体。

2. 发明授权

US09198983B2 Compositions and methods for inhibiting expression of Mylip/Idol gene 有权
标题翻译：抑制Mylip / Idol基因表达的组合物和方法
公开(公告)号：US09198983B2
公开(公告)日：2015-12-01
申请号：US13575040
申请日：2011-01-25
申请人： Brian Bettencourt , Kevin Fitzgerald , Muthiah Manoharan
发明人： Brian Bettencourt , Kevin Fitzgerald , Muthiah Manoharan
IPC分类号： C12N15/11 , A61K48/00 , C12N15/113
CPC分类号： C12N15/1137 , A61K48/005 , C12N15/113 , C12N2310/14 , C12N2310/351
摘要： The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the Mylip/Idol gene, and methods of using such dsRNA compositions to inhibit expression of Mylip/Idol.
摘要翻译：本发明涉及靶向Mylip / Idol基因的双链核糖核酸（dsRNA）组合物，以及使用这种dsRNA组合物抑制Mylip /偶像表达的方法。

3. 发明授权

US09187746B2 Dual targeting siRNA agents 有权
标题翻译：双重靶向siRNA试剂
公开(公告)号：US09187746B2
公开(公告)日：2015-11-17
申请号：US13497226
申请日：2010-09-22
申请人： Kevin Fitzgerald , Maria Frank-Kamenetsky , Klaus Charisse
发明人： Kevin Fitzgerald , Maria Frank-Kamenetsky , Klaus Charisse
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , A61K31/713 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/713 , C07H21/02 , C12N15/1137 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/3519 , C12Y304/21061
摘要： The invention relates to dual targeting siRNA agents targeting a PCSK9 gene and a second gene, and methods of using dual targeting siRNA agents to inhibit expression of PCSK.9 and to treat PCSK.9 related disorders, e.g., hyperlipidemia.
摘要翻译：本发明涉及靶向PCSK9基因和第二基因的双重靶向siRNA试剂，以及使用双重靶向siRNA试剂抑制PCSK.9表达并治疗PCSK.9相关病症例如高脂血症的方法。

4. 发明授权

US08765932B2 Compositions and methods for inhibiting expression of XBP-1 gene 有权
标题翻译：用于抑制XBP-1基因表达的组合物和方法
公开(公告)号：US08765932B2
公开(公告)日：2014-07-01
申请号：US13619728
申请日：2012-09-14
申请人： Kevin Fitzgerald , Gregory Hinkle
发明人： Kevin Fitzgerald , Gregory Hinkle
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting X-Box Protein 1 (XBP-1), and methods of using the dsRNA to inhibit expression of XBP-1.
摘要翻译：本发明涉及靶向X-Box蛋白1（XBP-1）的双链核糖核酸（dsRNA）以及使用dsRNA抑制XBP-1表达的方法。

5. 发明授权

US08557744B2 Membrane-translocating peptides 有权
标题翻译：膜易位肽
公开(公告)号：US08557744B2
公开(公告)日：2013-10-15
申请号：US11996496
申请日：2006-07-24
申请人： David Coomber , Kevin Fitzgerald , Duncan McGregor , Chris Ullman , Tomas Leanderson
发明人： David Coomber , Kevin Fitzgerald , Duncan McGregor , Chris Ullman , Tomas Leanderson
IPC分类号： C40B30/04 , C12Q1/70
CPC分类号： C12N15/1075
摘要： A method is selects membrane-translocating peptides (MTPs) from a peptide display library that are capable of crossing or penetrating a lipid membrane. A plurality of nucleic acid constructs that encode displayed peptides are expressed, resulting in the formation of a plurality of nucleic acid-peptide complexes, each complex comprising at least one displayed peptide associated with the corresponding nucleic acid construct encoding the displayed peptide; the complexes are exposed to a population of membrane-encapsulated compartments, allowing a translocating reaction to occur; complexes that remain unassociated with the membrane are removed; optionally complexes that are associated with the membrane are removed; and internalized nucleic acid-peptide complexes are recovered. The membrane-encapsulated compartments may be artificial vesicles such as liposomes, or populations of one or more cell types.
摘要翻译：一种方法是从能够穿透或穿透脂质膜的肽展示文库中选择膜 - 位移肽（MTP）。表达编码显示的肽的多个核酸构建体，导致形成多个核酸 - 肽复合物，每个复合物包含与编码所显示肽的相应核酸构建体相关联的至少一个显示的肽; 复合物暴露于膜包封的隔室群，允许发生易位反应; 与膜保持不相关的复合物被去除; 去除与膜相关的任选复合物; 并回收内化的核酸 - 肽复合物。膜包封的隔室可以是人造囊泡，例如脂质体或一种或多种细胞类型的群体。

6. 发明申请

US20110230546A1 dsRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTION 审中-公开
标题翻译： dsRNA组合物和治疗HPV感染的方法
公开(公告)号：US20110230546A1
公开(公告)日：2011-09-22
申请号：US13116947
申请日：2011-05-26
申请人： John Benson , Birgit Bramlage , Kevin Fitzgerald , Pamela Tan , Hans-Peter Vornlocher
发明人： John Benson , Birgit Bramlage , Kevin Fitzgerald , Pamela Tan , Hans-Peter Vornlocher
IPC分类号： A61K31/713 , C07H21/02 , C12N5/02 , C12N5/10 , C12N15/63 , A61P31/20
CPC分类号： C12N15/1137 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2320/31 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
摘要翻译：本发明涉及用于治疗人乳头瘤病毒（HPV）感染的双链核糖核酸（dsRNA）。 dsRNA包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸，并且与选自HPV E1，HPV E6中的HPV靶基因的至少一部分基本互补和人类E6AP基因。本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由HPV感染引起的疾病和使用该药物组合物表达E6AP基因的方法; 以及抑制细胞中HPV靶基因表达的方法。

7. 发明申请

US20110015252A1 LIPID FORMULATED DSRNA TARGETING THE PCSK9 GENE 有权
标题翻译：脂质制备的DSRNA靶向PCSK9基因
公开(公告)号：US20110015252A1
公开(公告)日：2011-01-20
申请号：US12816207
申请日：2010-06-15
申请人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
发明人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
IPC分类号： A61K31/713 , A61P9/10
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
摘要： This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
摘要翻译：本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。

8. 发明申请

US20100222417A1 Compostions and methods for enhancing oligonucleotide delivery across and into epithelial tissues 审中-公开
标题翻译：用于增强穿过和进入上皮组织的寡核苷酸递送的组合物和方法
公开(公告)号：US20100222417A1
公开(公告)日：2010-09-02
申请号：US12591629
申请日：2009-11-25
申请人： Tracy Zimmermann , Kevin Fitzgerald , Muthiah Manoharan
发明人： Tracy Zimmermann , Kevin Fitzgerald , Muthiah Manoharan
IPC分类号： A61K31/7088 , A61K31/56
CPC分类号： A61K31/56 , A61K31/7088
摘要： The present invention relates to the delivery of oligonucleotide across and into epithelial tissues by conjugating the oligonucleotide with a lipophile and/or coadministering with a penetration enhancer. In particular, the present invention provides a composition comprising a conjugated siRNA, which are advantageous for the in vivo delivery of nucleic acids across and into epithelial tissue. Additionally, the present invention provides methods of improving delivery of oligonucleotides across the epithelial tissues with the aid of a mechanical enhancer.
摘要翻译：本发明涉及通过将寡核苷酸与亲脂体共轭和/或与渗透增强剂共同引发而将寡核苷酸递送到上皮组织中并进入上皮组织。特别地，本发明提供了包含缀合siRNA的组合物，其有利于体内递送穿过和进入上皮组织的核酸。另外，本发明提供了借助于机械增强剂来改善跨越上皮组织的寡核苷酸递送的方法。

9. 外观设计

USD571689S1 Golf car 有权
标题翻译：高尔夫球车
公开(公告)号：USD571689S1
公开(公告)日：2008-06-24
申请号：US29279993
申请日：2007-05-14
申请人： Keith R. Andrews , Kevin Fitzgerald , Larry P. Johnson , Jim Wilson , Jun Imai
设计人： Keith R. Andrews , Kevin Fitzgerald , Larry P. Johnson , Jim Wilson , Jun Imai

10. 发明申请

US20080113930A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE 有权
标题翻译：抑制PCSK9基因表达的组合物和方法
公开(公告)号：US20080113930A1
公开(公告)日：2008-05-15
申请号：US11746864
申请日：2007-05-10
申请人： Pamela Tan , Birgit Bramlage , Maria Frank-Kamenetsky , Kevin Fitzgerald , Akin Akinc , Victor Kotelianski
发明人： Pamela Tan , Birgit Bramlage , Maria Frank-Kamenetsky , Kevin Fitzgerald , Akin Akinc , Victor Kotelianski
IPC分类号： C07H21/02 , A61K31/7115 , C12N15/00 , C12N5/10
CPC分类号： C12N15/1137 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition; and
摘要翻译：本发明涉及用于抑制PCSK9基因（PCSK9基因）表达的双链核糖核酸（dsRNA），其包含具有长度小于30个核苷酸的核苷酸序列的反义链，通常为19-25个核苷酸并且其与PCSK 9基因的至少一部分基本上互补。本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 使用该药物组合物治疗由PCSK9基因表达引起的疾病和PCSK 9基因的表达的方法; 和

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