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1. 发明授权

US09804088B2 Spatial frequency spectrometer for and method of detection of spatial structures in materials 有权
公开(公告)号：US09804088B2
公开(公告)日：2017-10-31
申请号：US14580892
申请日：2014-12-23
申请人： Robert R. Alfano , Yang Pu
发明人： Robert R. Alfano , Yang Pu
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01N21/4788
摘要： Spatial frequency spectra from periodic, aperiodic and quasi-random structures in materials are shown and used to detect differences among objects via internal coding from the spatial frequencies. The method is applied to different grades of human tissues for a new form of histology and pathology, and to detect art forgeries and coding boxes, money and papers and gems. The randomness of material structures on surface and at depths near surface can be detected from the spatial spectrum. In tissue spectral features from normal to different stages of cancer in tissue for ex vivo and in vivo applications can be recognized by different spectral fingerprints content of the spatial frequency. Similarly, the painting for the strokes of artist is different. A new type of instrument is described to analyze materials as a Spatial Frequency Spectrometer.

2. 发明授权

US10362983B2 Near infrared photonic prostatoscopy analyzer 有权
公开(公告)号：US10362983B2
公开(公告)日：2019-07-30
申请号：US14710222
申请日：2015-05-12
申请人： Robert R. Alfano , Wubao Wang , Yang Pu , Yury Budansky , Laura Sordillo , Guichen Tang , James Eastham
发明人： Robert R. Alfano , Wubao Wang , Yang Pu , Yury Budansky , Laura Sordillo , Guichen Tang , James Eastham
IPC分类号： A61B1/00 , A61B1/31 , A61B5/00
摘要： A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers/light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.

3. 发明授权

US09322769B2 Method and apparatus for detecting degree of spoilage of food 有权
标题翻译：检测食品腐败程度的方法和装置
公开(公告)号：US09322769B2
公开(公告)日：2016-04-26
申请号：US14309598
申请日：2014-06-19
申请人： Robert R. Alfano , Yang Pu , Wubao Wang
发明人： Robert R. Alfano , Yang Pu , Wubao Wang
IPC分类号： G01J3/00 , G01N21/27 , G01N33/12 , G01N21/64
CPC分类号： G01N21/27 , G01N21/6486 , G01N33/12
摘要： A method detects the degree of spoilage of food by exposing a food sample to an excitation wave having a first wavelength of about 340 nm or about 380 nm, wherein the excitation wave has a bandwidth of 40 nm or less. The excitation wave is permitted to interact with the food sample and return emission spectra. A detector detects the emission spectra. A predetermined threshold value is established which defines when a food sample is or is not spoiled. The emission spectra is analyzed at a second wavelength of about 400 nm, about 450 nm or about 530 nm to provide a test or measured value of the emission spectra indicative of the degree of spoilage of the food sample. Whether or not a food sample is spoiled beyond the predetermined threshold is determined by comparing the measured value to the predetermined threshold value.
摘要翻译：一种方法通过将食物样品暴露于第一波长为约340nm或约380nm的激发波来检测食物的变质程度，其中激发波具有40nm或更小的带宽。激发波被允许与食物样品相互作用并返回发射光谱。检测器检测发射光谱。建立了一个预定的阈值，其定义何时食物样本是否被损坏。在约400nm，约450nm或约530nm的第二波长处分析发射光谱，以提供指示食物样品的变质程度的发射光谱的测试值或测量值。通过将测量值与预定阈值进行比较来确定食物样品是否损坏超过预定阈值。

4. 发明授权

US10433731B2 Continuous diode laser stimulated Raman gain/loss vibrational microscope 有权
公开(公告)号：US10433731B2
公开(公告)日：2019-10-08
申请号：US15243207
申请日：2016-08-22
申请人： Robert R. Alfano
发明人： Robert R. Alfano , Lingyan Shi , Yury Budansky
IPC分类号： A61B5/00 , G01N21/65
摘要： There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.

5. 发明授权

US09620858B2 Compact electromagnetic-radiation antenna 有权
公开(公告)号：US09620858B2
公开(公告)日：2017-04-11
申请号：US14218864
申请日：2014-03-18
申请人： Robert R. Alfano
发明人： Robert R. Alfano , M. Yu Sharonov
IPC分类号： H01Q7/06 , H01Q7/08 , H01Q1/36
CPC分类号： H01Q7/08 , H01Q1/36 , H01Q7/06 , Y10T29/49016
摘要： A compact random media size antenna employing random magnetic and dielectrics nm to mm range size particles in polymer hosts is used to transfer E & M oscillations in 1 kHz to 900 Mhz range using a 1 cm to 1 meter length antenna. This is achieved by using small size particles and a random mean path length of E & M wavefront travel in and about a core tube of effective length matching Leff=L2/2ltr, equivalent to λ/2 for transmitting and receiving E & M radiation, where L is the physical size of the antenna, ltris the transport scattering random walk length between particles and λ is the frequency wavelength.

6. 发明申请

US20160128775A1 METHOD OF USING SUPERCONTINUUM LIGHT FOR MEDICAL AND BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：超光连接用于医疗和生物应用的方法
公开(公告)号：US20160128775A1
公开(公告)日：2016-05-12
申请号：US14996449
申请日：2016-01-15
申请人： Robert R. Alfano
发明人： Robert R. Alfano
IPC分类号： A61B18/20
CPC分类号： G02B21/0064 , A61B5/0066 , A61B18/20 , A61B2017/00508 , A61B2018/1807 , A61B2018/2065 , A61N5/0622 , A61N2005/0659 , A61N2005/067 , G01N33/4833 , G02B21/0032 , G02B21/0084 , G02F1/3515 , G02F1/3536 , G02F1/355 , G02F1/3551 , G02F1/365 , G02F2001/3528 , G06N99/002
摘要： A method and an apparatus are provided for producing SuperContinuum (SC) light for medical and biological applications is provided. Pulses are focused from a laser system into at least one of a pressurized cell and one or more fibers. A pump pulse is converted into the SC light at a specified rate of repetition. The SC light is applied at the specified rate of repetition to tissue for medical and biological applications.
摘要翻译：提供了用于生产用于医疗和生物应用的超级连续（SC）光的方法和装置。脉冲从激光系统聚焦成加压电池和一个或多个光纤中的至少一个。泵浦脉冲以指定的重复速率转换成SC光。以指定的重复速率将SC光施加到用于医疗和生物应用的组织。

7. 发明授权

US08974444B2 Method for picosecond and femtosecond laser tissue welding 有权
标题翻译：皮秒和飞秒激光组织焊接方法
公开(公告)号：US08974444B2
公开(公告)日：2015-03-10
申请号：US13642746
申请日：2011-04-20
申请人： Robert R. Alfano , Vidyasagar Sriramoju
发明人： Robert R. Alfano , Vidyasagar Sriramoju
IPC分类号： A61B18/20 , A61B17/00 , A61B18/00
CPC分类号： A61B18/20 , A61B18/203 , A61B2017/00508 , A61B2018/00452
摘要： A method for welding tissue wounds in an animal. The method comprises joining edges of a tissue wound and irradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser. The pulsed laser has a laser wavelength in a range of an absorption band of water, elastin and/or collagen in the tissue wound and tissue surrounding the tissue wound. The pulsed laser has a pulse width of not more than picoseconds in order of magnitude to heat tissue surrounding the tissue wound and facilitate bonding of native tissue protein present in the tissue surrounding the tissue wound to achieve tissue repair. The laser wavelength is in a range of between about 800 nm to about 2,700 nm.
摘要翻译：一种用于焊接动物组织伤口的方法。该方法包括接合伤口组织的边缘并用脉冲激光照射卷绕的组织周围的组织。脉冲激光在组织伤口和围绕组织伤口的组织的水吸收带，弹性蛋白和/或胶原的范围内具有激光波长。脉冲激光器具有不超过皮秒的脉冲宽度，以加热组织周围的组织，并促进存在于围绕组织伤口的组织中的天然组织蛋白质的结合以实现组织修复。激光波长在约800nm至约2,700nm之间的范围内。

8. 发明授权

US07706862B2 Detecting human cancer through spectral optical imaging using key water absorption wavelengths 失效
标题翻译：通过使用关键吸水波长的光谱成像检测人类癌症
公开(公告)号：US07706862B2
公开(公告)日：2010-04-27
申请号：US10926556
申请日：2004-08-26
申请人： Robert R. Alfano , Jamal H. Ali , Wubao Wang , Manuel Zevallos
发明人： Robert R. Alfano , Jamal H. Ali , Wubao Wang , Manuel Zevallos
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/4381 , A61B5/7264
摘要： Spectral optical imaging at one or more key water absorption fingerprint wavelengths measures the difference in water content between a region of cancerous or precancerous tissue and a region of normal tissue. Water content is an important diagnostic parameter because cancerous and precancerous tissues have different water content than normal tissues. Key water absorption wavelengths include at least one of 980 nanometers (nm), 1195 nm, 1456 nm, 1944 nm, 2880 nm to 3360 nm, and 4720 nm. In the range of 400 nm to 6000 nm, one or more points of negligible water absorption are used as reference points for a comparison with one or more key neighboring water absorption wavelengths. Different images are generated using at least two wavelengths, including a water absorption wavelength and a negligible water absorption wavelength, to yield diagnostic information relevant for classifying a tissue region as cancerous, precancerous, or normal. The results of this comparison can be used to identify regions of cancerous tissue in organs such as the breast, cervix and prostate.
摘要翻译：一个或多个关键的吸水指纹波长的光谱成像测量癌变或癌前组织区域与正常组织区域之间的含水量差异。水含量是重要的诊断参数，因为癌和癌前组织的含水量比正常组织水分含量高。关键的吸水波长包括980纳米（nm），1195nm，1456nm，1944nm，2880nm至3360nm和4720nm中的至少一个。在400nm至6000nm的范围内，使用可忽略的吸水点的一个或多个点作为与一个或多个关键相邻吸水波长的比较的参考点。使用包括吸水波长和可忽略的吸水波长的至少两个波长产生不同的图像，以产生与将癌组织区域分类为癌，癌前或正常相关的诊断信息。该比较的结果可以用于识别器官如乳腺，子宫颈和前列腺中癌组织的区域。

9. 发明授权

US07145148B2 Systems and methods for non-destructively detecting material abnormalities beneath a coated surface 有权
标题翻译：用于非破坏性地检测涂层表面下的材料异常的系统和方法
公开(公告)号：US07145148B2
公开(公告)日：2006-12-05
申请号：US10949571
申请日：2004-09-24
申请人： Robert R. Alfano , Baolong Yu
发明人： Robert R. Alfano , Baolong Yu
IPC分类号： G01J5/02 , G01N21/88 , G01N21/47
CPC分类号： G01N21/3581 , G01N21/3563 , G01N21/8422
摘要： The present invention provides systems and methods for non-destructively detecting material abnormalities beneath a coated surface. A terahertz (THz) illumination unit illuminates an area of the coated surface. A detection unit detects light reflected from the illuminated area of the coated surface, and a processing unit images the illuminated area of the coated surface from optical characteristics received from the detection unit.
摘要翻译：本发明提供用于非破坏性地检测涂覆表面下方的材料异常的系统和方法。太赫兹（THz）照明单元照亮涂层表面的一个区域。检测单元检测从涂覆表面的照射区域反射的光，并且处理单元从从检测单元接收的光学特性对涂覆表面的照射区域进行成像。

10. 发明授权

US07106972B2 Methods of improving line of sight wireless optical communication through adverse environmental conditions 有权
公开(公告)号：US07106972B2
公开(公告)日：2006-09-12
申请号：US10116194
申请日：2002-04-04
申请人： Robert R. Alfano , Jin Pin Ying , Swapan K. Gayen , Wei Cai
发明人： Robert R. Alfano , Jin Pin Ying , Swapan K. Gayen , Wei Cai
IPC分类号： H04B10/00
CPC分类号： H04B10/1121
摘要： A method of improving a signal-to-noise (S/N) ratio for a light signal transmitted by wireless optical communication through adverse environmental conditions, the light signal including a snake component and a ballistic component for carrying coded information, and a diffusive component that adds to background noise, the method comprising the steps of: encoding information to be transmitted by the light signal, wherein the light signal is one of a serial train of code pulses or a modulated light beam; selecting an appropriate wavelength for the encoded light signal; transmitting the encoded light signal though the adverse environmental conditions; receiving the encoded light signal; sorting the received encoded light signal to preferentially select the information carrying components and reduce the diffusive component; and detecting the sorted encoded light signal with a photo-detector.

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