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1. 发明申请

US20130276156A1 Multiple Inducible Gene Regulation System 审中-公开
公开(公告)号：US20130276156A1
公开(公告)日：2013-10-17
申请号：US13613597
申请日：2012-09-13
申请人： Tarlochan Singh DHADIALLA , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, JR. , Mohan Philip
发明人： Tarlochan Singh DHADIALLA , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, JR. , Mohan Philip
IPC分类号： C12N15/85
CPC分类号： C12N15/635 , A01K2217/05 , A61K48/00 , C07K14/721 , C07K2319/00 , C12N15/70 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/8217 , C12N15/8238 , C12N15/8241 , C12N15/85 , C12N15/861 , G01N33/6845
摘要： The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.

2. 发明授权

US07304162B2 Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex 有权
标题翻译：用于通过蜕皮激素受体复合物调节外源基因表达的恶二唑啉配体
公开(公告)号：US07304162B2
公开(公告)日：2007-12-04
申请号：US10783810
申请日：2004-02-19
申请人： Robert Eugene Hormann , Orestes Chortyk , Dat Phat Le
发明人： Robert Eugene Hormann , Orestes Chortyk , Dat Phat Le
IPC分类号： A61K31/4245 , C07D271/07 , A61K31/433 , C07D285/08
CPC分类号： C07D271/06 , C07D413/12
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

3. 发明授权

US5698716A Process for chroman carboxylates 失效
标题翻译：苯并二氢吡喃羧酸盐的工艺
公开(公告)号：US5698716A
公开(公告)日：1997-12-16
申请号：US744198
申请日：1996-11-05
申请人： Robert Eugene Hormann
发明人： Robert Eugene Hormann
IPC分类号： C07C69/757 , C07D311/58
CPC分类号： C07D311/58 , C07C69/757
摘要： This invention relates to an improved process for the preparation of 5-methylchroman-6-carboxylic acid, a useful intermediate in the preparation of chroman-containing diacylhydrazines which are useful as insecticides, by reacting a Hagemann's ester with a propargyl derivative in the presence of a base and a solvent to produce a propargyl ether, rearranging the propargyl ether by application of heat with a suitable catalyst being present, with or without a solvent, to produce a cyclic ether type compound and isomerizing the cyclic ether type compound with a catalyst in a suitable solvent to produce a chroman ester. The propargyl ethers and the cyclic ether type compounds produced by the process of the present invention are new.
摘要翻译：本发明涉及一种制备5-甲基苯并二氢吡喃-6-羧酸的改进方法，该5-甲基苯并二氢吡喃-6-羧酸是制备可用作杀虫剂的含色马酰二酰肼的有用中间体，可通过使Hagemann酯与炔丙基衍生物在碱和溶剂以产生炔丙基醚，通过在存在或不含有溶剂的情况下用合适的催化剂进行加热来重排丙炔醚，以产生环醚型化合物并用催化剂异构化环醚型化合物合适的溶剂以产生苯并二氢吡喃酯。通过本发明方法制备的炔丙醚和环醚型化合物是新的。

4. 发明授权

US08669072B2 Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex 有权
标题翻译：用于通过蜕皮激素受体复合物调节外源基因表达的恶二唑啉配体
公开(公告)号：US08669072B2
公开(公告)日：2014-03-11
申请号：US11838090
申请日：2007-08-13
申请人： Robert Eugene Hormann , Orestes Chortyk , Dat Phat Le
发明人： Robert Eugene Hormann , Orestes Chortyk , Dat Phat Le
IPC分类号： C12P21/02
CPC分类号： C07D271/06 , C07D413/12
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

5. 发明授权

US08105825B2 Multiple inducible gene regulation system 有权
公开(公告)号：US08105825B2
公开(公告)日：2012-01-31
申请号：US09965697
申请日：2001-09-27
申请人： Tarlochan Singh Dhadialla , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, Jr. , Mohan Philip
发明人： Tarlochan Singh Dhadialla , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, Jr. , Mohan Philip
IPC分类号： C12N5/00 , C12N15/00 , C12N5/07 , C12N5/10 , C12N5/071 , C12N5/02 , C12N1/00 , C12P21/06 , C07H21/04 , C07K1/00
CPC分类号： C12N15/635 , A01K2217/05 , A61K48/00 , C07K14/721 , C07K2319/00 , C12N15/70 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/8217 , C12N15/8238 , C12N15/8241 , C12N15/85 , C12N15/861 , G01N33/6845
摘要： The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.

6. 发明授权

US07563928B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex 有权
标题翻译：生物可利用的二酰肼配体，用于通过蜕皮激素受体复合物调节外源基因的表达
公开(公告)号：US07563928B2
公开(公告)日：2009-07-21
申请号：US11841568
申请日：2007-08-20
申请人： Robert Eugene Hormann , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
发明人： Robert Eugene Hormann , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
IPC分类号： C01C243/32 , A61K31/16
CPC分类号： C07C241/04 , A61K31/166 , A61K31/222 , A61K31/357 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/455 , A61K31/4965 , C07C243/18 , C07C243/24 , C07C243/38 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C315/02 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D213/86 , C07D213/87 , C07D231/14 , C07D231/56 , C07D235/06 , C07D235/24 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/08 , C07D319/18 , C07D319/20 , C07D405/12 , C12N9/0069 , C12N15/635 , C12P21/00 , Y02A50/471
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

7. 发明授权

US06258323B1 Apparatus and method used in multiple, simultaneous synthesis of general compounds 失效
标题翻译：用于多次同时合成一般化合物的装置和方法
公开(公告)号：US06258323B1
公开(公告)日：2001-07-10
申请号：US09193020
申请日：1998-11-16
申请人： Robert Eugene Hormann , Daryl Eugene Gilbert , Edward Michael Sioma
发明人： Robert Eugene Hormann , Daryl Eugene Gilbert , Edward Michael Sioma
IPC分类号： B01L300
CPC分类号： B01L3/50825 , B01F13/0818 , B01F15/00123 , B01F2013/1091 , B01F2215/0037 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00344 , B01J2219/00481 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring heating, cooling, agitation, reagent/solvent additions to the reactor contents at each reaction vessel location, supply and maintenance of inert atmosphere and means to facilitate the reflux of the reactor contents. Thus, it becomes necessary to monitor and control the reaction conditions during the simultaneous multiple synthesis of general compounds. The apparatus allows the user to connect various independently controlling and conveying means to each reaction vessel through multiple ports provided on a stopper mounted on each reaction vessel. The apparatus of the present invention permits user to readily access the reaction vessels without interrupting the reactions occurring in the adjacent reaction vessels. The unique geometry and shape of the stopper allows positioning of multiple ports, while still providing the stopper with a compact size. As a result, a large array of reaction vessels can be accommodated in the device of the present invention without significantly increasing the overall size of the apparatus. Some of the general compounds that can be readily synthesized by the apparatus and the method of the present invention include inorganic compounds as well as organic compounds, such as oligomers, polymers, agricultural chemicals, drugs, peptides and oligonucleotides.
摘要翻译：本发明的装置和方法提供了一般化合物的同时多重合成，这些化合物通常发生在需要加热，冷却，搅拌，每个反应容器位置的反应器内容物的试剂/溶剂添加的不同不均匀条件下，供应和维护的惰性气氛和促进反应器内容物回流的手段。因此，需要在通用化合物的同时多重合成中监测和控制反应条件。该装置允许用户通过设置在安装在每个反应容器上的止动件上的多个端口将各种独立控制和输送装置连接到每个反应容器。本发明的装置允许用户容易地进入反应容器而不中断相邻反应容器中发生的反应。止动器的独特几何形状和形状允许定位多个端口，同时仍然为塞子提供紧凑的尺寸。结果，可以在本发明的装置中容纳大量反应容器，而不会显着增加装置的总体尺寸。可以通过本发明的装置和方法容易地合成的一些一般化合物包括无机化合物以及有机化合物，例如低聚物，聚合物，农药，药物，肽和寡核苷酸。

8. 发明授权

US09169210B2 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex 有权
公开(公告)号：US09169210B2
公开(公告)日：2015-10-27
申请号：US13603965
申请日：2012-09-05
申请人： Robert Eugene Hormann , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
发明人： Robert Eugene Hormann , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
IPC分类号： C07C243/38 , C07D213/63 , C07D213/87 , C07C243/24 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D231/14 , C07D231/56 , C07D235/06 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/18 , C07D405/12 , C07C243/18
CPC分类号： C07C241/04 , A61K31/166 , A61K31/222 , A61K31/357 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/455 , A61K31/4965 , C07C243/18 , C07C243/24 , C07C243/38 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C315/02 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D213/86 , C07D213/87 , C07D231/14 , C07D231/56 , C07D235/06 , C07D235/24 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/08 , C07D319/18 , C07D319/20 , C07D405/12 , C12N9/0069 , C12N15/635 , C12P21/00 , Y02A50/471
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

9. 发明授权

US08748125B2 Diacylhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex 有权
标题翻译：二酰基肼配体，用于通过蜕皮激素受体复合物调节哺乳动物系统中外源基因的表达
公开(公告)号：US08748125B2
公开(公告)日：2014-06-10
申请号：US11838044
申请日：2007-08-13
申请人： Robert Eugene Hormann , Colin M. Tice , Orestes Chortyk , Howard Smith , Thomas Meteyer
发明人： Robert Eugene Hormann , Colin M. Tice , Orestes Chortyk , Howard Smith , Thomas Meteyer
IPC分类号： C12P21/06 , C12P21/04 , C12N5/07 , C12N5/071 , C12N5/00 , C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C07C243/38 , C07D213/87 , C07D311/58 , C07D311/66 , C07D319/20 , C07F7/1896 , C12N9/0069 , C12N15/85 , C12N2830/002
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体，以及调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合结构域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

10. 发明授权

US08168426B2 Multiple inducible gene regulation system 有权
标题翻译：多重诱导型基因调控系统
公开(公告)号：US08168426B2
公开(公告)日：2012-05-01
申请号：US12707599
申请日：2010-02-17
申请人： Tarlochan Singh Dhadialla , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, Jr. , Mohan Philip
发明人： Tarlochan Singh Dhadialla , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, Jr. , Mohan Philip
IPC分类号： C12N5/00 , C12N15/00 , C12N5/07 , C12N5/10 , C12N5/071 , C12N5/02 , C12N1/00 , C12P21/06 , C07H21/04
CPC分类号： C12N15/635 , A01K2217/05 , A61K48/00 , C07K14/721 , C07K2319/00 , C12N15/70 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/8217 , C12N15/8238 , C12N15/8241 , C12N15/85 , C12N15/861 , G01N33/6845
摘要： The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.
摘要翻译：本发明涉及生物技术或遗传工程领域。更具体地，本发明涉及在细胞内起作用以同时控制多个基因的定量表达的多重诱导型基因调控系统。

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