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1. 发明申请

US20180000559A1 SYSTEM AND METHOD FOR INTRODUCING PHOTOSENSITIVE DYES VIA AN INSERT INTO A ROOT CANAL IN A TOOTH, METHOD FOR PRODUCING SAID DYE IMPREGNATED INSERT AND METHOD OF USING SAID DYE-IMPREGNATED INSERT 审中-公开
公开(公告)号：US20180000559A1
公开(公告)日：2018-01-04
申请号：US15538227
申请日：2015-12-21
申请人： Richard Titlebaum , Som Tyagi
发明人： Richard Titlebaum , Som Tyagi
IPC分类号： A61C5/50 , A61C19/06 , A61N5/06 , A61K6/00
CPC分类号： A61C5/50 , A61C5/40 , A61C19/06 , A61C2201/002 , A61K6/0035 , A61N5/062 , A61N2005/0606
摘要： A bactericidal insert for introduction into a canal in a tooth during a root canal procedure is provided, along with a method of producing the insert and a method of using the insert in a root canal procedure. The insert is in the form of a carrier having a plurality of pores or interstices. The carrier had been impregnated with a liquid photosensitive dye so that the dye entered the pores or interstices and then the carrier with the liquid photosensitive dye forms a dye-impregnated carrier. The dye-impregnated carrier is configured and adapted for insertion within the canal of the tooth. The carrier, if dried, is adapted to receive a wetting agent to dissolve the dye therein to produce a liquefied dye, which is activatable to produce singlet oxygen within the canal when it is irradiated by light from outside of the tooth.

2. 发明授权

US10136963B2 System and method for introducing photosensitive dyes via an insert into a root canal in a tooth, method for producing said dye impregnated insert and method of using said dye-impregnated insert 有权
公开(公告)号：US10136963B2
公开(公告)日：2018-11-27
申请号：US15538227
申请日：2015-12-21
申请人： Richard Titlebaum , Som Tyagi
发明人： Richard Titlebaum , Som Tyagi
IPC分类号： A61C5/50 , A61C19/06 , A61K6/00 , A61N5/06
摘要： A bactericidal insert for introduction into a canal in a tooth during a root canal procedure is provided, along with a method of producing the insert and a method of using the insert in a root canal procedure. The insert is in the form of a carrier having a plurality of pores or interstices. The carrier had been impregnated with a liquid photosensitive dye so that the dye entered the pores or interstices and then the carrier with the liquid photosensitive dye forms a dye-impregnated carrier. The dye-impregnated carrier is configured and adapted for insertion within the canal of the tooth. The carrier, if dried, is adapted to receive a wetting agent to dissolve the dye therein to produce a liquefied dye, which is activatable to produce singlet oxygen within the canal when it is irradiated by light from outside of the tooth.

3. 发明授权

US09278855B2 Flexible SERS substrates with filtering capabilities 有权
标题翻译：具有过滤能力的柔性SERS衬底
公开(公告)号：US09278855B2
公开(公告)日：2016-03-08
申请号：US13480778
申请日：2012-05-25
申请人： Som Tyagi , Manuel Figueroa
发明人： Som Tyagi , Manuel Figueroa
IPC分类号： G01J3/44 , C23C16/52 , B05D1/12 , B05D3/02 , B82Y20/00 , G01N21/65
CPC分类号： G01N21/658 , B05D5/061 , B82Y20/00 , G01N21/65 , G01N2021/651
摘要： A method for the formation of flexible surface enhanced Raman spectroscopy substrates with filtering capabilities. The method produces thin flexible substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink which includes stabilized nanoparticles such as silver, gold or copper nanoparticles. The substrates and nanoparticle ink undergo a thermal treatment for an amount of time sufficient to remove liquid vehicle and a substantial portion of the stabilizer. The thermal treatment provides a fractal aggregate nanoparticle layer on the substrate suitable for Raman spectroscopy. Such flexible SERS substrates may be used to detect trace amounts of analyte in large volume samples.
摘要翻译：一种形成具有过滤能力的柔性表面增强拉曼光谱基板的方法。该方法产生具有沉积在其上的纳米颗粒油墨的薄柔性基底。纳米颗粒油墨可以是任何合适的纳米颗粒油墨，其包括稳定的纳米颗粒，例如银，金或铜纳米颗粒。底物和纳米颗粒油墨进行热处理足够的时间以去除液体载体和大部分稳定剂。热处理在适用于拉曼光谱的基板上提供分形聚集体纳米颗粒层。这种柔性SERS底物可用于检测大体积样品中痕量的分析物。

4. 发明申请

US20100130367A1 Methods of Quantitatively Assessing Inflammation with Biosensing Nanoparticles 审中-公开
标题翻译：使用生物传感纳米颗粒定量评估炎症的方法
公开(公告)号：US20100130367A1
公开(公告)日：2010-05-27
申请号：US12307901
申请日：2007-07-11
申请人： Sreekant Murthy , Elisabeth S. Papazoglou , Kambiz Pourrezaei , Som Tyagi , Amolkumar Karwa
发明人： Sreekant Murthy , Elisabeth S. Papazoglou , Kambiz Pourrezaei , Som Tyagi , Amolkumar Karwa
IPC分类号： C40B30/00 , G01N33/573 , G01N33/536 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/588 , B82Y15/00 , G01N33/54326 , G01N33/6893
摘要： The present invention includes a method of using one or more biomarkers to identify individuals with inflammatory disease using Quantum Dots conjugated to targeting moieties that will specifically bind to biomarker proteins or nucleic acids encoding the biomarker, where detection of the biomarker is associated with the inflammatory disease.
摘要翻译：本发明包括使用一种或多种生物标志物来鉴定具有炎性疾病的个体的方法，其使用与将特异性结合生物标志蛋白或编码生物标志物的核酸的靶向部分缀合的量子点，其中生物标志物的检测与炎性疾病相关。

5. 发明授权

US09945785B2 Flexible SERS substrates with filtering capabilities 有权
公开(公告)号：US09945785B2
公开(公告)日：2018-04-17
申请号：US15007417
申请日：2016-01-27
申请人： Som Tyagi , Manuel Figueroa
发明人： Som Tyagi , Manuel Figueroa
IPC分类号： G01J3/44 , G01N21/65 , B82Y20/00 , B05D5/06
CPC分类号： G01N21/658 , B05D5/061 , B82Y20/00 , G01N21/65 , G01N2021/651
摘要： A method for the formation of flexible surface enhanced Raman spectroscopy substrates with filtering capabilities. The method produces thin flexible substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink which includes stabilized nanoparticles such as silver, gold or copper nanoparticles. The substrates and nanoparticle ink undergo a thermal treatment for an amount of time sufficient to remove liquid vehicle and a substantial portion of the stabilizer. The thermal treatment provides a fractal aggregate nanoparticle layer on the substrate suitable for Raman spectroscopy. Such flexible SERS substrates may be used to detect trace amounts of analyte in large volume samples.

6. 发明授权

US09086380B2 Surface-enhanced raman scattering substrates 有权
标题翻译：表面增强拉曼散射基板
公开(公告)号：US09086380B2
公开(公告)日：2015-07-21
申请号：US14027154
申请日：2013-09-13
申请人： Som Tyagi , Kambiz Pourrezaei
发明人： Som Tyagi , Kambiz Pourrezaei
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01J3/44 , Y10T428/24372 , Y10T428/24413
摘要： A method for the formation of surface enhanced Raman scattering substrates. The method produces thin substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink such as silver, gold or copper nanoparticle ink which includes stabilized nanoparticles. The substrates and nanoparticle ink undergo a first step of heating in order to remove liquid vehicle from the ink The substrates and nanoparticles then undergo a second step of heating for an amount of time sufficient to remove a substantial portion of the stabilizer and provide a fractal aggregate nanoparticle layer on the substrate having a certain resistivity or conductivity suitable for Raman scattering. This creates SERS substrates with enhanced amplification properties.
摘要翻译：一种形成表面增强拉曼散射基板的方法。该方法产生沉积有纳米颗粒油墨的薄基材。纳米颗粒油墨可以是任何合适的纳米颗粒油墨，例如包括稳定的纳米颗粒的银，金或铜纳米颗粒油墨。底物和纳米颗粒油墨经历加热第一步骤以从油墨中除去液体载体。然后，底物和纳米颗粒经历第二步骤，加热足够时间以除去大部分稳定剂并提供分形聚集体具有适于拉曼散射的一定电阻率或电导率的衬底上的纳米颗粒层。这产生具有增强扩增性能的SERS底物。

7. 发明授权

US08559002B2 Method for the formation of SERS substrates 有权
标题翻译：形成SERS底物的方法
公开(公告)号：US08559002B2
公开(公告)日：2013-10-15
申请号：US12933001
申请日：2009-03-20
申请人： Som Tyagi , Kambiz Pourrezaei
发明人： Som Tyagi , Kambiz Pourrezaei
IPC分类号： G01J3/44 , C23C16/52 , B05D1/12 , B05D3/02
CPC分类号： G01N21/658 , G01J3/44 , Y10T428/24372 , Y10T428/24413
摘要： A method for the formation of surface enhanced Raman scattering substrates. The method produces thin substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink such as silver, gold or copper nanoparticle ink which includes stabilized nanoparticles. The substrates and nanoparticle ink undergo a first step of heating in order to remove liquid vehicle from the ink. The substrates and nanoparticles then undergo a second step of heating for an amount of time sufficient to remove a substantial portion of the stabilizer and provide a fractal aggregate nanoparticle layer on the substrate having a certain resistivity or conductivity suitable for Raman scattering. This creates SERS substrates with enhanced amplification properties.
摘要翻译：一种形成表面增强拉曼散射基板的方法。该方法产生沉积有纳米颗粒油墨的薄基材。纳米颗粒油墨可以是任何合适的纳米颗粒油墨，例如包括稳定的纳米颗粒的银，金或铜纳米颗粒油墨。底物和纳米颗粒油墨经历第一步加热以从油墨中除去液体载体。衬底和纳米粒子然后进行第二步骤的加热足够的时间以去除大部分的稳定剂，并在衬底上提供适合于拉曼散射的一定电阻率或电导率的分形聚集体纳米颗粒层。这产生具有增强扩增性能的SERS底物。

8. 发明申请

US20160161414A1 Flexible SERS Substrates With Filtering Capabilities 审中-公开
标题翻译：具有滤波功能的柔性SERS基板
公开(公告)号：US20160161414A1
公开(公告)日：2016-06-09
申请号：US15007417
申请日：2016-01-27
申请人： Som Tyagi , Manuel Figueroa
发明人： Som Tyagi , Manuel Figueroa
IPC分类号： G01N21/65 , B05D5/06
CPC分类号： G01N21/658 , B05D5/061 , B82Y20/00 , G01N21/65 , G01N2021/651
摘要： A method for the formation of flexible surface enhanced Raman spectroscopy substrates with filtering capabilities. The method produces thin flexible substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink which includes stabilized nanoparticles such as silver, gold or copper nanoparticles. The substrates and nanoparticle ink undergo a thermal treatment for an amount of time sufficient to remove liquid vehicle and a substantial portion of the stabilizer. The thermal treatment provides a fractal aggregate nanoparticle layer on the substrate suitable for Raman spectroscopy. Such flexible SERS substrates may be used to detect trace amounts of analyte in large volume samples.
摘要翻译：一种形成具有过滤能力的柔性表面增强拉曼光谱基板的方法。该方法产生具有沉积在其上的纳米颗粒油墨的薄柔性基底。纳米颗粒油墨可以是任何合适的纳米颗粒油墨，其包括稳定的纳米颗粒，例如银，金或铜纳米颗粒。底物和纳米颗粒油墨进行热处理足够的时间以去除液体载体和大部分稳定剂。热处理在适用于拉曼光谱的基板上提供分形聚集体纳米颗粒层。这种柔性SERS底物可用于检测大体积样品中痕量的分析物。

9. 发明申请

US20120300203A1 FLEXIBLE SERS SUBSTRATES WITH FILTERING CAPABILITIES 有权
标题翻译：具有过滤能力的柔性基体
公开(公告)号：US20120300203A1
公开(公告)日：2012-11-29
申请号：US13480778
申请日：2012-05-25
申请人： Som Tyagi , Manuel Figueroa
发明人： Som Tyagi , Manuel Figueroa
IPC分类号： G01N21/01 , B29D11/00 , G01N21/65 , B05D5/06 , B82Y20/00
CPC分类号： G01N21/658 , B05D5/061 , B82Y20/00 , G01N21/65 , G01N2021/651
摘要： A method for the formation of flexible surface enhanced Raman spectroscopy substrates with filtering capabilities. The method produces thin flexible substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink which includes stabilized nanoparticles such as silver, gold or copper nanoparticles. The substrates and nanoparticle ink undergo a thermal treatment for an amount of time sufficient to remove liquid vehicle and a substantial portion of the stabilizer. The thermal treatment provides a fractal aggregate nanoparticle layer on the substrate suitable for Raman spectroscopy. Such flexible SERS substrates may be used to detect trace amounts of analyte in large volume samples.
摘要翻译：一种形成具有过滤能力的柔性表面增强拉曼光谱基板的方法。该方法产生具有沉积在其上的纳米颗粒油墨的薄柔性基底。纳米颗粒油墨可以是任何合适的纳米颗粒油墨，其包括稳定的纳米颗粒，例如银，金或铜纳米颗粒。底物和纳米颗粒油墨进行热处理足够的时间以去除液体载体和大部分稳定剂。热处理在适用于拉曼光谱的基板上提供分形聚集体纳米颗粒层。这种柔性SERS底物可用于检测大体积样品中痕量的分析物。

10. 发明申请

US20110026019A1 METHOD FOR THE FORMATION OF SERS SUBSTRATES 有权
标题翻译：形成基体的方法
公开(公告)号：US20110026019A1
公开(公告)日：2011-02-03
申请号：US12933001
申请日：2009-03-20
申请人： Som Tyagi , Kambiz Pourrezaei
发明人： Som Tyagi , Kambiz Pourrezaei
IPC分类号： G01N21/65 , B82Y20/00 , B05D5/00
CPC分类号： G01N21/658 , G01J3/44 , Y10T428/24372 , Y10T428/24413
摘要： A method for the formation of surface enhanced Raman scattering substrates. The method produces thin substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink such as silver, gold or copper nanoparticle ink which includes stabilized nanoparticles. The substrates and nanoparticle ink undergo a first step of heating in order to remove liquid vehicle from the ink. The substrates and nanoparticles then undergo a second step of heating for an amount of time sufficient to remove a substantial portion of the stabilizer and provide a fractal aggregate nanoparticle layer on the substrate having a certain resistivity or conductivity suitable for Raman scattering. This creates SERS substrates with enhanced amplification properties.
摘要翻译：一种形成表面增强拉曼散射基板的方法。该方法产生沉积有纳米颗粒油墨的薄基材。纳米颗粒油墨可以是任何合适的纳米颗粒油墨，例如包括稳定的纳米颗粒的银，金或铜纳米颗粒油墨。底物和纳米颗粒油墨经历第一步加热以从油墨中除去液体载体。衬底和纳米粒子然后进行第二步骤的加热足够的时间以去除大部分的稳定剂，并在衬底上提供适合于拉曼散射的一定电阻率或电导率的分形聚集体纳米颗粒层。这产生具有增强扩增性能的SERS底物。

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