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1. 发明授权

US08859617B2 Use of furan alkyl for preparing an antidiabetic drug 有权
标题翻译：呋喃烷基用于制备抗糖尿病药物
公开(公告)号：US08859617B2
公开(公告)日：2014-10-14
申请号：US11597635
申请日：2005-05-27
申请人： Antoine Piccirilli , Philippe Msika , Nathalie Piccardi
发明人： Antoine Piccirilli , Philippe Msika , Nathalie Piccardi
IPC分类号： A61K31/341 , A61P7/12 , A61P3/08
CPC分类号： A61K31/341
摘要： The invention relates to using one or several synthetic or natural furan alkyls for preparing a drug for preventing and/or treating diabetes and insulin resistance, thereby preventing the risks of cardiovascular, nervous, cutaneous, renal, ocular and infectious diseases. The use of one or several synthetic or natural furan alkyls for cosmetically treating diabetes related skin disorders is also disclosed.
摘要翻译：本发明涉及使用一种或多种合成或天然呋喃烷基酯制备用于预防和/或治疗糖尿病和胰岛素抵抗的药物，从而防止心血管，神经，皮肤，肾脏，眼睛和感染性疾病的风险。还公开了使用一种或几种合成或天然呋喃烷基化妆品来治疗糖尿病相关的皮肤病。

2. 发明授权

US07589121B2 Use of furan alkyls for preparing a drug for treating obesity and cosmetically treating overweight 有权
标题翻译：使用呋喃烷基制备治疗肥胖和化妆品治疗超重的药物
公开(公告)号：US07589121B2
公开(公告)日：2009-09-15
申请号：US11597634
申请日：2005-05-27
申请人： Antoine Piccirilli , Philippe Msika , Nathalie Piccardi
发明人： Antoine Piccirilli , Philippe Msika , Nathalie Piccardi
IPC分类号： A61K31/34
CPC分类号： A61K31/341 , A61K8/4973 , A61Q19/06
摘要： The invention relates to the use of one or several synthetic or natural furan alkyls for preparing a drug preventing and/or treating obesity or overweight. The use of one or several synthetic or natural furan alkyls for cosmetically treating local excessive weight is also disclosed. Said furan alkyls preferably correspond to formula (I), wherein identical or different R1, R2, R3et R4 are independently of each other a hydrogen atom, a C1-C35alkyl radical, C1-C35 alcenyl radical or a C1-C35 alcynyl radical, preferably C10-C22, wherein said alkyl, alcenyl and alcynyl radicals are substitutable and R1, R2, R3 are preferably a hydrogen atom.
摘要翻译：本发明涉及一种或多种合成或天然呋喃烷基酯用于制备预防和/或治疗肥胖或超重的药物的用途。还公开了一种或几种合成或天然呋喃烷基化合物用于化妆处理局部过量的用途。所述呋喃烷基优选对应于式（I），其中相同或不同的R 1，R 2，R 3，R 4彼此独立地为氢原子，C 1 -C 35烷基，C 1 -C 35亚乙烯基或C 1 -C 35烷基，优选 C10-C22，其中所述烷基，烯基和烷酰基是可取代的，并且R 1，R 2，R 3优选为氢原子。

3. 发明授权

US07473434B2 Maca extract and cosmetic composition containing such an extract 有权
标题翻译：含有这种提取物的麦汁提取物和化妆品组合物
公开(公告)号：US07473434B2
公开(公告)日：2009-01-06
申请号：US10561271
申请日：2004-06-17
申请人： Nathalie Piccardi , Antoine Piccirilli , Philippe Msika , François Paul
发明人： Nathalie Piccardi , Antoine Piccirilli , Philippe Msika , François Paul
IPC分类号： A01N65/00
CPC分类号： A61K8/645 , A61K8/97 , A61Q19/08
摘要： The invention relates to a method for extracting substances from maca, to the obtained extract, to a cosmetic and pharmaceutical composition containing said extract, and to the use thereof as an anti-aging cosmetic agent. The method is characterized by a step involving the use of an enzymatic hydrolysis of proteins.
摘要翻译：本发明涉及从马卡提取物质，所得提取物，含有所述提取物的化妆品和药物组合物的方法及其作为抗衰老化妆剂的用途。该方法的特征在于涉及使用蛋白质的酶水解的步骤。

4. 发明申请

US20080113921A1 Use of a Compound Comprising D-Mannoheptulose and/or Perseitol for Treating and Preventing Innate Immunity Modification Diseases 有权
标题翻译：包含D-甘露庚酮糖和/或Perseitol的化合物用于治疗和预防先天性免疫修饰疾病的用途
公开(公告)号：US20080113921A1
公开(公告)日：2008-05-15
申请号：US11587961
申请日：2005-04-29
申请人： Antoine Piccirilli , Nathalie Piccardi , Philippe Msika , Francois Paul , Stéphanie Bredif
发明人： Antoine Piccirilli , Nathalie Piccardi , Philippe Msika , Francois Paul , Stéphanie Bredif
IPC分类号： A61K31/70 , A61K31/045
CPC分类号： A61K8/60 , A23L33/10 , A23L33/105 , A61K8/97 , A61K31/7004 , A61K36/48 , A61K2800/75 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/008 , A61K2300/00
摘要： The invention relates to the use of a compound comprising D-mannoheptulose and/or perseitol for producing a drug for treating and/or preventing diseases related to the modification of an innate and/or acquired immunity by increasing the production of antimicrobial peptides, preferably hBD-2 without inducing inflammatory reactions, irritation or intolerance. Said compound can also comprise a peptidic avocado extract and/or a peptidic lupin extract.
摘要翻译：本发明涉及包含D-甘露庚酮糖和/或去糖醇的化合物在制备用于治疗和/或预防与天然和/或获得性免疫的改变相关的疾病的药物中的用途，其通过增加抗微生物肽的产生，优选hBD -2不引起炎症反应，刺激或不耐受。所述化合物还可以包含肽鳄梨提取物和/或肽类羽扇豆提取物。

5. 发明授权

US07238377B2 Use of an oil of the gourd family for inhibiting 5 alpha-reductase activity 失效
标题翻译：使用葫芦科植物油抑制5α-还原酶活性
公开(公告)号：US07238377B2
公开(公告)日：2007-07-03
申请号：US10482280
申请日：2002-07-01
申请人： Antoine Piccirilli , Jacqueline Smadja , Philippe Msika , Isabelle Grondin , Nathalie Piccardi
发明人： Antoine Piccirilli , Jacqueline Smadja , Philippe Msika , Isabelle Grondin , Nathalie Piccardi
IPC分类号： A61K36/00
CPC分类号： A61Q19/008 , A23L33/115 , A61K8/922 , A61K36/42 , A61K2800/782 , A61Q5/00 , A61Q5/008 , A61Q5/02 , A61Q7/00 , A61Q7/02 , A61Q19/00 , A61Q19/10 , A61K2300/00
摘要： The invention concerns the use of at least an oil derived from the seeds of the gourd family selected from the group consisting of Lagenaria, Luffa and Momordica, for preparing a composition designed to inhibit 5α-reductase activity, and the use of said oil for preparing a composition for treating prostatic hypertrophy, prostatic adenoma, acne, hyperseborrhea, alopecia, and hirsutism. The invention also concerns cosmetic treatment methods, in particular for greasy skin. The invention further concerns the use of at least an oil derived from seeds of the gourd family in a nutritional food composition for humans and/or animals as additive for inhibiting 5α reductase activity.
摘要翻译：本发明涉及使用至少一种衍生自选自Lagenaria，Luffa和Momordica的葫芦科种子的油来制备抑制5α-还原酶活性的组合物，以及使用所述油制备用于治疗前列腺肥大，前列腺腺瘤，痤疮，高血脂，脱发和多毛症的组合物。本发明还涉及化妆品处理方法，特别是油性皮肤。本发明还涉及至少一种源自葫芦族的种子的油用于人和/或动物的营养食品组合物中，作为抑制5α还原酶活性的添加剂。

6. 发明申请

US20050256061A1 Use of isoflavones for preparing topical compositions for promoting slimming, and related cosmetic treatment method 审中-公开
标题翻译：异黄酮用于制备用于促进减肥的局部用组合物的用途以及相关的美容治疗方法
公开(公告)号：US20050256061A1
公开(公告)日：2005-11-17
申请号：US10519096
申请日：2003-06-25
申请人： Philippe Msika , Nathalie Piccardi
发明人： Philippe Msika , Nathalie Piccardi
IPC分类号： A61K8/02 , A61K8/04 , A61K8/49 , A61K8/60 , A61K8/97 , A61Q19/08 , A61K31/7048 , A61K31/353
CPC分类号： A61K8/602 , A61K8/02 , A61K8/046 , A61K8/4973 , A61K8/97 , A61Q19/08
摘要： The invention concerns the use of isoflavones for ping topical compositions for promoting slimming, and in particular for fighting against localized excess weight; the related cosmetic treatment method and a composition comprising additionally to isoflavones an extract of Sophora Japonica flowers.
摘要翻译：本发明涉及使用异黄酮来治疗用于促进减肥的局部用组合物，特别是用于防止局部超重; 相关的美容处理方法和另外包含异黄酮的混合物是槐花（Sophora Japonica）花的提取物。

7. 发明授权

US08236836B2 Composition comprising at least one oxazoline for inhibiting langerhans cell migration, and uses thereof 有权
标题翻译：包含至少一种用于抑制朗格汉斯细胞迁移的恶唑啉的组合物及其用途
公开(公告)号：US08236836B2
公开(公告)日：2012-08-07
申请号：US10499976
申请日：2002-12-27
申请人： Philippe Msika , Nathalie Piccardi , Antoine Piccirilli
发明人： Philippe Msika , Nathalie Piccardi , Antoine Piccirilli
IPC分类号： A61K31/42
CPC分类号： A61K31/42 , A61K8/49 , A61K2800/51 , A61K2800/70 , A61K2800/75 , A61K2800/782 , A61Q19/00 , A61Q19/005 , A61Q19/08 , Y10S514/861
摘要： The invention concerns a composition containing at least an oxazolin, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an alkanolamide, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such composition on the skin and/or mucosa.
摘要翻译：本发明涉及至少含有恶唑啉的组合物，任选地与至少一种化合物如金属蛋白酶抑制剂，PKC抑制剂，抗炎剂，舒缓剂，免疫抑制剂，离子螯合剂，链烷醇酰胺，恶唑烷酮和氨基甲酸衍生物。本发明还涉及使用这种组合物作为药物，特别是用于预防或治疗过敏和/或炎性和/或刺激性起源或由危险信号引起的皮肤病理学。本发明还涉及一种用于美容治疗敏感的，刺激的，不耐受的，过敏倾向的，老化的皮肤和/或表现皮肤屏障障碍的皮肤或/或表现出非病理性免疫不平衡的皮肤和/或粘膜的方法，其包括在皮肤和/ 或粘膜。

8. 发明申请

US20100035816A1 MEDICAMENT COMPRISING A PEPTIDE EXTRACT OF AVOCADO, WHICH IS INTENDED FOR THE TREATMENT AND PREVENTION OF ILLNESSES THAT ARE LINKED TO AN IMMUNE SYSTEM DEFICIENCY OR OXIDATIVE STRESS OR SKIN AGEING OR DRY SKIN 有权
标题翻译：含有AVOCADO的肽提取物的药物，其意在用于治疗和预防与免疫系统缺陷或氧化应激或皮肤老化或干性皮肤相关的不良事件
公开(公告)号：US20100035816A1
公开(公告)日：2010-02-11
申请号：US12539970
申请日：2009-08-12
申请人： Antoine Piccirilli , Nathalie Piccardi , Philippe Msika , François Paul , Stéphanie Bredif
发明人： Antoine Piccirilli , Nathalie Piccardi , Philippe Msika , François Paul , Stéphanie Bredif
IPC分类号： A61K38/00 , A61K38/02 , A61P31/04 , A61P31/10 , A61P31/12 , A61P29/00 , A61P17/00 , A61P17/06 , A61P17/10 , A61P17/02
CPC分类号： A61K36/54 , A61K31/198 , A61K2300/00
摘要： The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose an/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.
摘要翻译：本发明涉及一种药物，其包含鳄梨的肽提取物，并且还可以包含含有D-甘露庚酮糖和/或去糖醇的组合物，例如鳄梨糖的水溶性提取物和/或羽扇豆肽提取物。本发明的药物旨在通过增加抗微生物肽（优选hBD-2）的产生而不诱导炎症反应来治疗和/或预防与先天和/或获得性免疫的变化有关的疾病，激怒或不宽容

9. 发明申请

US20070098823A1 Maca extract and cosmetic composition containing such an extract 有权
标题翻译：含有这种提取物的麦汁提取物和化妆品组合物
公开(公告)号：US20070098823A1
公开(公告)日：2007-05-03
申请号：US10561271
申请日：2004-06-17
申请人： Nathalie Piccardi , Antoine Piccirilli , Philippe Msika , Francois Paul
发明人： Nathalie Piccardi , Antoine Piccirilli , Philippe Msika , Francois Paul
IPC分类号： A61K36/31
CPC分类号： A61K8/645 , A61K8/97 , A61Q19/08
摘要： The invention relates to a method for extracting substances from maca, to the obtained extract, to a cosmetic and pharmaceutical composition containing said extract, and to the use thereof as an anti-aging cosmetic agent. The method is characterized by a step involving the use of an enzymatic hydrolysis of proteins.
摘要翻译：本发明涉及从马卡提取物质，所得提取物，含有所述提取物的化妆品和药物组合物的方法及其作为抗衰老化妆剂的用途。该方法的特征在于涉及使用蛋白质的酶水解的步骤。

10. 发明申请

US20060194881A1 Composition comprising at least one alkanolamide to inhibit megration of langerhans cells and uses therof 有权
标题翻译：组合物，其包含至少一种烷醇酰胺以抑制朗格汉斯细胞的整理并使用该方法
公开(公告)号：US20060194881A1
公开(公告)日：2006-08-31
申请号：US11411870
申请日：2006-04-27
申请人： Philippe Msika , Nathalie Piccardi , Anthoine Piccirilli
发明人： Philippe Msika , Nathalie Piccardi , Anthoine Piccirilli
IPC分类号： A61K31/16
CPC分类号： A61K8/68 , A61K2800/75 , A61K2800/782 , A61Q19/00 , A61Q19/005
摘要： The invention concerns a composition containing at least an alkanolamide, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an oxazolin, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular its use for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such a composition on the skin and/or mucosa.
摘要翻译：本发明涉及至少含有烷醇酰胺的组合物，任选与至少一种化合物如金属蛋白酶抑制剂，PKC抑制剂，抗炎剂，舒缓剂，免疫抑制剂，离子螯合剂，恶唑啉，恶唑烷酮和氨基甲酸衍生物。本发明还涉及使用这样的组合物作为药物，特别是其用于预防或治疗过敏性和/或炎性和/或刺激性起源或由危险信号引起的皮肤病理学的用途。本发明还涉及一种用于美容治疗敏感的，刺激的，不耐受的，过敏倾向的，老化的皮肤和/或表现皮肤屏障障碍的皮肤或/或表现出非病理性免疫不平衡的方法，其包括将这样的组合物应用于皮肤和 /或粘膜。

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