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1. 发明授权

US4994025A Method of dissolving cholesterol-rich calculi with short chain halogenated organic solvents and cosolvents 失效
标题翻译：用短链卤代有机溶剂和共溶剂溶解富含胆固醇的结石的方法
公开(公告)号：US4994025A
公开(公告)日：1991-02-19
申请号：US400212
申请日：1989-08-29
申请人： Paul DeAntonio , Kenneth G. Mayhan , John T. Sorensen
发明人： Paul DeAntonio , Kenneth G. Mayhan , John T. Sorensen
IPC分类号： A61B17/22 , A61K31/02 , A61P1/16
CPC分类号： A61K31/02 , A61B2017/22084
摘要： Disclosed is a method for dissolving cholesterol-rich calculi, most preferably gallstones in vivo, comprising contacting the calculus with a fluid compound of the formula R-X, R having 2 to 4 carbon atoms with substituents consisting of hydrogen of halogen, X being halogen, and wherein if X is fluorine, at least one substituent is selected from the group consisting of hydrogen, chlorine, bromine, or iodine. Usually R-X is 2-bromo-2-chloro-1,1,1-trifluoroethane (also referred to as Halothane.) Other compounds of particular interest are 2-chloro-1,2,-dibromo-1,1,2-trifluoroethane, 1-bromo-2-chloro-1,1,2-trifluoroethane, 2,3-dibromo-1,1,1-trifluoropropane, 2-iodo-1,1,1-trifluoroethane, 1,2-dichloro-1,1-difluoroethane, 1,1,2-trichloro-2,3,3-trifluorocyclobutane, hexafluoro-1,1,3,4,-tetrachlorobutane, 1,1,1-trichlorotrifluoroethane, and 1,2-dibromo-tetrafluoroethane. Furthermore, Halothane and MtBE in combination effectively dissolve cholesterol-rich calculi.Finally, dissolution can be enhanced by adding to the dissolution solvent up to about 50 percent by volume of a lower alcohol. Usually the lower alcohol is ethanol in the amount of about 5 to 40, usually 10 to 30 and preferably about 10 percent by volume. Most preferably in this case, R-X is Halothane or 1,1,1-trichlorotrifluoroethane. Dissolution using previously known solvents such as MtBE is also enhanced by such addition of lower alcohols. In addition, the practical use of MtBE for dissolution can be improved by the addition of the compounds described above as R-X, particularly Halothane, and usually at levels of about 5 to 50 volume percent Halothane.
摘要翻译：公开了一种在体内溶解富胆固醇结石，最优选胆结石的方法，包括使结石与式RX的流体化合物，具有2至4个碳原子的R和R的卤素取代基组成的取代基，X是卤素，和其中如果X是氟，则至少一个取代基选自氢，氯，溴或碘。通常RX是2-溴-2-氯-1,1,1-三氟乙烷（也称为氟烷）。其它特别令人感兴趣的化合物是2-氯-1,2,2-二溴-1,1,2-三氟乙烷，1-溴-2-氯-1,1,2-三氟乙烷，2,3-二溴-1,1,1-三氟丙烷，2-碘-1,1,1-三氟乙烷，1,2-二氯-1 ，1,2-二氟乙烷，1,1,2-三氯-2,3,3-三氟环丁烷，六氟-1,1,3,4， - 四氯丁烷，1,1,1-三氯三氟乙烷和1,2-二溴 - 四氟乙烷。此外，氟烷和MtBE组合有效地溶解富含胆固醇的结石。最后，通过向溶解溶剂中加入高达约50体积％的低级醇可以提高溶解度。通常，低级醇是乙醇，其量为约5至40，通常为10至30，优选约10体积％。最优选在这种情况下，R-X是氟烷或1,1,1-三氯三氟乙烷。使用先前已知的溶剂如MtBE的溶解也通过这样加入低级醇来增强。另外，通过加入上述作为R-X，特别是氟烷的化合物，可以提高MtBE用于溶解的实际用途，通常为约5〜50体积％的卤代烷的水平。

2. 发明授权

US5534177A Compositions useful for removing products of metal corrosion 失效
标题翻译：用于去除金属腐蚀产物的组合物
公开(公告)号：US5534177A
公开(公告)日：1996-07-09
申请号：US835665
申请日：1992-02-14
申请人： Kenneth G. Mayhan
发明人： Kenneth G. Mayhan
IPC分类号： C02F5/10 , C23G1/02 , C23G1/08 , C02F5/00
CPC分类号： C02F5/10 , C23G1/025 , C23G1/088
摘要： The present invention is directed to compositions useful for removing products of metal corrosion from corroded metals which consists essentially of an aqueous liquid solution of malonic acid, a surfactant and an organic solvent selected from the group consisting of formamide, dimethylformamide, and dimethylsulfoxide.
摘要翻译：本发明涉及用于从腐蚀金属中除去金属腐蚀产物的组合物，其基本上由丙二酸水溶液，表面活性剂和选自甲酰胺，二甲基甲酰胺和二甲基亚砜的有机溶剂组成。

3. 发明授权

US4595632A Fluorocarbon grafting of polymeric substrates 失效
标题翻译：聚合物基材的氟碳接枝
公开(公告)号：US4595632A
公开(公告)日：1986-06-17
申请号：US577300
申请日：1984-02-06
申请人： Kenneth G. Mayhan , Robert A. Janssen , Roger F. Drake
发明人： Kenneth G. Mayhan , Robert A. Janssen , Roger F. Drake
IPC分类号： C08J3/00 , C08C19/40 , C08J7/12 , B32B27/28 , B32B25/16
CPC分类号： C08J7/12 , C08C19/40 , Y10T428/31 , Y10T428/3154 , Y10T428/31544 , Y10T428/31826 , Y10T428/31931
摘要： A process for modifying the surface of a preformed polymeric substrate to impart lubricity and other desired properties thereto, without at the same time significantly altering the bulk properties of the substrate, by epoxidizing the substrate's surface and reacting the epoxide groups so formed with a fluorocarbon capable of cleaving the epoxide rings and covalently bonding thereto. The article so formed is also disclosed.
摘要翻译：改进预成型聚合物基材的表面以赋予其润滑性和其它所需性质的方法，而不同时显着改变基材的整体性质，通过环氧化基材的表面并使如此形成的环氧化物基团与具有碳氟化合物的能力反应裂解环氧化物环并与其共价键合。也披露了如此形成的物品。

4. 发明授权

US4311573A Process for graft copolymerization of a pre-formed substrate 失效
标题翻译：预成型基材的接枝共聚方法
公开(公告)号：US4311573A
公开(公告)日：1982-01-19
申请号：US195103
申请日：1980-10-08
申请人： Kenneth G. Mayhan , Robert A. Janssen , William J. Bertrand
发明人： Kenneth G. Mayhan , Robert A. Janssen , William J. Bertrand
IPC分类号： C08F2/10 , C08F2/46 , C08F2/54 , C08F4/40 , C08F291/18 , C08F291/06 , C08J7/16
CPC分类号： C08F291/18 , Y10S525/904
摘要： A process for modifying the surface characteristics of a pre-formed polymeric substrate to impart hydrophilicity, hydrophobicity, or other desired properties thereto, by peroxidizing the surface of the substrate and then allowing the active sites along the polymer chains to generate free radicals which induce graft polymerization of a suitable ethylenic monomer (or other ethylenically-unsaturated compound) onto the surface of the substrate is described. Such graft copolymerization is undertaken in the presence of variable valence metal ions in a reduced state under acidic conditions and at selected reaction times and relatively low temperatures, and in the presence of squarate ions (diketocyclobutenediol) to control the physical characteristics of the surface graft and to restore the metal ions to their lower valence state without at the same time producing deleterious by-products.
摘要翻译：通过过氧化底物表面，然后使沿着聚合物链的活性位点产生诱导移植物的自由基，改变预成形聚合物基质的表面特性以赋予亲水性，疏水性或其它所需性质的方法描述了合适的乙烯单体（或其它烯属不饱和化合物）在基材表面上的聚合。在酸性条件下，在选定的反应时间和相对较低的温度下，在方酸离子（二环多环丁烯二醇）存在下，在可变价金属离子的存在下进行这种接枝共聚，以控制表面移植物的物理特性，以将金属离子还原成其较低的价态，而不产生有害的副产物。

5. 发明授权

US5244913A Compositions and methods for dissolving body calculi 失效
标题翻译：用于溶解体内结石的组合物和方法
公开(公告)号：US5244913A
公开(公告)日：1993-09-14
申请号：US794544
申请日：1991-11-19
申请人： Stephen L. Coulter , Kenneth G. Mayhan , Christy L. H. Oviatt , Steven R. Morehead
发明人： Stephen L. Coulter , Kenneth G. Mayhan , Christy L. H. Oviatt , Steven R. Morehead
IPC分类号： A61K31/14 , A61K31/16 , A61K31/255 , A61K31/44 , A61K31/785 , A61K45/06
CPC分类号： A61K45/06 , A61K31/14 , A61K31/16 , A61K31/255 , A61K31/44 , A61K31/785
摘要： Compositions and methods for dissolving calculi deposits in humans are disclosed. The compositions include solutions of quaternary ammonium salts and are particularly effective for the contact dissolution of pigment portions of biliary tract calculi such as gallstones. The solutions preferably further include mineral chelating agent and disulfide bond cleaving agent to aid in deaggregating mineral components and glycoprotein components of calculi.
摘要翻译：公开了将结石沉积物溶解在人体中的组合物和方法。组合物包括季铵盐溶液，并且对胆汁结石如胆结石的颜料部分的接触溶解特别有效。溶液优选还包括矿物螯合剂和二硫键切割剂，以帮助解离矿物组分和结石的糖蛋白组分。

6. 发明授权

US4863445A Assembly for inhibiting microbial growth in collected fluid 失效
标题翻译：用于抑制收集的流体中微生物生长的装置
公开(公告)号：US4863445A
公开(公告)日：1989-09-05
申请号：US635772
申请日：1984-07-30
申请人： Kenneth G. Mayhan , Bernice I. Romo , Robert L. Murtfeldt , William J. Bertrand
发明人： Kenneth G. Mayhan , Bernice I. Romo , Robert L. Murtfeldt , William J. Bertrand
IPC分类号： A61G9/00 , A01N25/26 , A01N59/00 , A61F5/441 , A61L2/16 , A61M1/00 , A61M1/02
CPC分类号： A61L2/16 , A01N25/26 , A01N59/00 , A61F5/441 , A61M1/0096
摘要： An assembly for inhibiting microbial growth in collected body fluid includes a reservoir for collecting the fluid, and a tablet in the reservoir, which tablet dissolves in the collected fluid to produce hydrogen peroxide in an amount sufficient to inhibit microbial growth in the collected fluid. The tablet is partially coated with an insoluble coating which leaves a portion of the tablet uncoated to provide a constant surface area exposed to the collected body fluid, which surface area is of a size to provide sufficient hydrogen peroxide for inhibition of microbial growth.
摘要翻译：用于抑制收集的体液中的微生物生长的组件包括用于收集流体的储存器和储存器中的片剂，该片剂溶解在收集的流体中以产生足以抑制收集的流体中微生物生长的量的过氧化氢。片剂部分地涂覆有不溶性涂层，其使片剂的一部分未涂覆以提供暴露于收集的体液的恒定表面积，该表面积的尺寸提供足够的过氧化氢以抑制微生物生长。

7. 发明授权

US4589964A Process for graft copolymerization of a pre-formed substrate 失效
标题翻译：预成型基材的接枝共聚方法
公开(公告)号：US4589964A
公开(公告)日：1986-05-20
申请号：US580119
申请日：1984-02-14
申请人： Kenneth G. Mayhan , Robert A. Janssen , William J. Bertrand
发明人： Kenneth G. Mayhan , Robert A. Janssen , William J. Bertrand
IPC分类号： C08F291/18
CPC分类号： C08F291/18 , Y10S525/904
摘要： A process for modifying the surface characteristics of a pre-formed polymeric substrate to impart hydrophilicity, hydrophobicity, or other desired properties thereto, by peroxidizing the surface of the substrate and then allowing the active sites along the polymer chains to generate free radicals which induce graft polymerization of a suitable ethylenic monomer (or other ethylenically-unsaturated compound) onto the surface of the substrate is described. Such graft copolymerization is undertaken in the presence of variable valence metal ions in a reduced state under acidic conditions and at selected reaction times and relatively low temperatures, and ideally in the presence of squarate ions (diketocyclobutenediol) to control the physical characteristics of the surface graft and to restore the metal ions to their lower valence state without at the same time producing deleterious by-products.
摘要翻译：通过过氧化底物表面，然后使沿着聚合物链的活性位点产生诱导移植物的自由基，改变预成形聚合物基质的表面特性以赋予亲水性，疏水性或其它所需性质的方法描述了合适的乙烯单体（或其它烯属不饱和化合物）在基材表面上的聚合。这种接枝共聚在酸性条件下和在选择的反应时间和相对较低的温度下在还原状态下在可变价金属离子的存在下进行，并且理想地在方酸离子（二环多环丁烯二醇）存在下控制表面移植物的物理特性并且将金属离子还原成其较低的价态，而不产生有害的副产物。

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