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1. 发明申请

US20140288076A1 HETEROARYL COMPOUNDS AND THEIR USES 审中-公开
标题翻译： HETEROARYL化合物及其用途
公开(公告)号：US20140288076A1
公开(公告)日：2014-09-25
申请号：US14295398
申请日：2014-06-04
申请人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： C07D409/14 , C07D401/14 , C07D405/14 , C07D401/04
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。还提供了治疗由CDK9介导的疾病或病症的方法。

2. 发明申请

US20110028492A1 Heteroaryl Compounds and Their Uses 失效
标题翻译：杂芳基化合物及其用途
公开(公告)号：US20110028492A1
公开(公告)日：2011-02-03
申请号：US12843494
申请日：2010-07-26
申请人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： A61K31/497 , C07D213/02 , C07D401/04 , A61K31/444 , A61K31/506 , A61P31/18 , A61P35/00
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。还提供了治疗由CDK9介导的疾病或病症的方法。

3. 发明授权

US08415381B2 Heteroaryl compounds and their uses 失效
标题翻译：杂芳基化合物及其用途
公开(公告)号：US08415381B2
公开(公告)日：2013-04-09
申请号：US12843494
申请日：2010-07-26
申请人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： A01N43/40 , A61K31/44
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。还提供了治疗由CDK9介导的疾病或病症的方法。

4. 发明申请

US20060287356A1 Thienopyridones as AMPK activators for the treatment of diabetes and obesity 审中-公开
公开(公告)号：US20060287356A1
公开(公告)日：2006-12-21
申请号：US11509383
申请日：2006-08-24
申请人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
发明人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
IPC分类号： C07D498/02 , A61K31/4743
CPC分类号： C07D495/04
摘要： The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

5. 发明申请

US20050038068A1 Thienopyridones as AMPK activators for the treatment of diabetes and obesity 有权
标题翻译：噻吩并吡啶酮作为治疗糖尿病和肥胖症的AMPK激活剂
公开(公告)号：US20050038068A1
公开(公告)日：2005-02-17
申请号：US10847144
申请日：2004-05-17
申请人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
发明人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
IPC分类号： A61K31/4743 , C07D495/04 , C07D498/02
CPC分类号： C07D495/04
摘要： The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
摘要翻译：本发明涉及活化AMP-活化蛋白激酶（AMPK）的化合物，包括化合物的制备，含有这些化合物的组合物以及该化合物在预防或治疗诸如糖尿病，代谢综合征和肥胖症中的用途。

6. 发明申请

US20050159423A1 Antibacterial compounds 有权
标题翻译：抗菌化合物
公开(公告)号：US20050159423A1
公开(公告)日：2005-07-21
申请号：US10762002
申请日：2004-01-21
申请人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
发明人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
IPC分类号： C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04 , C07D513/04 , A61K31/506 , A61K31/4439 , A61K31/497 , A61K31/501 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译：公开了具有式（I）的具有式（I）的细菌蛋白质合成抑制化合物及其前体药物的前体药物，其制备方法，含该化合物的组合物，使用该化合物的方法。

7. 发明申请

US20050056521A1 Apparatus and method for automatically unloading brick from kiln cars and preparation for shipment 失效
标题翻译：自动从窑车卸载砖块并准备装运的装置和方法
公开(公告)号：US20050056521A1
公开(公告)日：2005-03-17
申请号：US10660695
申请日：2003-09-12
申请人： Robert Keyes
发明人： Robert Keyes
IPC分类号： B65G57/24 , B65G57/26 , B65G47/30
CPC分类号： B65G57/26 , B65G57/24
摘要： Apparatus and methods for unloading and binding brick or other components include an infeed conveyor that delivers layers of brick to a transfer distribution carriage. The distribution carriage repositions the brick layers on either an outfeed conveyor or a tine conveyor. The layers of bricks carried by the outfeed conveyor are moved to where a tine layer is positioned on their upper surface. The tine conveyor divides the bricks into an arrangement of rows spaced apart to define openings for receiving a lifting or moving member, so that when the tine layer is positioned in a completed stack , enables movement of the stack by a forklift or other suitable moving means. Additional layer or layers are then positioned on the tine row on a packaging conveyor so that completed stacks are delivered to a package station that binds the stack of bricks or other components into an integrated structure.
摘要翻译：用于卸载和结合砖或其他部件的装置和方法包括将砖层传送到传送分配托架的进料输送机。分配托架将砖层重新定位在出料输送机或齿输送机上。由出料输送机承载的砖层被移动到在其上表面上定位有齿层的位置。齿形输送机将砖分成排间隔开的排列，以限定用于接收提升或移动构件的开口，使得当齿层位于完整的堆叠中时，能够通过叉车或其他合适的移动装置。然后将附加的层或层定位在包装输送机上的齿排上，使得完成的堆叠被递送到将砖或其它部件的堆叠结合成一体的结构的包装站。

8. 发明申请

US20070142353A1 ANTIBACTERIAL COMPOUNDS 有权
标题翻译：抗菌化合物
公开(公告)号：US20070142353A1
公开(公告)日：2007-06-21
申请号：US11675160
申请日：2007-02-15
申请人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
发明人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
IPC分类号： A61K31/519 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4743 , C07D498/02 , C07D487/02
CPC分类号： C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译：公开了具有式（I）的具有式（I）的细菌蛋白质合成抑制化合物及其前体药物的前体药物，其制备方法，含该化合物的组合物，使用该化合物的方法。

9. 发明申请

US20060178400A1 Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 审中-公开
标题翻译：新型乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用
公开(公告)号：US20060178400A1
公开(公告)日：2006-08-10
申请号：US11268698
申请日：2005-11-07
申请人： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
发明人： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
IPC分类号： C07D211/68 , A61K31/445
CPC分类号： C07D211/68
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译：本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。

10. 发明申请

US20070219258A1 NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 审中-公开
标题翻译：新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用
公开(公告)号：US20070219258A1
公开(公告)日：2007-09-20
申请号：US11675426
申请日：2007-02-15
申请人： Robert Keyes , Yu Gu , Hing Sham
发明人： Robert Keyes , Yu Gu , Hing Sham
IPC分类号： A61K31/428 , C07D277/62
CPC分类号： C07D277/68 , C07D277/82 , C07D417/12
摘要： The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译：本发明涉及抑制乙酰辅酶A羧化酶（ACC）的式（I）化合物，可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。

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