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1. 发明授权

US08617580B2 Compositions for topical application comprising a peroxide and retinoid 有权
标题翻译：用于局部应用的组合物，其包含过氧化物和类视色素
公开(公告)号：US08617580B2
公开(公告)日：2013-12-31
申请号：US13495701
申请日：2012-06-13
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
IPC分类号： A61Q19/02 , A61P17/10
CPC分类号： A61K9/0014 , A61K9/28 , A61K47/34
摘要： The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
摘要翻译：本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质，所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。

2. 发明授权

US09868103B2 Metal oxide coating of water insoluble ingredients 有权
公开(公告)号：US09868103B2
公开(公告)日：2018-01-16
申请号：US11997823
申请日：2006-08-02
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov
IPC分类号： A01N25/28 , A01N31/00 , A01N47/10 , A01N53/02 , A01N57/00 , A01P13/00 , A01P3/00 , A01P7/00 , A61K31/12 , A61K31/203 , A61K31/66 , A61K8/02 , A61K9/50 , B01J13/22 , A01N25/26 , A61K8/11 , A61K9/16 , A61Q19/00 , B01J13/02
CPC分类号： B01J13/22 , A01N25/26 , A61K8/11 , A61K9/1676 , A61K9/5078 , A61K2800/412 , A61K2800/434 , A61K2800/57 , A61Q19/00 , B01J13/02 , A01N51/00 , A01N53/00
摘要： The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer. The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.

3. 发明申请

US20100047357A1 COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING A PEROXIDE AND RETINOID 审中-公开
标题翻译：用于包含过氧化物和再生物的局部应用的组合物
公开(公告)号：US20100047357A1
公开(公告)日：2010-02-25
申请号：US12525329
申请日：2008-02-03
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
IPC分类号： A61K9/14 , A61K31/327 , A61K31/202 , A61K31/192 , A61K31/4436 , A61P17/00 , A61P17/06 , A61P17/10
CPC分类号： A61K9/0014 , A61K9/28 , A61K47/34
摘要： The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
摘要翻译：本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质，所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。

4. 发明授权

US10688462B2 Microcapsules comprising active ingredients and a metal oxide shell, a method for their preparation and uses thereof 有权
公开(公告)号：US10688462B2
公开(公告)日：2020-06-23
申请号：US13056952
申请日：2009-08-02
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Raed Abu-Reziq
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Raed Abu-Reziq
IPC分类号： B01J13/14 , A61K8/28 , A61K8/25 , A61K8/27 , A01N25/28 , A61K8/29 , A61K8/11 , A61Q19/00
摘要： The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.

5. 发明申请

US20110177951A1 MICROCAPSULES COMPRISING ACTIVE INGREDIENTS AND A METAL OXIDE SHELL, A METHOD FOR THEIR PREPARATION AND USES THEREOF 审中-公开
标题翻译：包含活性成分和金属氧化物壳的微球，其制备方法及其用途
公开(公告)号：US20110177951A1
公开(公告)日：2011-07-21
申请号：US13056952
申请日：2009-08-02
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Raed Abu-Reziq
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Raed Abu-Reziq
IPC分类号： A01N37/22 , A61K9/50 , A61K8/11 , A61K31/327 , A61K31/07 , A01N25/08 , A01P3/00 , A01P7/04 , A61P17/06 , A61P17/04 , A61P17/10 , A61P17/08 , A61P17/00 , A61P31/10 , A61P31/04 , A61P29/00 , A61Q19/00 , A01P13/00 , B82Y5/00
摘要： The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.
摘要翻译：本发明提供一种制备微胶囊的方法，其包含由金属氧化物壳包封的芯材料，由其获得的微胶囊及其用途。

6. 发明申请

US20090081262A1 METAL OXIDE COATING OF WATER INSOLUBLE INGREDIENTS 有权
标题翻译：水不溶性成分的金属氧化物涂层
公开(公告)号：US20090081262A1
公开(公告)日：2009-03-26
申请号：US11997823
申请日：2006-08-02
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Hiam Bar-Simantov
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Hiam Bar-Simantov
IPC分类号： A01N25/28 , A61K8/02 , A01N31/00 , A01N53/02 , A01N47/10 , A01N57/00 , A01P3/00 , A01P7/00 , A01P13/00 , A61K31/66 , A61K31/203 , A61K31/12 , A61K9/50
CPC分类号： B01J13/22 , A01N25/26 , A61K8/11 , A61K9/1676 , A61K9/5078 , A61K2800/412 , A61K2800/434 , A61K2800/57 , A61Q19/00 , B01J13/02 , A01N51/00 , A01N53/00
摘要： The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.
摘要翻译：本发明涉及一种用金属氧化物涂覆固体，不溶于水的颗粒物质的方法，包括：（a）将固体不溶于水的颗粒物质与阳离子添加剂接触在水性介质中，以获得具有正ζ电位; （b）通过将金属氧化物盐沉淀到颗粒物质的表面上来涂覆固体不溶于水的颗粒物质，在其上形成金属氧化物层; 和（c）老化所述涂层本发明还涉及通过该方法获得的包覆颗粒物质和包含由金属氧化物层涂覆的固体，水不溶性颗粒物质的组合物，所述颗粒物质是皮肤病学活性剂或农药。本发明还涉及使用包含由金属氧化物层涂覆的固体，水不溶性皮肤病学活性剂的组合物来治疗受试者的表面状况的方法。

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