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1. 发明申请

US20110092525A1 GABAA RECEPTOR MODULATORS 有权
标题翻译： GABAA受体调节剂
公开(公告)号：US20110092525A1
公开(公告)日：2011-04-21
申请号：US12936050
申请日：2009-04-02
申请人： Mogens Nielsen , Tommy Liljefors , Jakob Nilsson , Olov Sterner
发明人： Mogens Nielsen , Tommy Liljefors , Jakob Nilsson , Olov Sterner
IPC分类号： A61K31/519 , C07D471/04 , A61P25/22 , A61P25/08 , A61P25/20 , A61P21/02
CPC分类号： C07D487/04 , A61K31/519
摘要： The resent invention relates to novel compounds of the general formula (I) having anxiolytic, anticonvulsant, sedative-hypnotic and myorelaxant conditions as well as anxiogenic, somnolytic and convulsant conditions in mammals, including humans, as GABAA receptor modulator.
摘要翻译：本发明涉及具有抗焦虑药，抗惊厥药，镇静催眠药和嗜酸性症状的通式（I）的新化合物以及作为GABA A受体调节剂的哺乳动物（包括人）中的焦虑症，嗜酸性和惊厥症状。

2. 发明申请

US20110105553A1 NEW CLASSES OF GABAA/BZR LIGANDS 有权
标题翻译： GABAA / BZR配偶的新类别
公开(公告)号：US20110105553A1
公开(公告)日：2011-05-05
申请号：US12936045
申请日：2009-04-02
申请人： Mogens Nielsen , Tommy Liljefors , Jakob Nilsson , Olov Sterner
发明人： Mogens Nielsen , Tommy Liljefors , Jakob Nilsson , Olov Sterner
IPC分类号： A61K31/437 , C07D513/04 , C07D498/04 , A61P25/22 , A61P25/08 , A61P25/20 , A61P21/02
CPC分类号： C07D498/04 , C07D513/04
摘要： The present invention relates to novel GABAA/BzR ligands of the general formulas (I), (II) and (III) wherein R1 is selected from the group consisting of hydrogen, halogen, haloalkyl having 1-2 carbon atoms, alkoxy having 1 to 3 carbon atoms in the alkyl chain, alkyl having 1 to 3 carbon atoms, and nitro, and R2 is selected from the group consisting of hydrogen, halogen and alkyl having 1 to 2 carbon atoms, as well as the use of these compounds for treating anxiolytic, anticonvulsant, sedative-hypnotic and myorelaxant conditions as well as anxiogenic, somnolytic and convulsant conditions in mammals including pharmaceutical compositions comprising the same
摘要翻译：本发明涉及通式（I），（II）和（III）的新型GABAA / BzR配体，其中R 1选自氢，卤素，具有1-2个碳原子的卤代烷基，具有1至烷基链中的3个碳原子，具有1至3个碳原子的烷基和硝基，R 2选自氢，卤素和具有1至2个碳原子的烷基，以及这些化合物用于处理抗焦虑药，抗惊厥药，镇静催眠药和促神经痛药，以及哺乳动物的焦虑症，嗜酸性和惊厥症状，包括含有它们的药物组合物

3. 发明授权

US5803351A Method of detecting incorrectly closed freezing frame liners, and a liner and a system therefor 失效
标题翻译：检测不正确闭合的冷冻框架衬里的方法，以及衬管及其系统
公开(公告)号：US5803351A
公开(公告)日：1998-09-08
申请号：US776017
申请日：1997-01-17
申请人： Mogens Nielsen
发明人： Mogens Nielsen
IPC分类号： B65B57/02 , B65D79/02 , B65D5/42
CPC分类号： B65B57/02 , B65D79/02
摘要： Carton liners are used in freezing frames for the preparation of large frozen blocks of fresh food material, e.g. fish fillets. The liners have a lid with skirt flaps to be closed upon filling of the liner, and care should be taken that the lid flaps be located at the outsides of the liner walls inside the freezing frame, as they may otherwise be embedded in the material to be frozen and thus disturb the regularity of the frozen block material. The same applies to corner flaps which, already by the mounting of the liner, should be folded to assume an exterior position. According to the invention, in order to ascertain a correct mounting and closing of the liners once they have been removed from the freezing frames, such liners are used which are provided with printed marking on those outside area portions that are to be covered by exterior liner/lid flaps, and the closed liners are inspected for detection of any visible marking, which will be indicative of a potentially defect block product.
摘要翻译： PCT No.PCT / DK95 / 00311 Sec。 371日期1997年1月17日 102（e）日期1997年1月17日PCT提交1995年7月19日PCT公布。出版物WO96 / 0242200 日期1996年2月1日公司内衬用于冷冻框架，用于制备大型新鲜食品的冷冻块，例如鱼片。衬垫具有带有裙板的盖子，以在填充衬垫时封闭，并且应注意盖子盖片位于冷冻框架内的衬里壁的外侧，否则可能将其盖在材料中被冻结，从而扰乱了冻结块料的规律性。同样适用于已经通过衬垫的安装的角襟翼应该被折叠以呈现外部位置的角襟翼。根据本发明，为了确定衬垫一旦从冷冻框架中取出就正确地安装和封闭衬垫，使用这样的衬垫，其在被外衬层覆盖的那些外部区域部分上设置有印刷标记 /盖板，并且检查封闭衬垫以检测任何可见的标记，这将指示潜在的缺陷块产品。

4. 发明授权

US07991737B2 Synchronization of records of a table using bookmarks 有权
标题翻译：使用书签同步记录表
公开(公告)号：US07991737B2
公开(公告)日：2011-08-02
申请号：US12204703
申请日：2008-09-04
申请人： Mogens Nielsen , Tsvi M. Reiter , Julia Lisovaya , Oliver Morrison
发明人： Mogens Nielsen , Tsvi M. Reiter , Julia Lisovaya , Oliver Morrison
IPC分类号： G06F7/00 , G06F17/00
CPC分类号： G06F17/30306
摘要： A method and system for controlling an application server in order to provide application services to clients while maintaining synchronization between records of tables of a database server. An application server retrieves records of tables and stores them locally on the application server. When a client requests some fields of a record of a table, the application server generates a bookmark that uniquely identifies the record. The bookmark may contain a table identifier and a record identifier or a query identification and an identifier of a record within the query result. The bookmark is opaque to the client and only the application server need know how to interpret its contents. When the application server provides the requested fields of the record to the client, it also provides the record bookmark to the client. When the client wants to identify the record, it uses the bookmark provided by the application server.
摘要翻译：一种用于控制应用服务器的方法和系统，以便在维护数据库服务器的表的记录之间的同步的同时向客户端提供应用服务。应用程序服务器检索表的记录，并将其存储在应用程序服务器上。当客户端请求表的记录的某些字段时，应用服务器生成唯一标识记录的书签。书签可以包含查询结果中的表标识符和记录标识符或查询标识和记录的标识符。书签对客户端是不透明的，只有应用服务器需要知道如何解释其内容。当应用服务器向客户端提供记录的请求字段时，它还向客户端提供记录书签。当客户端想要识别记录时，它使用应用服务器提供的书签。

5. 发明申请

US20100057689A1 SYNCHRONIZATION OF RECORDS OF A TABLE USING BOOKMARKS 有权
标题翻译：使用书签记录表的同步
公开(公告)号：US20100057689A1
公开(公告)日：2010-03-04
申请号：US12204703
申请日：2008-09-04
申请人： Mogens Nielsen , Tsvi M. Reiter , Julia Lisovaya , Oliver Morisson
发明人： Mogens Nielsen , Tsvi M. Reiter , Julia Lisovaya , Oliver Morisson
IPC分类号： G06F7/10 , G06F17/30
CPC分类号： G06F17/30306
摘要： A method and system for controlling an application server in order to provide application services to clients while maintaining synchronization between records of tables of a database server. An application server retrieves records of tables and stores them locally on the application server. When a client requests some fields of a record of a table, the application server generates a bookmark that uniquely identifies the record. The bookmark may contain a table identifier and a record identifier or a query identification and an identifier of a record within the query result. The bookmark is opaque to the client and only the application server need know how to interpret its contents. When the application server provides the requested fields of the record to the client, it also provides the record bookmark to the client. When the client wants to identify the record, it uses the bookmark provided by the application server.
摘要翻译：一种用于控制应用服务器的方法和系统，以便在维护数据库服务器的表的记录之间的同步的同时向客户端提供应用服务。应用程序服务器检索表的记录，并将其存储在应用程序服务器上。当客户端请求表的记录的某些字段时，应用服务器生成唯一标识记录的书签。书签可以包含查询结果中的表标识符和记录标识符或查询标识和记录的标识符。书签对客户端是不透明的，只有应用服务器需要知道如何解释其内容。当应用服务器向客户端提供记录的请求字段时，它还向客户端提供记录书签。当客户端想要识别记录时，它使用应用服务器提供的书签。

6. 发明授权

US6065602A Method and a block carton blank for the lining of freezing frames 失效
标题翻译：冷冻框架衬里的方法和块纸箱
公开(公告)号：US6065602A
公开(公告)日：2000-05-23
申请号：US209
申请日：1998-02-04
申请人： Mogens Nielsen
发明人： Mogens Nielsen
IPC分类号： B65B43/26 , A23B4/06 , A23L3/36 , B31B1/74 , B65B57/02 , B65D5/20 , B65D5/28 , B65D5/42 , B65D5/66 , F25C1/22 , B65D85/00
CPC分类号： A23B4/068 , A23L3/364 , B65D5/28 , B65D5/4216 , B65D5/6664 , F25C1/22
摘要： When placing block carton linings in freezing frames it is important that the existing corner flaps (20, 27) on the carton insertion are placed externally on the adjoining side panels (8), so that they cannot be frozen when sticking into the material filled into the lined freezing frame. During a fast mounting of the block carton it may be difficult to perceive whether these corner flaps are placed inwardly or outwardly of the adjoining carton sides, since they visibly will become indistinguishable in relation to the surroundings. By the invention this will be changed, so that the inwardly facing sides of the corner flaps (20, 27) are made with a surface characteristic, e.g. a distinct signal colour, which is deviating in such a way from the outlook of the rest of the inside of the carton, that a faulty placing of the corner flaps will be discovered instantly by sight.
摘要翻译： PCT No.PCT / DK96 / 00335 Sec。 371日期：1998年2月4日 102（e）日期1998年2月4日PCT提交1996年8月5日PCT公布。出版物WO97 / 06064 日期1997年2月20日当将盒装纸箱放在冷冻框架中时，将纸箱插入件上现有的角襟翼（20,27）放置在相邻的侧板（8）外部是非常重要的，以致它们在粘贴时不能被冻结进入填充到衬里的冷冻框架中的材料。在块箱的快速安装期间，可能难以察觉这些角襟翼是否被放置在邻接的纸箱侧面的内侧或外侧，因为它们明显地将相对于周围环境变得难以区分。通过本发明，这将被改变，使得角襟翼（20,27）的向内的侧面被制成具有表面特征，例如，一种独特的信号颜色，以这种方式偏离纸箱内部其余部分的外观，可以通过视觉立即发现角襟翼的错误放置。

7. 发明授权

US09476888B2 Method and antibodies for the identification of ubiquitinated proteins and sites of ubiquitination 有权
标题翻译：用于鉴定泛素化蛋白质和泛素化位点的方法和抗体
公开(公告)号：US09476888B2
公开(公告)日：2016-10-25
申请号：US14237626
申请日：2012-07-31
申请人： Blagoy Blagoev , Jens Vanselow , Vyacheslav Akimov , Mogens Nielsen
发明人： Blagoy Blagoev , Jens Vanselow , Vyacheslav Akimov , Mogens Nielsen
IPC分类号： G01N33/68 , C07K7/08 , C07K16/18
CPC分类号： G01N33/6854 , C07K7/08 , C07K16/18 , C07K2317/34 , G01N33/6842 , G01N2440/36
摘要： There is provided antibodies, epitopes and methods for detecting ubiquitinated polypeptides and ubiquitination sites in proteins. The antibodies recognize a fragment of ubiquitin that is created after samples are treated with the proteoloytical enzyme LysC (or LysN).
摘要翻译：提供了用于检测泛素化多肽和蛋白质中泛素化位点的抗体，表位和方法。抗体识别在用蛋白质合成酶LysC（或LysN）处理样品后产生的泛素片段。

8. 发明申请

US20070281925A1 USE OF SERTINDOLE FOR THE PREVENTIVE TREATMENT OF SUICIDAL BEHAVIOUR 审中-公开
标题翻译：使用SERTINDOLE预防性治疗行为
公开(公告)号：US20070281925A1
公开(公告)日：2007-12-06
申请号：US11756100
申请日：2007-05-31
申请人： Mogens Nielsen , Mondher Toumi , Anders Pedersen
发明人： Mogens Nielsen , Mondher Toumi , Anders Pedersen
IPC分类号： A61K31/551 , A61K31/519 , A61K31/405
CPC分类号： A61K31/454
摘要： The present invention relates to the use of sertindole in the preparation of a pharmaceutical composition for the preventive treatment of suicidal behaviour in human subjects suffering from a psychotic illness such as schizophrenia or schizoaffective psychosis.
摘要翻译：本发明涉及用于制备用于预防精神病如精神分裂症或分裂感染性精神病的人类受试者的自杀行为的药物组合物的用途。

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