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1. 发明授权

US5504097A N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein 失效
标题翻译： N-羟基脲作为5-脂氧合酶抑制剂和低密度脂蛋白的氧化修饰抑制剂
公开(公告)号：US5504097A
公开(公告)日：1996-04-02
申请号：US423061
申请日：1995-04-17
申请人： Michael S. Malamas , James A. Nelson
发明人： Michael S. Malamas , James A. Nelson
IPC分类号： C07D263/32 , C07D277/24 , C07D277/30 , A61K31/42 , A61K31/425
CPC分类号： C07D263/32 , C07D277/24
摘要： This invention relates to compounds having 5-lipoxygenase inhibiting properties and inhibition of oxidative modification of low density lipoprotein which have the formula: ##STR1## wherein: R.sup.1 and R.sup.3 are independently hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, or C.sub.1 -C.sub.6 trifluoroalkoxy;R.sub.2 is hydrogen or methyl;R.sup.4 is hydrogen, methyl or hydroxy;R.sup.5 is hydrogen, --NH.sub.2, C.sub.1 -C.sub.6 alkyl, aryl, aralkyl, or --N.dbd.C(CH.sub.3).sub.2 ;X and Y are independently O or S; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. Compounds which inhibit 5-lipoxygenase are useful in the treatment of diseases mediated by leukotrienes such as inflammation or bronchoconstriction. Compounds which inhibit oxidative metabolism of low density lipoprotein are useful in the inhibition of atherosclerotic plaque formation.
摘要翻译：本发明涉及具有5-脂氧合酶抑制性质和抑制低密度脂蛋白氧化修饰的化合物，其具有下式：其中：R 1和R 3独立地是氢，卤素，C 1 -C 6烷基，C 1 -C 1-6烷氧基，三氟甲基或C 1 -C 6三氟烷氧基; R2是氢或甲基; R4是氢，甲基或羟基; R5是氢，-NH2，C1-C6烷基，芳基，芳烷基或-N = C（CH3）2; X和Y独立地为O或S; 并且n为0或1; 或其药学上可接受的盐。抑制5-脂氧合酶的化合物可用于治疗由白细胞三烯介导的疾病，例如炎症或支气管收缩。抑制低密度脂蛋白氧化代谢的化合物可用于抑制动脉粥样硬化斑块形成。

2. 发明授权

US5468760A Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein 失效
标题翻译：芳烷基-N-羟基脲作为5-脂氧合酶的抑制剂和低密度脂蛋白氧化
公开(公告)号：US5468760A
公开(公告)日：1995-11-21
申请号：US148474
申请日：1993-11-08
申请人： Michael S. Malamas , James A. Nelson
发明人： Michael S. Malamas , James A. Nelson
IPC分类号： A61K31/421 , A61K31/42
CPC分类号： A61K31/421
摘要： This invention relates to compounds compounds useful in treating diseases mediated by one or more leukotrienes or oxidative modification of low density lipoprotein such as inflammation, bronchoconstriction or atherosclerosis. The compounds of this invention have the formula: ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, fluorine, chlorine, bromine, iodine, C.sub.1 -C.sub.6 alkyl, trifluoromethyl, C.sub.1 -C.sub.6 alkoxy, or C.sub.1 -C.sub.6 trifluoroalkoxy; R.sup.2 and R.sup.4 are hydrogen or methyl independently;R.sup.5 is hydrogen, methyl or hydroxy;X and Z are independently oxygen or sulfur;andY is --CH.sub.2 --, --CH(CH.sub.3)--, or --CH.dbd.CHCH(CH.sub.3)--.
摘要翻译：本发明涉及可用于治疗由一种或多种白细胞三烯介导的疾病或低密度脂蛋白氧化修饰如炎症，支气管收缩或动脉粥样硬化的化合物化合物。本发明化合物具有下式：其中R 1和R 3独立地是氢，氟，氯，溴，碘，C 1 -C 6烷基，三氟甲基，C 1 -C 6烷氧基或C 1 -C 6三氟烷氧基; R2和R4独立地为氢或甲基; R5是氢，甲基或羟基; X和Z独立地是氧或硫; 并且Y是-CH 2 - ， - CH（CH 3） - 或-CH = CHCH（CH 3） - 。

3. 发明授权

US5459154A N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein 失效
标题翻译： N-羟基脲作为5-脂氧合酶抑制剂和低密度脂蛋白的氧化修饰抑制剂
公开(公告)号：US5459154A
公开(公告)日：1995-10-17
申请号：US148603
申请日：1993-11-08
申请人： Michael S. Malamas , James A. Nelson
发明人： Michael S. Malamas , James A. Nelson
IPC分类号： C07D263/32 , C07D277/24 , C07D277/30 , A61K31/42 , A61K31/425
CPC分类号： C07D263/32 , C07D277/24
摘要： This invention relates to compounds having 5-lipoxygenase inhibiting properties and inhibition of oxidative modification of low density lipoprotein which have the formula: ##STR1## wherein: R.sup.1 and R.sup.3 are independently hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, or C.sub.1 -C.sub.6 trifluoroalkoxy;R.sub.2 is hydrogen or methyl;R.sup.4 is hydrogen, methyl or hydroxy;R.sup.5 is hydrogen, --NH.sub.2, C.sub.1 -C.sub.6 alkyl, aryl, aralkyl, or --N.dbd.C(CH.sub.3).sub.2 ;X and Y are independently O or S;and n is 0 or 1; or a pharmaceutically acceptable salt thereof.Compounds which inhibit 5-lipoxygenase are useful in the treatment of diseases mediated by leukotrienes such as inflammation or bronchoconstriction. Compounds which inhibit oxidative metabolism of low density lipoprotein are useful in the inhibition of atherosclerotic plaque formation.
摘要翻译：本发明涉及具有5-脂氧合酶抑制性质和抑制低密度脂蛋白氧化修饰的化合物，其具有下式：其中：R1和R3独立地是氢，卤素，C1-C6烷基，C1-C6烷氧基，三氟甲基，或C 1 -C 6三氟烷氧基; R2是氢或甲基; R4是氢，甲基或羟基; R5是氢，-NH2，C1-C6烷基，芳基，芳烷基或-N = C（CH3）2; X和Y独立地为O或S; 并且n为0或1; 或其药学上可接受的盐。抑制5-脂氧合酶的化合物可用于治疗由白细胞三烯介导的疾病，例如炎症或支气管收缩。抑制低密度脂蛋白氧化代谢的化合物可用于抑制动脉粥样硬化斑块形成。

4. 发明授权

US10472886B2 Micro gap roller shade system and method of installation 有权
公开(公告)号：US10472886B2
公开(公告)日：2019-11-12
申请号：US15721515
申请日：2017-09-29
申请人： James A. Nelson
发明人： James A. Nelson
IPC分类号： E06B9/42 , E06B9/44 , E06B9/72
摘要： The invention is a roller shade tube assembly with a main housing having a lumen divided into two sections by an internal spring stop. The distal end of the main housing has a recessed mounting cavity coupleable to a motor. The proximal end of the main housing has one or more interlocking fingers. A spring inside the proximal lumen abuts the spring stop. An inner guide cylinder is coupled to slide inside the main housing against the spring and coupled to a lumen of an auxiliary housing that is movably coupled to the main housing. The distal end of the auxiliary housing includes one or more complementary interlocking fingers and a second recessed mounting cavity at its proximal end. Wall mounting brackets on each side of the tube assembly are configured to fit into the recessed mounting cavities. A shade fabric is coupled to the roller shade tube assembly.

5. 发明授权

US5071988A Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives 失效
标题翻译：取代的苯甲酰基苯，联苯基和2-恶唑烷酸衍生物
公开(公告)号：US5071988A
公开(公告)日：1991-12-10
申请号：US661734
申请日：1991-02-27
申请人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah
发明人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah
IPC分类号： C07C45/00 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07C205/45 , C07C255/40 , C07D215/14 , C07D263/32 , C07D413/12
CPC分类号： C07D413/10 , C07C205/45 , C07C255/40 , C07C45/004 , C07C45/63 , C07C45/72 , C07C59/90 , C07C69/738 , C07D215/14 , C07D263/32
摘要： There are disclosed compounds of the formulaA(CH.sub.2).sub.n O--BwhereinA is ##STR1## n is 1-2; B is ##STR2## wherein R.sup.4 and R.sup.5 are each, independently, hydrogen or lower alkyl;R.sup.6 is hydrogen, halo or nitro; ##STR3## R.sup.8 is lower alkyl; m is 0-3;and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated nasobronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
摘要翻译：公开了式A（CH 2）n O-B的化合物，其中A是n是1-2; B是，其中R 4和R 5各自独立地是氢或低级烷基; R6是氢，卤素或硝基; R8是低级烷基; m为0-3; 及其药理学上可接受的盐及其在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应中的用途; 治疗白三烯介导的鼻支气管阻塞性通气条件如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。

6. 再颁专利

USRE33334E Vehicle wash and dryer 失效
标题翻译：洗车和烘干机
公开(公告)号：USRE33334E
公开(公告)日：1990-09-18
申请号：US259339
申请日：1988-10-18
申请人： James A. Nelson
发明人： James A. Nelson
IPC分类号： B60S3/00 , B60S3/06
CPC分类号： B60S3/002 , B60S3/06
摘要： An apparatus for both washing and drying an automotive vehicle. The apparatus includes a track gantry that moves along the track and over the vehicle. Water outlets and brushes are on the gantry to wash the car. The apparatus further includes a blower, nozzle, and oscillator. The blower, also mounted on the gantry, expels air onto the vehicle. The nozzle, positioned on the blower, defines an orientation and directs the air from the blower substantially parallel to the orientation. The oscillator periodically changes the orientation of the nozzle and the direction of the air from the blower.

7. 发明授权

US4685169A Vehicle wash and dryer 失效
标题翻译：洗车和烘干机
公开(公告)号：US4685169A
公开(公告)日：1987-08-11
申请号：US769666
申请日：1985-08-26
申请人： James A. Nelson
发明人： James A. Nelson
IPC分类号： B60S3/00 , B60S3/06
CPC分类号： B60S3/002 , B60S3/06 , Y10S15/02
摘要： An apparatus for both washing and drying an automotive vehicle. The apparatus includes a track gantry that moves along the track and over the vehicle. Water outlets and brushes are on the gantry to wash the car. The apparatus further includes a blower, nozzle, and oscillator. The blower, also mounted on the gantry, expels air onto the vehicle. The nozzle, positioned on the blower, defines an orientation and directs the air from the blower substantially parallel to the orientation. The oscillator periodically changes the orientation of the nozzle and the direction of the air from the blower.
摘要翻译：一种用于洗涤和干燥机动车辆的装置。该装置包括沿轨道和车辆上方移动的轨道台架。龙门架上的出水口和刷子都要洗车。该装置还包括鼓风机，喷嘴和振荡器。也安装在龙门架上的鼓风机将空气排出到车辆上。定位在鼓风机上的喷嘴限定了取向，并将来自鼓风机的空气基本上平行于取向引导。振荡器周期性地改变喷嘴的方向和来自鼓风机的空气的方向。

8. 发明授权

US4553960A Peritoneal fluid treatment apparatus, package and method 失效
公开(公告)号：US4553960A
公开(公告)日：1985-11-19
申请号：US632956
申请日：1984-07-20
申请人： Harrison Lazarus , James A. Nelson
发明人： Harrison Lazarus , James A. Nelson
IPC分类号： A61B17/34 , A61B19/02 , A61M25/01 , A61M5/00
CPC分类号： A61B17/3415 , A61B50/33 , A61M25/0111
摘要： The cannula of a conventional intravascular catheter is placed into the peritoneal cavity through a small shallow incision in antiseptically prepared skin. The stylet or trocar of the conventional catheter is removed; and a stainless steel elongated flexible guide is inserted through the catheter's cannula into the peritoneal cavity. The catheter's cannula is removed and a flexible elongated cannula inserted into the cavity over the guide and secured in place with a suture. Fluid operation means is connected to the elongated cannula by connector means to permit fluid treatment after removal of the guide. Apparatus to effect peritoneal fluid treatment are placed in sterile openable sealed packages for storage and transport.

9. 发明授权

US4479792A Peritoneal fluid treatment apparatus, package and method 失效
标题翻译：腹膜液治疗仪，包装及方法
公开(公告)号：US4479792A
公开(公告)日：1984-10-30
申请号：US423034
申请日：1982-09-24
申请人： Harrison Lazarus , James A. Nelson
发明人： Harrison Lazarus , James A. Nelson
IPC分类号： A61B17/34 , A61B19/02 , A61M25/01 , A61M25/00
CPC分类号： A61B17/3415 , A61B50/33 , A61M25/0111
摘要： The cannula of a conventional intravascular catheter is placed into the peritoneal cavity through a small shallow incision in antiseptically prepared skin. The stylet or trocar of the conventional catheter is removed; and a stainless steel elongated flexible guide is inserted through the catheter's cannula into the peritoneal cavity. The catheter's cannula is removed and a flexible elongated cannula inserted into the cavity over the guide and secured in place with a suture. Fluid operation means is connected to the elongated cannula by connector means to permit fluid treatment after removal of the guide. Apparatus to effect peritoneal fluid treatment are placed in sterile openable sealed packages for storage and transport.
摘要翻译：常规血管内导管的插管通过在防腐剂制备的皮肤中的小的浅切口放入腹腔。去除常规导管的探针或套管针; 并且将不锈钢细长的柔性引导件穿过导管的插管插入腹膜腔中。去除导管的套管，并将柔性细长插管插入引导件上的空腔中并用缝合线固定在适当位置。流体操作装置通过连接器装置连接到细长插管，以在移除引导件之后允许流体处理。用于进行腹膜液处理的装置放置在用于储存和运输的无菌可打开的密封包装中。

10. 发明授权

US06374670B1 Non-invasive gut motility monitor 失效
标题翻译：非侵入性肠动力监测仪
公开(公告)号：US06374670B1
公开(公告)日：2002-04-23
申请号：US08402872
申请日：1995-03-13
申请人： Francis A. Spelman , Page Read , N. Mani Prakash , James A. Nelson , Charles E. Pope , Margaret Heitkemper , James D. Rothermel
发明人： Francis A. Spelman , Page Read , N. Mani Prakash , James A. Nelson , Charles E. Pope , Margaret Heitkemper , James D. Rothermel
IPC分类号： A61B522
CPC分类号： A61B5/42 , A61B5/0031 , A61B5/06 , A61B5/062
摘要： An apparatus (4) and method of non-invasive monitoring of gut motility. An ingestible magnet (10, M) is swallowed by the patient (12) and then linear and rotational movement is directionally detected by an external compass (14, 16). In preferred form, movements of the magnet (10, M) are recorded by a memory means (18) and graphically presented (20) over a period of predetermined time. An alternate embodiment includes multiple compasses (C1, C2) for directionally locating the magnet (10, M) within the patient (12).
摘要翻译：一种无创性监测肠道运动的装置（4）和方法。可摄入的磁体（10，M）被患者（12）吞咽，然后线性和旋转运动由外部指南针（14,16）定向检测。在优选形式中，磁体（10，M）的移动由存储装置（18）记录并在预定时间段内以图形方式呈现（20）。替代实施例包括用于将患者（12）内的磁体（10，M）定向定位的多个罗盘（C1，C2）。

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