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1. 发明授权

US09566454B2 Method and sysem for non-ablative acne treatment and prevention 有权
标题翻译：非烧蚀性痤疮治疗和预防的方法和系统
公开(公告)号：US09566454B2
公开(公告)日：2017-02-14
申请号：US11738682
申请日：2007-04-23
申请人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
发明人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
IPC分类号： A61N7/02 , A61B17/00 , A61B17/22 , A61B18/00 , A61N7/00 , A61B8/00 , A61M37/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B2017/00747 , A61B2017/22008 , A61B2018/00666 , A61M37/0092 , A61N7/00 , A61N2007/0008 , A61N2007/0078
摘要： A method and system for non-ablative acne treatment and prevention is disclosed. The method utilizes ultrasound energy which is targeted at a region of interest to treat existing acne and prevent future acne from forming. The application of ultrasound energy causes numerous physiological effects that treat acne. Some of these physiological effects comprise reducing sebum, increasing perfusion at the region of interest, denaturing proteins at the region of interest, creating an uninhabitable environment at the region of interest, initiating programmed cell death at the region of interest and the initiation of mechanical effects at the region of interest.
摘要翻译：公开了一种用于非烧蚀性痤疮治疗和预防的方法和系统。该方法利用针对感兴趣区域的超声能量来治疗现有的痤疮并防止将来的痤疮形成。超声能量的应用导致许多治疗痤疮的生理效应。这些生理作用中的一些包括减少皮脂，增加感兴趣区域的灌注，在感兴趣的区域变性蛋白质，在感兴趣的区域产生不适宜的环境，在感兴趣的区域启动程序性细胞死亡并引发机械效应在感兴趣的地区。

2. 发明授权

US09216276B2 Methods and systems for modulating medicants using acoustic energy 有权
标题翻译：使用声能调节药物的方法和系统
公开(公告)号：US09216276B2
公开(公告)日：2015-12-22
申请号：US12116810
申请日：2008-05-07
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61M37/00 , A61N7/00 , A61N7/02 , A61B19/00 , A61B8/00
CPC分类号： A61M37/0092 , A61B8/4281 , A61B2090/378 , A61M2037/0007 , A61M2205/3375 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0043 , A61N2007/0056
摘要： This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
摘要翻译：本发明提供了能够通过使用能量来预测性地破坏膜并机械和热调节细胞和组织来增强药物递送和/或有效性的方法和系统。在示例性实施例中，本文公开的方法和系统能够调制多层组织。在示例性实施例中，能量是声能（例如，超声）。在其它示例性实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流，或声能，电磁能和其他能量的各种组合形式或能量吸收器如冷却。首先通过扩散，循环和/或注射将药物引入感兴趣的区域。用于增强药物递送和/或有效性的示例性系统包括控制系统，探针和显示器或指示器系统。可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

3. 发明授权

US09114247B2 Method and system for ultrasound treatment with a multi-directional transducer 有权
标题翻译：用多向传感器进行超声处理的方法和系统
公开(公告)号：US09114247B2
公开(公告)日：2015-08-25
申请号：US13294004
申请日：2011-11-10
申请人： Peter G. Barthe , Michael H. Slayton
发明人： Peter G. Barthe , Michael H. Slayton
IPC分类号： A61B8/00 , A61N7/02 , A61B17/00 , A61B19/00 , A61N7/00
CPC分类号： A61N7/022 , A61B8/4272 , A61B2017/00084 , A61B2090/378 , A61N2007/0078
摘要： A method and system for ultrasound treatment utilizing a multi-directional transducer to facilitate treatment, such as therapy and/or imaging or other tissue parameter monitoring, in two or more directions. In accordance with an exemplary embodiment, a multi-directional transducer comprises at least two transduction elements configured to provide for ultrasound energy, such as radiation, acoustical energy, heat energy, imaging, positional information and/or tissue parameter monitoring signals in two or more directions. The transduction elements can comprise various materials for providing ultrasound energy or radiation, such as piezoelectric materials, with and without matching layers. In addition, the transduction elements can be configured for substantially uniform, focused and/or defocused radiation patterns, as well as for single, multiple-element and/or multiple-element array configurations. In addition, an exemplary multi-directional transducer can comprise multiple elements, either side by side, stacked or in an array.
摘要翻译：一种利用多向换能器来促进诸如在两个或更多个方向上的治疗和/或成像或其它组织参数监测的治疗的超声治疗的方法和系统。根据示例性实施例，多方向换能器包括至少两个换能元件，所述至少两个换能元件被配置为提供两个或更多个超声波能量，例如辐射，声能，热能，成像，位置信息和/或组织参数监测信号方向。转导元件可以包括用于提供超声能量或辐射的各种材料，例如具有和不具有匹配层的压电材料。此外，转导元件可以被配置为基本上均匀的，聚焦的和/或散焦的辐射图，以及用于单个，多元件和/或多元件阵列配置。此外，示例性多向换能器可以包括多个元件，并排，堆叠或阵列。

4. 发明授权

US09011336B2 Method and system for combined energy therapy profile 有权
标题翻译：联合能量治疗方案和系统
公开(公告)号：US09011336B2
公开(公告)日：2015-04-21
申请号：US12116845
申请日：2008-05-07
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61B8/00 , A61N7/00 , A61N7/02 , A61B18/14 , A61B18/20 , A61B19/00 , A61B17/22
CPC分类号： A61N7/022 , A61B8/4281 , A61B18/14 , A61B18/20 , A61B34/30 , A61B2017/22024 , A61B2017/22028 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0052 , A61N2007/0078
摘要： A method and system for treating tissue with a combined therapy profile is disclosed. In one exemplary embodiment, ultrasound energy is used to treat numerous depths of tissue within a region of interest and the spatial and temporal properties of the ultrasound energy are varied for more effective treatment. The method and system of the present invention are configured to treat all of the tissue from the surface on down and not spare intervening tissue.
摘要翻译：公开了一种用组合治疗方案处理组织的方法和系统。在一个示例性实施例中，使用超声能量来治疗感兴趣区域内的组织的许多深度，并且改变超声能量的空间和时间属性以进行更有效的治疗。本发明的方法和系统被配置为从表面上向下处理所有的组织，而不是备用的中间组织。

5. 发明授权

US08764687B2 Methods and systems for coupling and focusing acoustic energy using a coupler member 有权
标题翻译：使用耦合器部件耦合和聚焦声能的方法和系统
公开(公告)号：US08764687B2
公开(公告)日：2014-07-01
申请号：US12116828
申请日：2008-05-07
申请人： Michael H Slayton , Peter G. Barthe , Paul M. Jaeger
发明人： Michael H Slayton , Peter G. Barthe , Paul M. Jaeger
IPC分类号： A61N7/00
CPC分类号： A61B8/4281 , A61K49/226 , G10K11/02 , G10K11/30
摘要： An exemplary system for coupling acoustic energy using an encapsulated coupler member comprises a display or indicator, a control system, a probe, and a coupler member. This invention provides a coupler member adjustably configured to perform at least one of (i) providing a standoff, (ii) focusing or defocusing energy, and (iii) coupling energy. An exemplary gel coupler member is configured to hold the shape of a lens geometry. In one aspect of the present invention, gel coupler member comprises water, glycerol, and polyvinyl alcohol, and exhibits an increased desiccation time and shelf life when compared to the prior art. The probe can comprise various probe and/or transducer configurations. In an exemplary embodiment, the probe delivers focused, unfocused, and/or defocused ultrasound energy to the region of interest. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
摘要翻译：使用封装的耦合器部件耦合声能的示例性系统包括显示器或指示器，控制系统，探针和耦合器部件。本发明提供一种可调节地配置成执行（i）提供支座，（ii）聚焦或散焦能量和（iii）耦合能量中的至少一个的耦合器部件。示例性的凝胶耦合器构件被配置为保持透镜几何形状。在本发明的一个方面，凝胶偶联剂包含水，甘油和聚乙烯醇，并且与现有技术相比表现出增加的干燥时间和保存期限。探头可以包括各种探头和/或换能器构造。在示例性实施例中，探针将聚焦的，未聚焦的和/或散焦的超声能量传递到感兴趣的区域。可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

6. 发明申请

US20120330222A1 METHODS FOR TREATMENT OF HYPERHIDROSIS 有权
标题翻译：治疗高血压的方法
公开(公告)号：US20120330222A1
公开(公告)日：2012-12-27
申请号：US13603159
申请日：2012-09-04
申请人： Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
发明人： Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
IPC分类号： A61B18/04 , A61M37/00
CPC分类号： A61N7/02 , A61B8/4281 , A61B17/320068 , A61B2018/00005 , A61N7/00 , A61N2007/0004 , A61N2007/0052 , A61N2007/0078
摘要： Methods for ultrasound treatment of hyperhidrosis are provided. Various methods and systems for targeted treatment of sweat glands can be configured in various manners, such as through use of therapy only, therapy and monitoring, imaging and therapy, or therapy, imaging, and monitoring, and/or through use of focused, unfocused, or defocused ultrasound through control of various spatial and temporal parameters. As a result, thermal and/or ablative energy can be deposited at the particular depth at which the sweat gland population is located below the skin surface. Ultrasound and non-ultrasound treatments for hyperhidrosis are provided.
摘要翻译：提供超声治疗多汗症的方法。用于针对性治疗汗腺的各种方法和系统可以以各种方式配置，例如仅通过使用治疗，治疗和监测，成像和治疗，或治疗，成像和监测，和/或通过使用集中的，未聚焦的，或通过控制各种空间和时间参数来散焦超声波。结果，热汗和/或烧蚀能量可以沉积在汗腺群体位于皮肤表面下方的特定深度处。提供超声和非超声治疗多汗症。

7. 发明申请

US20120197120A1 METHODS FOR TREATMENT OF SWEAT GLANDS 有权
标题翻译：施肥方法
公开(公告)号：US20120197120A1
公开(公告)日：2012-08-02
申请号：US13444485
申请日：2012-04-11
申请人： Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
发明人： Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
IPC分类号： A61M37/00 , A61B8/00
CPC分类号： A61N7/02 , A61B8/4281 , A61B17/320068 , A61B2018/00005 , A61N7/00 , A61N2007/0004 , A61N2007/0052 , A61N2007/0078
摘要： A method and system for ultrasound treatment of sweat glands are provided. An exemplary method and system for targeted treatment of sweat glands can be configured in various manners, such as through use of therapy only, therapy and monitoring, imaging and therapy, or therapy, imaging, and monitoring, and/or through use of focused, unfocused, or defocused ultrasound through control of various spatial and temporal parameters. As a result, ablative energy can be deposited at the particular depth at which the aberrant sweat gland population is located below the skin surface.
摘要翻译：提供了一种用于汗腺超声处理的方法和系统。用于针对性治疗汗腺的示例性方法和系统可以以各种方式配置，例如仅通过使用治疗，治疗和监测，成像和治疗，或治疗，成像和监测，和/或通过使用聚焦，通过控制各种空间和时间参数，不聚焦或散焦超声波。因此，可以在异常汗腺群体位于皮肤表面下方的特定深度沉积烧蚀能量。

8. 发明申请

US20120143056A1 Methods and systems for treating plantar fascia 审中-公开
标题翻译：治疗足底筋膜的方法和系统
公开(公告)号：US20120143056A1
公开(公告)日：2012-06-07
申请号：US13136541
申请日：2011-08-02
申请人： Michael H. Slayton , Peter G. Barthe
发明人： Michael H. Slayton , Peter G. Barthe
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61N7/00 , A61B8/13 , A61B8/14 , A61B8/4254 , A61B8/4272 , A61B8/485 , A61B8/5246 , A61B17/320068 , A61B2018/00642 , A61B2018/00898 , A61B2090/378 , A61N7/02 , A61N2007/0013 , A61N2007/0034 , A61N2007/0052 , A61N2007/006 , A61N2007/0065 , A61N2007/0091 , A61N2007/0095 , A61N2007/027
摘要： Various embodiments, described herein, provide methods and systems for the treatment of plantar fascia. In some embodiments, a method of non-invasive treatment of plantar fasciacan include the steps of identifying a damage location comprising a planter fascia; directing a conformal distribution of ultrasound energy to the plantar fascia at the damage location; creating a plurality of micro lesions in the plantar fascia at the damage location; initiating healing of a plurality of micro tears in the plantar fascia at the damage location; and sparing intervening tissue between the plantar fascia and a surface of a sole of a foot.
摘要翻译：本文所述的各种实施例提供了用于治疗足底筋膜的方法和系统。在一些实施方案中，一种非侵入性治疗足底跖皮的方法包括鉴定包括花坛筋膜的损伤位置的步骤; 将损伤位置处的超声能量的适形分布引导到足底筋膜; 在损伤位置的足底筋膜中产生多个微小损伤; 在损伤位置引发足底筋膜中的多个微小眼泪的愈合; 并且在足底筋膜和足底的表面之间节省介入组织。

9. 发明授权

US08166332B2 Treatment system for enhancing safety of computer peripheral for use with medical devices by isolating host AC power 有权
标题翻译：通过隔离主机交流电源，提高计算机外围设备与医疗设备的安全性的处理系统
公开(公告)号：US08166332B2
公开(公告)日：2012-04-24
申请号：US12509254
申请日：2009-07-24
申请人： Peter G. Barthe , Michael H. Slayton , Vadim Kouklev , Paul M. Jaeger
发明人： Peter G. Barthe , Michael H. Slayton , Vadim Kouklev , Paul M. Jaeger
IPC分类号： G06F1/26
CPC分类号： G06F1/263 , A61B2560/0214 , G06F1/266
摘要： A method and system for enhancing computer peripheral safety is provided. In accordance with various aspects of the present invention, the exemplary method and system are configured to monitor and/or isolate alternating current (A.C.) supplies with and/or from any peripheral subsystems or devices. An exemplary method and system comprises an A.C. supply, a host computer system, and a peripheral subsystem or device connected to the host computer system, such as an ultrasound imaging and/or therapy peripheral, and an isolation subsystem configured for monitoring and/or isolating the A.C. supply from the peripheral subsystem or device. In accordance with an exemplary embodiment, an isolation subsystem comprises application software and associated modules and functions that when executed continuously monitors and/or polls the host computer's hardware and/or operating system for the presence of an isolated source, such as a battery, or an unisolated power source, such as through a battery charger and/or other connection path to the A.C. main supply. In accordance with other exemplary embodiments, an isolation subsystem can comprises a wireless or other safe/isolated electrical link for connecting a patient contact device, and/or a verification link or other verification mechanisms configured between an isolation transformer and host computer to monitor or observe usage to power the host computer and peripheral subsystem.
摘要翻译：提供了一种增强计算机外围安全性的方法和系统。根据本发明的各个方面，示例性方法和系统被配置为监视和/或隔离具有和/或来自任何外围子系统或设备的交流（A.C.）电源。示例性方法和系统包括AC电源，主计算机系统以及连接到主计算机系统的外围子系统或设备，诸如超声成像和/或治疗外围设备，以及被配置用于监测和/或隔离的隔离子系统来自外围子系统或设备的AC电源。根据示例性实施例，隔离子系统包括应用软件和相关联的模块和功能，当执行连续地监视和/或轮询主计算机的硬件和/或操作系统以存在诸如电池的隔离源的存在时，或非隔离电源，例如通过电池充电器和/或到AC主电源的其它连接路径。根据其他示例性实施例，隔离子系统可以包括用于连接患者接触装置的无线或其他安全/隔离的电气连接和/或配置在隔离变压器和主计算机之间的验证链路或其他验证机制以监视或观察用于为主机和外围子系统供电。

10. 发明授权

US07824348B2 System and method for variable depth ultrasound treatment 有权
标题翻译：可变深度超声治疗的系统和方法
公开(公告)号：US07824348B2
公开(公告)日：2010-11-02
申请号：US10944500
申请日：2004-09-16
申请人： Peter G. Barthe , Michael H. Slayton
发明人： Peter G. Barthe , Michael H. Slayton
IPC分类号： A61B17/22
CPC分类号： A61N7/00 , A61B34/30 , A61B2017/22024 , A61B2017/22028 , A61N2007/0065 , A61N2007/0069 , A61N2007/0073 , A61N2007/0095
摘要： A non-invasive variable depth ultrasound treatment method and system comprises a variable depth transducer system configured for providing ultrasound treatment to a patient. An exemplary variable depth transducer system can comprise a transducer configured to provide treatment to more than one region of interest, such as between a deep treatment region of interest and a superficial region of interest, and/or a subcutaneous region of interest. The variable depth transducer can comprise a transduction element having a piezoelectrically active layer, matching layers and/or other materials for generating radiation or acoustical energy. The variable depth transducer may be configured to operate at moderate frequencies within the range from approximately 750 kHz to 20 MHz or more. In addition, the transduction element may be configured with a variable depth device comprising one or more materials configured to allow for control and focusing/defocusing of the acoustic energy to more than one region of interest.
摘要翻译：非侵入性可变深度超声治疗方法和系统包括被配置为向患者提供超声治疗的可变深度换能器系统。示例性可变深度换能器系统可以包括被配置为向多于一个感兴趣的区域提供治疗的换能器，例如感兴趣的深部治疗区域和感兴趣的表面区域和/或感兴趣的皮下区域之间。可变深度换能器可以包括具有压电有源层，匹配层和/或用于产生辐射或声能的其它材料的换能元件。可变深度换能器可以被配置为在大约750kHz至20MHz或更大的范围内的中等频率下操作。另外，换能元件可以配置有可变深度装置，该可变深度装置包括一种或多种材料，其被配置为允许将声能控制和聚焦/散焦到多于一个感兴趣的区域。

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