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1. 发明授权

US09617567B2 Use of sucrose as substrate for fermentative production of 1,2-propanediol 有权
公开(公告)号：US09617567B2
公开(公告)日：2017-04-11
申请号：US14620492
申请日：2015-02-12
申请人： METABOLIC EXPLORER
发明人： Francois Voelker , Rainer Figge , Philippe Soucaille
IPC分类号： C12P7/18
CPC分类号： C12P7/18
摘要： The present invention is relative to a method for producing 1,2-propanediol by fermentation, comprising: cultivating a microorganism producing 1,2-propanediol in an appropriate medium comprising a source of sucrose, and recovering the 1,2-propanediol being produced, wherein the microorganism is able to utilize sucrose as sole carbon source for the production of 1,2-propanediol. In a preferred aspect of the invention, the source of sucrose is obtained from plant biomass, and is in particular sugar cane juice.

2. 发明申请

US20140134680A1 MICROORGANISM FOR METHIONINE PRODUCTION WITH ENHANCED GLUCOSE IMPORT 有权
标题翻译：具有增强葡萄糖进口的甲磺酸生产微生物
公开(公告)号：US20140134680A1
公开(公告)日：2014-05-15
申请号：US14128715
申请日：2012-06-29
申请人： METABOLIC EXPLORER
发明人： Wanda Dischert , Rainer Figge
IPC分类号： C12P13/12
CPC分类号： C12P13/12 , C07K14/245 , C12N9/1205 , Y02P20/52
摘要： The present invention is related to a recombinant microorganism for improved methionine production comprising modifications to produce methionine from glucose as main carbon source by fermentation, and modifications to improve glucose import, wherein the glucose import is improved by modifying the expression of at least one gene selected from ptsG, sgrT sgrS and dgsA.The invention is also related to a method for the fermentative production of methionine or methionine derivatives comprising the steps of: culturing the recombinant microorganism as described above in an appropriate culture medium comprising a fermentable source of carbon containing glucose and a source of sulphur, and recovering methionine or methionine derivatives from the culture medium.
摘要翻译：本发明涉及用于改进甲硫氨酸生产的重组微生物，包括通过发酵从葡萄糖作为主要碳源产生甲硫氨酸的改进，以及改进葡萄糖进口的改进，其中通过修饰所选择的至少一种基因的表达来改善葡萄糖进入来自ptsG，sgrT sgrS和dgsA。本发明还涉及发酵产生甲硫氨酸或甲硫氨酸衍生物的方法，其包括以下步骤：将培养上述重组微生物的培养基包括含可葡萄糖和硫源的可发酵源，并回收甲硫氨酸或甲硫氨酸衍生物。

3. 发明申请

US20140342419A1 MICROORGANISM STRAINS FOR THE PRODUCTION OF 2,3-BUTANEDIOL 审中-公开
标题翻译：用于生产2,3-丁二醇的微生物菌株
公开(公告)号：US20140342419A1
公开(公告)日：2014-11-20
申请号：US14359202
申请日：2012-11-21
申请人： Metabolic Explorer
发明人： Wanda Dischert , Guillaume Letellier , Rainer Figge , Véronique Douchin
IPC分类号： C12P7/18 , C12N9/04
CPC分类号： C12P7/18 , C12N9/0006 , C12N15/52 , C12P7/16 , C12Y101/01001
摘要： The present invention is related to a recombinant microorganism engineered for the production of 2,3-butanediol (BDO), wherein said microorganism overexpresses at least one gene encoding a polypeptide involved in the conversion of pyruvate into 2,3-butanediol. The invention is also related to a method of production of 2,3-butanediol comprising the following steps: providing a recombinant microorganism as described above, cultivating the recombinant microorganism in a culture medium containing a source of carbon, and recovering the 2,3-butanediol.
摘要翻译：本发明涉及用于生产2,3-丁二醇（BDO）的工程改造的重组微生物，其中所述微生物过表达至少一种编码涉及将丙酮酸转化为2,3-丁二醇的多肽的基因。本发明还涉及2,3-丁二醇的生产方法，其包括以下步骤：提供如上所述的重组微生物，在含有碳源的培养基中培养重组微生物，丁二醇。

4. 发明申请

US20130183726A1 METHODS FOR PRODUCING METHIONINE BY CULTURING A MICROORGANISM MODIFIED TO ENHANCE PRODUCTION OF CYSTEINE 审中-公开
标题翻译：通过培养修饰增强CYSTEINE生产的微生物生产甲硫氨酸的方法
公开(公告)号：US20130183726A1
公开(公告)日：2013-07-18
申请号：US13737188
申请日：2013-01-09
申请人： Metabolic Explorer
发明人： Rainer Figge , Fabien Lux , Céline Raynaud , Michel Chateau , Philippe Soucaille
IPC分类号： C12P13/12
CPC分类号： C12P13/12 , C12P13/06
摘要： A method of producing methionine, derivatives or precursors thereof includes culturing a modified microorganism in a culture medium comprising a source of carbon and a source of sulfur; and recovering methionine from the culture medium, wherein said modified microorganism has an increased expression of cysE gene encoding serine acetyltransferase, metH gene encoding methionine synthase and metF gene encoding 5,10-methylenetetrahydrofolate reductase compared to expression of the cysE, metH and metF genes in an unmodified microorganism.
摘要翻译：一种产生甲硫氨酸，其衍生物或前体的方法包括在包含碳源和硫源的培养基中培养修饰的微生物; 并从培养基中回收甲硫氨酸，其中与cysE，metH和metF基因的表达相比，所述修饰的微生物具有增加编码丝氨酸乙酰转移酶的cysE基因的表达，编码甲硫氨酸合成酶的metH基因和编码5,10-亚甲基四氢叶酸还原酶的metF基因未经修饰的微生物。

5. 发明授权

US09187775B2 Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine 有权
标题翻译：通过培养修饰以增强半胱氨酸生产的微生物来生产甲硫氨酸的方法
公开(公告)号：US09187775B2
公开(公告)日：2015-11-17
申请号：US13737188
申请日：2013-01-09
申请人： Metabolic Explorer
发明人： Rainer Figge , Fabien Lux , Céline Raynaud , Michel Chateau , Philippe Soucaille
IPC分类号： C12P13/12 , C12P13/06
CPC分类号： C12P13/12 , C12P13/06
摘要： A method of producing methionine, derivatives or precursors thereof includes culturing a modified microorganism in a culture medium comprising a source of carbon and a source of sulfur; and recovering methionine from the culture medium, wherein said modified microorganism has an increased expression of cysE gene encoding serine acetyltransferase, metH gene encoding methionine synthase and metF gene encoding 5,10-methylenetetrahydrofolate reductase compared to expression of the cysE, metH and metF genes in an unmodified microorganism.
摘要翻译：一种产生甲硫氨酸，其衍生物或前体的方法包括在包含碳源和硫源的培养基中培养修饰的微生物; 并从培养基中回收甲硫氨酸，其中与cysE，metH和metF基因的表达相比，所述修饰的微生物具有增加编码丝氨酸乙酰转移酶的cysE基因的表达，编码甲硫氨酸合成酶的metH基因和编码5,10-亚甲基四氢叶酸还原酶的metF基因未经修饰的微生物。

6. 发明授权

US10858679B2 Increasing methionine yield 有权
公开(公告)号：US10858679B2
公开(公告)日：2020-12-08
申请号：US15043138
申请日：2016-02-12
申请人： METABOLIC EXPLORER
发明人： Rainer Figge , Philippe Soucaille , Guillaume Barbier , Gwénaëlle Bestel-Corre , Cédric Boisart , Michel Chateau
IPC分类号： C12P13/12 , C12N9/80
摘要： Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described.

7. 发明申请

US20150247175A1 Recombinant Microorganism for the Fermentative Production of Methionine 有权
标题翻译：用于发酵甲硫氨酸生产的重组微生物
公开(公告)号：US20150247175A1
公开(公告)日：2015-09-03
申请号：US14408378
申请日：2012-06-18
申请人： Metabolic Explorer
发明人： Wanda Dischert , Rainer Figge
IPC分类号： C12P13/12 , C12N9/10
CPC分类号： C12P13/12 , C12N9/1007 , C12Y201/01014 , Y02P20/52
摘要： The present invention is related to a recombinant microorganism optimised for the fermentative production of methionine, wherein the activity of the cobalamin-independent methionine synthase MetE is attenuated in said microorganism. The invention is also related to a method for producing methionine by fermentation.
摘要翻译：本发明涉及针对甲硫氨酸的发酵生产而优化的重组微生物，其中所述微生物中不含钴胺素的甲硫氨酸合酶MetE的活性减弱。本发明还涉及通过发酵生产甲硫氨酸的方法。

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