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1. 发明申请

US20190175079A1 OPTIONAL SENSOR CALIBRATION IN CONTINUOUS GLUCOSE MONITORING 审中-公开
公开(公告)号：US20190175079A1
公开(公告)日：2019-06-13
申请号：US15840515
申请日：2017-12-13
申请人： MEDTRONIC MINIMED, INC.
发明人： Jeffrey Nishida , Andrea Varsavsky , Taly G. Engel , Keith Nogueira , Andy Y. Tsai , Peter Ajemba
IPC分类号： A61B5/1495 , A61B5/145 , A61B5/1473 , A61B5/00
摘要： A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

2. 发明申请

US20180261315A1 ADAPTIVE SIGNAL PROCESSING FOR INFUSION DEVICES AND RELATED METHODS AND SYSTEMS 审中-公开
公开(公告)号：US20180261315A1
公开(公告)日：2018-09-13
申请号：US15979374
申请日：2018-05-14
申请人： MEDTRONIC MINIMED, INC.
发明人： Keith Nogueira , Pratik Agrawal , Brian T. Kannard , Xiaolong Li , Bradley C. Liang , Rajiv Shah , Yuxiang Zhong
IPC分类号： G16H20/17 , A61M5/172 , G05B15/02 , A61M5/142
CPC分类号： G16H20/17 , A61M5/14244 , A61M5/1723 , A61M2205/3303 , A61M2230/201 , G05B15/02 , G06F19/3468
摘要： Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device involves obtaining a filtered measurement indicative of a physiological condition of a user, determining a metric indicative of a characteristic of the filtered measurement based at least in part on one or more derivative metrics associated with the filtered measurement, and determining an output measurement indicative of the physiological condition of the user based at least in part on the filtered measurement, the metric, and a previous output measurement.

3. 发明授权

US10007765B2 Adaptive signal processing for infusion devices and related methods and systems 有权
公开(公告)号：US10007765B2
公开(公告)日：2018-06-26
申请号：US14281766
申请日：2014-05-19
申请人： MEDTRONIC MINIMED, INC.
发明人： Keith Nogueira , Pratik Agrawal , Brian T. Kannard , Xiaolong Li , Bradley C. Liang , Rajiv Shah , Yuxiang Zhong
IPC分类号： G01N33/48 , G06F19/00 , A61M5/172 , G05B15/02 , A61M5/142 , G06F7/58
CPC分类号： G16H20/17 , A61M5/14244 , A61M5/1723 , A61M2205/3303 , A61M2230/201 , G05B15/02 , G06F19/3468
摘要： Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device involves obtaining a filtered measurement indicative of a physiological condition of a user, determining a metric indicative of a characteristic of the filtered measurement based at least in part on one or more derivative metrics associated with the filtered measurement, and determining an output measurement indicative of the physiological condition of the user based at least in part on the filtered measurement, the metric, and a previous output measurement.

4. 发明申请

US20170049964A1 PERSONALIZED PARAMETER MODELING METHODS AND RELATED DEVICES AND SYSTEMS 审中-公开
标题翻译：个性化参数建模方法及相关设备和系统
公开(公告)号：US20170049964A1
公开(公告)日：2017-02-23
申请号：US15240733
申请日：2016-08-18
申请人： MEDTRONIC MINIMED, INC.
发明人： Andrea Varsavsky , Yunfeng Lu , Keith Nogueira , Jeffrey Nishida
IPC分类号： A61M5/172 , G06F19/00 , A61B5/024 , A61B5/00 , A61B5/145
摘要： Medical devices and related patient management systems and parameter modeling methods are provided. An exemplary method involves obtaining, by a computing device, historical measurements of a condition in a body of the patient previously provided by a sensing device, obtaining, by the computing device, historical operational context information associated with preceding operation of one or more of an infusion device and the sensing device, obtaining, by the computing device, historical values for a parameter from one or more of the infusion device and the sensing device, determining, by the computing device a patient-specific model of the parameter based on relationships between the historical measurements, the historical operational context information and the historical values, and providing, by the computing device via a network, the patient-specific model to one of the infusion device, the sensing device or a client device.
摘要翻译：提供了医疗设备和相关的患者管理系统和参数建模方法。一种示例性方法包括由计算设备获得先前由感测设备提供的患者体内的状况的历史测量，由计算设备获得与先前操作中的一个或多个相关联的历史操作上下文信息输注装置和感测装置，由计算装置获得来自一个或多个输注装置和感测装置的参数的历史值，由计算装置根据患者特定的参数模型，根据历史测量，历史操作上下文信息和历史值，并且由计算设备经由网络将患者特定模型提供给输注设备，感测设备或客户端设备之一。

5. 发明申请

US20150331419A1 GLUCOSE SENSOR HEALTH MONITORING AND RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：葡萄糖传感器健康监测及相关方法与系统
公开(公告)号：US20150331419A1
公开(公告)日：2015-11-19
申请号：US14281773
申请日：2014-05-19
申请人： MEDTRONIC MINIMED, INC.
发明人： Keith Nogueira , Xiaolong Li , Rajiv Shah , Brian T. Kannard
IPC分类号： G05B23/00
CPC分类号： G05B23/00 , A61M5/14244 , A61M5/1723 , A61M2205/70 , A61M2205/702 , A61M2230/201
摘要： Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves determining one or more signal characteristics associated with a subset of the measurements corresponding to a monitoring period, determining a reliability metric for the monitoring period based on the one or more signal characteristics, and providing indication of a maintenance condition when the reliability metric violates a threshold.
摘要翻译：提供输液系统，输液装置和相关操作方法。操作能够向用户输送流体的输注装置的示例性方法包括确定与对应于监测周期的测量的子集相关联的一个或多个信号特征，基于一个或多个信号确定监测周期的可靠性度量特性，并且当可靠性度量违反阈值时提供维护条件的指示。

6. 发明授权

US12114972B2 Methods, systems, and devices for continuous glucose monitoring 有权
公开(公告)号：US12114972B2
公开(公告)日：2024-10-15
申请号：US16773422
申请日：2020-01-27
申请人： MEDTRONIC MINIMED, INC.
发明人： Georgios Mallas , Andrea Varsavsky , Peter Ajemba , Jeffrey Nishida , Keith Nogueira , Elaine Gee , Leonardo Nava-Guerra , Jing Liu , Sadaf S. Seleh , Taly G. Engel , Benyamin Grosman , Steven Lai , Luis A. Torres , Chi A. Tran , David M. Sniecinski
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/14532 , A61B5/1468 , A61B2560/0223 , A61B2562/16
摘要： A continuous glucose monitoring system may utilize electrode current (Isig) signals, Electrochemical Impedance Spectroscopy (EIS), and Vcntr values to optimize sensor glucose (SG) calculation in such a way as to enable reduction of the need for blood glucose (BG) calibration requests from users.

7. 发明申请

US20230017510A1 SENSOR SYSTEMS, DEVICES, AND METHODS FOR CONTINUOUS GLUCOSE MONITORING 有权
公开(公告)号：US20230017510A1
公开(公告)日：2023-01-19
申请号：US17892206
申请日：2022-08-22
申请人： Medtronic MiniMed, Inc.
发明人： Keith Nogueira , Taly G. Engel , Xiaolong Li , Bradley C. Liang , Rajiv Shah , Mike C. Liu , Andy Y. Tsai
IPC分类号： A61B5/1495 , A61B5/00 , A61B5/1486 , A61B5/145 , A61B5/1473 , A61M5/142 , A61M5/172
摘要： Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

8. 发明授权

US11311217B2 Methods, systems, and devices for calibration and optimization of glucose sensors and sensor output 有权
公开(公告)号：US11311217B2
公开(公告)日：2022-04-26
申请号：US16117617
申请日：2018-08-30
申请人： MEDTRONIC MINIMED, INC.
发明人： Peter Ajemba , Keith Nogueira , Brian T. Kannard
IPC分类号： A61B5/1495 , A61B5/145 , A61B5/00 , G06N5/02 , G01N27/02 , A61B5/1468 , A61B5/1455 , A61B5/1486 , G16H50/30 , G16H20/17 , G16H50/70 , G16H40/40 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/11
摘要： A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

9. 发明申请

US20220095964A1 OPTIONAL SENSOR CALIBRATION IN CONTINUOUS GLUCOSE MONITORING 有权
公开(公告)号：US20220095964A1
公开(公告)日：2022-03-31
申请号：US17546112
申请日：2021-12-09
申请人： Medtronic MiniMed, Inc.
发明人： Jeffrey Nishida , Andrea Varsavsky , Taly G. Engel , Keith Nogueira , Andy Y. Tsai , Peter Ajemba
IPC分类号： A61B5/1495 , A61B5/00 , A61B5/1473 , A61B5/145 , G01N27/327
摘要： A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

10. 发明授权

US11213230B2 Optional sensor calibration in continuous glucose monitoring 有权
公开(公告)号：US11213230B2
公开(公告)日：2022-01-04
申请号：US15840515
申请日：2017-12-13
申请人： MEDTRONIC MINIMED, INC.
发明人： Jeffrey Nishida , Andrea Varsavsky , Taly G. Engel , Keith Nogueira , Andy Y. Tsai , Peter Ajemba
IPC分类号： A61B5/1495 , A61B5/00 , A61B5/1473 , A61B5/145 , G01N27/327 , A61M5/172 , A61B5/1486
摘要： A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

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