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1. 发明申请

US20090021746A1 TOMOGRAPHY APPARATUS 审中-公开
公开(公告)号：US20090021746A1
公开(公告)日：2009-01-22
申请号：US11814063
申请日：2006-01-13
申请人： Masahiro Toida , Junji Nishigaki
发明人： Masahiro Toida , Junji Nishigaki
IPC分类号： G01B9/02
CPC分类号： A61B5/0073 , A61B5/0066 , G01N21/4795 , G01N21/6428 , G01N21/6456
摘要： In a tomograpy apparatus: low-coherence laser light is split into measurement light and reference light; the frequency of the reference light is slightly shifted from the frequency of reflected light generated by reflection of the measurement light by a sample; the reference light is optically combined with the reflected light; interference light generated by interference of the reference light with the reflected light when the reference light is combined with the reflected light is detected: fluorescence emitted by excitation of a fluorescent dye or a fluorescent pigment in the sample when the sample is irradiated with the measurement light is detected: a first tomographic image of the sample is formed by the detected interference light, and a second tomographic image of the sample is formed by the detected fluorescence.
摘要翻译：在断层摄影装置中：低相干激光被分为测量光和参考光; 参考光的频率与通过样品的测量光的反射产生的反射光的频率略微偏移; 参考光与反射光光学组合; 检测参考光与反射光组合时参考光与反射光的干涉产生的干涉光：当样品被测量光照射时，通过荧光染料或荧光颜料的激发而发出的荧光检测出：通过检测到的干涉光形成样本的第一断层图像，并且通过检测到的荧光形成样品的第二断层图像。

2. 发明授权

US07924428B2 Optical rotary adaptor and optical tomographic imaging apparatus using the same 失效
标题翻译：光学旋转适配器和使用其的光学断层成像设备
公开(公告)号：US07924428B2
公开(公告)日：2011-04-12
申请号：US12411098
申请日：2009-03-25
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： G01B9/02
CPC分类号： G01B9/02027 , A61B5/0066 , A61B5/6852 , G01B9/02007 , G01B9/0205 , G01B9/02061 , G01B9/02091 , G01J1/0407 , G01J1/0422 , G02B6/32 , G02B6/3604
摘要： An optical rotary adapter is featured by including: a fixed side optical fiber which is fixedly supported by a fixed sleeve and which has an end surface inclined with respect to a plane perpendicular to the optical axis of the optical fiber; a fixed side collimator lens which is arranged to be separated from the inclined end surface of the fixed side optical fiber by a predetermined interval; a rotation side optical fiber which is fixedly supported substantially at the center of a rotatably supported rotary cylinder, which is arranged to face the fixed side collimator lens, and which has an end surface inclined with respect to a plane perpendicular to the optical axis of the fixed side collimator lens; a rotation side collimator lens which is fixedly supported by the rotary cylinder, and which is arranged between the fixed side collimator lens and the rotation side optical fiber so as to be separated from the inclined end surface of the rotation side optical fiber by a predetermined interval; a second luminous flux optical fiber which guides a second luminous flux having a function different from that of a first luminous flux as a measuring light beam to the inside of the fixed sleeve; and a multiplexing device which is provided between the fixed side collimator lens and the rotation side collimator lens, and which multiplexes the first luminous flux with the second luminous flux.
摘要翻译：光学旋转适配器的特征在于包括：固定侧光纤，其固定地由固定的套筒支撑，并且具有相对于垂直于光纤的光轴的平面倾斜的端面; 固定侧准直透镜，其被配置成与固定侧光纤的倾斜端面隔开预定间隔; 旋转侧光纤被固定地支撑在可旋转地支撑的旋转圆筒的中心，所述旋转侧光纤布置成面向固定侧准直透镜，并且具有相对于垂直于所述固定侧准直透镜的光轴倾斜的端面固定侧准直透镜; 旋转侧准直透镜，其由旋转圆筒固定地支撑，并且设置在固定侧准直透镜和旋转侧光纤之间，以与旋转侧光纤的倾斜端面分开预定间隔 ; 第二光束光纤，其将具有与作为测量光束的第一光束的功能不同的功能的第二光束引导到固定套筒的内部; 以及设置在固定侧准直透镜和旋转侧准直透镜之间并将第一光束与第二光束复用的多路复用装置。

3. 发明授权

US06374128B1 Blood vessel imaging system 有权
标题翻译：血管成像系统
公开(公告)号：US06374128B1
公开(公告)日：2002-04-16
申请号：US09444378
申请日：1999-11-22
申请人： Masahiro Toida , Kazuo Hakamata
发明人： Masahiro Toida , Kazuo Hakamata
IPC分类号： A61B500
CPC分类号： A61B5/0261
摘要： A blood vessel imaging system includes a measuring light source which emits a measuring light beam. An optical heterodyne detection system consists of an optical system which splits the measuring light beam into a first light beam traveling to impinge upon an organism and a second light beam traveling not to impinge upon the organism and combines the second light beam with the first beam emanating from the organism into a combined light beam, a frequency shifter which causes the first and second light beams to have frequencies different from each other, and a beat component detector which detects beat components of the combined light beam. A band-pass filter detects, out of the beat component detection signal output from the beat component detector, off-centered components in a frequency band deviated from the center frequency of the beat component detection signal by a predetermined width. An image signal is generated according to whether the off-centered beat signal detected by the band-pass filter is higher or lower than a predetermined threshold level.
摘要翻译：血管成像系统包括发射测量光束的测量光源。光学外差检测系统由光学系统组成，该光学系统将测量光束分成行进以撞击生物体的第一光束和不撞击生物体的第二光束，并将第二光束与发射的第一光束组合从生物体到组合光束，使第一和第二光束彼此具有不同频率的频率移位器，以及检测组合光束的拍子分量的拍子分量检测器。带通滤波器在从拍子分量检测器输出的拍子分量检测信号中检测出偏离了拍子分量检测信号的中心频率的预定宽度的偏心分量。根据由带通滤波器检测到的偏心拍频信号是高于还是低于预定阈值电平来产生图像信号。

4. 发明授权

US5810719A Endoscope 失效
标题翻译：内窥镜
公开(公告)号：US5810719A
公开(公告)日：1998-09-22
申请号：US665640
申请日：1996-06-18
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： A61B1/04 , A61B5/00 , G01B9/02 , G01B9/04
CPC分类号： G01B9/02004 , A61B1/063 , A61B1/07 , A61B5/0084 , A61B5/1459 , G01B9/02003 , G01B9/02007 , G01B9/02028 , G01B9/0205 , G01B9/04 , A61B1/00172 , A61B1/0638 , A61B5/0073 , G01B2290/70
摘要： A deep portion visualizing endoscope comprises a flexible fiber bundle, into which a laser beam produced by a frequency-sweep single frequency laser beam source is entered. The laser beam is irradiated from a radiating end of the fiber bundle to the region inside of a sample to be viewed, and is reflected from reflection planes of the sample. The reflected laser beam interferes with a laser beam, which has been split from the laser beam before being reflected from the reflection planes and which has traveled by a predetermined optical path length, and an image signal is thereby obtained. The image signal is composed of a plurality of difference-frequency beat signals such that the frequencies, at which the signal intensities repeatedly become high and low, may vary in accordance with the difference between depths of the reflection planes from the inner surface of the sample. A beat signal, the intensity of which repeatedly becomes high and low at a predetermined frequency, is then discriminated from the image signal. An image of a reflection plane at a specific depth is reproduced from the discriminated beat signal.
摘要翻译：深部可视化内窥镜包括柔性纤维束，由频率扫描单频激光束源产生的激光束进入该柔性纤维束。激光束从光纤束的辐射端照射到要观察的样品的内部，并从样品的反射面反射。反射的激光束干涉激光束，该激光束在从反射面反射之前已被激光束分离，并且已经以预定的光程长度行进，从而获得图像信号。图像信号由多个差频拍子信号组成，使得信号强度重复变高和低的频率可以根据来自样品的内表面的反射平面的深度之间的差异而变化。然后从图像信号中辨别出以预定频率重复变为高和低的强度的差拍信号。从鉴别的拍子信号再现特定深度的反射平面的图像。

5. 发明申请

US20070019208A1 OPTICAL TOMOGRAPHY APPARATUS 有权
标题翻译：光学摄影装置
公开(公告)号：US20070019208A1
公开(公告)日：2007-01-25
申请号：US11535361
申请日：2006-09-26
申请人： Masahiro Toida , Yoshikatsu Morishima , Kazuhiro Tsujita , Hiroshi Fujita
发明人： Masahiro Toida , Yoshikatsu Morishima , Kazuhiro Tsujita , Hiroshi Fujita
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02004 , A61B5/0066 , A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B5/0086 , G01B9/02003 , G01B9/02014 , G01B9/02044 , G01B9/02091 , G01J3/10 , G01N21/4795
摘要： Low coherence light having a central wavelength λc of 1.1 μm and a full width at half maximum spectrum Δλ of 90 nm is emitted. The low coherence light has wavelength properties suited for the light absorbing properties, the diffusion properties, and the dispersion properties of living tissue. A light dividing means divides the low coherence light into a measuring light beam, which is irradiated onto a measurement target via an optical probe, and a reference light beam that propagates toward an optical path length adjusting means. A multiplexing means multiplexes a reflected light beam, which is the measuring light beam reflected at a predetermined depth of the measurement target, and the reference light beam, to form coherent light. A coherent light detecting means detects the optical intensity of the multiplexed coherent light. An image obtaining means performs image processes, and displays an optical tomographic image on a display apparatus.
摘要翻译：发射具有1.1μm的中心波长lambdac和半峰全宽度的低相干光，发射90nm的Deltalambda。低相干光具有适合于吸光性能，扩散性能和生物体组织的分散性能的波长特性。光分割装置将低相干光分成通过光学探针照射到测量对象上的测量光束和朝向光程长度调节装置传播的参考光束。多路复用装置将作为在测量对象的预定深度处反射的测量光束的反射光和参考光束进行多路复用，以形成相干光。相干光检测装置检测多路复用相干光的光强度。图像获取装置执行图像处理，并在显示装置上显示光学断层图像。

6. 发明授权

US06680779B2 Optical tomograph 失效
标题翻译：光学断层扫描仪
公开(公告)号：US06680779B2
公开(公告)日：2004-01-20
申请号：US09841484
申请日：2001-04-25
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： G01B902
CPC分类号： A61B5/0066 , A61B5/0073 , G01N21/4795
摘要： An optical tomograph obtains a tomogram of an object by dividing a low coherence light beam into a signal light beam and a reference light beam, shifting the frequency of at least one of the signal light beam and the reference light beam so that the signal light beam and the reference light beam becomes different from each other in frequency, causing the signal light beam to impinge upon the object, causing the signal light reflected at a predetermined depth of the object to interfere with the reference light beam, and measuring the intensity of the obtained interference light. A light amplifier amplifies the reflected signal light.
摘要翻译：光学断层摄影仪通过将低相干光束分成信号光束和参考光束来获得对象的断层图像，使信号光束和参考光束中的至少一个的频率移位，使得信号光束并且参考光束在频率上变得彼此不同，导致信号光束撞击物体，使得在物体的预定深度处反射的信号光与参考光束干涉，并且测量获得干涉光。光放大器放大反射信号光。

7. 发明授权

US06618152B2 Optical coherence tomography apparatus using optical-waveguide structure which reduces pulse width of low-coherence light 有权
标题翻译：使用减少低相干光的脉冲宽度的光波导结构的光学相干断层摄影装置
公开(公告)号：US06618152B2
公开(公告)日：2003-09-09
申请号：US09849294
申请日：2001-05-07
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： G01B902
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0073 , G01B9/02003 , G01B9/02014 , G01B9/02091 , G02B6/02085 , G02B6/2861
摘要： In an optical coherence tomography apparatus: low-coherence light from a light source is split into signal light and reference light; at least one of the frequencies of the signal light and the reference light is shifted so as to produce a predetermined frequency difference between the frequencies; the reference light and a portion of the signal light reflected from the object are optically multiplexed so as to produce interference light; and the optical intensity of the interference light is detected in order to obtain a tomographic image of the object. In the light source, the pulse width of pulsed light emitted from a pulsed light source unit is reduced by an optical-waveguide structure. The optical-waveguide structure is made of a material having a normal dispersion characteristic, and includes a structure which realizes an anomalous dispersion characteristic so as to reduce the pulse width of the pulsed light.
摘要翻译：在光学相干断层摄影装置中：来自光源的低相干光被分成信号光和参考光; 信号光和参考光的频率中的至少一个被移动，以产生频率之间的预定频率差; 将参考光和从物体反射的信号光的一部分光学多路复用以产生干涉光; 并且检测干涉光的光强度以获得物体的断层图像。在光源中，通过光波导结构减少从脉冲光源单元发射的脉冲光的脉冲宽度。光波导结构由具有正常色散特性的材料制成，并且包括实现异常色散特性以减小脉冲光的脉冲宽度的结构。

8. 发明授权

US06522911B1 Apparatus for imaging a blood vessel 失效
标题翻译：血管成像装置
公开(公告)号：US06522911B1
公开(公告)日：2003-02-18
申请号：US09444514
申请日：1999-11-22
申请人： Masahiro Toida , Tomoo Sato
发明人： Masahiro Toida , Tomoo Sato
IPC分类号： A61B500
CPC分类号： A61B5/02007 , A61B5/0059
摘要： A first measuring light beam of wavelength &lgr;1 equal to a wavelength at the isosbestic point between oxyhemoglobin and deoxyhemoglobin and a second measuring light beam of wavelength &lgr;2 differing from the first measuring light beam are incident on the same part of a subject such as a human finger and scan the subject by using an X-Y stage movable in X and Y directions. The first measuring light beam branches into two light beams. One of the two light beams is subjected to a frequency shift by a frequency shifter, while the other is transmitted through the subject. Thereafter, the two light beams are synthesized and a beat component of the synthesized first measuring light beam is detected by a first signal detection section. The first signal detection section outputs a first beat-component detection signal. For the second measuring light beam, a second beat-component detection signal is output in the same manner as the first measuring light beam. A personal computer generates an image signal based on a value of the second beat-component detection signal normalized by the first beat-component detection signal.
摘要翻译：波长lambd1的第一测量光束等于在氧合血红蛋白和脱氧血红蛋白之间的等腰点处的波长和与第一测量光束不同的波长lambd2的第二测量光束入射到诸如人的手指的对象的相同部分并通过使用在X和Y方向上可移动的XY台来扫描被摄体。第一测量光束分支成两个光束。两个光束中的一个被变频器进行频移，而另一个被透射通过被摄体。此后，合成两个光束，并且由第一信号检测部检测合成的第一测量光束的拍子分量。第一信号检测部分输出第一拍子分量检测信号。对于第二测量光束，以与第一测量光束相同的方式输出第二拍子分量检测信号。个人计算机基于由第一拍子分量检测信号归一化的第二拍子分量检测信号的值来生成图像信号。

9. 发明授权

US5716324A Endoscope with surface and deep portion imaging systems 失效
标题翻译：具有表面和深部成像系统的内窥镜
公开(公告)号：US5716324A
公开(公告)日：1998-02-10
申请号：US487639
申请日：1995-06-07
申请人： Masahiro Toida
发明人： Masahiro Toida
IPC分类号： A61B1/04 , A61B5/00 , G01B9/02 , G01B9/04
CPC分类号： G01B9/02004 , A61B1/063 , A61B1/07 , A61B5/0084 , A61B5/1459 , G01B9/02003 , G01B9/02007 , G01B9/02028 , G01B9/0205 , G01B9/04 , A61B1/00172 , A61B1/0638 , A61B5/0073 , G01B2290/70
摘要： A deep portion visualizing endoscope comprises a flexible fiber bundle, into which a laser beam produced by a frequency-sweep single frequency laser beam source is entered. The laser beam is irradiated from a radiating end of the fiber bundle to the region inside of a sample to be viewed, and is reflected from reflection planes of the sample. The reflected laser beam interferes with a laser beam, which has been split from the laser beam before being reflected from the reflection planes and which has traveled by a predetermined optical path length, and an image signal is thereby obtained. The image signal is composed of a plurality of difference-frequency beat signals such that the frequencies, at which the signal intensities repeatedly become high and low, may vary in accordance with the difference between depths of the reflection planes from the inner surface of the sample. A beat signal, the intensity of which repeatedly becomes high and low at a predetermined frequency, is then discriminated from the image signal. An image of a reflection plane at a specific depth is reproduced from the discriminated beat signal.
摘要翻译：深部可视化内窥镜包括柔性纤维束，由频率扫描单频激光束源产生的激光束进入该柔性纤维束。激光束从光纤束的辐射端照射到要观察的样品的内部，并从样品的反射面反射。反射的激光束干涉激光束，该激光束在从反射面反射之前已被激光束分离，并且已经以预定的光程长度行进，从而获得图像信号。图像信号由多个差频拍子信号组成，使得信号强度重复变高和低的频率可以根据来自样品的内表面的反射平面的深度之间的差异而变化。然后从图像信号中辨别出以预定频率重复变为高和低的强度的差拍信号。从鉴别的拍子信号再现特定深度的反射平面的图像。

10. 发明授权

US5231464A Highly directional optical system and optical sectional image forming apparatus employing the same 失效
标题翻译：高度方向光学系统和光学部分图像形成装置
公开(公告)号：US5231464A
公开(公告)日：1993-07-27
申请号：US672973
申请日：1991-03-21
申请人： Tsutomu Ichimura , Fumio Inaba , Masahiro Toida
发明人： Tsutomu Ichimura , Fumio Inaba , Masahiro Toida
IPC分类号： A61B5/00 , G01N21/25
CPC分类号： G01N21/255 , A61B5/0059 , A61B5/0068 , G01N2201/08
摘要： A light propagation region is divided into a plurality of subregions, each subregion being limited within a minimum spatial resolution unit where an interference occurs between discrete points, and a 0-order diffraction pattern of a Fraunhofer diffraction image is detected If a convex lens and either a pinhole or an optical fiber which is disposed on a focal plane of the convex lens are employed and the diameter of the pinhole or the core diameter of the optical fiber is set to be not greater than the first dark ring of a Fraunhofer diffraction image produced by the convex lens, it is possible to take out the greater part of the energy of a plane wave component that enters the lens from a predetermined direction and remove other components from different directions, i.e., scattering component. If a plurality of optical systems of this type are bundled together, only a plane wave with a one- or two-dimensional intensity distribution can be taken out with high brightness and high resolving power. Since the scattering component attenuates and only an information light component carried by the plane wave can be detected, it is possible to obtain information about an absorber even when the scattering component is greater than the information light component as in the case of light transmitted by a human body. Thus, it is possible to obtain great advantages in application to optical CT or the like.

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