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1. 发明申请

US20070141050A1 Methods of depleting antibodies directed towards major histocompatibility complex 审中-公开
标题翻译：消耗针对主要组织相容性复合物的抗体的方法
公开(公告)号：US20070141050A1
公开(公告)日：2007-06-21
申请号：US11380062
申请日：2006-04-25
申请人： Martin Barnardo , Andrea Harmer , Michael Bunce , Robert Vaughan , Kenneth Welsh
发明人： Martin Barnardo , Andrea Harmer , Michael Bunce , Robert Vaughan , Kenneth Welsh
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： G01N1/34 , A61K39/39525 , G01N33/543 , G01N33/56977 , Y10S435/962 , Y10S436/825 , Y10T436/25375
摘要： The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample.
摘要翻译：本发明提供了在样品中消耗抗MHC抗体的方法，包括使所述样品与一种或多种重组MHC分子或功能等同的变体，衍生物或其片段接触并除去至少重组MHC分子，所述重组MHC分子与所述重组MHC分子包含在样品中已经绑定。该方法允许从样品中消耗一种或多种特异性MHC，特别是HLA等位基因抗体。

2. 发明申请

US20080057521A1 Method 审中-公开
标题翻译：方法
公开(公告)号：US20080057521A1
公开(公告)日：2008-03-06
申请号：US11765745
申请日：2007-06-20
申请人： Martin Barnardo , Andrea Harmer , Michael Bunce , Robert Vaughn , Kenneth Walsh
发明人： Martin Barnardo , Andrea Harmer , Michael Bunce , Robert Vaughn , Kenneth Walsh
IPC分类号： G01N33/00
CPC分类号： G01N33/6854 , G01N33/543 , G01N33/566 , Y10S435/975
摘要： The invention provides a method of detecting the presence of anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and detecting the binding or absence of binding of antibodies to said recombinant MHC molecules. This method allows the detection and/or identification of one or more specific MHC particularly HLA allele antibodies
摘要翻译：本发明提供了一种检测样品中抗MHC抗体的存在的方法，包括使所述样品与一种或多种重组MHC分子或功能等同的变体，衍生物或片段接触并检测抗体与所述重组体的结合或结合 MHC分子。该方法允许检测和/或鉴定一种或多种特异性MHC，特别是HLA等位基因抗体

3. 发明申请

US20130115601A1 TISSUE TYPING ASSAYS AND KITS 审中-公开
标题翻译：组织类型测试和工具
公开(公告)号：US20130115601A1
公开(公告)日：2013-05-09
申请号：US13697814
申请日：2011-05-16
申请人： Michael Bunce , Benjamin John Passey , David Charvill
发明人： Michael Bunce , Benjamin John Passey , David Charvill
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6848 , C12Q1/6858 , C12Q2600/16 , C12Q2527/137 , C12Q2527/125 , C12Q2525/161 , C12Q2535/125 , C12Q2525/204 , C12Q2537/143
摘要： The present invention relates generally to compositions of lyophilised reagents suitable for nucleic acid amplification use in in-vitro diagnostics. More particularly, the invention relates to lyophilised PCR reagent compositions and methods for genotyping including HLA and/or ABO and/or HFE typing.
摘要翻译：本发明一般涉及适于核酸扩增用于体外诊断的冻干试剂的组合物。更具体地，本发明涉及用于基因分型的冻干PCR试剂组合物和方法，包括HLA和/或ABO和/或HFE分型。

4. 发明授权

US08609436B2 Method 有权
公开(公告)号：US08609436B2
公开(公告)日：2013-12-17
申请号：US09809029
申请日：2001-03-16
申请人： Martin C. N. M. Barnardo , Andrea W. Harmer , Michael Bunce , Robert W. Vaughn , Kenneth I. Welsh
发明人： Martin C. N. M. Barnardo , Andrea W. Harmer , Michael Bunce , Robert W. Vaughn , Kenneth I. Welsh
IPC分类号： G01N33/543
CPC分类号： G01N33/6854 , G01N33/543 , G01N33/566 , Y10S435/975
摘要： The invention provides a method of detecting the presence of anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and detecting the binding or absence of binding of antibodies to said recombinant MHC molecules. This method allows the detection and/or identification of one or more specific MHC particularly HLA allele antibodies.

5. 发明授权

US07511610B2 Multiple passenger vehicle seat belt notification system with force feedback 有权
标题翻译：多辆乘用车安全带通知系统具有反馈力
公开(公告)号：US07511610B2
公开(公告)日：2009-03-31
申请号：US11388716
申请日：2006-03-24
申请人： Brian Downey , Michael Bunce
发明人： Brian Downey , Michael Bunce
IPC分类号： B60Q1/00
CPC分类号： B60R22/48 , B60R2022/4816 , B60R2022/4858 , B60R2022/4866
摘要： A seat belt notification system and process for a vehicle can include an occupant detection sensor operable to determine if a vehicle seat is in one of an occupied condition or an unoccupied condition. A seat belt sensor can be operable to determine if a seat belt associated with the vehicle seat is in one of a buckled condition and an unbuckled condition. A feedback device can be operable to provide a physical response to a particular vehicle seat, if the occupant detection sensor determines that the particular vehicle seat is in an occupied condition and the seat belt sensor determines that the seat belt associated with the particular vehicle seat is in an unbuckled condition.
摘要翻译：一种用于车辆的座椅安全带通知系统和过程可以包括：乘客检测传感器，其可操作以确定车辆座椅是否处于占用状态或未占用状态。座椅安全带传感器可操作以确定与车辆座椅相关联的座椅安全带是否处于弯曲状态和未弯曲状态之一。如果乘客检测传感器确定特定车辆座椅处于占用状态，并且座椅安全带传感器确定与特定车辆座椅相关联的座椅安全带是否为车辆座椅，则反馈装置可操作以向特定车辆座椅提供物理响应在一个无忧的条件。

6. 发明申请

US20060269916A1 Probes 审中-公开
标题翻译：探头
公开(公告)号：US20060269916A1
公开(公告)日：2006-11-30
申请号：US10536048
申请日：2003-11-19
申请人： Michael Bunce , Ian Crosby
发明人： Michael Bunce , Ian Crosby
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6881 , C12Q1/6816 , C12Q2600/156 , C12Q2525/197
摘要： The present invention relates to probes, methods and apparatus for the detection of the presence or absence of non-contiguous cis-located nucleic acid sequences which are characteristic of alleles including those relating to the human leukocyte antigen (HLA) which is of interest in the field of human transplantation and disease.
摘要翻译：本发明涉及用于检测存在或不存在不连续顺式定位的核酸序列的探针，方法和装置，其是等位基因的特征，包括与人白细胞抗原（HLA）有关的等位基因的相关性人类移植和疾病领域。

7. 发明申请

US20120220049A1 ASSAY METHOD AND DEVICE 审中-公开
标题翻译：测定方法和装置
公开(公告)号：US20120220049A1
公开(公告)日：2012-08-30
申请号：US13262623
申请日：2010-03-31
申请人： Michael Bunce , Benjamin John Passey , David Charvill
发明人： Michael Bunce , Benjamin John Passey , David Charvill
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/56977 , G01N33/80 , G01N2333/70539 , G01N2800/245
摘要： The present invention relates to a method and a device for detecting the presence of an analyte. More particularly, the present invention relates to the method and device for detecting the presence of immunoglobulins directed at polymorphic alloantigens such as HLA antigens and/or other products of the major histocompatibility complex (MHC).
摘要翻译：本发明涉及用于检测分析物的存在的方法和装置。更具体地，本发明涉及用于检测针对多形性同种异体抗体如HLA抗原和/或主要组织相容性复合物（MHC）的其它产物的免疫球蛋白的存在的方法和装置。

8. 发明申请

US20070222572A1 Multiple passenger vehicle seat belt notification system with force feedback 有权
标题翻译：多辆乘用车安全带通知系统具有反馈力
公开(公告)号：US20070222572A1
公开(公告)日：2007-09-27
申请号：US11388716
申请日：2006-03-24
申请人： Brian Downey , Michael Bunce
发明人： Brian Downey , Michael Bunce
IPC分类号： B60Q1/00
CPC分类号： B60R22/48 , B60R2022/4816 , B60R2022/4858 , B60R2022/4866
摘要： A seat belt notification system and process for a vehicle can include an occupant detection sensor operable to determine if a vehicle seat is in one of an occupied condition or an unoccupied condition. A seat belt sensor can be operable to determine if a seat belt associated with the vehicle seat is in one of a buckled condition and an unbuckled condition. A feedback device can be operable to provide a physical response to a particular vehicle seat, if the occupant detection sensor determines that the particular vehicle seat is in an occupied condition and the seat belt sensor determines that the seat belt associated with the particular vehicle seat is in an unbuckled condition.
摘要翻译：一种用于车辆的座椅安全带通知系统和过程可以包括：乘客检测传感器，其可操作以确定车辆座椅是否处于占用状态或未占用状态。座椅安全带传感器可操作以确定与车辆座椅相关联的座椅安全带是否处于弯曲状态和未弯曲状态之一。如果乘客检测传感器确定特定车辆座椅处于占用状态，并且座椅安全带传感器确定与特定车辆座椅相关联的座椅安全带是否为车辆座椅，则反馈装置可操作以向特定车辆座椅提供物理响应在一个无忧的条件。

9. 发明申请

US20130024094A1 METHODS FOR CONTROLLING COMBUSTION OF BLENDED BIOFUELS 审中-公开
标题翻译：控制混合生物燃料的方法
公开(公告)号：US20130024094A1
公开(公告)日：2013-01-24
申请号：US13519756
申请日：2010-12-31
申请人： Gregory Matthew Shaver , David Benjamin Snyder , Carrie Michele Hall , Gayatri Adi , Michael Bunce
发明人： Gregory Matthew Shaver , David Benjamin Snyder , Carrie Michele Hall , Gayatri Adi , Michael Bunce
IPC分类号： F02B47/08 , F02M25/07 , F02D41/30
CPC分类号： F02D41/0025 , F02B1/12 , F02D19/061 , F02D19/0628 , F02D19/0652 , F02D19/081 , F02D19/088 , F02D41/005 , F02D41/1456 , F02D41/1458 , F02D41/38 , F02D41/3836 , F02D41/401 , F02D41/402 , F02D41/403 , F02D41/405 , F02D2200/0612 , F02M37/0088 , Y02T10/36 , Y02T10/44 , Y02T10/47
摘要： A closed-loop control algorithm that reduces the increases in nitrogen oxides (NOx) commonly observed with biodiesel combustion while retaining particulate matter (PM) reductions with variable biodiesel blend fractions. One embodiment includes a control algorithm that is closed-loop with regards to combustible oxygen mass fraction (COMF) instead of exhaust gas recirculation (EGR) fraction. Yet another algorithm includes biodiesel blend estimation and “fuel-flexible” accommodation. A physics-based model has also been developed which predicts experimentally observed engine performance and emissions for biodiesel.
摘要翻译：一种闭环控制算法，可以减少通常用生物柴油燃烧观察到的氮氧化物（NOx）的增加，同时通过可变的生物柴油混合物馏分保留颗粒物质（PM）。一个实施例包括关于可燃氧质量分数（COMF）而不是废气再循环（EGR）分数的闭环的控制算法。另一种算法包括生物柴油混合估计和燃料柔性调节。还开发了基于物理学的模型，其预测了实验观察到的发动机性能和生物柴油的排放。

10. 发明授权

US08088586B2 Method of producing a body fluid sample depleted of anti-MHC antibodies 有权
标题翻译：制备消耗抗MHC抗体的体液样品的方法
公开(公告)号：US08088586B2
公开(公告)日：2012-01-03
申请号：US10623802
申请日：2003-07-22
申请人： Martin C. N. M. Barnardo , Andrea W. Harmer , Michael Bunce , Robert W. Vaughan , Kenneth I. Welsh
发明人： Martin C. N. M. Barnardo , Andrea W. Harmer , Michael Bunce , Robert W. Vaughan , Kenneth I. Welsh
IPC分类号： G01N33/53
CPC分类号： G01N1/34 , A61K39/39525 , G01N33/543 , G01N33/56977 , Y10S435/962 , Y10S436/825 , Y10T436/25375
摘要： The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample.
摘要翻译：本发明提供了在样品中消耗抗MHC抗体的方法，包括使所述样品与一种或多种重组MHC分子或功能等同的变体，衍生物或其片段接触并除去至少重组MHC分子，所述重组MHC分子与所述重组MHC分子包含在样品中已经绑定。该方法允许从样品中消耗一种或多种特异性MHC，特别是HLA等位基因抗体。

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