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1. 发明申请

US20090215077A1 METHODS FOR DIAGNOSIS OF ACUTE CORONARY SYNDROME 审中-公开
标题翻译：急性冠状动脉综合征诊断方法
公开(公告)号：US20090215077A1
公开(公告)日：2009-08-27
申请号：US12417496
申请日：2009-04-02
申请人： Mark B. CHANDLER , Michael D. SPAIN , James MAPES , George RODGERS
发明人： Mark B. CHANDLER , Michael D. SPAIN , James MAPES , George RODGERS
IPC分类号： G01N33/53 , C12Q1/00 , C12Q1/48
CPC分类号： C12Q1/48 , C12Q1/37 , G01N33/573 , G01N33/6893 , G01N2333/91188 , G01N2333/96486 , G01N2800/324
摘要： Provided are methods for the detection and diagnosis of acute coronary syndrome or ACS. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of ACS. At least two new biomarkers for ACS are thus disclosed, MMP-3 and SGOT. Altogether the concentrations of twelve analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering a heart attack. Other important biomarkers for ACS are described, including but not limited to IL-18, Factor VII, ICAM-1, Creatine Kinase-MB, MCP-1, Myoglobin, C Reactive Protein, von Willebrand Factor, TIMP-1, Ferritin, Glutathione S-Transferase, Prostate Specific Antigen (free), IL-3, Tissue Factor, alpha-Fetoprotein, Prostatic Acid Phosphatase, Stem Cell Factor, MIP-1-beta, Carcinoembryonic Antigen, IL-13, TNF-alpha, IgE, Fatty Acid Binding Protein, ENA-78, IL-1-beta, Brain-Derived Nerotrophic Factor, Apolipoprotein A1, Serum Amyloid P, Growth Hormone, Beta-2 microglobulin, Lipoprotein (a), MMP-9, Thyroid Stimulating hormone, alpha-2 Macroglobulin, Complement 3, IL-7, Leptin, and IL-6. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了用于急性冠状动脉综合征或ACS的检测和诊断的方法。这些方法基于以下发现：患有风险的患者的样品液体（通常为血液样本）中所选分析物的异常水平支持ACS的诊断。因此公开了至少两种用于ACS的新生物标志物，MMP-3和SGOT。总共有十二种分析物的浓度可以提供对病人状况的敏感和有选择性的图片，即患者是否患有心脏病发作。描述了ACS的其他重要生物标志物，包括但不限于IL-18，因子VII，ICAM-1，肌酸激酶-MB，MCP-1，肌红蛋白，C反应蛋白，血管性血友病因子，TIMP-1，铁蛋白，谷胱甘肽 S转移酶，前列腺特异性抗原（游离），IL-3，组织因子，α-甲胎蛋白，前列腺酸性磷酸酶，干细胞因子，MIP-1-β，癌胚抗原，IL-13，TNF-α，IgE，脂肪酸结合蛋白，ENA-78，IL-1-β，脑源性神经营养因子，载脂蛋白A1，血清淀粉样蛋白P，生长激素，β-2微球蛋白，脂蛋白（a），MMP-9，甲状腺刺激激素， 2大球蛋白，补体3，IL-7，瘦蛋白和IL-6。还描述了含有辅助分析流体样品的试剂的试剂盒。

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