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1. 发明授权

US08691523B2 Primitive and proximal hepatic stem cells 有权
标题翻译：原始和近端肝干细胞
公开(公告)号：US08691523B2
公开(公告)日：2014-04-08
申请号：US11609729
申请日：2006-12-12
申请人： Lola M. Reid , Nicholas Moss , Mark E. Furth , John W. Ludlow , Andrew T. Bruce
发明人： Lola M. Reid , Nicholas Moss , Mark E. Furth , John W. Ludlow , Andrew T. Bruce
IPC分类号： C12N5/00
CPC分类号： C12N5/0672 , C12N2500/25 , C12N2500/36 , C12N2500/90 , C12N2501/11 , C12N2502/13 , G01N33/5005 , G01N33/68 , G01N2333/705 , G01N2333/70525 , G01N2333/70596
摘要： Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.
摘要翻译：肝祖细胞包含两个人类肝干细胞，原始和近端肝干细胞，以及两个定型祖细胞群，一个为胆汁细胞，一个为肝细胞。人原始肝干细胞是肝细胞群体的非常小的一部分，并且引起近端肝干细胞构成肝脏的大部分。人近端肝干细胞产生胆汁和肝细胞定向的祖细胞。原始和近端干细胞是人类肝脏的主要干细胞。人原始肝干细胞可以通过人肝脏的免疫选择或在选择人原始肝干细胞的条件下培养人肝细胞来分离。可以通过免疫选择或通过在包括发育因子的条件下培养人肝细胞来分离近端肝干细胞。也可以通过在包括发育因子的条件下培养包含原始肝干细胞的菌落来分离近端肝干细胞。所得组合物可用于治疗肝脏疾病和用于生产生物人造器官。

2. 发明授权

US07413897B2 Primitive and proximal hepatic stem cells 有权
标题翻译：原始和近端肝干细胞
公开(公告)号：US07413897B2
公开(公告)日：2008-08-19
申请号：US10387547
申请日：2003-03-14
申请人： Lola M. Reid , Nicholas Moss , Mark Furth , John W. Ludlow , Andrew T. Bruce
发明人： Lola M. Reid , Nicholas Moss , Mark Furth , John W. Ludlow , Andrew T. Bruce
IPC分类号： C12N5/00 , A01N63/00
CPC分类号： C12N5/0672 , C12N2500/25 , C12N2500/36 , C12N2500/90 , C12N2501/11 , C12N2502/13 , G01N33/5005 , G01N33/68 , G01N2333/705 , G01N2333/70525 , G01N2333/70596
摘要： Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.
摘要翻译：肝祖细胞包含两个人类肝干细胞，原始和近端肝干细胞，以及两个定型祖细胞群，一个为胆汁细胞，一个为肝细胞。人原始肝干细胞是肝细胞群体的非常小的一部分，并且引起近端肝干细胞构成肝脏的大部分。人近端肝干细胞产生胆汁和肝细胞定向的祖细胞。原始和近端干细胞是人类肝脏的主要干细胞。人原始肝干细胞可以通过人肝脏的免疫选择或在选择人原始肝干细胞的条件下培养人肝细胞来分离。可以通过免疫选择或通过在包括发育因子的条件下培养人肝细胞来分离近端肝干细胞。也可以通过在包括发育因子的条件下培养包含原始肝干细胞的菌落来分离近端肝干细胞。所得组合物可用于治疗肝脏疾病和用于生产生物人造器官。

3. 发明申请

US20100197015A1 HUMAN LIVER PROGENITORS 审中-公开
标题翻译：人类生殖器
公开(公告)号：US20100197015A1
公开(公告)日：2010-08-05
申请号：US12695855
申请日：2010-01-28
申请人： Lola M. Reid , Nicholas Moss , Hiroshi Kubota
发明人： Lola M. Reid , Nicholas Moss , Hiroshi Kubota
IPC分类号： C12N5/071
CPC分类号： C12N5/0672 , A61K35/12 , A61K2039/55594 , C12N2500/20 , C12N2500/22 , C12N2500/25 , C12N2500/36 , C12N2503/02
摘要： Methods of isolating and cryopreserving progenitors from human liver are disclosed which include processing human liver tissue to provide a substantially single cell suspension comprising progenitors and non-progenitors of one or more cell lineages found in human liver; subjecting the suspension to a debulking step, which reduces substantially the number of non-progenitors in the suspension, and which provides a debulked suspension enriched in progenitors exhibiting one or more markers associated with at least one of the one or more cell lineages; and selecting from said debulked suspension those cells, which themselves, their progeny, or more mature forms thereof express one or more markers associated with at least one of the one or more cell lineages. Among these markers are CD14, CD34, CD38, CD45, and ICAM. Hepatic progenitors are characterized as being 6-15μ in diameter, diploid, glycophorin A−, CD45−, AFP+++, ALB+, ICAM+, and with subpopulations varying in expression of CD14+. CD34++, CD38++, CD117+. These progenitor subpopulations have characteristics expected for cells that are particularly useful in liver cell and gene therapies and for establishing bioartificial organs.
摘要翻译：公开了从人肝脏分离和冷冻保存祖细胞的方法，其包括加工人肝组织以提供包含在人肝脏中发现的一种或多种细胞谱系的祖细胞和非祖细胞的基本上单细胞悬浮液; 使悬浮液经历减压步骤，其减少了悬浮液中的非祖细胞的数量，并且提供了富含前体细胞的减数分裂的悬浮液，其显示出与一种或多种细胞系中的至少一种相关联的一种或多种标志物; 以及从所述减粘悬浮液中选择这些细胞，其本身，其子代或更成熟的形式表达与所述一种或多种细胞谱系中的至少一种相关联的一种或多种标志物。这些标记物中有CD14，CD34，CD38，CD45和ICAM。肝祖细胞的特征是直径为6-15μ，二倍体，血型糖蛋白A-，CD45-，AFP +++，ALB +，ICAM +，以及与CD14 +表达不同的亚群。 CD34 ++，CD38 ++，CD117 +。这些祖细胞亚群具有特别适用于肝细胞和基因疗法以及建立生物人造器官的细胞的特征。

4. 发明申请

US20200368629A1 REMOTE CONTROL VEHICLE 审中-公开
公开(公告)号：US20200368629A1
公开(公告)日：2020-11-26
申请号：US16767940
申请日：2018-11-21
申请人： Nicholas Moss
发明人： Nicholas Moss
IPC分类号： A63H17/00 , A63H30/04 , A63H17/21
摘要： A remote-control vehicle is disclosed. The vehicle comprises a first wheel and a second wheel offset along the longitudinal axis of the vehicle. The vehicle further comprises a device adapted to apply a torque to the first wheel, a sensor configured to monitor the pitch angle of the vehicle, and a control module. The control module is configured to control the torque applied by the device to the first wheel in accordance with the monitored vehicle pitch angle so as to accelerate the vehicle while maintaining the vehicle pitch angle within a range of acute angles. Also disclosed is a second remote-control vehicle, comprising: a first wheel and a second wheel offset along the longitudinal axis of the vehicle, a steering system adapted to steer the first wheel, a sensor configured to monitor the roll angle of the vehicle, and a control module configured to control the steering of the first wheel in accordance with the monitored vehicle roll angle while the vehicle is travelling so as to maintain the vehicle roll angle within a range of acute angles. A third remote-control vehicle is also disclosed and comprises: a first wheel and a second wheel, a device adapted to apply a torque to the first wheel, a sensor configured to monitor the pitch angle of the vehicle, and a control module configured to control the torque applied by the device to the first wheel in accordance with the monitored vehicle pitch angle when the vehicle is in free fall so as to maintain the vehicle pitch angle within a specified range of angles.

5. 发明申请

US20050148072A1 Human liver progenitors 审中-公开
标题翻译：人肝脏祖细胞
公开(公告)号：US20050148072A1
公开(公告)日：2005-07-07
申请号：US10944919
申请日：2004-09-21
申请人： Lola Reid , Nicholas Moss , Hiroshi Kubota
发明人： Lola Reid , Nicholas Moss , Hiroshi Kubota
IPC分类号： G01N33/53 , A61K35/12 , A61K35/407 , A61K48/00 , A61P1/16 , A61P7/00 , A61P35/00 , C12N5/00 , C12N5/074 , C12N15/09 , C12Q1/02 , C12Q1/68 , C12N5/08
CPC分类号： C12N5/0672 , A61K35/12 , A61K2039/55594 , C12N2500/20 , C12N2500/22 , C12N2500/25 , C12N2500/36 , C12N2503/02
摘要： Methods of isolating and cryopreserving progenitors from human liver are disclosed which include processing human liver tissue to provide a substantially single cell suspension comprising progenitors and non-progenitors of one or more cell lineages found in human liver; subjecting the suspension to a debulking step, which reduces substantially the number of non-progenitors in the suspension, and which provides a debulked suspension enriched in progenitors exhibiting one or more markers associated with at least one of the one or more cell lineages; and selecting from said debulked suspension those cells, which themselves, their progeny, or more mature forms thereof express one or more markers associated with at least one of the one or more cell lineages. Among these markers are CD14, CD34, CD38, CD45, and ICAM. Hepatic progenitors are characterized as being 6-15μ in diameter, diploid, glycophorin A−, CD45−, AFP+++, ALB+, ICAM+, and with subpopulations varying in expression of CD14+. CD34++, CD38++, CD117+. These progenitor subpopulations have characteristics expected for cells that are particularly useful in liver cell and gene therapies and for establishing bioartificial organs.
摘要翻译：公开了从人肝脏分离和冷冻保存祖细胞的方法，其包括加工人肝组织以提供包含在人肝脏中发现的一种或多种细胞谱系的祖细胞和非祖细胞的基本上单细胞悬浮液; 使悬浮液经历减压步骤，其减少了悬浮液中的非祖细胞的数量，并且提供了富含前体细胞的减数分裂的悬浮液，其显示出与一种或多种细胞系中的至少一种相关联的一种或多种标志物; 以及从所述减粘悬浮液中选择这些细胞，其本身，其子代或更成熟的形式表达与所述一种或多种细胞谱系中的至少一种相关联的一种或多种标志物。这些标记物中有CD14，CD34，CD38，CD45和ICAM。肝祖细胞的特征在于直径为6-15μm，二倍体，血型糖蛋白，CD45 - ，AFP +++，ALB + > + ，ICAM ，以及与CD14 + + / / SUP的表达变化的亚群。 CD34 ++ ++，CD38 ++，CD117 + + / / 这些祖细胞亚群对于在肝细胞和基因治疗中特别有用的细胞以及用于建立生物人造器官的细胞具有预期的特征。

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