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1. 发明申请

US20060174385A1 Method and apparatus for detecting targets 审中-公开
标题翻译：检测目标的方法和装置
公开(公告)号：US20060174385A1
公开(公告)日：2006-08-03
申请号：US11048059
申请日：2005-02-02
申请人： Lewis Gruber , Joseph Plewa , Misty Gruber
发明人： Lewis Gruber , Joseph Plewa , Misty Gruber
IPC分类号： G01N23/00
CPC分类号： G01N21/41 , B82Y15/00
摘要： A nano-sensor for sensing one or more targets has a plurality of sensor units, each including a nano-structure and an encapsulating sensible medium surrounding the nano-structure. Each nano-sensor unit being positioned by holographic optical trapping and operative to produce a signal output indicative of the presence of a particular target. A substrate has a sensor location for each sensor unit, each operative to produce an output in response to the signal from the corresponding sensor unit indicative of the presence of a particular target. The sensor may employ a disposable support for the sensor units adapted to be positioned in registration with the sensor locations and disposed of after use.
摘要翻译：用于感测一个或多个靶的纳米传感器具有多个传感器单元，每个传感器单元包括纳米结构和围绕纳米结构的封装敏感介质。每个纳米传感器单元通过全息光学捕获定位并且可操作以产生指示特定目标的存在的信号输出。衬底具有用于每个传感器单元的传感器位置，每个传感器单元响应于来自相应传感器单元的指示存在特定目标的信号而产生输出。传感器可以采用一次性支撑件，用于适于定位成与传感器位置对准的传感器单元并在使用后进行处理。

2. 发明申请

US20090108190A1 System and method for manipulating and processing materials using holographic optical trapping 审中-公开
标题翻译：使用全息光学捕获来操纵和处理材料的系统和方法
公开(公告)号：US20090108190A1
公开(公告)日：2009-04-30
申请号：US12230304
申请日：2008-08-27
申请人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
IPC分类号： H05H3/04
CPC分类号： B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： A method for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译：一种通过用衍射光学元件（DOE）调制激光束形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法。选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。根据材料的至少一个所选特征计算DOE的值。光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。

3. 发明授权

US07411181B2 System and method for manipulating and processing materials using holographic optical trapping 失效
标题翻译：使用全息光学捕获来操纵和处理材料的系统和方法
公开(公告)号：US07411181B2
公开(公告)日：2008-08-12
申请号：US10974976
申请日：2004-10-28
申请人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
IPC分类号： G02B5/18 , G02B15/32
CPC分类号： G03H1/22 , G02B5/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/2284
摘要： A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic. The trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译：一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法和装置。选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。根据材料的至少一个所选特征计算DOE的值。束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱。陷阱聚焦到光束对焦或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。

4. 发明申请

US20050121604A1 Multiple laminar flow-based particle and cellular separation with laser steering 有权
标题翻译：多层次流动粒子与细胞分离与激光转向
公开(公告)号：US20050121604A1
公开(公告)日：2005-06-09
申请号：US10934597
申请日：2004-09-03
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC分类号： A61M1/36 , A61M1/38 , G01N33/483 , G21K1/00 , H05H3/04
CPC分类号： A61M1/3681 , A61M1/36 , A61M1/3693 , A61M1/38 , A61M2206/11 , B01L3/502761 , B03C1/28 , B03C5/005 , B03C2201/02 , B03C2201/18 , G01N30/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , Y10T436/25375
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
摘要翻译：本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

5. 发明授权

US07699767B2 Multiple laminar flow-based particle and cellular separation with laser steering 有权
公开(公告)号：US07699767B2
公开(公告)日：2010-04-20
申请号：US12213109
申请日：2008-06-13
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
IPC分类号： B04B7/08
CPC分类号： G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

6. 发明申请

US20050122550A1 System and method for manipulating and processing materials using holographic optical trapping 失效
公开(公告)号：US20050122550A1
公开(公告)日：2005-06-09
申请号：US10974976
申请日：2004-10-28
申请人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
IPC分类号： G02B5/32 , G03H1/08 , G03H1/22 , G03H1/10
CPC分类号： G03H1/22 , G02B5/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/2284
摘要： A method an apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.

7. 发明授权

US08653442B2 Multiple laminar flow-based particle and cellular separation with laser steering 有权
标题翻译：多层次流动粒子与细胞分离与激光转向
公开(公告)号：US08653442B2
公开(公告)日：2014-02-18
申请号：US13412969
申请日：2012-03-06
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
IPC分类号： B01D21/01
CPC分类号： G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
摘要： The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first cellular component of the plurality of components into the second flow while concurrently maintaining a second cellular component of the plurality of components in the first flow. The second flow having the first cellular component is then differentially removed from the first flow having the second cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
摘要翻译：本发明提供一种用于分离细胞成分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。一个示例性方法包括提供具有多个部件的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个部件的第一细胞组分差异沉积到所述第二流中，同时将所述多个组分的第二细胞组分保持在所述第一流中。然后将具有第一细胞组分的第二流与具有第二细胞组分的第一流差异地去除。全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

8. 发明授权

US07449679B2 System and method for manipulating and processing materials using holographic optical trapping 失效
标题翻译：使用全息光学捕获来操纵和处理材料的系统和方法
公开(公告)号：US07449679B2
公开(公告)日：2008-11-11
申请号：US11079533
申请日：2005-03-15
申请人： Joseph Plewa , Evan Tanner , Daniel Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Daniel Mueth , Lewis Gruber , Kenneth Bradley
IPC分类号： H05H3/02 , C12N13/00
CPC分类号： B82Y20/00 , B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译：一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法和装置。选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。根据材料的至少一个所选特征计算DOE的值。光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。

9. 发明申请

US20070029257A1 Multiple laminar flow-based particle and cellular separation with laser steering 有权
标题翻译：多层次流动粒子与细胞分离与激光转向
公开(公告)号：US20070029257A1
公开(公告)日：2007-02-08
申请号：US11543773
申请日：2006-10-06
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC分类号： B01D61/00
CPC分类号： A61M1/3681 , A61M1/36 , A61M1/3693 , A61M1/38 , A61M2206/11 , B01L3/502761 , B03C1/28 , B03C5/005 , B03C2201/02 , B03C2201/18 , G01N30/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , Y10T436/25375
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
摘要翻译：本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

10. 发明申请

US20100216208A1 Multiple laminar flow-based particle and cellular separation with laser steering 有权
标题翻译：多层次流动粒子与细胞分离与激光转向
公开(公告)号：US20100216208A1
公开(公告)日：2010-08-26
申请号：US12659277
申请日：2010-03-02
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
IPC分类号： C12N13/00 , C12M1/00
CPC分类号： G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
摘要翻译：本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

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