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1. 发明授权

US11821011B2 Polymerase compositions, methods of making and using same 有权
公开(公告)号：US11821011B2
公开(公告)日：2023-11-21
申请号：US17445047
申请日：2021-08-13
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Daniel Mazur , Theo Nikiforov , Mindy Landes , Eileen Tozer
IPC分类号： C12N9/12 , C12Q1/68 , C12Q1/686 , C12Q1/6869
CPC分类号： C12N9/1252 , C12Q1/686 , C12Q1/6869
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.

2. 发明授权

US10240134B2 Polymerase compositions, methods of making and using same 有权
公开(公告)号：US10240134B2
公开(公告)日：2019-03-26
申请号：US15481858
申请日：2017-04-07
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Daniel Mazur , Theo Nikiforov , Mindy Landes , Eileen Tozer
IPC分类号： C12N9/12 , C12Q1/68 , C12Q1/686 , C12Q1/6869
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.

3. 发明授权

US10633641B2 Polymerase compositions, methods of making and using same 有权
公开(公告)号：US10633641B2
公开(公告)日：2020-04-28
申请号：US15959839
申请日：2018-04-23
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Theo Nikiforov , Guobin Luo , Mindy Landes , Daniel Mazur , Eileen Tozer , Tommie Lloyd Lincecum
IPC分类号： C12N9/12 , C12Q1/6844 , C12Q1/686
CPC分类号： C12N9/1252 , C12Q1/686 , C12Q1/6846 , C12Y207/07007
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.

4. 发明授权

US09976128B2 Polymerase compositions, methods of making and using same 有权
公开(公告)号：US09976128B2
公开(公告)日：2018-05-22
申请号：US14754203
申请日：2015-06-29
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Theo Nikiforov , Guobin Luo , Mindy Landes , Daniel Mazur , Eileen Tozer , Tommie Lincecum
IPC分类号： C12N9/12 , C12Q1/68
CPC分类号： C12N9/1252 , C12Q1/6846 , C12Q1/686 , C12Y207/07007
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.

5. 发明授权

US09657281B2 Polymerase compositions, methods of making and using same 有权
公开(公告)号：US09657281B2
公开(公告)日：2017-05-23
申请号：US14502201
申请日：2014-09-30
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Daniel Mazur , Theo Nikiforov , Mindy Landes , Eileen Tozer
IPC分类号： C12N9/12 , C12Q1/68
CPC分类号： C12N9/1252 , C12Q1/686 , C12Q1/6869
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.

6. 发明申请

US20180305673A1 POLYMERASE COMPOSITIONS, METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：US20180305673A1
公开(公告)日：2018-10-25
申请号：US15959839
申请日：2018-04-23
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Theo Nikiforov , Guobin Luo , Mindy Landes , Daniel Mazur , Eileen Tozer , Tommie Lloyd Lincecum
IPC分类号： C12N9/12 , C12Q1/686 , C12Q1/6844
CPC分类号： C12N9/1252 , C12Q1/6846 , C12Q1/686 , C12Y207/07007
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.

7. 发明申请

US20150368626A1 Polymerase Compositions, Methods of Making and Using Same 有权
标题翻译：聚合酶组合物，制备和使用方法
公开(公告)号：US20150368626A1
公开(公告)日：2015-12-24
申请号：US14754203
申请日：2015-06-29
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Theo Nikiforov , Guobin Luo , Mindy Landes , Daniel Mazur , Eileen Tozer , Tommie Lincecum
IPC分类号： C12N9/12 , C12Q1/68
CPC分类号： C12N9/1252 , C12Q1/6846 , C12Q1/686 , C12Y207/07007
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.
摘要翻译：本公开提供了可用于核酸聚合的组合物，方法，试剂盒，系统和装置。特别地，提供了允许核酸扩增的修饰的聚合酶及其生物活性片段。一方面，本公开涉及可用于核酸测序，基因分型，拷贝数变异分析，配对末端测序和其他形式遗传分析的修饰聚合酶。在一些方面，本公开涉及可用于产生用于各种下游过程的核酸文库或核酸模板的修饰聚合酶。在一些方面，本公开涉及可以跨聚合酶类或家族转移的同源氨基酸突变的鉴定，以提供具有改变的催化性质的新型聚合酶。在一些方面，本公开提供与参考聚合酶相比具有增强的催化性质的修饰聚合酶。

8. 发明授权

US11208636B2 Polymerase compositions, methods of making and using same 有权
公开(公告)号：US11208636B2
公开(公告)日：2021-12-28
申请号：US16850629
申请日：2020-04-16
申请人： Life Technologies Corporation
发明人： Peter Vander Horn , Theo Nikiforov , Guobin Luo , Mindy Landes , Daniel Mazur , Eileen Tozer , Tommie Lincecum
IPC分类号： C12N9/12 , C12Q1/6844 , C12Q1/686
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.

9. 发明授权

US11091746B2 Polymerase compositions, methods of making and using same 有权
公开(公告)号：US11091746B2
公开(公告)日：2021-08-17
申请号：US16894469
申请日：2020-06-05
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Daniel Mazur , Theo Nikiforov , Mindy Landes , Eileen Tozer
IPC分类号： C12N9/12 , C12Q1/6869 , C12Q1/686
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.

10. 发明授权

US10676724B2 Polymerase compositions, methods of making and using same 有权
公开(公告)号：US10676724B2
公开(公告)日：2020-06-09
申请号：US16270129
申请日：2019-02-07
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Peter Vander Horn , Daniel Mazur , Theo Nikiforov , Mindy Landes , Eileen Tozer
IPC分类号： C12N9/12 , C12Q1/6869 , C12Q1/686
摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.

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