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1. 发明申请

US20110129481A1 Antibody specifically binding to c-Met and methods of use 有权
标题翻译：抗体特异性结合c-Met和使用方法
公开(公告)号：US20110129481A1
公开(公告)日：2011-06-02
申请号：US12807191
申请日：2010-08-30
申请人： Kwang Ho Cheong , Sung-young Jeong , Sang-hyun Paek
发明人： Kwang Ho Cheong , Sung-young Jeong , Sang-hyun Paek
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/12 , G01N33/53 , A61P35/00 , C12N5/10 , C12N1/19
CPC分类号： G01N33/57407 , C07K16/2863 , C07K2317/33 , G01N33/57492
摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.
摘要翻译：本文公开了与c-Met蛋白，杂交瘤细胞系以及包含抗体的组合特异性结合的抗体。还公开了制备和使用抗体和组合物的方法。

2. 发明授权

US08728793B2 Amphipathic alpha-helical peptide compositions as antiviral agents 有权
标题翻译：两亲性α-螺旋肽组合物作为抗病毒剂
公开(公告)号：US08728793B2
公开(公告)日：2014-05-20
申请号：US12172796
申请日：2008-07-14
申请人： Jeffrey Glenn , Nam-Joon Cho , Curtis W. Frank , Kwang Ho Cheong
发明人： Jeffrey Glenn , Nam-Joon Cho , Curtis W. Frank , Kwang Ho Cheong
IPC分类号： C12N7/04 , C12N7/08 , A61K39/29
CPC分类号： A61K38/162 , A01N37/46 , A61L2/0082 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/408
摘要： The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-containing vesicles, such as enveloped viruses, in a size-dependent manner.
摘要翻译：本发明的特征在于利用两亲性α-螺旋（AH）肽以大小依赖的方式引起含脂质囊泡如包膜病毒破坏的能力的方法和组合物。

3. 发明授权

US08211712B2 Method of fabricating lipid bilayer membranes on solid supports 失效
标题翻译：在固体支持物上制备脂质双层膜的方法
公开(公告)号：US08211712B2
公开(公告)日：2012-07-03
申请号：US11887669
申请日：2006-03-29
申请人： Nam-Joon Cho , Curtis W. Frank , Jeffrey S. Glenn , Kwang Ho Cheong
发明人： Nam-Joon Cho , Curtis W. Frank , Jeffrey S. Glenn , Kwang Ho Cheong
IPC分类号： G01N33/543
CPC分类号： G01N33/533 , B82Y5/00 , G01N33/554 , Y10T428/31678
摘要： The present invention provides a method of producing a planar lipid bilayer on a solid support. With this method, a solution of lipid vesicles is first deposited on the solid support. Next, the lipid vesicles are destabilized by adding an amphipathic peptide solution to the lipid vesicle solution. This destabilization leads to production of a planar lipid bilayer on the solid support. The present invention also provides a supported planar lipid bilayer, where the planar lipid bilayer is made of naturally occurring lipids and the solid support is made of unmodified gold or titanium oxide. Preferably, the supported planar lipid bilayer is continuous. The planar lipid bilayer may be made of any naturally occurring lipid or mixture of lipids, including, but not limited to phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinsitol, cardiolipin, cholesterol, and sphingomyelin.
摘要翻译：本发明提供了一种在固体支持物上制备平面脂双层的方法。使用该方法，首先将脂质囊泡溶液沉积在固体支持物上。接下来，通过向脂质囊泡溶液中加入两亲肽溶液使脂质囊泡不稳定。这种不稳定性导致在固体支持物上产生平面脂双层。本发明还提供了一种支撑的平面脂质双层，其中平面脂质双层由天然存在的脂质制成，并且固体支持物由未改性的金或氧化钛制成。优选地，支撑的平面脂质双层是连续的。平面脂质双层可以由任何天然存在的脂质或脂质混合物制成，包括但不限于磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰丝氨酸，磷脂酰胰岛素，心磷脂，胆固醇和鞘磷脂。

4. 发明授权

US07968331B2 Cell co-culture apparatus for researching cell interaction and method thereof 有权
标题翻译：用于细胞相互作用研究的细胞共培养装置及其方法
公开(公告)号：US07968331B2
公开(公告)日：2011-06-28
申请号：US11626523
申请日：2007-01-24
申请人： Kwang Ho Cheong , Chin-sung Park
发明人： Kwang Ho Cheong , Chin-sung Park
IPC分类号： C12M1/14 , C12M3/04
CPC分类号： C12M23/12 , C12M23/44 , C12M35/08 , C12M47/04
摘要： A cell co-culture apparatus and a method of co-culturing and isolating cells using the cell co-culture apparatus to research interactions between cells by direct contact between the cells are provided. The cell co-culture apparatus includes a first substrate including a substrate portion and a plurality of projections provided on a surface of the substrate portion, each of the projections having a top surface for culturing cells, a second substrate including a same number of first channels as a number of the projections such that the channels fit with the projections and substrate surfaces formed between the first channels, and a third substrate including a plurality of second channels corresponding with the top surfaces and a plurality of third channels corresponding with the substrate surfaces.
摘要翻译：提供了一种细胞共培养装置和使用细胞共培养装置共培养和分离细胞的方法，以通过细胞之间的直接接触来研究细胞之间的相互作用。细胞共培养装置包括：第一基板，包括基板部分和设置在基板部分的表面上的多个突起，每个突起具有用于培养单元的顶表面;第二基板，包括相同数量的第一通道作为多个突起，使得通道与形成在第一通道之间的突起和基板表面配合，以及包括与顶表面相对应的多个第二通道的第三基板和对应于基板表面的多个第三通道。

5. 发明授权

US07972819B2 Method and apparatus for disrupting cells and amplifying nucleic acids using gold nanorods 有权
标题翻译：使用金纳米棒破坏细胞和扩增核酸的方法和装置
公开(公告)号：US07972819B2
公开(公告)日：2011-07-05
申请号：US11838550
申请日：2007-08-14
申请人： Kwang Ho Cheong , Dong-kee Yi , Jeong-gun Lee , Jong-myeon Park
发明人： Kwang Ho Cheong , Dong-kee Yi , Jeong-gun Lee , Jong-myeon Park
IPC分类号： C12P19/34 , C12N13/00 , C12N1/08
CPC分类号： C12N1/066 , C12M47/06 , C12N13/00 , C12P19/34
摘要： Provided is a method of disrupting cells comprising adding gold nanorods to a solution containing cells and irradiating the gold nanorods with a laser to disrupt the cells. A method and an apparatus for continuously disrupting cells and amplifying nucleic acids in a single microchamber are also provided, wherein the method comprises introducing a solution containing cells and gold nanorods into a microchamber, irradiating a laser onto the gold nanorods to disrupt the cells, and amplifying a nucleic acid from the disrupted cells in the microchamber.
摘要翻译：提供一种破坏细胞的方法，包括向含有细胞的溶液中加入金纳米棒并用激光照射金纳米棒以破坏细胞。还提供了用于在单个微室中连续破坏细胞和扩增核酸的方法和装置，其中所述方法包括将含有细胞和金纳米棒的溶液引入微室中，将激光照射到金纳米棒上以破坏细胞，以及在微室中从破碎的细胞中扩增核酸。

6. 发明申请

US20140294838A1 BISPECIFIC ANTI-CMET/ANTI-HER2 ANTIBODIES 审中-公开
标题翻译：双重抗体/抗HER2抗体
公开(公告)号：US20140294838A1
公开(公告)日：2014-10-02
申请号：US14229308
申请日：2014-03-28
申请人： Mi Young CHO , Powei Lin , Seung Hyun Lee , Kwang Ho Cheong , Young Jun Koh , Christina Yi , Jae Woong Hwang
发明人： Mi Young CHO , Powei Lin , Seung Hyun Lee , Kwang Ho Cheong , Young Jun Koh , Christina Yi , Jae Woong Hwang
IPC分类号： C07K16/32
CPC分类号： A61K39/39558 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/92
摘要： There are provided an anti-c-Met/anti-Her2 bispecific antibody, and a method for preventing and/or treating cancer using the same.
摘要翻译：提供抗c-Met /抗Her2双特异性抗体，以及使用其的预防和/或治疗癌症的方法。

7. 发明申请

US20090105151A1 AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITIONS AS ANTIVIRAL AGENTS 有权
公开(公告)号：US20090105151A1
公开(公告)日：2009-04-23
申请号：US12172796
申请日：2008-07-14
申请人： Jeffrey Glenn , Nam-Joon Cho , Curtis W. Frank , Kwang Ho Cheong
发明人： Jeffrey Glenn , Nam-Joon Cho , Curtis W. Frank , Kwang Ho Cheong
IPC分类号： A61K38/10 , C12N7/00 , A01N1/02
CPC分类号： A61K38/162 , A01N37/46 , A61L2/0082 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/408
摘要： The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-containing vesicles, such as enveloped viruses, in a size-dependent manner.
摘要翻译：本发明的特征在于利用两亲性α-螺旋（AH）肽以大小依赖的方式引起含脂质囊泡如包膜病毒破坏的能力的方法和组合物。

8. 发明授权

US09101610B2 Anti c-Met humanized antibody and uses thereof 有权
标题翻译：抗c-Met人源化抗体及其用途
公开(公告)号：US09101610B2
公开(公告)日：2015-08-11
申请号：US13589789
申请日：2012-08-20
申请人： Kwang Ho Cheong , Seunghyun Lee , Geun Woong Kim , Kyung-Ah Kim , Young Mi Oh , Saet Byoul Lee , Soo-yeon Jung , Yunju Jeong , Young Kue Han
发明人： Kwang Ho Cheong , Seunghyun Lee , Geun Woong Kim , Kyung-Ah Kim , Young Mi Oh , Saet Byoul Lee , Soo-yeon Jung , Yunju Jeong , Young Kue Han
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/24 , C07K2317/53 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/92
摘要： An anti c-Met antibody, a composition comprising the antibody, and a method for preventing or treating cancer by administering the composition is provided.
摘要翻译：提供了抗c-Met抗体，包含该抗体的组合物，以及通过施用该组合物预防或治疗癌症的方法。

9. 发明授权

US08557568B2 Method and apparatus for disrupting cells and amplifying nucleic acids using gold nanorods 有权
标题翻译：使用金纳米棒破坏细胞和扩增核酸的方法和装置
公开(公告)号：US08557568B2
公开(公告)日：2013-10-15
申请号：US13107677
申请日：2011-05-13
申请人： Kwang Ho Cheong , Dong-kee Yi , Jeong-gun Lee , Jong-myeon Park
发明人： Kwang Ho Cheong , Dong-kee Yi , Jeong-gun Lee , Jong-myeon Park
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00
CPC分类号： C12N1/066 , C12M47/06 , C12N13/00 , C12P19/34
摘要： Provided is a method of disrupting cells comprising adding gold nanorods to a solution containing cells and irradiating the gold nanorods with a laser to disrupt the cells. A method and an apparatus for continuously disrupting cells and amplifying nucleic acids in a single microchamber are also provided, wherein the method comprises introducing a solution containing cells and gold nanorods into a microchamber, irradiating a laser onto the gold nanorods to disrupt the cells, and amplifying a nucleic acid from the disrupted cells in the microchamber. The apparatus comprises a cell disruption chamber comprising a sample inlet, and gold nanorods introduced therein; a laser attached to the cell disruption chamber, wherein the laser is for generating light at a wavelength absorbed by the gold nanorods; and a heater and a cooler for heating and cooling the cell disruption chamber. Also disclosed is a lab-on-a chip comprising the apparatus.
摘要翻译：提供一种破坏细胞的方法，包括向含有细胞的溶液中加入金纳米棒并用激光照射金纳米棒以破坏细胞。还提供了用于在单个微室中连续破坏细胞和扩增核酸的方法和装置，其中所述方法包括将含有细胞和金纳米棒的溶液引入微室中，将激光照射到金纳米棒上以破坏细胞，以及在微室中从破碎的细胞中扩增核酸。该装置包括一个细胞破碎室，包括一个样品入口和引入其中的金纳米棒; 附着到细胞破碎室的激光器，其中所述激光器用于产生由所述金纳米棒吸收的波长的光; 以及用于加热和冷却细胞破碎室的加热器和冷却器。还公开了一种包括该装置的芯片实验室。

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