会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明申请
    • Acid addition salt of carbasugar amine derivative
    • 碳酰胺衍生物的酸加成盐
    • US20070010585A1
    • 2007-01-11
    • US10557851
    • 2004-05-19
    • Kiyoshi SuzukiMasami IidaYuji KanedaNaoko KajimotoMiwa Sawa
    • Kiyoshi SuzukiMasami IidaYuji KanedaNaoko KajimotoMiwa Sawa
    • C07C215/10A61K31/13
    • C07C215/44
    • An acid addition salt of a carba-sugar amine derivative represented by the following formula (1): wherein R1 and R2 each independently represents a hydrogen atom, or an alkyl group, an alkenyl group, an alkynyl group, an acyl group, an aryl group or an aralkyl group which may have one or at least two of the following substituent (I) or (II), or R1 and R2 are taken together to represent a substituent (III) (R8 to R12 each independently represents an alkyl group, an alkenyl group, an alkynyl group, an acyl group, an aryl group or an aralkyl group), with the proviso that both R1 and R2 are not a hydrogen atom at the same time; R3, R4 and R7 each independently represents a hydroxyl group or a hydroxyl group having a substituent; and R5 and R6 each independently represents a hydrogen atom, or a hydroxyl group or a hydroxyl group having a substituent, with the proviso that when one of R5 and R6 is a hydrogen atom, the other is a hydroxyl group or a hydroxyl group having a substituent.
    • 由下式(1)表示的卡巴糖胺衍生物的酸加成盐:其中R 1和R 2各自独立地表示氢原子或烷基 基团,烯基,炔基,酰基,芳基或芳烷基,其可以具有以下取代基(I)或(II)中的一个或至少两个,或R 1〜 >和R 2'一起表示取代基(III)(R 8至R 12)各自独立地表示烷基,烯基 基团,炔基,酰基,芳基或芳烷基),条件是R 1和R 2都不是氢原子 同时; R 3,R 4和R 7各自独立地表示羟基或具有取代基的羟基; R 5和R 6各自独立地表示氢原子或羟基或具有取代基的羟基,条件是当R“ 5和R 6是氢原子,另一个是羟基或具有取代基的羟基。
    • 2. 发明授权
    • Acid addition salt of carbasugar amine derivative
    • 碳酰胺衍生物的酸加成盐
    • US07485755B2
    • 2009-02-03
    • US10557851
    • 2004-05-19
    • Kiyoshi SuzukiMasami IidaYuji KanedaNaoko KajimotoMiwa Sawa
    • Kiyoshi SuzukiMasami IidaYuji KanedaNaoko KajimotoMiwa Sawa
    • C07C211/40A61K31/13
    • C07C215/44
    • An acid addition salt of a carba-sugar amine derivative represented by the following formula (1): wherein R1 and R2 each independently represents a hydrogen atom, or an alkyl group, an alkenyl group, an alkynyl group, an acyl group, an aryl group or an aralkyl group which may have one or at least two of the following substituent (I) or (II), or R1 and R2 are taken together to represent a substituent (III) (R8 to R12 each independently represents an alkyl group, an alkenyl group, an alkynyl group, an acyl group, an aryl group or an aralkyl group), with the proviso that both R1 and R2 are not a hydrogen atom at the same time; R3, R4 and R7 each independently represents a hydroxyl group or a hydroxyl group having a substituent; and R5 and R6 each independently represents a hydrogen atom, or a hydroxyl group or a hydroxyl group having a substituent, with the proviso that when one of R5 and R6 is a hydrogen atom, the other is a hydroxyl group or a hydroxyl group having a substituent.
    • 由下式(1)表示的碳 - 糖胺衍生物的酸加成盐:其中R1和R2各自独立地表示氢原子,或烷基,烯基,炔基,酰基,芳基 基团或可以具有以下取代基(I)或(II)中的一个或至少两个的芳烷基,或者R 1和R 2一起表示取代基(III)(R8〜R12各自独立地表示烷基, 烯基,炔基,酰基,芳基或芳烷基),条件是R 1和R 2同时不是氢原子; R 3,R 4和R 7各自独立地表示羟基或具有取代基的羟基; 并且R 5和R 6各自独立地表示氢原子或具有取代基的羟基或羟基,条件是当R 5和R 6中的一个为氢原子时,另一个为羟基或具有 取代基。
    • 7. 发明申请
    • PROMOTER FOR HARD TISSUE FORMATION
    • 促进器硬组织形成
    • US20110288048A1
    • 2011-11-24
    • US13196713
    • 2011-08-02
    • Takashi TAKATAYuji Kaneda
    • Takashi TAKATAYuji Kaneda
    • A61K31/727A61P19/10A61P19/00
    • A61K31/726A61K31/727A61K31/728
    • The present invention provides an agent which induces acceleration of hard tissue formation, acceleration of cell differentiation and increase in cellular alkaline phosphatase activity, by directly acting on the cell. Specifically, it provides a hard tissue formation promoter, a cell differentiation inducer and a cellular alkaline phosphatase activity reinforcing agent comprising, as an active ingredient, a glycosaminoglycan or a salt thereof that keeps sulfate group and has the characteristics of the following (1) and (2): (1) a basic structure is a disaccharide repeating structure consisting of a hexuronic acid residue and a glucosamine residue, (2) one or less of the position among a 2-position hydroxyl group of a hexuronic acid residue, a 6-position hydroxyl group of a glucosamine residue and a 2-position amino group of the glucosamine residue in the basic structure of the aforementioned (1) does not have the sulfate group. In this connection, it is preferable that the hexuronic acid residue is a glucuronic acid residue or an iduronic acid residue.
    • 本发明提供通过直接作用于细胞来诱导硬组织形成加速,细胞分化加速和细胞碱性磷酸酶活性增加的药剂。 具体地说,提供了一种硬组织形成促进剂,细胞分化诱导剂和细胞碱性磷酸酶活性增强剂,其包含作为活性成分的硫酸根基团的糖胺聚糖或其盐,具有以下(1)和 (2):(1)基本结构是由己糖酸残基和葡糖胺残基构成的二糖重复结构,(2)己糖醛酸残基的2位羟基中的1个以下的位置,6 上述(1)的碱性结构中的葡糖胺残基和葡糖胺残基的2-位氨基的 - 位羟基不具有硫酸基。 在这方面,优选的是,己糖酸残基是葡萄糖醛酸残基或艾杜糖醛酸残基。