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1. 发明申请

US20060009712A1 Dual lumen device for biopsy and treatment of breast tumors and method for use 审中-公开
标题翻译：用于乳腺肿瘤活检和治疗的双腔装置及其使用方法
公开(公告)号：US20060009712A1
公开(公告)日：2006-01-12
申请号：US11229250
申请日：2005-09-16
申请人： Kevin Van Bladel , Seth Stabinsky , Lisa Zindel , Glenn Foy , Paul Mikus
发明人： Kevin Van Bladel , Seth Stabinsky , Lisa Zindel , Glenn Foy , Paul Mikus
IPC分类号： A61B10/00 , A61B18/18 , A61B18/04
CPC分类号： A61B18/02 , A61B10/0041 , A61B10/0283 , A61B2018/00291
摘要： A device for diagnosis and treatment of tumors and lesions within the body. A cannula adapted to apply suction through the lumen of the catheter to the tumor or lesion is described. The lumen has a self sealing valve through which a cryoprobe is inserted while the suction is being applied. The cryoprobe is then inserted into the lesion, and operated to ablate the lesion.
摘要翻译：用于诊断和治疗体内肿瘤和病变的装置。描述了适于将吸引通过导管的内腔的套管到肿瘤或病变。管腔具有自密封阀，当施加抽吸时通过该自封闭阀插入冷冻探针。然后将冷冻探针插入病变，并操作以烧蚀病变。

2. 发明授权

US06945942B2 Device for biopsy and treatment of breast tumors 失效
标题翻译：用于乳腺肿瘤活检和治疗的装置
公开(公告)号：US06945942B2
公开(公告)日：2005-09-20
申请号：US10321136
申请日：2002-12-16
申请人： Kevin H. Van Bladel , Seth Stabinsky , Lisa Zindel , Glenn Foy , Paul Mikus
发明人： Kevin H. Van Bladel , Seth Stabinsky , Lisa Zindel , Glenn Foy , Paul Mikus
IPC分类号： A61B17/22 , A61B10/00 , A61B10/02 , A61B17/34 , A61B18/02
CPC分类号： A61B18/02 , A61B10/0041 , A61B10/0283 , A61B2018/00291
摘要： A device for diagnosis and treatment of tumors and lesions within the body. A cannula adapted to apply suction through the lumen of the catheter to the tumor or lesion is described. The lumen has a self sealing valve through which a cryoprobe is inserted while the suction is being applied. The cryoprobe is then inserted into the lesion, and operated to ablate the lesion.
摘要翻译：用于诊断和治疗体内肿瘤和病变的装置。描述了适于将吸引通过导管的内腔的套管到肿瘤或病变。管腔具有自密封阀，当施加抽吸时通过该自封闭阀插入冷冻探针。然后将冷冻探针插入病变，并操作以烧蚀病变。

3. 发明授权

US06494844B1 Device for biopsy and treatment of breast tumors 有权
标题翻译：用于乳腺肿瘤活检和治疗的装置
公开(公告)号：US06494844B1
公开(公告)日：2002-12-17
申请号：US09598124
申请日：2000-06-21
申请人： Kevin H. Van Bladel , Seth Stabinsky , Lisa Zindel , Glenn Foy , Paul Mikus
发明人： Kevin H. Van Bladel , Seth Stabinsky , Lisa Zindel , Glenn Foy , Paul Mikus
IPC分类号： A61B1000
CPC分类号： A61B18/02 , A61B10/0041 , A61B10/0283 , A61B2018/00291
摘要： A device for diagnosis and treatment of tumors and lesions within the body. A cannula adapted to apply suction through the lumen of the catheter to the tumor or lesion is described. The lumen has a self sealing valve through which a cryoprobe is inserted while the suction is being applied. The cryoprobe is then inserted into the lesion, and operated to ablate the lesion.
摘要翻译：用于诊断和治疗体内肿瘤和病变的装置。描述了适于将吸引通过导管的内腔的套管到肿瘤或病变。管腔具有自密封阀，当施加抽吸时通过该自封闭阀插入冷冻探针。然后将冷冻探针插入病变，并操作以烧蚀病变。

4. 发明申请

US20080132885A1 Methods for treating tissue sites using electroporation 审中-公开
标题翻译：使用电穿孔处理组织部位的方法
公开(公告)号：US20080132885A1
公开(公告)日：2008-06-05
申请号：US11945781
申请日：2007-11-27
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/12
CPC分类号： A61N1/327 , A61B5/0536 , A61B5/055 , A61B8/13 , A61B18/1206 , A61B18/1477 , A61B90/37 , A61B2018/00702 , A61B2018/00875 , A61N1/0512
摘要： Methods for treating a tissue site. Introducing at least first and second mono-polar electrodes to a tissue site of the patient. Positioning the at least first and second mono-polar electrodes at or near the tissue site. Applying an electric field in a controlled manner to the tissue site in an amount sufficient to produce electroporation of cells at the tissue site and below an amount that causes thermal damage to a majority of the tissue site.
摘要翻译：治疗组织部位的方法将至少第一和第二单极电极引入患者的组织部位。将至少第一和第二单极极放置在组织部位处或附近。以足以在组织部位产生细胞电穿孔并且低于对大部分组织部位造成热损伤的量的量以受控的方式将电场施加到组织部位。

5. 发明申请

US20080132884A1 Systems for treating tissue sites using electroporation 审中-公开
标题翻译：使用电穿孔处理组织部位的系统
公开(公告)号：US20080132884A1
公开(公告)日：2008-06-05
申请号：US11945772
申请日：2007-11-27
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/12
CPC分类号： A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/143 , A61N1/327
摘要： A systems for treating a tissue site. At least first and second mono-polar electrodes are configured to be introduced at or near a tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tissue site, to create necrosis of cells of the tissue site, but insufficient to create a thermal damaging effect to a majority of the tissue site.
摘要翻译：用于治疗组织部位的系统。至少第一和第二单极电极被配置为在患者的组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导组织部位中的细胞的电穿孔，以产生组织部位的细胞的坏死，但不足以对其产生热损伤作用大部分组织部位。

6. 发明授权

US06416545B1 Urological stent therapy system and method 失效
标题翻译：泌尿支架治疗系统及方法
公开(公告)号：US06416545B1
公开(公告)日：2002-07-09
申请号：US09699082
申请日：2000-10-27
申请人： Paul Mikus , William Moseley
发明人： Paul Mikus , William Moseley
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/04 , A61F2002/048 , A61F2250/0039 , A61L31/022 , A61L2400/16
摘要： A stent system and method for use in the prostate gland. The stent is made of a shape memory alloy such as nitinol, and has a low temperature martensite state, with a martensite transition temperature below body temperature, and a high temperature austenite state, with an austenite transition temperature at or above body temperature, and a memorized shape in the high temperature austenite state which is a helical coil of diameter large enough to hold the prostatic urethra open. The stent is used to heat the prostate and is left in the prostatic urethra while the prostate heals. After the prostate is substantially healed, the stent is cooled to its martensite state and is easily removed from the urethra.
摘要翻译：用于前列腺的支架系统和方法。该支架由镍钛诺镍等形状记忆合金制成，具有马氏体转变温度低于体温的低温马氏体状态和奥氏体转变温度在体温以上的高温奥氏体状态，在高温奥氏体状态下记忆形状，其为直径足够大以容纳前列腺尿道打开的螺旋线圈。支架用于加热前列腺，并在前列腺治疗时留在前列腺尿道。在前列腺基本上愈合之后，支架被冷却到其马氏体状态，并且容易地从尿道中移出。

7. 发明授权

US6139536A Urological stent therapy system and method 失效
公开(公告)号：US6139536A
公开(公告)日：2000-10-31
申请号：US360591
申请日：1999-07-26
申请人： Paul Mikus , William Moseley
发明人： Paul Mikus , William Moseley
IPC分类号： A61F2/00 , A61F2/04 , A61F2/88 , A61M31/00
CPC分类号： A61F2/88 , A61F2/04 , A61L31/022 , A61F2002/048 , A61F2250/0039 , A61L2400/16
摘要： A stent system and method for use in the prostate gland. The stent is made of a shape memory alloy such as nitinol, and has a low temperature martensite state, with a martensite transition temperature below body temperature, and a high temperature austenite state, with an austenite transition temperature at or above body temperature, and a memorized shape in the high temperature austenite state which is a helical coil of diameter large enough to hold the prostatic urethra open. The stent is used to heat the prostate and is left in the prostatic urethra while the prostate heals. After the prostate is substantially healed, the stent is cooled to its martensite state and is easily removed from the urethra.

8. 发明授权

US08114070B2 Methods and systems for treating BPH using electroporation 有权
标题翻译：使用电穿孔治疗BPH的方法和系统
公开(公告)号：US08114070B2
公开(公告)日：2012-02-14
申请号：US11166974
申请日：2005-06-24
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/18
CPC分类号： A61N1/327 , A61N1/0412 , A61N1/0476
摘要： A system for treating benign prostate hyperplasia (BPH) of a prostate. At least first and second mono-polar electrodes are configured to be introduced at or near a BPH tissue site of the prostate gland of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the BPH tissue site, to create necrosis of cells of the BPH tissue site, but insufficient to create a thermal damaging effect to a majority of the BPH tissue site.
摘要翻译：一种用于治疗前列腺良性前列腺增生（BPH）的系统。至少第一和第二单极电极被配置为在患者的前列腺的BPH组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导BPH组织部位中的细胞的电穿孔，以产生BPH组织部位的细胞坏死，但不足以产生热损伤作用到大多数BPH组织部位。

9. 发明申请

US20080021371A1 Methods and systems for treating restenosis using electroporation 有权
标题翻译：使用电穿孔治疗再狭窄的方法和系统
公开(公告)号：US20080021371A1
公开(公告)日：2008-01-24
申请号：US11864320
申请日：2007-09-28
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61N1/30
CPC分类号： A61B18/1492 , A61B2017/22002 , A61B2018/00214 , A61B2018/0022 , A61B2018/00422
摘要： A system is provided for reducing restenosis. A catheter apparatus is provided with at least first and second mono-polar electrodes positioned at an inflatable balloon. The balloon is sized to be positioned and expanded at a restenosis site. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply an electric field, in a controlled manner, to the restenosis site in an amount sufficient to produce electroporation of the restenosis site, and below an amount that causes thermal damage to the restenosis site.
摘要翻译：提供减少再狭窄的系统。导管装置设置有位于可充气气囊的至少第一和第二单极电极。气囊的大小可在再狭窄部位定位和扩张。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为以足以产生再狭窄部位的电穿孔并且低于对再狭窄部位造成热损伤的量以受控的方式将电场施加到再狭窄部位。

10. 发明申请

US20080015571A1 Methods and systems for treating tumors using electroporation 审中-公开
标题翻译：使用电穿孔治疗肿瘤的方法和系统
公开(公告)号：US20080015571A1
公开(公告)日：2008-01-17
申请号：US11864217
申请日：2007-09-28
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/00
CPC分类号： A61B18/1477 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00797 , A61B2018/143
摘要： A system is provided for treating tumor tissue sites of a patient. At least first and second mono-polar electrodes are configured to be introduced at or near the tumor tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tumor tissue site, to create necrosis of cells of the tumor tissue site, but insufficient to create a thermal damaging effect to a majority of the tumor tissue site.
摘要翻译：提供了一种用于治疗患者的肿瘤组织部位的系统。至少第一和第二单极电极被配置为在患者的肿瘤组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导肿瘤组织部位的细胞的电穿孔，以产生肿瘤组织部位的细胞坏死，但不足以产生热损伤作用到大多数肿瘤组织部位。

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