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1. 发明申请

US20060165647A1 Immunosuppressive substance adsorbent, extracorporeal cicrulation column and method of treating cancer 审中-公开
标题翻译：免疫抑制物质吸附剂，体外培养柱和治疗癌症的方法
公开(公告)号：US20060165647A1
公开(公告)日：2006-07-27
申请号：US10516015
申请日：2003-04-03
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： A61K38/18 , A61K31/785
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.
摘要翻译：本发明的目的是提供一种用于免疫抑制物质的吸附剂，该吸附剂可以高效地和选择性地从体液中直接吸附过量的免疫抑制物质，可以安全地进行体外灌注，并可用于治疗癌症。这种过量的免疫抑制物质可能参与癌细胞的生长。本发明的免疫抑制物质的吸附剂包括水不溶性载体和固定在水不溶性载体上的亲水性氨基。本发明的体外灌注柱含有本发明的吸附剂。本发明的治疗癌症的方法使用本发明的体外灌注柱进行体外灌注。

2. 发明授权

US08932590B2 Method of adsorbing transforming growth factor β 有权
标题翻译：吸附转化生长因子的方法
公开(公告)号：US08932590B2
公开(公告)日：2015-01-13
申请号：US13067627
申请日：2011-06-15
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： A61K39/395 , B01J20/26 , B01J20/28 , B01J20/32 , B01J20/30 , A61M1/36
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 m2 or more per gram.
摘要翻译：可以直接从体液吸附过量免疫抑制物质的免疫抑制物质吸附剂可以安全地进行体外灌注，可用于治疗癌症。过量的免疫抑制物质可能参与癌细胞的生长。用于免疫抑制物质的吸附剂包括固定在水不溶性载体上的水不溶性载体和亲水性氨基。体外灌注柱包含本发明的吸附剂。一种治疗癌症的方法使用体外灌注柱进行体外灌注。吸附转化生长因子的方法其与另一种蛋白质组合，包括吸收转化生长因子和bgr; 和含有每个氮原子上具有3〜18个碳原子的季铵基的水不溶性载体的吸附剂上的蛋白质，并且比表面积为0.1m 2以上。

3. 发明申请

US20110240560A1 Method of adsorbing transforming growth factor ß 审中-公开
标题翻译：吸附转化生长因子的方法
公开(公告)号：US20110240560A1
公开(公告)日：2011-10-06
申请号：US13067627
申请日：2011-06-15
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： B01D15/00
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 m2 or more per gram.
摘要翻译：可以直接从体液吸附过量免疫抑制物质的免疫抑制物质吸附剂可以安全地进行体外灌注，可用于治疗癌症。过量的免疫抑制物质可能参与癌细胞的生长。用于免疫抑制物质的吸附剂包括固定在水不溶性载体上的水不溶性载体和亲水性氨基。体外灌注柱包含本发明的吸附剂。一种治疗癌症的方法使用体外灌注柱进行体外灌注。吸附转化生长因子的方法其与另一种蛋白质组合，包括吸收转化生长因子和bgr; 和含有每个氮原子上具有3〜18个碳原子的季铵基的水不溶性载体的吸附剂上的蛋白质，并且比表面积为0.1m 2以上。

4. 发明授权

US08584869B2 Absorbent and column for extracorporeal circulation 有权
标题翻译：用于体外循环的吸收剂和柱
公开(公告)号：US08584869B2
公开(公告)日：2013-11-19
申请号：US11887388
申请日：2006-03-31
申请人： Masaaki Shimagaki , Yasufumi Yamamura , Katsuhisa Sato , Kazuo Teramoto , Takeshige Oozeki , Shigehisa Wada
发明人： Masaaki Shimagaki , Yasufumi Yamamura , Katsuhisa Sato , Kazuo Teramoto , Takeshige Oozeki , Shigehisa Wada
IPC分类号： B01D15/38 , B01D39/00 , B01D69/08 , B01D63/00
CPC分类号： B01D61/00 , A61M1/3679 , B01D67/0093 , B01J20/26 , B01J20/265 , B01J20/28004 , B01J20/28014 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/28069 , B01J20/28085 , B01J20/3248
摘要： The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of −20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.
摘要翻译：本发明提供一种吸收剂，其能够除去存在于血液中的细胞，包括活性白细胞如粒细胞和单核细胞，以及癌细胞，以及可以除去促进剩余细胞活化的细胞因子，并且还不需要担心压力损失，并且具有高配置稳定性。也就是说，本发明提供吸收血液中的粒细胞和单核细胞的吸收剂，吸收免疫抑制蛋白的癌症治疗用吸收剂和具有ζ电位的网状和无纺布的双层结构的吸收体， 20mV以上，以及含有填充有任何吸收剂的血液循环柱。

5. 发明申请

US20090275874A1 Absorbent and Column for Extracorporeal Circulation 有权
标题翻译：体外循环吸收柱和柱
公开(公告)号：US20090275874A1
公开(公告)日：2009-11-05
申请号：US11887388
申请日：2006-03-31
申请人： Masaaki Shimagaki , Yasufumi Yamamura , Katsuhisa Sato , Kazuo Teramoto , Takeshige Oozeki , Shigehisa Wada
发明人： Masaaki Shimagaki , Yasufumi Yamamura , Katsuhisa Sato , Kazuo Teramoto , Takeshige Oozeki , Shigehisa Wada
IPC分类号： A61M1/34
CPC分类号： B01D61/00 , A61M1/3679 , B01D67/0093 , B01J20/26 , B01J20/265 , B01J20/28004 , B01J20/28014 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/28069 , B01J20/28085 , B01J20/3248
摘要： The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of −20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.
摘要翻译：本发明提供一种吸收剂，其能够除去存在于血液中的细胞，包括活性白细胞如粒细胞和单核细胞，以及癌细胞，以及可以除去促进剩余细胞活化的细胞因子，并且还不需要担心压力损失，并且具有高配置稳定性。也就是说，本发明提供吸收血液中的粒细胞和单核细胞的吸收剂，吸收免疫抑制蛋白的癌症治疗用吸收剂和具有ζ电位的网状和无纺布的双层结构的吸收体， 20mV以上，以及含有填充有任何吸收剂的血液循环柱。

6. 发明授权

US4563425A Enzyme reaction method for isomerization of glucose to fructose 失效
标题翻译：葡萄糖异构化为果糖的酶反应方法
公开(公告)号：US4563425A
公开(公告)日：1986-01-07
申请号：US596101
申请日：1984-04-02
申请人： Toshio Yoshioka , Kazuo Teramoto , Masaharu Shimamura
发明人： Toshio Yoshioka , Kazuo Teramoto , Masaharu Shimamura
IPC分类号： C12N9/00 , C12N9/92 , C12P19/24 , C12N9/96 , C12N11/02 , C12N11/08
CPC分类号： C12N9/00 , C12N9/92 , C12P19/24
摘要： A metal ion that inhibits enzyme deactivation is bonded to a carrier and inhibits enzyme deactivation when contacted with a substrate for the enzyme. A carrier-bound metal ion such as ions of iron is particularly suitable for inhibiting deactivation of glucose isomerase when isomerizing glucose to fructose. Glucose isomerase life is remarkably prolonged by contacting carrier-bound iron ions with a glucose substrate solution prior to isomerizing with glucose isomerase.
摘要翻译：抑制酶失活的金属离子与载体结合，并在与酶的底物接触时抑制酶失活。载体结合的金属离子如铁离子特别适用于当将葡萄糖异构化成果糖时抑制葡萄糖异构酶的失活。在用葡萄糖异构酶异构化之前，通过使载体结合的铁离子与葡萄糖底物溶液接触，显着延长了葡萄糖异构酶的寿命。

7. 发明授权

US4347316A Process for isomerizing glucose to fructose 失效
标题翻译：将葡萄糖异构化为果糖的方法
公开(公告)号：US4347316A
公开(公告)日：1982-08-31
申请号：US266155
申请日：1981-05-22
申请人： Toshio Yoshioka , Kazuo Teramoto , Masaharu Shimamura
发明人： Toshio Yoshioka , Kazuo Teramoto , Masaharu Shimamura
IPC分类号： D06M13/00 , C12N11/06 , C12N11/08 , C12P19/24 , D06M13/02 , D06M13/322 , D06M13/325 , D06M13/402 , D06M13/41 , D06M13/412
CPC分类号： C12P19/24 , C12N11/08
摘要： An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having .beta.-aminopropionamidomethyl group as side chains represented by the formula I: ##STR1## wherein R.sub.1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R.sub.2 is selected from C(1-6) alkyl, C(2-6) hydroxyalkyl, ##STR2## (where X, Z.sub.1 and Z.sub.2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R.sub.1 and R.sub.2 form together with the N atom, to which R.sub.1 and R.sub.2 are bonded, heterocyclic structure of the formula: ##STR3## where A is --CH.sub.2 --, --O-- or --NR.sub.6 -- (wherein R.sub.6 is H or C(1-6) alkyl), and R.sub.3, R.sub.4 and R.sub.5 are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the .beta.-aminopropionamidomethyl group side chain of the organic polymeric material.

8. 发明授权

US4275156A Glucose isomerase immobilized product and process for preparing same 失效
标题翻译：葡萄糖异构酶固定化产物及其制备方法
公开(公告)号：US4275156A
公开(公告)日：1981-06-23
申请号：US114270
申请日：1980-01-22
申请人： Toshio Yoshioka , Kazuo Teramoto , Masaharu Shimamura
发明人： Toshio Yoshioka , Kazuo Teramoto , Masaharu Shimamura
IPC分类号： D06M13/00 , C12N11/06 , C12N11/08 , C12P19/24 , D06M13/02 , D06M13/322 , D06M13/325 , D06M13/402 , D06M13/41 , D06M13/412
CPC分类号： C12P19/24 , C12N11/08
摘要： An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having .beta.-aminopropionamidomethyl group as side chains represented by the formula I: ##STR1## wherein R.sub.1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R.sub.2 is selected from C(1-6) alkyl, C(2-6)hydroxyalkyl, ##STR2## (where X, Z.sub.1 and Z.sub.2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R.sub.1 and R.sub.2 form together with the N atom, to which R.sub.1 and R.sub.2 are bonded, a heterocylic structure of the formula: ##STR3## where A is --CH.sub.2 --, --O-- or --NR.sub.6 -- (wherein R.sub.6 is H or C(1-6) alkyl), and R.sub.3, R.sub.4 and R.sub.5 are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the .beta.-aminopropionamidomethyl group side chain of the organic polymeric material.
摘要翻译：提供了用于将葡萄糖异构化成果糖的酶活性产物。活性产物包含主要由具有β-氨基丙酰氨基甲基作为由式I表示的侧链的单乙烯基芳族化合物聚合物组成的有机聚合物：其中R 1选自H，C（1-6）烷基和C（ 2-6）羟烷基，R2选自C（1-6）烷基，C（2-6）羟烷基，其中X，Z1和Z2选自H和C（1-6）烷基，和 n为2至6），或R 1和R 2与R 1和R 2结合的N原子一起形成下式的杂环结构：其中A为-CH 2 - ， - O-或-NR 6 - （其中R 6是H或C（1-6）烷基），并且R 3，R 4和R 5选自H和甲基。有机聚合物材料具有固定有机聚合材料的β-氨基丙酰氨基甲基侧链的葡萄糖异构酶。

9. 发明申请

US20140017667A1 Immunosuppressive Cell-Capturing Material and Immunosuppressive Cell-Capturing Column 有权
标题翻译：免疫抑制细胞捕获材料和免疫抑制细胞捕获柱
公开(公告)号：US20140017667A1
公开(公告)日：2014-01-16
申请号：US14008538
申请日：2012-03-27
申请人： Kazumasa Ogasawara , Kazuo Teramoto , Yuji Ueda , Yasushi Itoh , Hirohito Ishigaki
发明人： Kazumasa Ogasawara , Kazuo Teramoto , Yuji Ueda , Yasushi Itoh , Hirohito Ishigaki
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61K35/14 , A61M1/3679 , B01J20/26 , B01J20/264 , B01J20/28042
摘要： This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.
摘要翻译：本发明公开了一种免疫抑制细胞捕获材料，其包含成型体，其包含：具有氨基的容易水解的缩聚物; 涂覆易水解的缩合聚合物的难溶于水的聚合物; 和配合物共轭的难以水解的聚合物，其涂覆不易水解的聚合物，其中配体是选自NH 2基，仲氨基，叔氨基，多胺残基，碱性环状多肽残基中的至少一种，氨基糖苷类化合物残基，氯喹，普氨氨酸，甲氟喹，咪喹莫特和制霉菌素，其中成型体中氨基的含量为150mol / g以下。本发明还公开了一种填充有捕获材料的免疫抑制细胞捕获柱。

10. 发明授权

US09127250B2 Immunosuppressive cell-capturing material and immunosuppressive cell-capturing column 有权
标题翻译：免疫抑制细胞捕获材料和免疫抑制细胞捕获柱
公开(公告)号：US09127250B2
公开(公告)日：2015-09-08
申请号：US14008538
申请日：2012-03-27
申请人： Kazumasa Ogasawara , Kazuo Teramoto , Yuji Ueda , Yasushi Itoh , Hirohito Ishigaki
发明人： Kazumasa Ogasawara , Kazuo Teramoto , Yuji Ueda , Yasushi Itoh , Hirohito Ishigaki
IPC分类号： C12N5/078 , B01J20/26 , B01J20/28 , A61M1/36 , A61K35/14
CPC分类号： C12N5/0634 , A61K35/14 , A61M1/3679 , B01J20/26 , B01J20/264 , B01J20/28042
摘要： This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.
摘要翻译：本发明公开了一种免疫抑制细胞捕获材料，其包含成型体，其包含：具有氨基的容易水解的缩聚物; 涂覆易水解的缩合聚合物的难溶于水的聚合物; 和配合物共轭的难以水解的聚合物，其涂覆不易水解的聚合物，其中配体是选自NH 2基，仲氨基，叔氨基，多胺残基，碱性环状多肽残基中的至少一种，氨基糖苷类化合物残基，氯喹，普氨氨酸，甲氟喹，咪喹莫特和制霉菌素，其中成型体中的氨基含量为150μmol/ g以下。本发明还公开了一种填充有捕获材料的免疫抑制细胞捕获柱。

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