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1. 发明授权

US4456601A 3-Chloro-pregnane derivatives and a process for the preparation thereof 失效
标题翻译： 3-氯 - 孕烷衍生物及其制备方法
公开(公告)号：US4456601A
公开(公告)日：1984-06-26
申请号：US434335
申请日：1982-10-14
申请人： Jozsef Toth , Gyorgy Hajos , Gyorgy Fekete , Istvan Horvath , Laszlo Szporny , Anna Boor nee Mezei , Peter Aranyi , Aniko Naray , Sandor Gorog , Sandor Holly , Csaba Molnar
发明人： Jozsef Toth , Gyorgy Hajos , Gyorgy Fekete , Istvan Horvath , Laszlo Szporny , Anna Boor nee Mezei , Peter Aranyi , Aniko Naray , Sandor Gorog , Sandor Holly , Csaba Molnar
IPC分类号： C07J5/00 , A61K31/58 , A61P29/00 , C07J71/00 , A61K31/56
CPC分类号： C07J71/0031
摘要： New .DELTA..sup.1,3,5 -3-chloro-pregnane derivatives of the general formula (I), ##STR1## wherein X is hydrogen atom, acetyl group or a chloroacetyl group, andY and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of them is other than hydrogen,are prepared by reacting a .DELTA..sup.1,4 -3-oxo-pregnane derivative of the general formula (II), ##STR2## wherein X' is acetyl group or a chloroacetyl group and Y and Z are as defined above, with a chloromethyleneiminium salt of the general formula (III), ##STR3## wherein A.sup.(-) is a salt-forming anion, in an aprotic solvent in the presence of a tertiary base, and, if desired, subjecting the resulting product to hydrolysis.The compounds of the general formula (I) exert antiphlogistic effects and can be used in the therapy for the treatment of inflammations.
摘要翻译：通式（I），其中X是氢原子，乙酰基或氯代乙酰基的新的具有通式（I）的1,3,5-三氯 - 孕烷衍生物，Y和Z代表氢原子或卤素原子，条件是它们中的至少一个不是氢，通过使通式（II）的DELTA 1,4-3-氧代 - 孕烷衍生物，其中X' 与乙酰基或氯乙酰基，Y和Z如上所定义，与通式（III）的氯亚甲基亚胺鎓盐，其中A（ - ）是形成盐的阴离子，在非质子传递溶剂在叔碱存在下，如果需要，使所得产物水解。通式（I）的化合物发挥消炎作用，可用于治疗炎症的治疗。

2. 发明授权

US5082835A Novel steroid diols, pharmaceutical compositions containing them and process for preparing same 失效
标题翻译：新型甾体糊剂，含有它们的药物组合物及其制备方法
公开(公告)号：US5082835A
公开(公告)日：1992-01-21
申请号：US491683
申请日：1990-03-09
申请人： Csaba Molnar , Gyorgy Hajos , Laszlo Szporny , Jozsef Toth , Arpad Kiraly , Anna Boor nee Mezei , Janos Csorgei , Kristina Szekely , Lilla Forgacs , Gyorgy Fekete , Bulcsu Herenyi , Sandor Holly , Jozsef Szunyog
发明人： Csaba Molnar , Gyorgy Hajos , Laszlo Szporny , Jozsef Toth , Arpad Kiraly , Anna Boor nee Mezei , Janos Csorgei , Kristina Szekely , Lilla Forgacs , Gyorgy Fekete , Bulcsu Herenyi , Sandor Holly , Jozsef Szunyog
IPC分类号： A61K31/57 , A61P29/00 , C07J5/00 , C07J13/00
CPC分类号： C07J5/0092 , C07J13/005
摘要： The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen, hydroxyl or trifluoroacetoxy group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group; and represents a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.

3. 发明授权

US5053404A Novel steroid derivatives, pharmaceutical compositions containing them and process for preparing same 失效
标题翻译：新型甾体衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：US5053404A
公开(公告)日：1991-10-01
申请号：US491682
申请日：1990-03-09
申请人： Csaba Molnar , Gyorgy Hajos , Laszlo Szporny , Jozsef Toth , Arpad Kiraly , Anna Boor nee Mezei , Janos Csorgei , Kristina Szekely , Lilla Forgacs , Gyorgy Fekete , Bulcsu Herenyi , Sandor Holly , Jozsef Szunyog
发明人： Csaba Molnar , Gyorgy Hajos , Laszlo Szporny , Jozsef Toth , Arpad Kiraly , Anna Boor nee Mezei , Janos Csorgei , Kristina Szekely , Lilla Forgacs , Gyorgy Fekete , Bulcsu Herenyi , Sandor Holly , Jozsef Szunyog
IPC分类号： A61K31/58 , A61P29/00 , C07J7/00 , C07J71/00
CPC分类号： C07J71/0031 , C07J7/008
摘要： The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen or hydroxyl group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group;R.sup.1 and R.sup.2, which are the same or different, stand for hydrogen or a C.sub.1-4 alkyl group; or one of R.sup.1 and R.sup.2 is hydrogen and the other is phenyl group; or R.sup.1 and R.sup.2 together form a C.sub.4-5 alkylene group;means a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.

4. 发明授权

US4368160A Process for preparing 17.alpha.-hydroxy-pregn-4-en-3,20-dione derivatives 失效
标题翻译：制备17α-羟基孕甾-4-en-3,20-二酮衍生物的方法
公开(公告)号：US4368160A
公开(公告)日：1983-01-11
申请号：US365015
申请日：1982-04-02
申请人： Anna Boor nee Mezei , Jozsef Toth , Tamas Szen , Laszlo Gabor , Piroska Major nee Fastner , Sandor Holly
发明人： Anna Boor nee Mezei , Jozsef Toth , Tamas Szen , Laszlo Gabor , Piroska Major nee Fastner , Sandor Holly
IPC分类号： C07J5/00 , A61K31/57 , B01J23/06 , B01J31/04 , C07B61/00 , C07J1/00 , C07J7/00
CPC分类号： C07J1/0048 , C07J1/0096 , C07J7/0045
摘要： The invention relates to a novel process for the preparation of pregnane derivatives of formula I, ##STR1## wherein R.sup.1 stands for a methyl or an ethyl group,R.sup.2 represents a hydrogen atom or a methyl group, andX is a hydrogen atom or a formyl or acetyl group, and the bond indicated by a dotted and a continuous line stands for a single or a double bond between the two neighboring carbon atoms.According to the invention a trifluoroacetate ester of formula II, ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, is reacted with formic acid or acetic acid in the presence of a catalytic amount of a mercury salt in a dipolar proton-free or basic solvent. The formyl or acetyl group being in the place of X can be split off in a way known per se.The process provides a novel advantageous method for building up the pregnane side chain characteristic of corticoids.
摘要翻译：本发明涉及一种制备式I的孕烷衍生物的新方法，其中R1代表甲基或乙基，R2代表氢原子或甲基，X是氢原子或甲酰基或乙酰基，并且由点和连续线表示的键表示两个相邻碳原子之间的单键或双键。根据本发明，将式II的三氟乙酸酯，其中R 1和R 2如上定义，在催化量的汞盐存在下，在偶极子质子中与甲酸或乙酸反应，游离或碱性溶剂。代替X的甲酰基或乙酰基可以以本身已知的方式分离。该过程提供了一种新颖有利的方法来建立皮质激素的孕烷侧链特征。

5. 发明授权

US4764613A 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process for preparing same 失效
标题翻译： 2,6-二（氯甲氧基 - 羰氧基甲基）吡啶及其制备方法
公开(公告)号：US4764613A
公开(公告)日：1988-08-16
申请号：US88875
申请日：1987-08-24
申请人： Jozsef Toth , Mate Kovatsits , Laszlo Csutoras , Gabor Szabo , Sandor Gorog , Ferenc Trischler , Sandor Holly , Erzsebet Francsics , Bela Losonczi , Gabor Havasi
发明人： Jozsef Toth , Mate Kovatsits , Laszlo Csutoras , Gabor Szabo , Sandor Gorog , Ferenc Trischler , Sandor Holly , Erzsebet Francsics , Bela Losonczi , Gabor Havasi
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61P9/10 , A61P29/00 , C07D213/28 , C07D213/30 , C07D213/55
CPC分类号： C07D213/30
摘要： The invention relates to the novel 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine of the formula (I) ##STR1## as well as a process for the preparation of this compound, which is a useful intermediate in the preparation of the anti-atherosclerotic 2,6-bis(hydroxymethyl)pyridine bis(N-methylcarbamate) (pyridinolcarbamate) and other drugs.According to the invention, the compound of the formula (I) is prepared by reacting 2,6-bis(hydroxymethyl)pyridine of the formula (II) ##STR2## with chloromethyl chloroformate of the formula (III) ##STR3## in a polar-aprotic, water-immiscible organic solvent, in the presence of a basic substance between about -30.degree. C. and +10.degree. C.
摘要翻译：本发明涉及式（I）的新型2,6-双（氯甲氧基 - 羰基氧基甲基）吡啶（I）以及制备该化合物的方法，该方法是制备抗动脉粥样硬化的2,6-双）羟甲基）吡啶双（N-甲基氨基甲酸酯）（吡啶基氨基甲酸酯）等药物。根据本发明，式（I）化合物通过式（II）的2,6-二羟甲基吡啶与式（III）的氯甲酸酯反应来制备，（III）在极性 - 非质子，水不混溶的有机溶剂中，在约-30℃至+ 10℃的碱性物质存在下

6. 发明授权

US4482494A Process for preparing 17.alpha.-hydroxy-pregn-4-en-3,20-dione 失效
标题翻译：制备17α-羟基孕甾-4-en-3,20-二酮的方法
公开(公告)号：US4482494A
公开(公告)日：1984-11-13
申请号：US435494
申请日：1982-10-20
申请人： Anna Boor , Jozsef Toth , Tamas Szen , Laszlo Gabor , Piroska Major nee Feistner , Sandor Holly
发明人： Anna Boor , Jozsef Toth , Tamas Szen , Laszlo Gabor , Piroska Major nee Feistner , Sandor Holly
IPC分类号： C07J1/00 , C07J7/00 , C07J5/00
CPC分类号： C07J1/0096 , C07J1/0048 , C07J7/0045
摘要： The invention relates to a novel process for the preparations of pregnane derivatives of formula I, ##STR1## wherein R.sup.1 stands for a methyl or an ethyl group,R.sup.2 represents a hydrogen atom or a methyl group, andX is a hydrogen atom or a formyl or acetyl group, and the bond indicated by a dotted and a continuous line stands for a single or a double bond beween the two neighboring carbon atoms.According to the invention a trifluoroacetate ester of formula II, ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, is reacted with formic acid or acetic acid in the presence of a catalytic amount of a mercury salt in a dipolar proton-free or basic solvent. The formyl or acetyl group being in the place of X can be split off in a way known per se.The process provides a novel advantageous method for building up the pregnane side chain characteristic of corticoids.
摘要翻译：本发明涉及制备式I的孕烷衍生物的新方法，其中R1代表甲基或乙基，R2代表氢原子或甲基，X是氢原子或甲酰基或乙酰基，并且由点和连续线表示的键代表在两个相邻碳原子之间的单键或双键。根据本发明，将式II的三氟乙酸酯，其中R 1和R 2如上定义，在催化量的汞盐存在下，在偶极子质子中与甲酸或乙酸反应，游离或碱性溶剂。代替X的甲酰基或乙酰基可以以本身已知的方式分离。该过程提供了一种新颖有利的方法来建立皮质激素的孕烷侧链特征。

7. 发明授权

US08289201B2 Method and apparatus for using non-linear ground penetrating radar to detect objects located in the ground 有权
标题翻译：使用非线性地面穿透雷达来检测位于地面的物体的方法和装置
公开(公告)号：US08289201B2
公开(公告)日：2012-10-16
申请号：US11758785
申请日：2007-06-06
申请人： Sandor Holly , Nicholas Koumvakalis , Robert Alan Smith
发明人： Sandor Holly , Nicholas Koumvakalis , Robert Alan Smith
IPC分类号： G01S13/04 , G01V3/12 , G01S13/00 , G01V3/00
CPC分类号： G01S13/885 , F41H11/136 , G01S7/41 , G01V3/17
摘要： A method and apparatus for detecting objects located underground. In one advantageous embodiment, a detection system detects objects having electrical non-linear characteristics located underground. The detection system comprises a transmitter unit, a receiver, and a processor. The transmitter transmits a plurality of pulsed radio frequency signals having a first frequency and a second frequency into a ground. The receiver monitors for a response radio frequency signal having a frequency equal to a difference between the first frequency and a second frequency, wherein the response radio frequency signal is generated by an object having the non-linear conductive characteristics in response to receiving the plurality of electromagnetic signals. The processor is connected to the transmitter unit and the receiver, wherein the processor controls an operation of the transmitter unit and the receiver, wherein the object is detected when the response radio frequency signal is detected by the receiver.
摘要翻译：一种用于检测位于地下的物体的方法和装置。在一个有利的实施例中，检测系统检测具有位于地下的电气非线性特性的物体。检测系统包括发射器单元，接收器和处理器。发射机将具有第一频率和第二频率的多个脉冲射频信号发射到地面中。接收机监视具有等于第一频率和第二频率之间的差的频率的响应射频信号，其中响应于具有非线性导电特性的对象响应于接收到多个电磁信号。处理器连接到发射机单元和接收机，其中处理器控制发射机单元和接收机的操作，其中当接收机检测到响应射频信号时检测对象。

8. 发明授权

US08179149B1 Electromagnetic fence 有权
标题翻译：电磁围栏
公开(公告)号：US08179149B1
公开(公告)日：2012-05-15
申请号：US13106107
申请日：2011-05-12
申请人： Sandor Holly
发明人： Sandor Holly
IPC分类号： G01R27/04 , G01R27/32
CPC分类号： G08B13/2497
摘要： A system and method can use a transmission line to remotely detect border violations. For example, the transmission line can be configured to use time domain reflectometry to determine when a person and/or object crosses a border. The border can be the border of a country or the perimeter of a facility such as an airport, for example.
摘要翻译：系统和方法可以使用传输线来远程检测边界违规。例如，可以将传输线配置为使用时域反射计来确定人和/或物体何时穿过边界。边界可以是一个国家的边界，也可以是诸如机场等设施的边界。

9. 发明授权

US07142147B2 Method and apparatus for detecting, locating, and identifying microwave transmitters and receivers at distant locations 有权
标题翻译：用于在远处的位置检测，定位和识别微波发射器和接收器的方法和装置
公开(公告)号：US07142147B2
公开(公告)日：2006-11-28
申请号：US10994811
申请日：2004-11-22
申请人： Sandor Holly
发明人： Sandor Holly
IPC分类号： G01S7/38
CPC分类号： G01S13/74 , G01S7/021 , G01S13/04 , G01S13/42 , G01S13/46 , G01V8/005
摘要： Methods and apparatuses for detecting, locating, and identifying microwave transmitters and receivers at distant locations are disclosed. First and second electromagnetic beams at first and second frequencies, respectively, are transmitted in first and second directions. The second frequency is offset from the first frequency to define an interference difference frequency. As such, the first and second electromagnetic beams interfere at a far field distance corresponding to an intersection of the first and second electromagnetic beams. In the far field the beams interfere with microwave devices that reradiate a return radiation at the difference frequency. The methods and apparatuses detect the return radiation at the difference frequency, such as by way of a receiver, and locate the interference zone to determine the location of the microwave device, such as by a processor.
摘要翻译：公开了用于在远处位置检测，定位和识别微波发射器和接收器的方法和装置。分别在第一和第二频率的第一和第二电磁波在第一和第二方向上传送。第二频率与第一频率偏移以限定干扰差频率。这样，第一和第二电磁波束在对应于第一和第二电磁波束的相交处的远场距离处干扰。在远场中，光束干扰以不同频率重新辐射返回辐射的微波装置。方法和装置例如通过接收机检测差分频率处的返回辐射，并定位干扰区以确定微波设备的位置，例如由处理器。

10. 发明申请

US20050179606A1 FOCAL PLANE ARRAY FOR THZ IMAGER AND ASSOCIATED METHODS 有权
标题翻译：用于THZ图像和相关方法的FOCAL PLANE ARRAY
公开(公告)号：US20050179606A1
公开(公告)日：2005-08-18
申请号：US10780535
申请日：2004-02-16
申请人： Sandor Holly
发明人： Sandor Holly
IPC分类号： H01Q1/24 , H01Q15/00 , H01Q19/06 , H01Q21/29 , H01Q21/30
CPC分类号： H01Q19/062 , H01Q1/248 , H01Q15/002 , H01Q21/29 , H01Q21/30
摘要： A high-frequency imaging system for the millimeter and submillimeter radiation includes a high frequency lens to image an object at its focal plane. The object emits electromagnetic radiation at a first frequency above the microwave band of the electromagnetic spectrum. A local oscillator generates an electromagnetic beam at a second frequency to illuminate a plurality of dual-frequency antennas at the focal plane of the lens. Intermodulation of first and second frequencies generates a signal distribution of a third frequency over the focal plane, which represents an image. Also, a method of providing an image at the third frequency of an object emitting electromagnetic radiation at a first frequency is provided. The method includes imaging the electromagnetic radiation at the first frequency from each point of the object onto the focal plane. An electromagnetic beam is transmitted to illuminate all elements of the focal plane array.
摘要翻译：用于毫米和亚毫米辐射的高频成像系统包括在其焦平面上对物体进行成像的高频透镜。物体以高于电磁光谱的微波带的第一频率发射电磁辐射。本地振荡器以第二频率产生电磁波束，以照射透镜焦平面处的多个双频天线。第一和第二频率的互调产生表示图像的焦平面上的第三频率的信号分布。此外，提供了以第一频率提供发射电磁辐射的物体的第三频率处的图像的方法。该方法包括将来自物体的每个点的第一频率的电磁辐射成像到焦平面上。传输电磁波束照射焦平面阵列的所有元件。

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